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  1. Article: Lumbar epidural blood patch: An effective treatment for intracranial hypotension.

    Leung, Lok Wa Laura / Chan, Yuen Chung David / Chan, Tat Ming Danny

    Surgical neurology international

    2022  Volume 13, Page(s) 517

    Abstract: Background: The literature has demonstrated the efficacy of lumbar epidural blood patch (LEBP) in the management of spontaneous intracranial hypotension (SIH). However, the underlying pathophysiology of such management remains unclear. In this study, we ...

    Abstract Background: The literature has demonstrated the efficacy of lumbar epidural blood patch (LEBP) in the management of spontaneous intracranial hypotension (SIH). However, the underlying pathophysiology of such management remains unclear. In this study, we aim to evaluate the utility of LEBP injections in the management of SIH and develop a potential management algorithm used in the triage and management of SIH patients.
    Methods: We retrospectively examined the clinical case notes of 14 patients with SIH (age: 25-69 years) who were managed with LEBP injections during the year of 2016-2021. We evaluated the presenting symptoms of each selected patient and radiological findings as well as treatment outcomes. Our aim is to evaluate the effectiveness of LEBP in the treatment of SIH patients through follow-up clinical and imaging assessment.
    Results: About 93% of patients describe the presence of headache at presentation, while 43% describe it as being of an orthostatic nature. All patients demonstrated typical findings on magnetic resonance imaging brain. Treatment success assessed through symptomatic improvement and radiological resolution was found in 85% of our patients at a 2-month interval.
    Conclusion: LEBP injection is an effective method of management in patients with a diagnosis of SIH. It should be considered in all SIH patients irrespective of whether a "dural leak" can be localized through radiological investigations.
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_795_2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Urokinase Is Safe and Effective in Reducing Recurrence in Chronic Subdural Hematoma After Burr-Hole Drainage.

    Cheung, Eric Yuk Hong / Chan, David Yuen Chung / Lee, Michael Wing Yan / Hung, Cheung Yu / Pang, Kai Yuen

    World neurosurgery

    2022  Volume 164, Page(s) e1209–e1213

    Abstract: Objective: This study aimed to evaluate the safety and efficacy of subdural urokinase in reducing the recurrence of chronic subdural hematoma (cSDH).: Methods: Consecutive adults with cSDH and burr-hole drainage from 1 January 2013 to 31 December ... ...

    Abstract Objective: This study aimed to evaluate the safety and efficacy of subdural urokinase in reducing the recurrence of chronic subdural hematoma (cSDH).
    Methods: Consecutive adults with cSDH and burr-hole drainage from 1 January 2013 to 31 December 2017 were retrospectively analyzed. Clinical records, radiologic images, laboratory data, and medication records were reviewed. The primary outcome was the recurrence rate of cSDH in patients with or without urokinase instillation. Secondary outcomes included complication rates such as infection and acute intracranial hemorrhage. Univariate and multivariate analyses were conducted to identify independent factors associated with cSDH recurrence.
    Results: A total of 297 consecutive patients were identified for analysis. The average dosage of urokinase instillation via the subdural drain into the subdural space was 15,800 units (5000-60,000 units) over a mean duration of 2 days (1-6 days). The symptomatic recurrence rate of cSDH was significantly lower with urokinase at 3.0% versus 11.7% with no urokinase (odds ratio: 0.234; P = 0.022). Univariate analysis and multivariate analysis showed that bilateral cSDH and the presence of underlying liver disease were significantly associated with higher recurrence, while the instillation of urokinase was significantly and independently associated with lower recurrence (odds ratio = 0.311; P = 0.005). Complication rates including infection and hemorrhage were comparable with patients with or without urokinase and had no significant difference.
    Conclusions: Instillation of urokinase was safe for patients with cSDH. The recurrence rate of cSDH was significantly lower with urokinase.
    MeSH term(s) Adult ; Drainage/adverse effects ; Drainage/methods ; Hematoma, Subdural, Chronic/surgery ; Humans ; Recurrence ; Retrospective Studies ; Treatment Outcome ; Trephining/methods ; Urokinase-Type Plasminogen Activator/therapeutic use
    Chemical Substances Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.05.143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-COVID-19 Pandemic Rebound of Macrolide-Resistant

    Xing, Fan-Fan / Chiu, Kelvin Hei-Yeung / Deng, Chao-Wen / Ye, Hai-Yan / Sun, Lin-Lin / Su, Yong-Xian / Cai, Hui-Jun / Lo, Simon Kam-Fai / Rong, Lei / Chen, Jian-Liang / Cheng, Vincent Chi-Chung / Lung, David Christopher / Sridhar, Siddharth / Chan, Jasper Fuk-Woo / Hung, Ivan Fan-Ngai / Yuen, Kwok-Yung

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital were tested for common respiratory viruses ... ...

    Abstract The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital were tested for common respiratory viruses and
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13030262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Deep brain stimulation in a young child with

    Fung, Eva Lai-Wah / Mo, Chung-Yin / Fung, Sharon Tsui-Hang / Chan, Anne Yin-Yan / Lau, Ka-Yee / Chan, Emily Kit-Ying / Chan, David Yuen-Chung / Zhu, Xian-Lun / Chan, Danny Tat-Ming / Poon, Wai-Sang

    Surgical neurology international

    2022  Volume 13, Page(s) 285

    Abstract: Background: GNAO1: Case description: A 4-year-old girl diagnosed to have : Conclusion: DBS should be considered early in the treatment of drug-resistant movement disorders in young children ... ...

    Abstract Background: GNAO1
    Case description: A 4-year-old girl diagnosed to have
    Conclusion: DBS should be considered early in the treatment of drug-resistant movement disorders in young children with
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_166_2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters.

    Li, Can / Song, Wenchen / Chan, Jasper Fuk-Woo / Chen, Yanxia / Liu, Feifei / Ye, Zhanhong / Lam, Alvin Hiu-Chung / Cai, Jianpiao / Lee, Andrew Chak-Yiu / Wong, Bosco Ho-Yin / Chu, Hin / Lung, David Christopher / Sridhar, Siddharth / Chen, Honglin / Zhang, Anna Jin-Xia / Yuen, Kwok-Yung

    Emerging microbes & infections

    2023  Volume 12, Issue 1, Page(s) 2207678

    Abstract: Summary: Intranasal infection of newly-weaned Syrian hamsters by SARS-CoV-2 Omicron variants can lead to brain inflammation and neuron degeneration with detectable low level of viral load and sparse expression of viral nucleoprotein. ...

    Abstract Summary: Intranasal infection of newly-weaned Syrian hamsters by SARS-CoV-2 Omicron variants can lead to brain inflammation and neuron degeneration with detectable low level of viral load and sparse expression of viral nucleoprotein.
    MeSH term(s) Animals ; Cricetinae ; COVID-19 ; SARS-CoV-2 ; Encephalitis ; Mesocricetus ; Brain
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2207678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Letter: Rongeurs, Neurosurgeons, and COVID-19: How Do We Protect Health Care Personnel During Neurosurgical Operations in the Midst of Aerosol-Generation From High-Speed Drills?

    Chan, David Yuen Chung / Chan, Danny Tat Ming / Mak, Wai Kit / Wong, George Kwok Chu / Poon, Wai Sang

    Neurosurgery

    2020  Volume 87, Issue 2, Page(s) E164–E165

    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transmission of Omicron (B.1.1.529) - SARS-CoV-2 Variant of Concern in a designated quarantine hotel for travelers: a challenge of elimination strategy of COVID-19.

    Wong, Shuk-Ching / Au, Albert Ka-Wing / Chen, Hong / Yuen, Lithia Lai-Ha / Li, Xin / Lung, David Christopher / Chu, Allen Wing-Ho / Ip, Jonathan Daniel / Chan, Wan-Mui / Tsoi, Hoi-Wah / To, Kelvin Kai-Wang / Yuen, Kwok-Yung / Cheng, Vincent Chi-Chung

    The Lancet regional health. Western Pacific

    2021  Volume 18, Page(s) 100360

    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2021.100360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Chronic subdural haematoma during the COVID-19 lockdown period: late presentation with a longer interval from the initial head injury to the final presentation and diagnosis.

    Chan, David Yuen Chung / Poon, Wai Sang / Chan, Danny Tat Ming / Mak, Wai Kit / Wong, George Kwok Chu

    Chinese neurosurgical journal

    2021  Volume 7, Issue 1, Page(s) 4

    Abstract: Background: The COVID-19 novel coronavirus is contagious, and the mortality is higher in the elderly population. Lockdown in different parts of the world has been imposed since January 2020. Chronic subdural haematoma (cSDH) has a unique natural history ...

    Abstract Background: The COVID-19 novel coronavirus is contagious, and the mortality is higher in the elderly population. Lockdown in different parts of the world has been imposed since January 2020. Chronic subdural haematoma (cSDH) has a unique natural history in which symptoms can be non-specific, and the onset is insidious. This study aims to evaluate the impact of the COVID-19 pandemic on the presentation of cSDH.
    Methods: Consecutive adult cSDH patients admitted from 1 March 2020 to 30 April 2020 were reviewed. Exclusion criteria including those who had no definite history of head injury or the diagnosis of cSDH were made from a scheduled follow-up scan. Corresponding data during the same period in 2019 were reviewed for comparison. The primary outcome was the interval between the initial head injury and the final radiological diagnosis of cSDH. Secondary outcomes include Markwalder chronic subdural haematoma grade upon admission, length of stay in the acute hospital, and the modified Rankin scale (mRS) upon discharge.
    Results: For the primary outcome, the average interval between head injury and the diagnosis of cSDH was significantly longer at 56.6 days (49 to 74 days, SD 9.83 days) during the period from March to April 2020, versus 29.4 days (17 to 42 days, SD 8.59 days) in 2019 for the corresponding period (p = 0.00703). There was no significant difference in the functional outcome upon discharge.
    Conclusions: cSDH patients can present late during the COVID-19 lockdown period. The functional outcome was comparable when operations for drainage were timely performed.
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2836334-6
    ISSN 2057-4967 ; 2057-4967
    ISSN (online) 2057-4967
    ISSN 2057-4967
    DOI 10.1186/s41016-020-00229-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Semi-Autonomous Stereotactic Brain Biopsy Robotic System With Enhanced Surgical Safety and Surgeon-Robot Collaboration.

    Xian, Yitian / Zhang, Xue / Luo, Xiao / Li, Jixiu / Zou, Limin / Xie, Ke / Li, Jian / Li, Yehui / Huang, Yisen / Chan, Danny Tat Ming / Chan, David Yuen Chung / Li, Zheng

    IEEE transactions on bio-medical engineering

    2023  Volume 70, Issue 12, Page(s) 3288–3299

    Abstract: Objective: Despite benefits brought by recent neurosurgical robots, surgical safety and surgeon-robot collaboration remain significant challenges. In this article, we analyze and address these problems in the context of brain biopsy, by proposing a semi- ...

    Abstract Objective: Despite benefits brought by recent neurosurgical robots, surgical safety and surgeon-robot collaboration remain significant challenges. In this article, we analyze and address these problems in the context of brain biopsy, by proposing a semi-autonomous system.
    Methods: A robotic module is designed for the automation of all the brain biopsy procedures, and a biopsy cannula with tissue blocker is developed to avoid tissue excess and haemorrhage. In addition, two methods are proposed for surgical safety and surgeon-robot collaboration enhancement. First, a priority-based control framework is proposed for neuronavigation with simultaneous optical tracking line-of-sight maintenance and surgeon avoidance. Second, after neuronavigation, an adaptive reconfiguration method is developed to optimize the arm angle of KUKA robot based on the surgeon's pose, for workspace interference minimization, high robot dexterity, and joint-limit avoidance.
    Result: Effectiveness of the proposed solution demonstrated by simulations and experiments.
    Conclusion: The system can perform automatic navigation with simultaneous optical tracking maintenance and surgeon avoidance, autonomous brain biopsy, and adaptive reconfiguration for workspace interference minimization.
    Significance: This work improves existing neurosurgical systems, in terms of autonomy level from mechanical guidance to task autonomy, surgical safety, and surgeon-robot collaboration.
    MeSH term(s) Humans ; Robotics ; Robotic Surgical Procedures/methods ; Biopsy ; Surgeons ; Brain/surgery
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2023.3281590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Stool protein mass spectrometry identifies biomarkers for the early detection of diffuse-type gastric cancer.

    Ho, Chi-Lee C / Gilbert, Michael B / Urtecho, Guillaume / Lee, Hyoungjoo / Drew, David A / Klempner, Samuel J / Cho, Jin S / Ryan, Thomas J / Rustgi, Naryan / Lee, Hyuk / Lee, Jeeyun / Caraballo, Alexander / Magicheva-Gupta, Marina V / Rios, Carmen / Shin, Alice E / Tseng, Yuen-Yi / Davis, Jeremy L / Chung, Daniel C / Chan, Andrew T /
    Wang, Harris H / Ryeom, Sandra

    Cancer prevention research (Philadelphia, Pa.)

    2024  

    Abstract: There is a high unmet need for early detection approaches for diffuse gastric cancer (DGC). We examined whether the stool proteome of mouse models of GC or individuals with hereditary diffuse GC (HDGC) have utility as biomarkers for early detection. ... ...

    Abstract There is a high unmet need for early detection approaches for diffuse gastric cancer (DGC). We examined whether the stool proteome of mouse models of GC or individuals with hereditary diffuse GC (HDGC) have utility as biomarkers for early detection. Proteomic mass spectrometry of stool from a genetically engineered mouse model driven by oncogenic KrasG12D and loss of p53 and Cdh1 in gastric parietal cells (known as TCON mice) identified differentially abundant proteins compared to littermate controls. Immunoblot assays validated a panel of proteins including actinin alpha 4 (ACTN4), N-acylsphingosine amidohydrolase 2 (ASAH2), dipeptidyl peptidase 4 (DPP4), and valosin-containing protein (VCP) as enriched in TCON stool compared to littermate control stool. Immunofluorescence analysis of these proteins in TCON stomach sections revealed increased protein expression as compared to littermate controls. Proteomic mass spectrometry of stool obtained from HDGC patients with CDH1 mutations identified increased expression of ASAH2, DPP4, VCP, lactotransferrin (LTF), and tropomyosin-2 (TPM2) relative to stool from healthy sex and age-matched donors. Chemical inhibition of ASAH2 using C6-urea ceramide was toxic to GC cell lines and patient derived-GC organoids. This toxicity was reversed by adding downstream products of the S1P synthesis pathway, suggesting a dependency on ASAH2 activity in GC. An exploratory analysis of the HDGC stool microbiome identified features which correlated with patient tumors. Here we provide evidence supporting the potential of analyzing stool biomarkers for the early detection of DGC.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-23-0449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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