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  1. Article ; Online: Delivery of Adeno-Associated Virus Vectors to the Central Nervous System for Correction of Single Gene Disorders.

    Daci, Rrita / Flotte, Terence R

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Genetic disorders of the central nervous system (CNS) comprise a significant portion of disability in both children and adults. Several preclinical animal models have shown effective adeno-associated virus (AAV) mediated gene transfer for either ... ...

    Abstract Genetic disorders of the central nervous system (CNS) comprise a significant portion of disability in both children and adults. Several preclinical animal models have shown effective adeno-associated virus (AAV) mediated gene transfer for either treatment or prevention of autosomal recessive genetic disorders. Owing to the intricacy of the human CNS and the blood-brain barrier, it is difficult to deliver genes, particularly since the expression of any given gene may be required in a particular CNS structure or cell type at a specific time during development. In this review, we analyzed delivery methods for AAV-mediated gene therapy in past and current clinical trials. The delivery routes analyzed were direct intraparenchymal (IP), intracerebroventricular (ICV), intra-cisterna magna (CM), lumbar intrathecal (IT), and intravenous (IV). The results demonstrated that the dose used in these routes varies dramatically. The average total doses used were calculated and were 1.03 × 10
    MeSH term(s) Adult ; Animals ; Child ; Infant ; Humans ; Dependovirus/genetics ; Central Nervous System ; Blood-Brain Barrier ; Administration, Intravenous ; Genetic Therapy
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Conference proceedings: Evolving Trends in the Management of Paraclinoid Aneurysms: A Review of the Literature and Examination of a Current Dual-Trained Practice

    Daci, Rrita / Carvahlo, Brian / Amenta, Peter S.

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780387
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Letter: Safety Considerations for Neurosurgical Procedures During the COVID-19 Pandemic.

    Daci, Rrita / Natarajan, Sabareesh K / Johnson, Mark D

    Neurosurgery

    2020  Volume 87, Issue 2, Page(s) E239–E240

    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

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  4. Article: Spontaneous

    Smith, Jordan L / Cruz-Gordillo, Peter / Luiselli, Gabrielle / Daci, Rrita / Owusu-Adjei, Brittany / Ogagan, Charles / Moses, Ziev B

    Clinical case reports

    2022  Volume 10, Issue 1, Page(s) e05216

    Abstract: Previously viewed as a culture contaminant, ...

    Abstract Previously viewed as a culture contaminant,
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.5216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diffusely invasive supratentorial rosette-forming glioneuronal tumor: illustrative case.

    Owusu-Adjei, Brittany / Mietus, Constance J / Lim, Jeewoo Chelsea / Lambert, William / Daci, Rrita / Cachia, David / Smith, Thomas W / Amenta, Peter S

    Journal of neurosurgery. Case lessons

    2023  Volume 6, Issue 16

    Abstract: Background: Rosette-forming glioneuronal tumors (RGNTs) are rare tumors composed of mixed glial and neurocytic components. Most lesions are confined to the posterior fossa, especially in the region of the fourth ventricle, in young adults. In few ... ...

    Abstract Background: Rosette-forming glioneuronal tumors (RGNTs) are rare tumors composed of mixed glial and neurocytic components. Most lesions are confined to the posterior fossa, especially in the region of the fourth ventricle, in young adults. In few instances, diffuse involvement of the supratentorial region is identified, thereby creating significant challenges in diagnosis, surgical intervention, and prognostication.
    Observations: The authors present a 23-year-old female with chronic headaches, papilledema, and hydrocephalus who underwent radiographic evaluation revealing obstructive hydrocephalus and diffuse supratentorial enhancing and nonenhancing cystic and nodular lesions. The patient underwent a right frontal craniotomy and septostomy. An exophytic nonenhancing right frontal horn lesion was resected, and an enhancing third-ventricular lesion was biopsied. Final pathology of both of the lesions sampled was consistent with RGNT. Next-generation sequencing demonstrated tumor alterations in the FGFR-1 and PIK3CA genes. Targeted therapy with the FGFR inhibitor erdafitinib demonstrated a partial remission.
    Lessons: Diffuse supratentorial spread of RGNT is an extremely rare presentation of an already uncommon pathology. In some cases, gross-total resection may not be feasible. Goals of surgery include acquiring tissue for diagnosis, maximizing safe resection, and treating any associated hydrocephalus. FGFR inhibitors may be of benefit in cases of disease progression.
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE23435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Letter

    Daci, Rrita / Natarajan, Sabareesh K / Johnson, Mark D

    Neurosurgery

    Safety Considerations for Neurosurgical Procedures During the COVID-19 Pandemic

    2020  Volume 87, Issue 2, Page(s) E239–E240

    Keywords Surgery ; Clinical Neurology ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa196
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

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  8. Article ; Online: Utilization of anterior lumbar interbody fusion for severe kyphotic deformity secondary to Pott's disease: illustrative case.

    Luiselli, Gabrielle / Daci, Rrita / Cruz-Gordillo, Peter / Panda, Ashwin / Sorour, Omar / Slavin, Justin

    Journal of neurosurgery. Case lessons

    2021  Volume 2, Issue 4, Page(s) CASE21126

    Abstract: Background: Spinal tuberculosis may result in severe kyphotic deformity. Effective restoration of lordosis and correction of sagittal balance often requires invasive osteotomies associated with significant morbidity. The advantages of focusing on ... ...

    Abstract Background: Spinal tuberculosis may result in severe kyphotic deformity. Effective restoration of lordosis and correction of sagittal balance often requires invasive osteotomies associated with significant morbidity. The advantages of focusing on symptomatic management and staging in the initial treatment of these deformities have not been well reported to date.
    Observations: The authors reported the case of a 64-year-old Vietnamese woman with a history of spinal tuberculosis who underwent anterior lumbar interbody fusion (ALIF) for symptomatic treatment of L5-S1 radiculopathy resulting from fixed kyphotic deformity. Postoperatively, the patient experienced near immediate symptom improvement, and radiographic evidence at 1-year follow-up showed continued lordotic correction of 30° as well as stable sagittal balance.
    Lessons: In this case, an L5-S1 ALIF was sufficient to treat the patient's acute symptoms and provided satisfactory correction of a tuberculosis-associated fixed kyphotic deformity while effectively delaying more invasive measures, such as a vertebral column resection. Patients with adult spinal deformity may benefit from less invasive staging procedures before treating these deformities with larger surgeries.
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Case Reports
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE21126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Would you use novel oral anticoagulants (NOACs) for thromboprophylaxis in patients with an underlying hypercoagulable state? A literature review through a case report.

    Kakadia, Bhavika / Suero-Abreu, Giselle Alexandra / Daci, Rrita / Then, Ryna Karina

    BMJ case reports

    2020  Volume 13, Issue 10

    Abstract: Antiphospholipid syndrome (APLS) is an autoimmune condition that predisposes to venous and arterial thrombosis. Warfarin is the agent of choice for anticoagulation. However, a need for routine international normalised ratio (INR) checks and multiple drug ...

    Abstract Antiphospholipid syndrome (APLS) is an autoimmune condition that predisposes to venous and arterial thrombosis. Warfarin is the agent of choice for anticoagulation. However, a need for routine international normalised ratio (INR) checks and multiple drug interactions are some of the difficulties with warfarin. Currently, there is mixed evidence for and against the use of novel oral anticoagulants (NOACs) for thromboprophylaxis. We present a case report of a patient with APLS on a NOAC for secondary thromboprophylaxis who developed a stroke and discuss current evidence regarding the use of NOACs in patients with APLS. The patient was switched to warfarin for secondary thromboprophylaxis with an INR goal of 2-3. Literature review revealed mixed case reports for and against NOACs for secondary prevention of thrombotic events in patients with APLS. There needs to be further randomised controlled trials to evaluate the efficacy of NOACs for thromboprophylaxis in patients with APLS.
    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/drug therapy ; Blood Coagulation/drug effects ; Computed Tomography Angiography ; Echocardiography ; Female ; Humans ; Middle Aged ; Secondary Prevention/methods ; Venous Thromboembolism/blood ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-10-30
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-237238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Letter

    Daci, Rrita / Natarajan, Sabareesh K. / Johnson, Mark D.

    COVID-19 Publications by UMMS Authors

    Safety Considerations for Neurosurgical Procedures During the COVID-19 Pandemic

    2020  

    Abstract: The highest viral load for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in the lungs, nasopharynx, and oropharynx. Thus, working in close proximity to the face likely represents the greatest risk of SARS-CoV-2 exposure for ... ...

    Abstract The highest viral load for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in the lungs, nasopharynx, and oropharynx. Thus, working in close proximity to the face likely represents the greatest risk of SARS-CoV-2 exposure for neurosurgeons, many of whom have contracted and/or died from COVID-19. However, sources of exposure other than the respiratory tract should also be considered. SARS-CoV-2 viremia has been reported. SARS-CoV (which is closely related to SARS-CoV-2) can invade the brain. SARS-CoV-2 ribonucleic acid has been detected in the cerebrospinal fluid (CSF) of COVID-19 patients with altered mental status, intracranial hypertension, and/or brain imaging abnormalities, raising the possibility of SARS-CoV-2 meningitis or encephalitis. Thus, blood, brain, and CSF should be treated as potentially infectious until proven otherwise.
    Keywords COVID-19 ; Coronavirus ; neurosurgery ; infection ; safety ; Health Services Administration ; Infectious Disease ; Nervous System Diseases ; Neurology ; Surgery ; Surgical Procedures ; Operative ; Virus Diseases ; covid19
    Subject code 610
    Publishing date 2020-05-07T07:00:00Z
    Publisher eScholarship@UMMS
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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