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Book: Advanced dermatologic surgery

Bailin, Philip L.

(Dermatologic clinics ; 5,2)

1987

Author's details	Philip L. Bailin ..., guest ed
Series title	Dermatologic clinics ; 5,2
Collection
Keywords	Skin / surgery
Size	XI S., S. 259 - 466 : zahlr. Ill., graph. Darst.
Publisher	Saunders
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT002943269
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: History of Mohs surgery.

Trost, Leonid B / Bailin, Philip L

Dermatologic clinics

2011 Volume 29, Issue 2, Page(s) 135–9, vii

Abstract: Mohs micrographic surgery (MMS) has become the gold standard for treating many forms of primary and recurrent contiguous skin cancers and offers the highest cure rates and maximum tissue conservation compared with other modalities. Developed by Dr ... ...

Abstract	Mohs micrographic surgery (MMS) has become the gold standard for treating many forms of primary and recurrent contiguous skin cancers and offers the highest cure rates and maximum tissue conservation compared with other modalities. Developed by Dr Frederic E. Mohs in the 1930s, it was initially called chemosurgery and used zinc chloride paste in a process called fixed tissue technique. Although this technique had high cure rates, it could take days to complete, and it gradually gave way to fresh tissue technique, renamed MMS. Now, MMS is practiced widely as part of a multidisciplinary approach for treating skin cancer.
MeSH term(s)	Dermatology/history ; History, 20th Century ; Humans ; Melanoma/history ; Melanoma/surgery ; Mohs Surgery/history ; Skin Neoplasms/history ; Skin Neoplasms/surgery
Language	English
Publishing date	2011-04
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	82798-8
ISSN	1558-0520 ; 0733-8635
ISSN (online)	1558-0520
ISSN	0733-8635
DOI	10.1016/j.det.2011.01.010
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Article ; Online: Pre-analytical considerations in the development of a prototype SARS-CoV-2 antigen ARCHITECT automated immunoassay.

Hemken, Philip M / Israeli, Eitan / Taylor, Russell / Jacobson, Chris / Datwyler, Maria / Geissler, Rene / Hadji, Abbas / Jeanblanc, Nicolette / Pandya, Kinnari / Marcinkus, Marilee / Piktel, Ryan / Bogdan, M Felicia / Rodgers, Mary / Anderson, Mark / Ziemann, Robert / Tieman, Bryan C / Hawksworth, David / Moore, Jeffrey / Otis, Kathy S /

Marohnic, Christopher C / Corby, Josie / Tu, Bailin / Lin, Zhihong / Kar, Alak / Hartnett, James / Strobel, Carolyn / Gregory, Svetoslava / Rae, Tracey / Muerhoff, A Scott / Brophy, Susan / Hackett, John R / Daghfal, David / Faron, Matthew L / Cruz, Amorina / Mohr, Phaedre / Sokoll, Lori / Davis, Gerard J

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 8, Page(s) 1511–1517

Abstract: Objectives: To evaluate pre-analytical challenges related to high-volume central laboratory SARS-CoV-2 antigen testing with a prototype qualitative SARS-CoV-2 antigen immunoassay run on the automated Abbott ARCHITECT instrument.: Methods: Contrived ... ...

Abstract	Objectives: To evaluate pre-analytical challenges related to high-volume central laboratory SARS-CoV-2 antigen testing with a prototype qualitative SARS-CoV-2 antigen immunoassay run on the automated Abbott ARCHITECT instrument. Methods: Contrived positive and negative specimens and de-identified nasal and nasopharyngeal specimens in transport media were used to evaluate specimen and reagent on-board stability, assay analytical performance and interference, and clinical performance. Results: TCID50/mL values were similar for specimens in various transport media. Inactivated positive clinical specimens and viral lysate (USA-WA1/2020) were positive on the prototype immunoassay. Within-laboratory imprecision was ≤0.10 SD (<1.00 S/C) with a ≤10% CV (≥1.00 S/C). Assay reagents were stable on board the instrument for 14 days. No high-dose hook effect was observed with a SARS-CoV-2 stock of Ct 13.0 (RLU>1.0 × 10 Conclusions: The prototype SARS-CoV-2 antigen ARCHITECT immunoassay is sensitive and specific for detection of SARS-CoV-2 in nasal and nasopharyngeal specimens. Endogenous proteases in mucus may degrade the target antigen, which limits specimen storage and transport times and complicates assay workflow.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Sensitivity and Specificity ; COVID-19 Testing ; Immunoassay
Language	English
Publishing date	2023-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-1292
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Article: Primary melanoma of the umbilicus: report of a case and review of the relevant anatomy.

Meine, Jon G / Bailin, Philip L

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2002 Volume 29, Issue 4, Page(s) 405–407

Abstract: Background: Malignant melanoma presenting on the umbilicus is rare. Treatment of melanoma on the umbilicus is difficult because of the unusual anatomy of the umbilicus.: Objective: To present the case of a patient with a primary malignant melanoma of ...

Abstract	Background: Malignant melanoma presenting on the umbilicus is rare. Treatment of melanoma on the umbilicus is difficult because of the unusual anatomy of the umbilicus. Objective: To present the case of a patient with a primary malignant melanoma of the umbilicus and to discuss treatment concerns that are relevant to the umbilical anatomy. Methods: This is a case report as well as a review of the pertinent anatomy. Results: The initial excision was read as having clear deep and lateral margins on histopathologic examination. Postoperative complications led to a re-excision down to and including the umbilical attachment to the peritoneum. The re-excision revealed residual primary cutaneous malignant melanoma in a remnant umbilical cyst. Conclusion: When a malignant melanoma is located on the vertical sidewall or bottom of the umbilicus, one should consider surgical excision down to peritoneum, including the umbilical attachment to the peritoneum. Because this is beyond the scope of training for most dermatologic surgeons, it would be appropriate to refer these patients to a surgical oncologist or a plastic surgeon.
MeSH term(s)	Aged ; Female ; Humans ; Melanoma/pathology ; Melanoma/surgery ; Reoperation ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Umbilicus/anatomy & histology
Language	English
Publishing date	2002-11-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1046/j.1524-4725.2003.29094.x
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Article: Physician management and leadership education at the Cleveland Clinic Foundation: program impact and experience over 14 years.

Stoller, James K / Berkowitz, Eric / Bailin, Philip L

The Journal of medical practice management : MPM

2007 Volume 22, Issue 4, Page(s) 237–242

Abstract: As the challenges of leading in healthcare become more complex, healthcare institutions have increasingly emphasized the importance of leadership training for physicians. Several institutions have offered in-house training programs. This paper describes ... ...

Abstract	As the challenges of leading in healthcare become more complex, healthcare institutions have increasingly emphasized the importance of leadership training for physicians. Several institutions have offered in-house training programs. This paper describes the 14-year experience and evolution of physician leadership development training at the Cleveland Clinic. We describe the curriculum, organization, and goals of the Leading in Health Care course, which is offered to high-potential physician leaders. As a metric of the success of this physician leadership effort, we report the number and types of business plans developed in the course that have been either implemented at the Cleveland Clinic or have directly affected plans for program implementation.
MeSH term(s)	Education, Continuing ; Foundations ; Leadership ; Ohio ; Physicians ; Program Development ; Staff Development/organization & administration
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632714-x
ISSN	8755-0229 ; 0038-075X
ISSN	8755-0229 ; 0038-075X
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Article: Leadership and organization development in health-care: lessons from the Cleveland Clinic.

Hopkins, Margaret M / O'Neil, Deborah A / FitzSimons, Kathleen / Bailin, Philip L / Stoller, James K

Advances in health care management

2011 Volume 10, Page(s) 151–165

Abstract: Leaders in health-care today are faced with a wide array of complex issues. This chapter describes an innovative physician leadership development program at the Cleveland Clinic intended to enhance the leadership capacities of individuals and the ... ...

Abstract	Leaders in health-care today are faced with a wide array of complex issues. This chapter describes an innovative physician leadership development program at the Cleveland Clinic intended to enhance the leadership capacities of individuals and the organization. Propositions regarding the program's impact on organizational innovation, organizational commitment, social capital, and the human element of physician practice are offered for future examination.
MeSH term(s)	Delivery of Health Care/organization & administration ; Health Facility Administration ; Humans ; Interprofessional Relations ; Leadership ; Ohio ; Organizational Case Studies ; Organizational Innovation ; Program Development ; Staff Development
Language	English
Publishing date	2011-08-30
Publishing country	Netherlands
Document type	Journal Article
ISSN	1474-8231
ISSN	1474-8231
DOI	10.1108/s1474-8231(2011)0000010015
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Article: Metastatic basal cell carcinoma presenting as unilateral axillary lymphadenopathy: report of a case and review of the literature.

Berlin, Joshua M / Warner, Michael R / Bailin, Philip L

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2002 Volume 28, Issue 11, Page(s) 1082–1084

Abstract: Background: Although basal cell carcinoma (BCC) is one of the most common forms of cancer worldwide, the incidence of metastatic basal cell carcinoma (MBCC) is exceedingly low. Of reported cases, it is estimated that up to 85% arise in the head and neck ...

Abstract	Background: Although basal cell carcinoma (BCC) is one of the most common forms of cancer worldwide, the incidence of metastatic basal cell carcinoma (MBCC) is exceedingly low. Of reported cases, it is estimated that up to 85% arise in the head and neck region. Objective: Case presentation of a BCC measuring 1.1 cm arising in a nonfacial site that presented with unilateral axillary lymphadenopathy. Methods: Case presentation with literature review. Results: Risk factors which should lead to a higher index of suspicion among clinicians for identifying these patients include large tumor size, previous irradiation, local invasion, and recurrence. The lymph nodes, lungs, bones, and skin are among the most common sites in which metastases arise. Conclusion: We report an unusual case of MBCC arising from a small, nonfacial primary BCC that presented with unilateral axillary lymphadenopathy.
MeSH term(s)	Axilla ; Carcinoma, Basal Cell/classification ; Carcinoma, Basal Cell/secondary ; Carcinoma, Basal Cell/surgery ; Female ; Humans ; Lymphatic Diseases/etiology ; Lymphatic Metastasis ; Middle Aged ; Mohs Surgery ; Neoplasms, Multiple Primary/pathology ; Neoplasms, Multiple Primary/surgery ; Risk Factors ; Skin Neoplasms/classification ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2002-08-12
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1046/j.1524-4725.2002.02090.x
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Article: Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex.

Clinical proteomics

2023 Volume 20, Issue 1, Page(s) 53

Abstract: Background: Diagnosis of liver disease at earlier stages can improve outcomes and reduce the risk of progression to malignancy. Liver biopsy is the gold standard for diagnosis of liver disease, but is invasive and sample acquisition errors are common. ... ...

Abstract	Background: Diagnosis of liver disease at earlier stages can improve outcomes and reduce the risk of progression to malignancy. Liver biopsy is the gold standard for diagnosis of liver disease, but is invasive and sample acquisition errors are common. Serum biomarkers for liver function and fibrosis, combined with patient factors, may allow for noninvasive detection of liver disease. In this pilot study, we tested and validated the performance of an algorithm that combines GP73 and LG2m serum biomarkers with age and sex (GLAS) to differentiate between patients with liver disease and healthy individuals in two independent cohorts. Methods: To develop the algorithm, prototype immunoassays were used to measure GP73 and LG2m in residual serum samples collected between 2003 and 2016 from patients with staged fibrosis and cirrhosis of viral or non-viral etiology (n = 260) and healthy subjects (n = 133). The performance of five predictive models using combinations of age, sex, GP73, and/or LG2m from the development cohort were tested. Residual samples from a separate cohort with liver disease (fibrosis, cirrhosis, or chronic liver disease; n = 395) and healthy subjects (n = 106) were used to validate the best performing model. Results: GP73 and LG2m concentrations were higher in patients with liver disease than healthy controls and higher in those with cirrhosis than fibrosis in both the development and validation cohorts. The best performing model included both GP73 and LG2m plus age and sex (GLAS algorithm), which had an AUC of 0.92 (95% CI: 0.90-0.95), a sensitivity of 88.8%, and a specificity of 75.9%. In the validation cohort, the GLAS algorithm had an estimated an AUC of 0.93 (95% CI: 0.90-0.95), a sensitivity of 91.1%, and a specificity of 80.2%. In both cohorts, the GLAS algorithm had high predictive probability for distinguishing between patients with liver disease versus healthy controls. Conclusions: GP73 and LG2m serum biomarkers, when combined with age and sex (GLAS algorithm), showed high sensitivity and specificity for detection of liver disease in two independent cohorts. The GLAS algorithm will need to be validated and refined in larger cohorts and tested in longitudinal studies for differentiating between stable versus advancing liver disease over time.
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2205154-5
ISSN	1542-6416
ISSN	1542-6416
DOI	10.1186/s12014-023-09444-7
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Article: Topical protease therapy as a novel method of epidermal ablation: preliminary report.

Fein, Howard / Maytin, Edward V / Mutasim, Diya F / Bailin, Philip L

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2005 Volume 31, Issue 2, Page(s) 139–47; discussion 147–8

Abstract: Background: For more than 50 years, proteolytic enzymes have been extensively used in laboratory settings for the purposes of in vitro epidermal separation and keratinocyte isolation. However, the topical, in vivo pharmacologic properties of these ... ...

Abstract	Background: For more than 50 years, proteolytic enzymes have been extensively used in laboratory settings for the purposes of in vitro epidermal separation and keratinocyte isolation. However, the topical, in vivo pharmacologic properties of these enzymes are virtually unknown. Previous therapeutic applications for topically applied proteases have been limited to wound debridement. Objective: To characterize the clinical and histologic effects of topically applied proteases as a method of therapeutic epidermal ablation. Materials and methods: SKH-1 hairless mouse and human skin samples were exposed both in vitro and in vivo to varying concentrations of the proteases subtilisin, trypsin, and dispase for different exposure durations. The effects of protease exposure were then assessed by both clinical and histologic examination. Results: Exposure of both human and mouse skin samples to topical protease solutions resulted in reproducible, differential patterns of epidermal ablation: subcorneal, intraepidermal, and subepidermal. In a limited study, topical application of trypsin solution resulted in the scar-free ablation of lesions of seborrheic keratosis located on the lower extremity. Conclusion: Topically applied proteases represent an alternative method of epidermal ablation with several potential advantages over existing techniques. Further studies are needed to delineate ideal enzyme formulations, vehicles, and applications.
MeSH term(s)	Administration, Cutaneous ; Animals ; Chemexfoliation/methods ; Endopeptidases/administration & dosage ; Endopeptidases/pharmacology ; Humans ; Keratolytic Agents/administration & dosage ; Keratolytic Agents/pharmacology ; Keratosis/pathology ; Keratosis/surgery ; Mice ; Mice, Hairless ; Peptide Hydrolases/administration & dosage ; Peptide Hydrolases/pharmacology ; Skin/drug effects ; Skin/pathology ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Subtilisin/administration & dosage ; Subtilisin/pharmacology ; Trypsin/administration & dosage ; Trypsin/pharmacology
Chemical Substances	Keratolytic Agents ; Endopeptidases (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-) ; Trypsin (EC 3.4.21.4) ; Subtilisin (EC 3.4.21.62) ; dispase (EC 3.4.99.-)
Language	English
Publishing date	2005-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1111/j.1524-4725.2005.31034
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Article ; Online: Noninvasive fluorescence monitoring of protoporphyrin IX production and clinical outcomes in actinic keratoses following short-contact application of 5-aminolevulinate.

Warren, Christine B / Lohser, Sara / Wene, Lauren C / Pogue, Brian W / Bailin, Philip L / Maytin, Edward V

Journal of biomedical optics

2010 Volume 15, Issue 5, Page(s) 51607

Abstract: Topical 5-aminolevulinic acid (ALA) is widely used in photodynamic therapy (PDT) of actinic keratoses (AK), a type of premalignant skin lesion. However, the optimal time between ALA application and exposure to light has not been carefully investigated. ... ...

Abstract	Topical 5-aminolevulinic acid (ALA) is widely used in photodynamic therapy (PDT) of actinic keratoses (AK), a type of premalignant skin lesion. However, the optimal time between ALA application and exposure to light has not been carefully investigated. Our objective is to study the kinetics of protoporphyrin IX (PpIX) accumulation in AK after short contact ALA and relate this to erythemal responses. Using a noninvasive dosimeter, PpIX fluorescence measurements (5 replicates) were taken at 20-min intervals for 2 h following ALA application, in 63 AK in 20 patients. Data were analyzed for maximal fluorescent signal obtained, kinetic slope, and changes in erythema. Our results show that PpIX accumulation was linear over time, becoming statistically higher than background in 48% of all lesions by 20 min, 92% of lesions by 1 h, and 100% of lesions by 2 h. PpIX accumulation was roughly correlated with changes in lesional erythema post-PDT. We conclude that significant amounts of PpIX are produced in all AK lesions by 2 h. The linear kinetics of accumulation suggest that shorter ALA application times may be efficacious in many patients. Noninvasive fluorescence monitoring of PpIX may be useful to delineate areas of high PpIX accumulation within precancerous areas of the skin.
MeSH term(s)	Administration, Topical ; Aged ; Aminolevulinic Acid/administration & dosage ; Erythema/etiology ; Erythema/pathology ; Female ; Fluorescence ; Humans ; Keratosis, Actinic/drug therapy ; Keratosis, Actinic/metabolism ; Keratosis, Actinic/pathology ; Male ; Middle Aged ; Photobleaching ; Photochemotherapy/methods ; Protoporphyrins/biosynthesis ; Treatment Outcome
Chemical Substances	Protoporphyrins ; Aminolevulinic Acid (88755TAZ87) ; protoporphyrin IX (C2K325S808)
Language	English
Publishing date	2010-11-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1309154-2
ISSN	1560-2281 ; 1083-3668
ISSN (online)	1560-2281
ISSN	1083-3668
DOI	10.1117/1.3484255
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