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  1. Article ; Online: An unexpected cellular fountain of youth: platelets provide factors rejuvenating brain functions.

    Langer, Harald F

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 461

    MeSH term(s) Humans ; Adolescent ; Aging ; Blood Platelets ; Brain
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01716-w
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  2. Article ; Online: An unexpected cellular fountain of youth

    Harald F. Langer

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    platelets provide factors rejuvenating brain functions

    2023  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Chronic inflammation in atherosclerosis-The CD40L/CD40 axis belongs to dendritic cells and T cells, not platelets.

    Langer, Harald F

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 20, Issue 1, Page(s) 3–5

    MeSH term(s) Atherosclerosis ; Blood Platelets ; CD40 Ligand ; Dendritic Cells ; Humans ; Inflammation ; T-Lymphocytes
    Chemical Substances CD40 Ligand (147205-72-9)
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15591
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 295: Show issues

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  4. Article ; Online: Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation.

    Rawish, Elias / Langer, Harald F

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5'-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of ... ...

    Abstract P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5'-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of important pathophysiological processes such as the modulation of cardiovascular physiology, mediation of nociception, platelet and macrophage activation, or neuronal-glial integration. While P2X1 receptor activation is long known to drive platelet aggregation, P2X7 receptor antagonists have recently been reported to inhibit platelet activation. Considering the role of both P2X receptors and platelet-mediated inflammation in neuronal diseases such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and stroke, targeting purinergic receptors may provide a valuable novel therapeutic approach in these diseases. Therefore, the present review illuminates the role of platelets and purinergic signaling in these neurological conditions to evaluate potential translational implications.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Blood Platelets/metabolism ; Humans ; Inflammation/metabolism ; Nociception ; Pain/metabolism ; Receptors, Purinergic P2X/metabolism ; Receptors, Purinergic P2X7/metabolism ; Thromboinflammation ; Thrombosis/metabolism
    Chemical Substances Receptors, Purinergic P2X ; Receptors, Purinergic P2X7 ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126585
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  5. Article ; Online: Platelets, Thromboinflammation and Neurovascular Disease.

    Sun, Ying / Langer, Harald F

    Frontiers in immunology

    2022  Volume 13, Page(s) 843404

    Abstract: The brain and spinal cord are immune-privileged organs, but in the disease state protection mechanisms such as the blood brain barrier (BBB) are ineffective or overcome by pathological processes. In neuroinflammatory diseases, microglia cells and other ... ...

    Abstract The brain and spinal cord are immune-privileged organs, but in the disease state protection mechanisms such as the blood brain barrier (BBB) are ineffective or overcome by pathological processes. In neuroinflammatory diseases, microglia cells and other resident immune cells contribute to local vascular inflammation and potentially a systemic inflammatory response taking place in parallel. Microglia cells interact with other cells impacting on the integrity of the BBB and propagate the inflammatory response through the release of inflammatory signals. Here, we discuss the activation and response mechanisms of innate and adaptive immune processes in response to neuroinflammation. Furthermore, the clinical importance of neuroinflammatory mediators and a potential translational relevance of involved mechanisms are addressed also with focus on non-classical immune cells including microglia cells or platelets. As illustrative examples, novel agents such as Anfibatide or Revacept, which result in reduced recruitment and activation of platelets, a subsequently blunted activation of the coagulation cascade and further inflammatory process, demonstrating that mechanisms of neuroinflammation and thrombosis are interconnected and should be further subject to in depth clinical and basic research.
    MeSH term(s) Blood Platelets ; Humans ; Inflammation ; Microglia/pathology ; Thromboinflammation ; Thrombosis
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.843404
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  6. Article ; Online: Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation

    Elias Rawish / Harald F. Langer

    International Journal of Molecular Sciences, Vol 23, Iss 6585, p

    2022  Volume 6585

    Abstract: P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of ... ...

    Abstract P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of important pathophysiological processes such as the modulation of cardiovascular physiology, mediation of nociception, platelet and macrophage activation, or neuronal–glial integration. While P2X1 receptor activation is long known to drive platelet aggregation, P2X7 receptor antagonists have recently been reported to inhibit platelet activation. Considering the role of both P2X receptors and platelet-mediated inflammation in neuronal diseases such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and stroke, targeting purinergic receptors may provide a valuable novel therapeutic approach in these diseases. Therefore, the present review illuminates the role of platelets and purinergic signaling in these neurological conditions to evaluate potential translational implications.
    Keywords inflammation ; P2X receptor ; thrombosis ; platelets ; stroke ; Alzheimer’s disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Novel Aspects Targeting Platelets in Atherosclerotic Cardiovascular Disease-A Translational Perspective.

    Huseynov, Aydin / Reinhardt, Julius / Chandra, Leonard / Dürschmied, Daniel / Langer, Harald F

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a distinguished anti-platelet drug treatment regimen for cardiovascular patients could be established. ...

    Abstract Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a distinguished anti-platelet drug treatment regimen for cardiovascular patients could be established. Furthermore, platelets are increasingly considered as cells mediating effects "beyond thrombosis", including vascular inflammation, tissue remodeling and healing of vascular and tissue lesions. This review has its focus on the functions and interactions of platelets with potential translational and clinical relevance. The role of platelets for the development of atherosclerosis and therapeutic modalities for primary and secondary prevention of atherosclerotic disease are addressed. Furthermore, novel therapeutic options for inhibiting platelet function and the use of platelets in regenerative medicine are considered.
    MeSH term(s) Humans ; Cardiovascular Diseases/drug therapy ; Blood Platelets ; Atherosclerosis/drug therapy ; Atherosclerosis/pathology ; Thrombosis/drug therapy ; Myocardial Infarction/drug therapy
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076280
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  8. Article ; Online: Protocol to isolate and analyze mouse bone marrow derived dendritic cells (BMDC).

    Sauter, Manuela / Sauter, Reinhard J / Nording, Henry / Olbrich, Marcus / Emschermann, Frederic / Langer, Harald F

    STAR protocols

    2022  Volume 3, Issue 3, Page(s) 101664

    Abstract: Different types of immune cells are involved in atherogenesis and may act atheroprotective or atheroprogressive. Here, we describe an in vitro approach to analyze ... ...

    Abstract Different types of immune cells are involved in atherogenesis and may act atheroprotective or atheroprogressive. Here, we describe an in vitro approach to analyze CD11c
    MeSH term(s) Animals ; Apolipoproteins E ; Bone Marrow ; Bone Marrow Cells ; CD11c Antigen ; Dendritic Cells ; Mice
    Chemical Substances Apolipoproteins E ; CD11c Antigen
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101664
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  9. Article ; Online: Novel Aspects Targeting Platelets in Atherosclerotic Cardiovascular Disease—A Translational Perspective

    Aydin Huseynov / Julius Reinhardt / Leonard Chandra / Daniel Dürschmied / Harald F. Langer

    International Journal of Molecular Sciences, Vol 24, Iss 6280, p

    2023  Volume 6280

    Abstract: Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a distinguished anti-platelet drug treatment regimen for cardiovascular patients could be established. ...

    Abstract Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a distinguished anti-platelet drug treatment regimen for cardiovascular patients could be established. Furthermore, platelets are increasingly considered as cells mediating effects “beyond thrombosis”, including vascular inflammation, tissue remodeling and healing of vascular and tissue lesions. This review has its focus on the functions and interactions of platelets with potential translational and clinical relevance. The role of platelets for the development of atherosclerosis and therapeutic modalities for primary and secondary prevention of atherosclerotic disease are addressed. Furthermore, novel therapeutic options for inhibiting platelet function and the use of platelets in regenerative medicine are considered.
    Keywords platelets ; atherosclerosis ; coronary artery disease ; myocardial infarction ; neuroinflammation ; ischemic stroke ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Mutual Relation of Platelet Activation and Innate Immunity.

    Eisinger, Felix / Langer, Harald F

    Hamostaseologie

    2018  Volume 38, Issue 4, Page(s) 186–202

    Abstract: Platelets are known to be central regulators of haemostasis, inflammation and immune response. Formed by megakaryocytes in the bone marrow and the lungs, platelets express a broad range of adhesion ... ...

    Abstract Platelets are known to be central regulators of haemostasis, inflammation and immune response. Formed by megakaryocytes in the bone marrow and the lungs, platelets express a broad range of adhesion receptors
    MeSH term(s) Animals ; Blood Platelets/immunology ; Complement System Proteins/immunology ; Humans ; Immunity, Innate ; Infection/immunology ; Inflammation/immunology ; Neoplasms/immunology ; Platelet Activation
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2018-09-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0038-1669450
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
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