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Article ; Online: A Sweet Solution: Glycolysis-Dependent Treg Cell Migration.

Alon, Ronen

2017 Volume 47, Issue 5, Page(s) 805–807

Abstract: mTORC2 is a metabolic regulatory complex activated by PI3K. In this issue of Immunity, Kishore et al. (2017) demonstrate a specialized role for this complex in the migration of regulatory T (Treg) cells to sites of inflammation rather than their ... ...

Abstract	mTORC2 is a metabolic regulatory complex activated by PI3K. In this issue of Immunity, Kishore et al. (2017) demonstrate a specialized role for this complex in the migration of regulatory T (Treg) cells to sites of inflammation rather than their differentiation and survival.
MeSH term(s)	Cell Movement ; Glucokinase ; Glycolysis ; Mechanistic Target of Rapamycin Complex 2 ; T-Lymphocytes, Regulatory
Chemical Substances	Glucokinase (EC 2.7.1.2) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1)
Language	English
Publishing date	2017-11-22
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2017.11.006
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Article: Motivational stimuli to donate sperm among non-donor students.

Ronen, Maya / Kedem, Alon / Avraham, Sarit / Youngster, Michal / Yerushalmi, Gil / Hourvitz, Ariel / Gat, Itai

Basic and clinical andrology

2023 Volume 33, Issue 1, Page(s) 29

Abstract: Background: Sperm banks face a continuously evolving gap between the increasing demand for sperm donation (SD) vs. limited available reserve. To improve donors' recruitment and increase supply, motivations towards SD should be investigated specifically ... ...

Abstract	Background: Sperm banks face a continuously evolving gap between the increasing demand for sperm donation (SD) vs. limited available reserve. To improve donors' recruitment and increase supply, motivations towards SD should be investigated specifically among young men who have the potential to become donors. Our aim was to evaluate factors which increase and decrease predisposition to donate sperm among non-donor students, who represent a "potential pool" for possible donors' recruitment. Results: Ninety-three men fulfilled the questionnaire with mean age of 28.2 ± 4.5 years. The most powerful incentive to donate sperm was financial reward followed by a willingness to help others to build a family (3.8 and 3.4, respectively). The most dominant consideration to decline donation was the fear of anonymity loss and future regret (4 and 3.8). While participants' willingness for anonymous SD was fair (2.8), the open-identity donation was rated significantly lower (1.75, p < 0.01). Familiarity with recipients and offspring had lower scores (1.9-2.2) as well. Conclusions: Young single men represent a suitable cohort for anonymous donation. Financial reward and willingness to help others are important positive incentives while anonymity preservation is crucial to maintain their willingness towards SD. Regulatory shifting towards open-identity SD necessitates the establishment of an alternative "potential pool" population as a reliable source to recruit donors.
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2732675-5
ISSN	2051-4190
ISSN	2051-4190
DOI	10.1186/s12610-023-00201-2
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Article: Sperm Donors' Identity Disclosure: Is It REALLY Crucial? For Whom?

Ronen, Maya / Kaufman, Sarita / Kedem, Alon / Avraham, Sarit / Youngster, Michal / Yerushalmi, Gil / Hourvitz, Ariel / Gat, Itai

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2023 , Page(s) 102337

Abstract: Objective: To study the preference of sperm donors with identity disclosure (ID) versus anonymous donors (AD) and to understand if this selection affects clinical outcomes in an Israeli population.: Methods: This retrospective study included patients ...

Abstract	Objective: To study the preference of sperm donors with identity disclosure (ID) versus anonymous donors (AD) and to understand if this selection affects clinical outcomes in an Israeli population. Methods: This retrospective study included patients who chose imported sperm donation during 2017-2021. Of these, 526 used their own (autologous) oocytes and 43 patients used donated oocytes (DO). The primary endpoint was the type of chosen donor with ID versus AD. We examined the tendency toward ID according to demographic parameters and the theoretical impact of donor-type selection on reproductive outcome and compared patients who performed cycles with autologous oocytes with those using DO. Results: Single women had a significantly higher probability of choosing sperm donors with ID than heterosexual couples (55.6% vs. 33.3%, OR 2.5, CI 95% 1.52-4.11, P < 0.001). Although not significant, same-sex couples were more likely to choose sperm donors with ID than heterosexual couples (49.1% vs. 33.3%, OR 1.93, CI 95% 0.97-3.85, P = 0.06). Sperm donor samples, 2501 vials, were imported. It was performed 698 intra-uterine insemination and 812 in vitro fertilization cycles were performed, respectively, resulting in 283 pregnancies without differences between patients who chose sperm donors with ID versus AD sperm. No significant differences were observed regarding the option for sperm donors with ID between patients using DO (44.2%) and those using autologous oocytes (51.3%). Conclusion: While ID is important for a certain section (mainly single) of recipients, it is far from the only dominant factor during donor selection. Sperm donation type does not impact clinical outcomes.
Language	English
Publishing date	2023-12-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2023.102337
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Book ; Online: GPT-Calls

Malkiel, Itzik / Alon, Uri / Yehuda, Yakir / Keren, Shahar / Barkan, Oren / Ronen, Royi / Koenigstein, Noam

Enhancing Call Segmentation and Tagging by Generating Synthetic Conversations via Large Language Models

2023

Abstract: Transcriptions of phone calls are of significant value across diverse fields, such as sales, customer service, healthcare, and law enforcement. Nevertheless, the analysis of these recorded conversations can be an arduous and time-intensive process, ... ...

Abstract	Transcriptions of phone calls are of significant value across diverse fields, such as sales, customer service, healthcare, and law enforcement. Nevertheless, the analysis of these recorded conversations can be an arduous and time-intensive process, especially when dealing with extended or multifaceted dialogues. In this work, we propose a novel method, GPT-distilled Calls Segmentation and Tagging (GPT-Calls), for efficient and accurate call segmentation and topic extraction. GPT-Calls is composed of offline and online phases. The offline phase is applied once to a given list of topics and involves generating a distribution of synthetic sentences for each topic using a GPT model and extracting anchor vectors. The online phase is applied to every call separately and scores the similarity between the transcripted conversation and the topic anchors found in the offline phase. Then, time domain analysis is applied to the similarity scores to group utterances into segments and tag them with topics. The proposed paradigm provides an accurate and efficient method for call segmentation and topic extraction that does not require labeled data, thus making it a versatile approach applicable to various domains. Our algorithm operates in production under Dynamics 365 Sales Conversation Intelligence, and our research is based on real sales conversations gathered from various Dynamics 365 Sales tenants.
Keywords	Computer Science - Computation and Language ; Computer Science - Machine Learning
Publishing date	2023-06-09
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: The Vocal Signature of Social Anxiety

Alon-Ronen, Or / Shrem, Yosi / Keshet, Yossi / Gilboa-Schechtman, Eva

Exploration using Hypothesis-Testing and Machine-Learning Approaches

2022

Abstract: Background - Social anxiety (SA) is a common and debilitating condition, negatively affecting life quality even at sub-diagnostic thresholds. We sought to characterize SA's acoustic signature using hypothesis-testing and machine learning (ML) approaches. ...

Abstract	Background - Social anxiety (SA) is a common and debilitating condition, negatively affecting life quality even at sub-diagnostic thresholds. We sought to characterize SA's acoustic signature using hypothesis-testing and machine learning (ML) approaches. Methods - Participants formed spontaneous utterances responding to instructions to refuse or consent to commands of alleged peers. Vocal properties (e.g., intensity and duration) of these utterances were analyzed. Results - Our prediction that, as compared to low-SA (n=31), high-SA (n=32) individuals exhibit a less confident vocal speech signature, especially with respect to refusal utterances, was only partially supported by the classical hypothesis-testing approach. However, the results of the ML analyses and specifically the decision tree classifier were consistent with such speech patterns in SA. Using a Gaussian Process (GP) classifier, we were able to distinguish between high- and low-SA individuals with high (75.6%) accuracy and good (.83 AUC) separability. We also expected and found that vocal properties differentiated between refusal and consent utterances. Conclusions - Our findings provide further support for the usefulness of ML approach for the study of psychopathology, highlighting the utility of developing automatic techniques to create behavioral markers of SAD. Clinically, the simplicity and accessibility of these procedures may encourage people to seek professional help.
Keywords	Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
Publishing date	2022-07-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.

Roncato, Francesco / Regev, Ofer / Yadav, Sandeep Kumar / Alon, Ronen

Cell adhesion & migration

2021 Volume 15, Issue 1, Page(s) 166–179

Abstract: Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT- ... ...

Abstract	Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slow-moving cells. ZMP-treated B16 cells failed to follow chemotactic gradients across rigid confinements and could not generate stable sub-endothelial pseudopodia under endothelial monolayers. In vivo, ZMP-treated Β16 cells failed to extravasate though lung capillaries. In contrast to melanoma cells, the chemotaxis and transendothelial migration of ZMP-treated Tcells were largely conserved. This is afirst demonstration that MT disassembly is akey checkpoint in the directional migration of cancer cells but not of lymphocytes.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/physiology ; Chemotaxis/drug effects ; Macrolides/pharmacology ; Male ; Melanoma/pathology ; Mice ; Mice, Inbred C57BL ; Microtubules/drug effects ; Microtubules/metabolism ; Pseudopodia/drug effects ; T-Lymphocytes/drug effects ; Transendothelial and Transepithelial Migration/drug effects
Chemical Substances	Macrolides ; zampanolide
Language	English
Publishing date	2021-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2268518-2
ISSN	1933-6926 ; 1933-6918
ISSN (online)	1933-6926
ISSN	1933-6918
DOI	10.1080/19336918.2021.1934958
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Article ; Online: Potential "Healthy Vaccinee Bias" in a Study of BNT162b2 Vaccine against Covid-19. Reply.

Arbel, Ronen / Sergienko, Ruslan / Netzer, Doron / Hammerman, Ariel / Friger, Michael / Peretz, Alon / Razi, Talish / Duskin-Bitan, Hadar / Yaron, Shlomit

The New England journal of medicine

2023 Volume 389, Issue 3, Page(s) 285–286

MeSH term(s)	Humans ; COVID-19/prevention & control ; BNT162 Vaccine ; COVID-19 Vaccines
Chemical Substances	BNT162 Vaccine ; COVID-19 Vaccines
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2306683
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Article ; Online: Trapped versus soluble chemokines: functions in leukocyte adhesion and motility.

Alon, Ronen

Immunity

2010 Volume 33, Issue 5, Page(s) 654–656

Abstract: In this issue of Immunity, Bao et al. (2010) provide in vivo evidence that heparan sulfate glycosaminoglycans (GAGs) are indispensable for immobilization and function of major chemokines required for leukocyte adhesion to and crossing through blood and ... ...

Abstract	In this issue of Immunity, Bao et al. (2010) provide in vivo evidence that heparan sulfate glycosaminoglycans (GAGs) are indispensable for immobilization and function of major chemokines required for leukocyte adhesion to and crossing through blood and lymphatic vessels.
Language	English
Publishing date	2010-11-24
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2010.11.012
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Article ; Online: Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands.

Alon, Ronen

Cell adhesion & migration

2010 Volume 4, Issue 2, Page(s) 211–214

Abstract: Integrin heterodimers acquire high affinity to endothelial ligands by extensive conformational changes in both their alpha and beta subunits. These heterodimers are maintained in an inactive state by inter-subunit constraints. Changes in the cytoplasmic ... ...

Abstract	Integrin heterodimers acquire high affinity to endothelial ligands by extensive conformational changes in both their alpha and beta subunits. These heterodimers are maintained in an inactive state by inter-subunit constraints. Changes in the cytoplasmic interface of the integrin heterodimer (referred to as inside-out integrin activation) can only partially remove these constraints. Full integrin activation is achieved when both inter-subunit constraints and proper rearrangements of the integrin headpiece by its extracellular ligand (outside-in activation) are temporally coupled. A universal regulator of these integrin rearrangements is talin1, a key integrin-actin adaptor that regulates integrin conformation and anchors ligand-occupied integrins to the cortical cytoskeleton. The arrest of rolling leukocytes at target vascular sites depends on rapid activation of their alpha4 and beta2 integrins at endothelial contacts by chemokines displayed on the endothelial surface. These chemotactic cytokines can signal within milliseconds through specialized Gi-protein coupled receptors (GPCRs) and Gi-triggered GTPases on the responding leukocytes. Some chemokine signals can alter integrin conformation by releasing constraints on integrin extension, while other chemokines activate integrins to undergo conformational activation mainly after ligand binding. Both of these modalities involve talin1 activation. In this opinion article, I propose that distinct chemokine signals induce variable strengths of associations between talin1 and different target integrins. Weak interactions of the integrin cytoplasmic tail with talin1 (the cytoplasmic integrin ligand) dissociate unless the extracellular ligand can simultaneously occupy the integrin headpiece and transmit, within milliseconds, proper allosteric changes across the integrin heterodimer back to the tail-talin1 complex. The fate of this bi-directional occupancy of integrins by both their extracellular and intracellular ligands is likely to benefit from immobilization of both ligands to cortical cytoskeletal elements. To properly anchor talin1 onto the integrin tail, a second integrin partner, Kindlin-3 may be also required, although an evidence that both partners can simultaneously bind the same integrin heterodimer is still missing. Once linked to the cortical actin cytoskeleton, the multi-occupied integrin complex can load weak forces, which deliver additional allosteric changes to the integrin headpiece resulting in further bond strengthening. Surface immobilized chemokines are superior to their soluble counterparts in driving this bi-directional occupancy process, presumably due to their ability to facilitate local co-occupancy of individual integrin heterodimers with talin1, Kindlin-3 and surface-bound extracellular ligands.
MeSH term(s)	Animals ; Chemokines/genetics ; Chemokines/metabolism ; Dimerization ; Humans ; Integrins/chemistry ; Integrins/metabolism ; Leukocytes/metabolism ; Models, Biological ; Signal Transduction/genetics ; Signal Transduction/physiology
Chemical Substances	Chemokines ; Integrins
Language	English
Publishing date	2010-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2268518-2
ISSN	1933-6926 ; 1933-6918
ISSN (online)	1933-6926
ISSN	1933-6918
DOI	10.4161/cam.4.2.11133
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Article ; Online: LFA-1 in T cell priming, differentiation, and effector functions.

Gérard, Audrey / Cope, Andrew P / Kemper, Claudia / Alon, Ronen / Köchl, Robert

Trends in immunology

2021 Volume 42, Issue 8, Page(s) 706–722

Abstract: The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of ...

Abstract	The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell-T cell (T-T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.
MeSH term(s)	Animals ; Antigen-Presenting Cells ; Cell Differentiation ; Intercellular Adhesion Molecule-1 ; Lymphocyte Function-Associated Antigen-1 ; Th1 Cells
Chemical Substances	Lymphocyte Function-Associated Antigen-1 ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2021.06.004
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