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Article: Frequency of ragweed sensitization and allergy among patients with respiratory allergy.

Esmail, Dina H / Ashour, Zeinab A / Sheha, Dina S / Mohamed, Nesrine A / AbdAllah, Amany M / Zeyad, Omneya M / Elmahdi, Amira R

The Egyptian journal of immunology

2022 Volume 29, Issue 4, Page(s) 115–124

Abstract: Pollen is well known to cause seasonal allergy. Ragweed sensitization and allergy represent a worldwide challenge for allergists. Ambrosia is one of the major genera in the Asteraceae family which includes at least 51 species known as "ragweed". The ... ...

Abstract	Pollen is well known to cause seasonal allergy. Ragweed sensitization and allergy represent a worldwide challenge for allergists. Ambrosia is one of the major genera in the Asteraceae family which includes at least 51 species known as "ragweed". The current study aimed at determining frequency of ragweed sensitization and allergy among patients with respiratory allergy. The study included 220 subjects selected from patients attended the Allergy Clinic, Ain Shams University. All patients were subjected to detailed medical history, clinical examination, asthma severity grading according to the Global Initiative for Asthma (GINA) guidelines, allergic rhinitis severity grading according to the allergic rhinitis and its impact on asthma (ARIA) guidelines, pulmonary function tests for asthmatic patients, complete blood count with differential for detection of eosinophilia, serum total IgE and skin prick testing (SPT) to ragweed pollen together with common inhalants and common food allergens. Specific IgE for Ambrosia artemisiifolia was done for patients who showed positive SPT to ragweed pollen. About 34% of patients had positive SPT to ragweed, 30.5% were sensitized to ragweed and 3.2% allergic. Specific IgE for A. artemisiifolia was positive in 33.8%. There was a statistically significant association between ragweed sensitization and level of asthma control and disease duration. We concluded that ragweed sensitization is less common as the frequency of Ambrosia pollen sensitization was about one third of the studied allergic patients.
MeSH term(s)	Allergens ; Ambrosia ; Asthma/epidemiology ; Food Hypersensitivity ; Humans ; Immunoglobulin E ; Rhinitis, Allergic
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2022-10-01
Publishing country	Egypt
Document type	Journal Article
ISSN	1110-4902
ISSN	1110-4902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Toll like receptor 4 (TLR4) expression on peripheral blood mononuclear cells (PBMCs) among patients with Graves disease.

Mahfouz, Youssra G / Hosny, Salwa S / Farres, Mohamed N / Sheha, Dina S / Marawan, Dina A / ElKady, Hossam M

The Egyptian journal of immunology

2021 Volume 28, Issue 4, Page(s) 215–223

Abstract: Graves disease (GD) is a multifactorial disease due to multiple environmental and genetic factors as well as immune malfunction. Human Toll-like receptors (TLRs) play a key role in activating innate and adaptive immune cells. Their role in modulating ... ...

Abstract	Graves disease (GD) is a multifactorial disease due to multiple environmental and genetic factors as well as immune malfunction. Human Toll-like receptors (TLRs) play a key role in activating innate and adaptive immune cells. Their role in modulating immunity also interferes with the mechanisms that maintain tolerance in the host. Thus, expression or activation of TLRs can contribute to the loss of tolerance by a lot of mechanisms. In order to confirm the importance of TLR4 in the pathogenesis of GD, this study intended to measure TLR4 expression on peripheral blood mononuclear cells in GD patients before and after control of disease with Carbimazole as compared to a group of normal controls. We conducted a case-control study on 36 patients with newly diagnosed Graves disease and 36 individuals as the control group. Patients were recruited from the endocrinology outpatient clinic, Ain-Shams University Hospitals and were followed up till achieving the euthyroid state (for a minimum period of 6 months). In GD patients at baseline, the mean monocyte percentage was 4.46%, and the mean TLR4 on monocytes 90.91%. After achieving euthyroid state, the mean monocyte was 6.16%, and the mean TLR4 on monocytes 72.30%. In the control group, the mean monocyte was 3.88%, and the mean TLR4 on monocytes 66.30%. Results indicated significant differences in expression of TLR4 between GD patients before treatment, after achieving euthyroid state and in the control group (p< 0.0001). In conclusion, the present study showed a higher expression of TLR4 on monocytes among newly diagnosed GD patients in comparison to normal individuals. TLR4 expression on monocytes decreased significantly among GD patients after treatment.
MeSH term(s)	Case-Control Studies ; Graves Disease ; Humans ; Leukocytes, Mononuclear ; Monocytes ; Toll-Like Receptor 4
Chemical Substances	TLR4 protein, human ; Toll-Like Receptor 4
Language	English
Publishing date	2021-12-09
Publishing country	Egypt
Document type	Journal Article
ISSN	1110-4902
ISSN	1110-4902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of the RSNA chest CT classification system and CO-RADS system in reporting COVID-19 pneumonia in symptomatic and asymptomatic patients

Aliaa S. Sheha / Nada H. Mohamed / Yara M. Eid / Dina S. Sheha / Mohamed El-Shayeb / Mariam M. Amin / Alia Mohammed Saeed / Dina Abdou / Ahmed M. Osman

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Background Coronavirus disease (COVID-19) is a new infection with three pandemic waves up till now. CT plays an important role in diagnosis with multiple reporting systems that can be used during CT analysis. We aimed to compare reporting using ... ...

Abstract	Abstract Background Coronavirus disease (COVID-19) is a new infection with three pandemic waves up till now. CT plays an important role in diagnosis with multiple reporting systems that can be used during CT analysis. We aimed to compare reporting using the recommendations of the radiological society of North America (RSNA) versus the coronavirus disease reporting and data system (CO-RADS) and to assess the performance of CT if used in asymptomatic patients as a screening. Two hundred and fifty-one patients who underwent chest CT scanning either due to clinical suspicion or as screening before hospital admission were included in this retrospective observational cross-sectional study. This was followed by RT-PCR for confirmation. Three radiologists with different years of experience interpreted the CT findings using the RSNA recommendations and the CO-RADS reporting. The data were collected and compared. Results There was no statistically significant difference noted in the diagnostic accuracy obtained while using the RSNA recommendations and the CO-RADS reporting system. Also, a good inter-rater agreement was noticed while using the two reporting systems. The CT showed a highly significant value while used in the assessment of symptomatic patients in controversy to the screening of asymptomatic patients. Conclusion Both reporting systems show similar diagnostic accuracy with a good almost similar inter-rater agreement. Both can be used while interpreting the CT images of cases with suspected COVID-19 infection. CT can be used effectively in the detection of COVID-19 infection between symptomatic patients while it is of a lower value in the screening of asymptomatic patients.
Keywords	Coronavirus ; COVID-19 ; Computed tomography (CT) ; CO-RADS ; RSNA ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Vascular endothelial growth factor profile and Vitamin D level in Systemic Sclerosis Egyptian patients.

El Gharbawy, Nermin H / Sheha, Dina S / Bawady, Somia A / El Leithy, Sally A

The Egyptian journal of immunology

2021 Volume 28, Issue 3, Page(s) 168–175

Abstract: Vascular endothelial growth factor (VEGF) was described as a potentially important driver of systemic sclerosis (SSc) pathogenesis. Additionally, recent literature elucidated that vitamin D serum level was found to be significantly lower in SSc patients ... ...

Abstract	Vascular endothelial growth factor (VEGF) was described as a potentially important driver of systemic sclerosis (SSc) pathogenesis. Additionally, recent literature elucidated that vitamin D serum level was found to be significantly lower in SSc patients in comparison to healthy individuals. The aim of the current study was to evaluate serum level of VEGF and its correlation with clinical features and vitamin D level in systemic sclerosis (SSc) Egyptian patients. This current case control study included 30 female SSc patients and 20 healthy controls. VEGF level was measured by ELISA. Serum level of 25-OH vitamin D was measured by electrochemiluminescence. Nailfold video capillaroscopy and modified Rodnan skin score (mRSS) were assessed. Thirty SSc female patients were included in the study, 13 patients had diffuse cutaneous SSc. The mean age of the patients' group was 49.3±4.3years, and the mean serum VEGF level was 3445.9±1183 ng/dl. The mean serum level of vitamin D was 15.57±9.9ng/ml in SSc patients and 30.6±2.26 in the controls. There was a significant association between high level of VEGF and hypovitaminosis D. Serum level of VEGF positively correlated with nailfold capillaroscopy changes and mRSS. In conclusion, high level of VEGF is associated with hypovitaminosis D, suggesting a role of vitamin D in SSc pathogenesis. VEGF levels correlate positively with nailfold capillaroscopy changes and extent of skin involvement.
MeSH term(s)	Case-Control Studies ; Egypt ; Female ; Humans ; Middle Aged ; Scleroderma, Systemic ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Vitamin D
Chemical Substances	Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-08-28
Publishing country	Egypt
Document type	Journal Article
ISSN	1110-4902
ISSN	1110-4902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neutrophil Respiratory Burst: an immunological indicator of post stroke infection.

Okba, Ashraf M / Farres, Mohamed N / Shahin, Rasha Y / Mostafa, Asmaa S / Elkady, Hossam M / Sheha, Dina S / Hossam, Afify / Sheha, Aliaa S / Rushdy, Marwa

The Egyptian journal of immunology

2022 Volume 29, Issue 3, Page(s) 80–89

Abstract: Stroke is long known to be followed by a series of immunosuppressive events, and infections might be a cause of death after an acute insult of stroke. The aim of our work was to assess the percentage of neutrophils showing spontaneous oxidative burst in ... ...

Abstract	Stroke is long known to be followed by a series of immunosuppressive events, and infections might be a cause of death after an acute insult of stroke. The aim of our work was to assess the percentage of neutrophils showing spontaneous oxidative burst in patients with acute ischemic stroke. The study included 30 patients with acute cerebral infarction subjected to the following: magnetic resonance imaging of the brain immediately on admission, and blood sampling on day one of admission (baseline) and after 3 days of admission. Blood samples were used for the assessment of: differential leucocyte count and percentage of neutrophils showing spontaneous oxidative burst, performed by flow cytometry. Thirty age and gender matched controls were also recruited. Neutrophil respiratory burst percentage was significantly lower in stroke patients in comparison to controls (P < 0.001), and stroke patients had significantly lower neutrophil respiratory burst percent on day 3 of admission compared to the baseline (P < 0.001). Stroke-induced immune alterations including impairment of the first-line defense performed by neutrophils against bacteria. The hypothesis that these changes enhance susceptibility to acquired infections is supported by our observation that oxidative burst in neutrophils was more impaired in patients with stroke who exhibited subsequent stroke-associated infections.
MeSH term(s)	Humans ; Ischemic Stroke ; Leukocyte Count ; Neutrophils ; Respiratory Burst ; Stroke/complications ; Stroke/pathology
Language	English
Publishing date	2022-03-01
Publishing country	Egypt
Document type	Journal Article
ISSN	1110-4902
ISSN	1110-4902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dyslipidemia among allergic rhinitis patients: Frequency and risk factors.

Sheha, Dina S / El-Korashi, Lobna A / AbdAllah, Amany M / El-Begermy, Marwa M / Elmahdi, Amira R

The World Allergy Organization journal

2021 Volume 14, Issue 3, Page(s) 100523

Abstract: Background: Although cumulative data strongly suggest an association between dyslipidemia and allergic disorders, especially asthma, evidence regarding allergic rhinitis (AR) is lacking. We aimed to assess frequency and associated risk factors of ... ...

Abstract	Background: Although cumulative data strongly suggest an association between dyslipidemia and allergic disorders, especially asthma, evidence regarding allergic rhinitis (AR) is lacking. We aimed to assess frequency and associated risk factors of dyslipidemia among patients with AR. Methods: The current study is a cross-sectional study that recruited 150 AR patients by systematic randomization. Blood samples for serum lipid profile, total immunoglobulin E (IgE) and serum interleukin-17A (IL-17A) were withdrawn from all patients. Results: Dyslipidemia was prevalent in 84 AR patients (56%). Higher levels of total IgE, IL17-A, and sensitization to hay dust and mixed mites significantly increased the risk of dyslipidemia among AR patients by 1.004, 1.062, 4.057 and 3.652 respectively ( Conclusion: High serum total IgE level, high serum IL-17A level, and sensitization to hay dust and mixed mites are independent risk factors for dyslipidemia among AR patients.
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2021.100523
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Article: Vitamin D level among Egyptian patients with chronic spontaneous urticaria and its relation to severity of the disease.

Abdel-Rehim, Asmaa S M / Sheha, Dina S / Mohamed, Nesrine A

The Egyptian journal of immunology

2014 Volume 21, Issue 2, Page(s) 85–90

Abstract: Vitamin D has an important role in the immune system. Decreased serum vitamin D level is known to be associated with autoimmune and atopic diseases. This study aimed to assess vitamin D status in patients with chronic spontaneous urticaria (CSU) and its ... ...

Abstract	Vitamin D has an important role in the immune system. Decreased serum vitamin D level is known to be associated with autoimmune and atopic diseases. This study aimed to assess vitamin D status in patients with chronic spontaneous urticaria (CSU) and its relation with severity of the disease. This case-control study was conducted on 22 patients and 20 age and sex matched controls. Patients were subjected to clinical assessment, routine laboratory examination: complete blood picture (CBC), erythrocyte sedimentation rate (ESR), hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab), anti-thyroid antibody, anti-nuclear antibody (ANA), total immunoglobulin E (IgE), vitamin D assay and stool analysis, and special investigations including: skin prick test (SPT), autologous serum skin test (ASST) and urticaria activity score (UAS). Patients' mean age was 32.8 ± 13.17 years. The median and interquartile range of duration of illness was 2.5 (1-4) years and of Ig E was 79 (62-312) IU/ml. According to UAS; 14 (63.6%) had severe and 8 (36.4%) had moderate degree illness. The mean vitamin D level among the patients was 28.4 ± 9.09 nmol/L. Vitamin D level was significantly lower among patients in comparison to controls (28.4 ± 9.09 vs. 104.5 ± 76.8, t = 4.4 P < 0.01). Vitamin D correlated negatively with IgE level (r = -0.45, P < 0.05), meanwhile it was insignificantly correlated with age and duration of illness (r = -0.117 and 0.34 respectively, P > 0.05). In conclusion; Low vitamin D level (r = 0.45) is associated with chronic spontaneous urticaria but has no relation with the severity of the disease.
MeSH term(s)	Adult ; Autoimmune Diseases/blood ; Autoimmune Diseases/pathology ; Case-Control Studies ; Chronic Disease ; Egypt ; Female ; Humans ; Immunoglobulin E/blood ; Male ; Middle Aged ; Severity of Illness Index ; Urticaria/blood ; Urticaria/mortality ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2014
Publishing country	Egypt
Document type	Clinical Trial ; Journal Article
ISSN	1110-4902
ISSN	1110-4902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Suspected Allergic Bronchopulmonary Aspergillosis Cases in Adult Bronchial Asthma Patients Attending a Tertiary Care Clinic.

Sabry, Mohammed K / Shahin, Rasha Y / Sheha, Dina S / Saleh, Asmaa M / Yassin, Aya A

The Egyptian journal of immunology

2016 Volume 23, Issue 1, Page(s) 31–37

Abstract: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus species (generally Aspergillus fumigatus) that occurs almost exclusively in patients with asthma or, less commonly, cystic fibrosis. Immune responses to ... ...

Abstract	Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus species (generally Aspergillus fumigatus) that occurs almost exclusively in patients with asthma or, less commonly, cystic fibrosis. Immune responses to Aspergillus antigens cause airway obstruction and, if untreated, bronchiectasis and pulmonary fibrosis. Our objective was to define the clinical characteristics, laboratory and radiological findings of suspected ABPA cases among a cohort of Egyptian patients with bronchial asthma. 52 moderate and severe asthma patients were recruited from the Allergy and Immunology clinic at Ain Shams University hospitals. Patients were subjected to history taking for asthma symptoms, skin test with Aspergillus fumigatus antigen, total IgE level, peripheral blood eosinophilia, chest x-ray and high resolution CT chest. 27 patients had positive skin prick and /or intradermal test to Aspergillus fumigatus antigen, and 11 (21.2%) of them fulfilled 4 of the criteria for ABPA diagnosis. Patients with suspected ABPA had significantly higher serum total IgE levels (median (IQR) = 625 IU/ml (514.9-762) with P-value <0.0001). Our study suggests a high frequency of suspected ABPA cases for further confirmation by appropriate diagnostic tests; there is a need for better recognition of ABPA as it is yet under recognized in Egypt Clinicians ought to have a high index of suspicion for ABPA while managing any patient with bronchial asthma to detect ABPA prior to development of irreversible complications.
Language	English
Publishing date	2016-01
Publishing country	Egypt
Document type	Journal Article
ISSN	1110-4902
ISSN	1110-4902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unfolding of sickle cell trait by coronavirus disease 2019 (COVID-19) infection.

Sheha, Dina / El-Shayeb, Mohamed / Eid, Yara / Amin, Mariam / Saeed, Alia / Abdou, Dina / Aly, Tarek / Samy, Sherief / Elziaty, Rahma / Aboelyazed, Sherihan / Osman, Ahmed / Sheha, Aliaa

British journal of haematology

2020 Volume 191, Issue 2, Page(s) e38–e40

MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Anticoagulants/therapeutic use ; Azithromycin/therapeutic use ; COVID-19/blood ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/therapy ; Combined Modality Therapy ; Delayed Diagnosis ; Diagnostic Errors ; Erythrocyte Transfusion ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Immunocompromised Host ; Osteonecrosis/diagnostic imaging ; Osteonecrosis/etiology ; Oxygen Inhalation Therapy ; Rheumatic Fever/diagnosis ; SARS-CoV-2 ; Sickle Cell Trait/blood ; Sickle Cell Trait/complications ; Sickle Cell Trait/diagnosis ; Sickle Cell Trait/immunology ; Splenectomy/adverse effects ; Superinfection ; Tachycardia/etiology ; Thrombocytopenia/etiology ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Anticoagulants ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
Keywords	covid19
Language	English
Publishing date	2020-09-23
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17089
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Article: Unfolding of sickle cell trait by coronavirus disease 2019 (COVID-19) infection

Sheha, Dina / El-Shayeb, Mohamed / Eid, Yara / Amin, Mariam / Saeed, Alia / Abdou, Dina / Aly, Tarek / Samy, Sherief / Elziaty, Rahma / Aboelyazed, Sherihan / Osman, Ahmed / Sheha, Aliaa

Br. j. haematol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #787578
Database	COVID19

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