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Article ; Online: The Usefulness of Rare Blood Group Systems in the Risk Determination for Severe COVID-19.

Konstantinidis, Theocharis G / Iliadi, Valeria / Martinis, Georges / Panopoulou, Maria

Pathophysiology : the official journal of the International Society for Pathophysiology

2021 Volume 28, Issue 4, Page(s) 496–500

Abstract: The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by ... ...

Abstract	The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by SARS-CoV, while blood type A individuals have an increased risk of severe illness. The Forssman antigen, or Forssman glycolipid synthase (FS), was first described in 1911 by John Frederick Forssman. Blood type A/B glycosyltransferases (AT/BTs) and Forssman glycolipid synthase (FS) are encoded by the evolutionarily related ABO (A/B alleles) and
Language	English
Publishing date	2021-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1212740-1
ISSN	1873-149X ; 0928-4680
ISSN (online)	1873-149X
ISSN	0928-4680
DOI	10.3390/pathophysiology28040032
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Article: The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives.

Papadopoulos, Panagiotis D / Tsigalou, Christina / Valsamaki, Pipitsa N / Konstantinidis, Theocharis G / Voidarou, Chrysoula / Bezirtzoglou, Eugenia

Biomedicines

2022 Volume 10, Issue 5

Abstract: The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as "dysbiosis", have been proven to play a vital role in ... ...

Abstract	The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as "dysbiosis", have been proven to play a vital role in the pathophysiology of several diseases, including cardiovascular disease (CVD). Although therapeutic regimes are available to treat this group of diseases, they have long been the main cause of mortality and morbidity worldwide. While age, sex, genetics, diet, tobacco use, and alcohol consumption are major contributors (World Health Organization, 2018), they cannot explain all of the consequences of CVD. In addition to the abovementioned traditional risk factors, the constant search for novel preventative and curative tools has shed light on the involvement of gut bacteria and their metabolites in the pathogenesis of CVD. In this narrative review, we will discuss the established interconnections between the gut microbiota and CVD, as well as the plausible therapeutic perspectives.
Language	English
Publishing date	2022-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10050948
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Article: Legionella pneumophila

Iliadi, Valeria / Staykova, Jeni / Iliadis, Sergios / Konstantinidou, Ina / Sivykh, Polina / Romanidou, Gioulia / Vardikov, Daniil F / Cassimos, Dimitrios / Konstantinidis, Theocharis G

Journal of clinical medicine

2022 Volume 11, Issue 20

Abstract: An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time ... ...

Abstract	An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11206126
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Article ; Online: The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19

Valeria Iliadi / Ina Konstantinidou / Konstantina Aftzoglou / Sergios Iliadis / Theocharis G. Konstantinidis / Christina Tsigalou

International Journal of Molecular Sciences, Vol 22, Iss 5368, p

2021 Volume 5368

Abstract: Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. ... ...

Abstract	Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. During an infection, neutrophils migrate from circulation to the infection site, contributing to killing pathogens. This mechanism is regulated by chemokines such as IL-8. Moreover, it was shown that neutrophils play an important role in thromboinflammation. Through a diverse repertoire of mechanisms, neutrophils, apart from directly killing pathogens, are able to activate the formation of thrombi. In COVID-19 patients, neutrophil activation promotes neutrophil extracellular trap (NET) formation, platelet aggregation, and cell damage. Furthermore, neutrophils participate in the pathogenesis of endothelitis. Overall, this review summarizes recent progress in research on the pathogenesis of COVID-19, highlighting the role of the prothrombotic action of neutrophils in NET formation.
Keywords	COVID-19 ; SARS CoV-2 ; NETs ; immunothrombosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19.

Iliadi, Valeria / Konstantinidou, Ina / Aftzoglou, Konstantina / Iliadis, Sergios / Konstantinidis, Theocharis G / Tsigalou, Christina

International journal of molecular sciences

2021 Volume 22, Issue 10

Abstract	Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. During an infection, neutrophils migrate from circulation to the infection site, contributing to killing pathogens. This mechanism is regulated by chemokines such as IL-8. Moreover, it was shown that neutrophils play an important role in thromboinflammation. Through a diverse repertoire of mechanisms, neutrophils, apart from directly killing pathogens, are able to activate the formation of thrombi. In COVID-19 patients, neutrophil activation promotes neutrophil extracellular trap (NET) formation, platelet aggregation, and cell damage. Furthermore, neutrophils participate in the pathogenesis of endothelitis. Overall, this review summarizes recent progress in research on the pathogenesis of COVID-19, highlighting the role of the prothrombotic action of neutrophils in NET formation.
MeSH term(s)	COVID-19/complications ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Cytokine Release Syndrome/metabolism ; Cytokine Release Syndrome/virology ; Extracellular Traps/immunology ; Extracellular Traps/virology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Inflammation/pathology ; Kidney/cytology ; Kidney/immunology ; Kidney/pathology ; Kidney/virology ; Lung/cytology ; Lung/immunology ; Lung/pathology ; Lung/virology ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/immunology ; Mucocutaneous Lymph Node Syndrome/virology ; Neutrophils/immunology ; SARS-CoV-2 ; Thrombosis/complications ; Thrombosis/immunology ; Thrombosis/pathology ; Thrombosis/virology
Language	English
Publishing date	2021-05-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22105368
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Article ; Online: The Emerging Role of the Gut Microbiome in Cardiovascular Disease

Panagiotis D. Papadopoulos / Christina Tsigalou / Pipitsa N. Valsamaki / Theocharis G. Konstantinidis / Chrysoula Voidarou / Eugenia Bezirtzoglou

Biomedicines, Vol 10, Iss 948, p

Current Knowledge and Perspectives

2022 Volume 948

Abstract: The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as “dysbiosis”, have been proven to play a vital role in ... ...

Abstract	The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as “dysbiosis”, have been proven to play a vital role in the pathophysiology of several diseases, including cardiovascular disease (CVD). Although therapeutic regimes are available to treat this group of diseases, they have long been the main cause of mortality and morbidity worldwide. While age, sex, genetics, diet, tobacco use, and alcohol consumption are major contributors (World Health Organization, 2018), they cannot explain all of the consequences of CVD. In addition to the abovementioned traditional risk factors, the constant search for novel preventative and curative tools has shed light on the involvement of gut bacteria and their metabolites in the pathogenesis of CVD. In this narrative review, we will discuss the established interconnections between the gut microbiota and CVD, as well as the plausible therapeutic perspectives.
Keywords	microbiome ; cardiovascular disease ; gut dysbiosis ; CVD ; bacterial metabolites ; TMAO ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Legionella pneumophila

Valeria Iliadi / Jeni Staykova / Sergios Iliadis / Ina Konstantinidou / Polina Sivykh / Gioulia Romanidou / Daniil F. Vardikov / Dimitrios Cassimos / Theocharis G. Konstantinidis

Journal of Clinical Medicine, Vol 11, Iss 20, p

The Journey from the Environment to the Blood

2022 Volume 6126

Abstract: An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that Legionella spp. was identified. Thereafter, the term Legionnaires’ disease (LD) was established. The infection in ... ...

Abstract	An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that Legionella spp. was identified. Thereafter, the term Legionnaires’ disease (LD) was established. The infection in humans is transmitted by the inhalation of aerosols that contain the microorganisms that belong to the Legionellaceae family and the genus Legionella. The genus Legionella contains genetically heterogeneous species and serogroups. The Legionella pneumophila serogroup 1 (Lp1) is the most often detected strain in outbreaks of LD. The pathogenesis of LD infection initiates with the attachment of the bacterial cells to the host cells, and subsequent intracellular replication. Following invasion, Legionella spp. activates its virulence mechanisms: generation of specific compartments of Legionella-containing vacuole (LCV), and expression of genes that encode a type IV secretion system (T4SS) for the translocation of proteins. The ability of L. pneumophila to transmigrate across the lung’s epithelium barrier leads to bacteremia, spread, and invasion of many organs with subsequent manifestations, complications, and septic shock. The clinical manifestations of LD depend on the bacterial load in the aerosol, the virulence factors, and the immune status of the patient. The infection has two distinct forms: the non- pneumatic form or Pontiac fever, which is a milder febrile flu-like illness, and LD, a more severe form, which includes pneumonia. In addition, the extrapulmonary involvement of LD can include heart, brain, abdomen, and joints.
Keywords	Legionella pneumophila ; bloodstream infection ; bacteremia ; Medicine ; R
Subject code	572
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy.

Romanidou, Gioulia / Konstantinidis, Theocharis G / Natsi, Anastasia-Maria / Kantartzi, Konstantia / Panopoulou, Maria / Kontomanolis, Emmanouil / Tsigalou, Christina / Lambropoulou, Maria / Gavriilaki, Eleni / Panagoutsos, Stylianos / Pasadakis, Ploumis / Mitroulis, Ioannis

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with ... ...

Abstract	HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 (DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrates that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1, and that the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which must be further evaluated.
MeSH term(s)	Pregnancy ; Female ; Humans ; HELLP Syndrome/metabolism ; Pre-Eclampsia/metabolism ; Placenta/metabolism ; Endothelial Cells/metabolism ; Thrombotic Microangiopathies/metabolism
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411762
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Article ; Online: Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights.

Papadakos, Stavros P / Argyrou, Alexandra / Lekakis, Vasileios / Arvanitakis, Konstantinos / Kalisperati, Polyxeni / Stergiou, Ioanna E / Konstantinidis, Ippokratis / Schizas, Dimitrios / Koufakis, Theocharis / Germanidis, Georgios / Theocharis, Stamatios

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Esophageal cancer (EC) remains a formidable malignancy with limited treatment options and high mortality rates, necessitating the exploration of innovative therapeutic avenues. Through a systematic analysis of a multitude of studies, we synthesize the ... ...

Abstract	Esophageal cancer (EC) remains a formidable malignancy with limited treatment options and high mortality rates, necessitating the exploration of innovative therapeutic avenues. Through a systematic analysis of a multitude of studies, we synthesize the diverse findings related to metformin's influence on EC. This review comprehensively elucidates the intricate metabolic pathways and molecular mechanisms through which metformin may exert its anti-cancer effects. Key focus areas include its impact on insulin signaling, AMP-activated protein kinase (AMPK) activation, and the mTOR pathway, which collectively contribute to its role in mitigating esophageal cancer progression. This review critically examines the body of clinical and preclinical evidence surrounding the potential role of metformin, a widely prescribed anti-diabetic medication, in EC management. Our examination extends to the modulation of inflammation, oxidative stress and angiogenesis, revealing metformin's potential as a metabolic intervention in esophageal cancer pathogenesis. By consolidating epidemiological and clinical data, we assess the evidence that supports metformin's candidacy as an adjuvant therapy for esophageal cancer. By summarizing clinical and preclinical findings, our review aims to enhance our understanding of metformin's role in EC management, potentially improving patient care and outcomes.
MeSH term(s)	Humans ; Metformin/pharmacology ; Antineoplastic Agents/pharmacology ; AMP-Activated Protein Kinases/metabolism ; Esophageal Neoplasms/drug therapy ; Signal Transduction
Chemical Substances	Metformin (9100L32L2N) ; Antineoplastic Agents ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052978
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Article ; Online: Views and Attitudes of Blood Donors toward Blood Donation during the COVID-19 Pandemic in Thrace Region, Greece.

Gkirtsou, Christina / Konstantinidis, Theocharis / Cassimos, Dimitrios / Konstantinidou, Eleni I / Kontekaki, Eftychia G / Rekari, Viki / Bezirtzoglou, Eugenia / Martinis, Georges / Stergiannis, Pantelis / For Thrace Study Group On Blood Donors' Attitude During The Covid-Pandemic

International journal of environmental research and public health

2022 Volume 19, Issue 9

Abstract: The COVID-19 pandemic has been going on for the last two years and it has affected our society and, amongst other things, has had a negative impact on blood donation, which has led to a significant reduction in blood supplies worldwide. The imposed ... ...

Abstract	The COVID-19 pandemic has been going on for the last two years and it has affected our society and, amongst other things, has had a negative impact on blood donation, which has led to a significant reduction in blood supplies worldwide. The imposed restrictions in terms of physical presence and transportation, and the fear of the unknown, have aggravated the situation. In Greece, after the first cases of COVID-19 were reported, the blood supplies at the blood transfusion units (BTUs) were dramatically reduced. Although the blood transfusions were lessened during the COVID-19 pandemic period, the blood stocks at all the BTUs of the country were also reduced.
MeSH term(s)	Attitude ; Blood Donors ; COVID-19/epidemiology ; Greece/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19094963
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