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  1. Book ; Thesis: Einfluss von mechanischen und chemischen Vorbehandlungen auf die Verbundfestigkeit bei der Reparatur einer Hybridkeramik

    Jung, Sascha Niklas

    2022  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Sascha Niklas Jung aus Darmstadt
    Keywords Verbundverhalten
    Subject Verbundfestigkeit ; Bindefestigkeit ; Bonding strength ; Bond strength
    Subject code 616.994
    Language German ; English
    Size 30 Seiten, Diagramme, 30 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2023
    Note Zusammenfassung auf Deutsch und Englisch ; Literaturverzeichnis: Seite 29-30 ; Enthält 1 Sonderabdruck
    HBZ-ID HT030346312
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2023 E 1255 order for loan Magazin

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  2. Article ; Online: Measuring biological age using a functionally interpretable multi-tissue RNA clock.

    Jung, Sascha / Arcos Hodar, Javier / Del Sol, Antonio

    Aging cell

    2023  Volume 22, Issue 5, Page(s) e13799

    Abstract: The quantification of the biological age of cells yields great promises for accelerating the discovery of novel rejuvenation strategies. Here, we present MultiTIMER, the first multi-tissue aging clock that measures the biological, rather than ... ...

    Abstract The quantification of the biological age of cells yields great promises for accelerating the discovery of novel rejuvenation strategies. Here, we present MultiTIMER, the first multi-tissue aging clock that measures the biological, rather than chronological, age of cells from their transcriptional profiles by evaluating key cellular processes. We applied MultiTIMER to more than 70,000 transcriptional profiles and demonstrate that it accurately responds to cellular stressors and known interventions while informing about dysregulated cellular functions.
    MeSH term(s) RNA/genetics ; Aging
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13799
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  3. Article: VSFlow: an open-source ligand-based virtual screening tool.

    Jung, Sascha / Vatheuer, Helge / Czodrowski, Paul

    Journal of cheminformatics

    2023  Volume 15, Issue 1, Page(s) 40

    Abstract: Ligand-based virtual screening is a widespread method in modern drug design. It allows for a rapid screening of large compound databases in order to identify similar structures. Here we report an open-source command line tool which includes a ... ...

    Abstract Ligand-based virtual screening is a widespread method in modern drug design. It allows for a rapid screening of large compound databases in order to identify similar structures. Here we report an open-source command line tool which includes a substructure-, fingerprint- and shape-based virtual screening. Most of the implemented features fully rely on the RDKit cheminformatics framework. VSFlow accepts a wide range of input file formats and is highly customizable. Additionally, a quick visualization of the screening results as pdf and/or pymol file is supported.
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2486539-4
    ISSN 1758-2946
    ISSN 1758-2946
    DOI 10.1186/s13321-023-00703-1
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  4. Article ; Online: VSFlow

    Sascha Jung / Helge Vatheuer / Paul Czodrowski

    Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-

    an open-source ligand-based virtual screening tool

    2023  Volume 10

    Abstract: Abstract Ligand-based virtual screening is a widespread method in modern drug design. It allows for a rapid screening of large compound databases in order to identify similar structures. Here we report an open-source command line tool which includes a ... ...

    Abstract Abstract Ligand-based virtual screening is a widespread method in modern drug design. It allows for a rapid screening of large compound databases in order to identify similar structures. Here we report an open-source command line tool which includes a substructure-, fingerprint- and shape-based virtual screening. Most of the implemented features fully rely on the RDKit cheminformatics framework. VSFlow accepts a wide range of input file formats and is highly customizable. Additionally, a quick visualization of the screening results as pdf and/or pymol file is supported. Graphical Abstract
    Keywords Virtual screening ; Substructure ; Fingerprints ; Shape ; Python ; RDKit ; Information technology ; T58.5-58.64 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Iatrogenic Macular Hemorrhage after Dexamethasone Implant Injection.

    Friesacher, Anna / Jung, Sascha Mathias / Tschuppert, Scott / Valmaggia, Christophe / Todorova, Margarita G

    Klinische Monatsblatter fur Augenheilkunde

    2024  Volume 241, Issue 4, Page(s) 498–499

    Title translation Iatrogene Makulablutung nach Injektion eines Dexamethason-Implantats.
    MeSH term(s) Humans ; Dexamethasone/administration & dosage ; Dexamethasone/adverse effects ; Iatrogenic Disease ; Drug Implants/adverse effects ; Retinal Hemorrhage/chemically induced ; Retinal Hemorrhage/etiology ; Retinal Hemorrhage/diagnosis ; Male ; Female ; Intravitreal Injections/adverse effects ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects
    Chemical Substances Dexamethasone (7S5I7G3JQL) ; Drug Implants ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2282-3278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influence of mechanical and chemical pre-treatments on the repair of a hybrid ceramic.

    Jung, Sascha Niklas / Rüttermann, Stefan

    Dental materials : official publication of the Academy of Dental Materials

    2022  Volume 38, Issue 7, Page(s) 1140–1148

    Abstract: Objectives: This study aimed to investigate the influence of the respective mechanical and chemical pre-treatments on the composite repair of a CAD/CAM hybrid ceramic using a microtensile bond strength test (μTBS).: Methods: 15 CAD/CAM Blocks of Vita ...

    Abstract Objectives: This study aimed to investigate the influence of the respective mechanical and chemical pre-treatments on the composite repair of a CAD/CAM hybrid ceramic using a microtensile bond strength test (μTBS).
    Methods: 15 CAD/CAM Blocks of Vita Enamic (VE) were randomly sectioned into three mechanical pre-treatments: (1.) Diamond bur (D), (2.) Airborne abrasion (A), (3.) Tribochemical silica coating (T) and subsequently five chemical pre-treatments: (1.) Clearfil SE Bond Bond (B; negative control), (2.) ESPE Sil (S), (3.) Clearfil Ceramic Primer Plus (CPP), (4.) Clearfil Repair (CR) and (5.) Scotchbond Universal (SCB). Per block, n = 20 specimens were sawn. Half of the specimens were randomly selected and subjected to an immediate bond strength test, while the other half was subjected to artificial aging for 6 months 180 days at 37 °C and subsequent thermocycling of 5000 cycles. A μTBS was performed and data (MPa) were compared in one-way and two-way ANOVA and Tukey's HSD. Paired-t-test was used for artificial aging (α = 0.05). Debonded specimens were analyzed of for failure modes with a stereomicroscope (SEM).
    Results: The results of one-way ANOVA for the fifteen fastening procedures after aging indicated significant differences according to SCB-A and CPP-T. Two-way ANOVA after aging observed inferior bond strength for SCB. No differences were observed for mechanical pre-treatments. Artificial aging showed a significant reduction in bond strength on most of the fastening procedures.
    Significance: SCB showed the lowest bond strength values besides B, S, CPP, and CR. MDP and silane are both suitable for the repair of VE.
    MeSH term(s) Ceramics/chemistry ; Composite Resins/chemistry ; Dental Bonding/methods ; Materials Testing ; Resin Cements/chemistry ; Silanes/chemistry ; Surface Properties ; Tensile Strength ; Random Allocation
    Chemical Substances Composite Resins ; Resin Cements ; Silanes ; VITA Enamic
    Language English
    Publishing date 2022-06-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605995-8
    ISSN 1879-0097 ; 0109-5641
    ISSN (online) 1879-0097
    ISSN 0109-5641
    DOI 10.1016/j.dental.2022.05.003
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  7. Article ; Online: How Electrodiagnostics Can Help in Differentiating Non-Arteritic Ischemic Optic Neuropathy from Normal Tension Glaucoma.

    Jung, Sascha Mathias / Valmaggia, Christophe / Todorova, Margarita

    Klinische Monatsblatter fur Augenheilkunde

    2022  Volume 239, Issue 4, Page(s) 460–463

    Title translation Wie mithilfe der Elektrodiagnostik eine nicht arteriitische ischämische Optikusneuropathie von einem Normadruckglaukom unterschieden werden kann.
    MeSH term(s) Humans ; Low Tension Glaucoma/diagnosis ; Optic Disk ; Optic Nerve ; Optic Neuropathy, Ischemic/diagnosis
    Language English
    Publishing date 2022-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1788-3879
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  8. Book ; Online ; Thesis: The Last Year of Life in Cologne: Comparison of health care provision for terminally ill cancer and non-cancer patients

    Kasdorf, Alina [Verfasser] / Jung, Norma [Gutachter] / Köpke, Sascha [Gutachter]

    2023  

    Author's details Alina Kasdorf ; Gutachter: Norma Jung, Sascha Köpke
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Article ; Online: Corrigendum to: FunRes: resolving tissue-specific functional cell states based on a cell-cell communication network model.

    Jung, Sascha / Singh, Kartikeya / Del Sol, Antonio

    Briefings in bioinformatics

    2021  Volume 22, Issue 5

    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbab018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Multiomics data integration unveils core transcriptional regulatory networks governing cell-type identity.

    Jung, Sascha / Del Sol, Antonio

    NPJ systems biology and applications

    2020  Volume 6, Issue 1, Page(s) 26

    Abstract: A plethora of computational approaches have been proposed for reconstructing gene regulatory networks (GRNs) from gene expression data. However, gene regulatory processes are often too complex to predict from the transcriptome alone. Here, we present a ... ...

    Abstract A plethora of computational approaches have been proposed for reconstructing gene regulatory networks (GRNs) from gene expression data. However, gene regulatory processes are often too complex to predict from the transcriptome alone. Here, we present a computational method, Moni, that systematically integrates epigenetics, transcriptomics, and protein-protein interactions to reconstruct GRNs among core transcription factors and their co-factors governing cell identity. We applied Moni to 57 datasets of human cell types and lines and demonstrate that it can accurately infer GRNs, thereby outperforming state-of-the-art methods.
    MeSH term(s) Epigenesis, Genetic ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; Protein Interaction Mapping ; Systems Biology
    Language English
    Publishing date 2020-08-24
    Publishing country England
    Document type Journal Article
    ISSN 2056-7189
    ISSN (online) 2056-7189
    DOI 10.1038/s41540-020-00148-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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