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  1. Article: Allergologie-immunologie: Effets secondaires des immunothérapies du cancer : du travail pour l’immunologue clinique.

    Obeid, Michel

    Revue medicale suisse

    2019  Volume 15, Issue N° 632-633, Page(s) 17–19

    Abstract: The immune checkpoint inhibitors (ICI) have radically changed the treatment and the prognostic of certain types of cancer. This reprogramming of the immune system can sometimes lead to immuno-related adverse events (irAEs) involving, depending on the ... ...

    Title translation Side effects of cancer immunotherapies : important role for the clinical immunologist.
    Abstract The immune checkpoint inhibitors (ICI) have radically changed the treatment and the prognostic of certain types of cancer. This reprogramming of the immune system can sometimes lead to immuno-related adverse events (irAEs) involving, depending on the immunotherapy used, multiple organ (s) with different severity, frequency and chronology. In theory all organs can be affected, often in a reversible and rapid manner if an immunosuppressive therapy is initiated in time. In contrast, endocrinopathies and some neuropathies are of long lasting and sometimes of irreversible nature. The management of high-grade autoimmune toxicities requires, first, the suspension of treatment and second, the introduction of steroids as first-line or, in case of failure, of a second immunosuppressive agent.
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions ; Humans ; Immunologic Factors ; Immunosuppressive Agents ; Immunotherapy/adverse effects ; Neoplasms/therapy
    Chemical Substances Immunologic Factors ; Immunosuppressive Agents
    Language French
    Publishing date 2019-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
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  2. Article: The mediating role of anxiety and depression between problematic social media use and bulimia nervosa among Lebanese university students.

    Sfeir, Michel / Rahme, Clara / Obeid, Sahar / Hallit, Souheil

    Journal of eating disorders

    2023  Volume 11, Issue 1, Page(s) 52

    Abstract: Background: Bulimia nervosa (BN) is a disorder that is characterized by binge eating and inappropriate compensatory behavior to control weight. The aim of this study was to evaluate the mediating role of anxiety and depression between problematic social ...

    Abstract Background: Bulimia nervosa (BN) is a disorder that is characterized by binge eating and inappropriate compensatory behavior to control weight. The aim of this study was to evaluate the mediating role of anxiety and depression between problematic social media use (PSMU) and BN among a sample of Lebanese university students.
    Methods: This cross-sectional study was carried out between July and September 2021; a total of 363 university students was recruited through convenience sampling. The PROCESS SPSS Macro version 3.4, model four was used to test the indirect effect and calculate three pathways. Pathway A determined the regression coefficient for the effect of PSMU on mental health issues (depression/anxiety); Pathway B examined the association between mental health issues on BN, and Pathway C' estimated the direct effect of PSMU on BN. Pathway AB was used to calculate the indirect effect of PSMU on BN via depression/anxiety.
    Results: Results showed that depression and anxiety partially mediated the association between PSMU and BN. Higher levels of PSMU were associated with more depression and anxiety; higher depression and anxiety were associated with more BN. PSMU was directly and significantly associated with more BN. When entering anxiety (M1) then depression (M2) as consecutive mediators in a first model, the results showed that only depression mediated the association between PSMU and bulimia. When taking depression (M1) then anxiety (M2) as consecutive mediators in a second model, the results showed that the mediation PSMU → Depression → Anxiety → Bulimia was significant. Higher PSMU was significantly associated with more depression, which was significantly associated with more anxiety, which was significantly associated with more bulimia. Finally, higher PSMU was directly and significantly associated with more bulimia CONCLUSION: The current paper highlights the relationship that social media use has on BN and other aspects of mental health such as anxiety and depression in Lebanon. Future studies should replicate the mediation analysis conducted in the current study while taking into account other eating disorders. Additional investigations of BN and its correlates must strive to improve the comprehension of these associations' pathways through designs that allow to draw temporal frameworks, in order to efficiently treat this eating disorder and prevent its negative outcomes.
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699357-0
    ISSN 2050-2974
    ISSN 2050-2974
    DOI 10.1186/s40337-023-00776-1
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  3. Article ; Online: Personalized treatment of immune-related adverse events - balance is required.

    Martins, Filipe / Obeid, Michel

    Nature reviews. Clinical oncology

    2020  Volume 17, Issue 8, Page(s) 517

    MeSH term(s) Humans ; Immunotherapy ; Precision Medicine ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-0400-4
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  4. Article ; Online: Attachment styles and orthorexia nervosa among Lebanese adolescents: The indirect effect of self-esteem.

    Azzi, Reine / Mhanna, Mariam / Hallit, Souheil / Obeid, Sahar / Soufia, Michel

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2023  Volume 30, Issue 5, Page(s) 314–320

    Abstract: Background: Orthorexia nervosa (ON), defined as the pathological obsession for pure foods, remains a novelty in the field of eating disorders. Many studies in the literature have shown that attachment styles correlate with the development of eating ... ...

    Abstract Background: Orthorexia nervosa (ON), defined as the pathological obsession for pure foods, remains a novelty in the field of eating disorders. Many studies in the literature have shown that attachment styles correlate with the development of eating disorders. Patients with eating disorders were found to be more avoidant and anxious and less secure than individuals who do not have eating disorders. However, studies on the relationship between attachment styles and ON remain limited, particularly in adolescents. This study assessed the relationship between attachment styles and ON in Lebanese adolescents (15-18 years), along with evaluating the indirect effect of self-esteem on this association.
    Methods: This study used a cross-sectional design and was carried out during May-June 2020 with 555 students (15-18 years) enrolled. The Düsseldorf Orthorexia Scale was utilized to screen for ON tendencies. A linear regression was conducted taking the DOS score as the dependent variable. The PROCESS Macro was used to test the indirect effect of self-esteem between attachment styles and ON.
    Results: Higher fearful and preoccupied attachment styles, female gender, and more physical activity were significantly associated with more ON tendencies, whereas higher self-esteem was significantly associated with less ON tendencies. When adjusting for all sociodemographic characteristics and other attachment styles, none of the attachment styles remained significantly correlated with ON tendencies. Self-esteem mediated the association between secure attachment style and ON and between dismissive attachment style and ON.
    Conclusions: The rise in ON warrants further studies and investigations to raise awareness and plan behavioral interventions in order to treat it.
    MeSH term(s) Humans ; Adolescent ; Female ; Orthorexia Nervosa ; Cross-Sectional Studies ; Feeding and Eating Disorders ; Self Concept ; Anxiety ; Surveys and Questionnaires
    Language English
    Publishing date 2023-06-14
    Publishing country France
    Document type Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2023.04.003
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  5. Article ; Online: Presence of a psychiatric patient at home and work fatigue in family caregivers: The moderating effect of spirituality.

    Sfeir, Michel / Zeitoun, Abeer / Hallit, Souheil / Obeid, Sahar

    Perspectives in psychiatric care

    2022  Volume 58, Issue 4, Page(s) 2664–2675

    Abstract: Objectives: To assess the association between the mental health of caregivers having a psychiatric patient at home and work fatigue, and if this association is moderated by spirituality.: Methods: This case-control study enrolled 600 caregivers (July- ...

    Abstract Objectives: To assess the association between the mental health of caregivers having a psychiatric patient at home and work fatigue, and if this association is moderated by spirituality.
    Methods: This case-control study enrolled 600 caregivers (July-September 2019).
    Results: Stress, anxiety, insomnia and the presence of a psychiatric patient at home were associated with higher levels of physical, mental, and emotional work fatigue. In the case of caregivers who have a psychiatric patient at home, those with low spirituality had more mental and emotional work fatigue.
    Practical implications: Healthcare professionals should enlighten caregivers more on the risks and the consequences of their job, assist them with information on what to expect, and teach them how to normalize feelings that they may face.
    MeSH term(s) Humans ; Caregivers/psychology ; Spirituality ; Case-Control Studies ; Fatigue/psychology ; Patients
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391097-0
    ISSN 1744-6163 ; 0031-5990
    ISSN (online) 1744-6163
    ISSN 0031-5990
    DOI 10.1111/ppc.13107
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  6. Article ; Online: Reactivation of IgA vasculitis after COVID-19 vaccination.

    Obeid, Michel / Fenwick, Craig / Pantaleo, Giuseppe

    The Lancet. Rheumatology

    2021  Volume 3, Issue 9, Page(s) e617

    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(21)00211-3
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  7. Article: Association between religiosity and orthorexia nervosa with the mediating role of self-esteem among a sample of the Lebanese population - short communication.

    Sfeir, Michel / Malaeb, Diana / Obeid, Sahar / Hallit, Souheil

    Journal of eating disorders

    2022  Volume 10, Issue 1, Page(s) 151

    Abstract: Background: Orthorexia Nervosa is not yet classified as an eating disorder albeit it can be found in different populations. This condition can be characterized by a preoccupation with the quality of food, accompanied by obsessive thoughts regarding ... ...

    Abstract Background: Orthorexia Nervosa is not yet classified as an eating disorder albeit it can be found in different populations. This condition can be characterized by a preoccupation with the quality of food, accompanied by obsessive thoughts regarding eating behaviors, leading to malnutrition. Previous associations have been reported between high levels of eating disorders and lower levels of self-esteem; where individuals have low self-esteem due to the pressured felt to fit the norms of society in beauty standards. The aim of the present study was to evaluate the relationship between religiosity and orthorexia nervosa via either trait or state self-esteem.
    Methods: This study was conducted between September 2021 and February 2022 and included 428 participants from all Lebanese governorates. The Teruel Orthorexia Nervosa scale was used to measure orthorexia nervosa. The following scales state self-esteem and religiosity were used to measure self-esteem.
    Results: Sociodemographic characteristics (age, gender, marital status, household crowding index, body mass index and education) were entered in the mediation model as confounding variables. Higher religiosity was significantly associated with higher state self-esteem (Beta = 0.07), while higher state self-esteem was significantly associated with lower identification of those that exhibited ON tendencies or symptoms (Beta= -0.11).
    Conclusion: A high state self-esteem was correlated with a lower level of orthorexia nervosa. Higher religiosity was shown to be associated with higher self-esteem, which in turn was associated with a decrease in the scores of orthorexia nervosa.
    Language English
    Publishing date 2022-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699357-0
    ISSN 2050-2974
    ISSN 2050-2974
    DOI 10.1186/s40337-022-00672-0
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  8. Article: Factors associated with general well-being among Lebanese adults: The role of emotional intelligence, fear of COVID, healthy lifestyle, coping strategies (avoidance and approach).

    Sfeir, Michel / Akel, Marwan / Hallit, Souheil / Obeid, Sahar

    Current psychology (New Brunswick, N.J.)

    2022  , Page(s) 1–10

    Abstract: General well-being is best described as the state of mind that gives people happiness and satisfaction in life. This concept is influenced by behaviors and attitudes that individuals do on a daily basis. The purpose of this study was to understand how ... ...

    Abstract General well-being is best described as the state of mind that gives people happiness and satisfaction in life. This concept is influenced by behaviors and attitudes that individuals do on a daily basis. The purpose of this study was to understand how general well-being is correlated with other factors such as emotional intelligence, Covid-19-induced fear, healthy lifestyle, and coping strategies. This cross-sectional study was carried out between December 2020 and January 2021 during the COVID-19 pandemic when lockdown restrictions were implemented at different instances. A total of 470 individuals participated. The results of a linear regression, taking the general well-being schedule score as the dependent variable, showed that more avoidance coping (B = 1.05, t(459) =8.44, p < 0.001), higher healthy lifestyle scores (B = 0.45, t(459) = 5.45, p < 0.001), and more approach coping (B = 0.42, t(459) = 4.03, p < 0.001) were significantly associated with higher GWB schedule scores. Moreover, having more fear of COVID-19 (B = -0.62, t(459) = -5.09, p < 0.001) and female gender (B = -6.80, t(459) = -4.34, p < 0.001) were significantly associated with lower GWB schedule scores. To our knowledge, this is the first study in Lebanon to evaluate GWB and factors that predict it among the general population. Nevertheless, more comprehensive future studies with longitudinal designs, more diverse socio-demographic backgrounds of sampled population recruited via probability sampling, and more reliable and valid instruments utilized are warranted to confirm our findings and draw a more certain conclusion.
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021598-8
    ISSN 1936-4733 ; 1046-1310
    ISSN (online) 1936-4733
    ISSN 1046-1310
    DOI 10.1007/s12144-021-02549-y
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  9. Article ; Online: Cyberchondria Severity and Quality of Life Among Lebanese Adults: The Moderating Effect of Emotions.

    Tarabay, Christina / Bitar, Zeinab / Akel, Marwan / Hallit, Souheil / Obeid, Sahar / Soufia, Michel

    The primary care companion for CNS disorders

    2023  Volume 25, Issue 2

    Abstract: Objective:: Methods:: Results:: Conclusions: ...

    Abstract Objective:
    Methods:
    Results:
    Conclusions:
    MeSH term(s) Adult ; Humans ; Quality of Life/psychology ; Cross-Sectional Studies ; Pandemics ; COVID-19 ; Emotions/physiology
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7780
    ISSN (online) 2155-7780
    ISSN 2155-7780
    DOI 10.4088/PCC.22m03252
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  10. Article ; Online: Response-adjusted regimen combining ruxolitinib, etoposide and dexamethasone (adRED) in adult patients with acute myeloid leukemia-associated hemophagocytic lymphohistiocytosis: a single-center pilot trial.

    Stalder, Grégoire / Suffiotti, Madeleine / Segot, Amandine / Noto, Alessandra / Pantaleo, Giuseppe / Spertini, Olivier / Obeid, Michel

    Haematologica

    2023  Volume 108, Issue 1, Page(s) 234–239

    MeSH term(s) Adult ; Humans ; Clinical Trials as Topic ; Dexamethasone ; Etoposide ; Leukemia, Myeloid, Acute ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Lymphohistiocytosis, Hemophagocytic/etiology ; Pilot Projects
    Chemical Substances Dexamethasone (7S5I7G3JQL) ; Etoposide (6PLQ3CP4P3) ; ruxolitinib (82S8X8XX8H)
    Language English
    Publishing date 2023-01-01
    Publishing country Italy
    Document type Clinical Trial ; Letter
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281221
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