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  1. Article ; Online: Treating Attention-Deficit/Hyperactivity Disorder Matters.

    Levin, Frances R / Hernandez, Mariely / Mariani, John J

    JAMA

    2024  Volume 331, Issue 10, Page(s) 831–833

    MeSH term(s) Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.1755
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  2. Book: Addiction

    Danovitch, Itai / Mariani, John J.

    (The psychiatric clinics of North America ; 35,2)

    2012  

    Author's details guest ed. Itai Danovitch ; John J. Mariani
    Series title The psychiatric clinics of North America ; 35,2
    Psychiatric clinics of North America
    Collection Psychiatric clinics of North America
    Language English
    Size XIV S., S. 279 - 555 : Ill., graph. Darst., Kt.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT017310008
    ISBN 978-1-4557-3926-4 ; 1-4557-3926-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 550 -35,2- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Electroconvulsive therapy-a shocking inducer of neuroplasticity?

    Tartt, Alexandria N / Mariani, Madeline / Hen, Rene / Mann, J John / Boldrini, Maura

    Molecular psychiatry

    2023  

    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Letter
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02015-0
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  4. Article ; Online: Clinical Significance and Outcomes in Trial of Nabiximols for Treatment of Cannabis Dependence.

    Levin, Frances R / Mariani, John J

    JAMA internal medicine

    2019  Volume 180, Issue 1, Page(s) 162–163

    MeSH term(s) Cannabidiol ; Dronabinol ; Drug Combinations ; Humans ; Marijuana Abuse
    Chemical Substances Drug Combinations ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S) ; nabiximols (K4H93P747O)
    Language English
    Publishing date 2019-12-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2019.5664
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  5. Article ; Online: Open-label investigation of rapid initiation of extended-release buprenorphine in patients using fentanyl and fentanyl analogs.

    Mariani, John J / Dobbins, Robert L / Heath, Amy / Gray, Frank / Hassman, Howard

    The American journal on addictions

    2023  Volume 33, Issue 1, Page(s) 8–14

    Abstract: Background and objectives: Synthetic opioids, including fentanyl and fentanyl analogs, account for over 70,000 annual overdose deaths in the United States, but there is limited information examining methods of induction and maintenance outcomes for ... ...

    Abstract Background and objectives: Synthetic opioids, including fentanyl and fentanyl analogs, account for over 70,000 annual overdose deaths in the United States, but there is limited information examining methods of induction and maintenance outcomes for buprenorphine treatment of patients with opioid use disorder (OUD) using these opioids.
    Methods: A secondary analysis of results grouped by fentanyl use status was completed for an open-label study with rapid induction of extended-release buprenorphine in the inpatient research unit. Eligible participants received a single 4 mg dose of transmucosal buprenorphine (BUP-TM) followed by an extended-release buprenorphine 300 mg injection ([BUP-XR]) after approximately 1 h. An extension study continued follow-up up to 6 months (6 monthly injections).
    Results: Among participants with fentanyl-positive urine samples (FEN+; n = 19), all received BUP-TM, 17 received BUP-XR, 13 elected to receive a second BUP-XR injection, and 10 received all six scheduled injections. Among participants with fentanyl-negative samples (FEN-; n = 7), all received BUP-TM and BUP-XR, four elected to receive a second injection, and two participants received all six scheduled injections. Induction day clinical opioid withdrawal scale (COWS) scores were similar for FEN+ and FEN- groups. In the FEN+ group, mean COWS scores fell to below 5 within 24 h of BUP-XR injection.
    Discussion and conclusions: The treatment of individuals with OUD using fentanyl with a rapid 1-day induction to BUP-XR 300 mg injection is feasible and well-tolerated.
    Scientific significance: A prospective trial of participants grouped by fentanyl use status at induction demonstrates comparable patient retention and clinical response following single-day induction of BUP-XR in participants who are FEN+ and FEN-.
    MeSH term(s) Humans ; United States ; Buprenorphine ; Narcotic Antagonists ; Naltrexone/therapeutic use ; Fentanyl/therapeutic use ; Prospective Studies ; Opioid-Related Disorders/drug therapy ; Analgesics, Opioid/therapeutic use ; Delayed-Action Preparations
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Narcotic Antagonists ; Naltrexone (5S6W795CQM) ; Fentanyl (UF599785JZ) ; Analgesics, Opioid ; Delayed-Action Preparations
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141440-6
    ISSN 1521-0391 ; 1055-0496
    ISSN (online) 1521-0391
    ISSN 1055-0496
    DOI 10.1111/ajad.13484
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    Zs.A 3594: Show issues Location:
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  6. Article ; Online: Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications.

    Tartt, Alexandria N / Mariani, Madeline B / Hen, Rene / Mann, J John / Boldrini, Maura

    Molecular psychiatry

    2022  Volume 27, Issue 6, Page(s) 2689–2699

    Abstract: Major depressive disorder (MDD) was previously hypothesized to be a disease of monoamine deficiency in which low levels of monoamines in the synaptic cleft were believed to underlie depressive symptoms. More recently, however, there has been a paradigm ... ...

    Abstract Major depressive disorder (MDD) was previously hypothesized to be a disease of monoamine deficiency in which low levels of monoamines in the synaptic cleft were believed to underlie depressive symptoms. More recently, however, there has been a paradigm shift toward a neuroplasticity hypothesis of depression in which downstream effects of antidepressants, such as increased neurogenesis, contribute to improvements in cognition and mood. This review takes a top-down approach to assess how changes in behavior and hippocampal-dependent circuits may be attributed to abnormalities at the molecular, structural, and synaptic level. We conclude with a discussion of how antidepressant treatments share a common effect in modulating neuroplasticity and consider outstanding questions and future perspectives.
    MeSH term(s) Adult ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Depression/therapy ; Depressive Disorder, Major/drug therapy ; Hippocampus ; Humans ; Neuronal Plasticity/physiology
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01520-y
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  7. Article: Neural correlates of drinking reduction during cognitive behavioral therapy for alcohol use disorder.

    Naqvi, Nasir H / Srivastava, A Benjamin / Sanchez-Peña, Juan / Lee, Jessica / Mariani, John J / Patel, Gaurav H / Levin, Frances R

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a brain region implicated in cognitive control and goal-directed behavior, plays a role behavior ...

    Abstract Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a brain region implicated in cognitive control and goal-directed behavior, plays a role behavior change during CBT by facilitating regulation of craving. To examine this, treatment-seeking participants with AUD (N=22) underwent functional MRI scanning both before and after a 12-week single-arm trial of CBT, using a regulation of craving (ROC) fMRI task designed to measure an individual's ability to control alcohol craving and previously shown to engage the DLPFC. We found that both the number of heavy drinking days (NHDD, the primary clinical outcome) and the self-reported alcohol craving measured during the ROC paradigm were significantly reduced from pre- to post-CBT [NHDD: t=15.69, p<0.0001; alcohol craving: (F(1,21)=16.16; p=0.0006)]. Contrary to our hypothesis, there was no change in regulation effects on self-reported craving over time (F(1,21)=0.072; p=0.79), nor was there was a significant change in regulation effects over time on activity in any parcel. Searching the whole brain for neural correlates of reductions in drinking and craving after CBT, we found a significant 3-way interaction between the effects of cue-induced alcohol craving, cue-induced brain activity and timepoint of assessment (pre- or post-CBT) on NHDD in a parcel corresponding to area 46 of the right DLPFC (ß=-0.37, p=0.046, FDR corrected). Follow-up analyses showed that reductions in cue-induced alcohol craving from pre- to post-CBT were linearly related to reductions in alcohol cue-induced activity in area 46 only among participants who ceased heavy drinking during CBT (r=0.81, p=0.005) but not among those who continued to drink heavily (r=0.28, p=0.38). These results are consistent with a model in which CBT impacts heavy drinking by increasing the engagement of the DLPFC during cue-induced craving.
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.08.527703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New directions in the treatment of opioid withdrawal.

    Srivastava, A Benjamin / Mariani, John J / Levin, Frances R

    Lancet (London, England)

    2020  Volume 395, Issue 10241, Page(s) 1938–1948

    Abstract: The treatment of opioid withdrawal is an important area of clinical concern when treating patients with chronic, non-cancer pain, patients with active opioid use disorder, and patients receiving medication for opioid use disorder. Current standards of ... ...

    Abstract The treatment of opioid withdrawal is an important area of clinical concern when treating patients with chronic, non-cancer pain, patients with active opioid use disorder, and patients receiving medication for opioid use disorder. Current standards of care for medically supervised withdrawal include treatment with μ-opioid receptor agonists, (eg, methadone), partial agonists (eg, buprenorphine), and α2-adrenergic receptor agonists (eg, clonidine and lofexidine). Newer agents likewise exploit these pharmacological mechanisms, including tramadol (μ-opioid receptor agonism) and tizanidine (α2 agonism). Areas for future research include managing withdrawal in the context of stabilising patients with opioid use disorder to extended-release naltrexone, transitioning patients with opioid use disorder from methadone to buprenorphine, and tapering opioids in patients with chronic, non-cancer pain.
    MeSH term(s) Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Adrenergic alpha-2 Receptor Agonists/adverse effects ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Drug Administration Schedule ; Humans ; Narcotic Antagonists/administration & dosage ; Narcotic Antagonists/adverse effects ; Opiate Substitution Treatment/methods ; Opioid-Related Disorders/drug therapy ; Substance Withdrawal Syndrome/drug therapy
    Chemical Substances Adrenergic alpha-2 Receptor Agonists ; Analgesics, Opioid ; Narcotic Antagonists
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30852-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neural correlates of drinking reduction during a clinical trial of cognitive behavioral therapy for alcohol use disorder.

    Naqvi, Nasir H / Srivastava, A Benjamin / Sanchez-Peña, Juan / Lee, Jessica K / Drysdale, Andrew T / Mariani, John J / Ochsner, Kevin N / Morgenstern, Jon / Patel, Gaurav H / Levin, Frances R

    Alcohol, clinical & experimental research

    2024  Volume 48, Issue 2, Page(s) 260–272

    Abstract: Background: Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a region implicated in cognitive control and goal-directed behavior, plays a role ... ...

    Abstract Background: Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a region implicated in cognitive control and goal-directed behavior, plays a role in behavior change during CBT by facilitating the regulation of craving (ROC).
    Methods: Treatment-seeking participants with AUD (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning both before and after a 12-week, single-arm trial of CBT, using an ROC task that was previously shown to engage the DLPFC.
    Results: We found that both the percentage of heavy drinking days (PHDD) and the overall self-reported alcohol craving measured during the ROC task were significantly reduced from pre- to post-CBT. However, we did not find significant changes over time in either the ability to regulate craving or regulation-related activity in any brain region. We found a significant 3-way interaction between the effects of cue-induced craving, cue-induced brain activity and timepoint of assessment (pre- or post-CBT) on PHDD in the left DLPFC. Follow-up analysis showed that cue-induced craving was associated with cue-induced activity in the left DLPFC among participants who ceased heavy drinking during CBT, both at pre-CBT and post-CBT timepoints. No such associations were present at either timepoint among participants who continued to drink heavily.
    Conclusions: These results suggest that patients in whom DLPFC functioning is more strongly related to cue-induced craving may preferentially respond to CBT.
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ISSN 2993-7175
    ISSN (online) 2993-7175
    DOI 10.1111/acer.15259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Correction to "Drinking reduction during a clinical trial of cognitive behavioral therapy for alcohol use disorder is associated with reduction in anterior insula-bed nucleus of the stria terminalis resting state functional connectivity".

    Srivastava, A Benjamin / Sanchez-Peña, Juan / Levin, Frances R / Mariani, John J / Patel, Gaurav H / Naqvi, Nasir H

    Alcohol (Hanover, York County, Pa.)

    2022  Volume 47, Issue 7, Page(s) 1423–1424

    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Published Erratum
    DOI 10.1111/acer.14767
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