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  1. Article ; Online: Status of Current Biofluid Biomarkers in Parkinson's Disease.

    Mollenhauer, Brit

    Movement disorders clinical practice

    2023  Volume 10, Issue Suppl 2, Page(s) S18–S20

    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The long road to neuroprotection for Parkinson's disease.

    Trenkwalder, Claudia / Mollenhauer, Brit

    The Lancet. Neurology

    2023  Volume 23, Issue 1, Page(s) 2–3

    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Neuroprotection ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use
    Chemical Substances Neuroprotective Agents
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00462-3
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    Zs.A 5955: Show issues Location:
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  3. Article ; Online: Prodromal Parkinson disease - time is brain.

    Weber, Sandrina / Mollenhauer, Brit

    Nature reviews. Neurology

    2021  Volume 17, Issue 6, Page(s) 329–330

    MeSH term(s) Brain/diagnostic imaging ; Humans ; Parkinson Disease/diagnosis ; Prodromal Symptoms ; REM Sleep Behavior Disorder
    Language English
    Publishing date 2021-04-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00489-6
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    Zs.A 6257: Show issues Location:
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    Zs.MG 88: Show issues

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  4. Book ; Thesis: Differentialdiagnosen der Creuzfeldt-Jakob-Krankheit

    Mollenhauer, Brit

    1998  

    Author's details vorgelegt von Brit Mollenhauer
    Language German
    Size V, 110 Bl., graph. Darst., 30 cm
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Diss., 2000
    HBZ-ID HT013387923
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 3422 order for loan Magazin

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  5. Article ; Online: Can we prevent and slow down neurodegeneration with diet and exercise?

    Mollenhauer, Brit

    Movement disorders : official journal of the Movement Disorder Society

    2016  Volume 31, Issue 3, Page(s) 299

    MeSH term(s) Cognition Disorders/prevention & control ; Diet ; Exercise ; Exercise Therapy ; Humans ; Male ; Vascular Diseases/epidemiology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.26449
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    Zs.MO 238: Show issues

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  6. Article ; Online: Toward preventing Parkinson's disease.

    Mollenhauer, Brit / von Arnim, Christine A F

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6608, Page(s) 818–819

    Abstract: A glycoprotein is a possible biomarker of pathogenic progression for Parkinson's disease. ...

    Abstract A glycoprotein is a possible biomarker of pathogenic progression for Parkinson's disease.
    MeSH term(s) Biomarkers/analysis ; Biomarkers/metabolism ; Disease Progression ; Early Diagnosis ; Humans ; Membrane Glycoproteins/analysis ; Membrane Glycoproteins/metabolism ; Parkinson Disease/diagnosis ; Parkinson Disease/prevention & control
    Chemical Substances Biomarkers ; GPNMB protein, human ; Membrane Glycoproteins
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add7162
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    Zs.MG 77: Show issues

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  7. Article ; Online: Prediagnostic presentation of Parkinson's disease in primary care: A case-control study.

    Mollenhauer, Brit

    Movement disorders : official journal of the Movement Disorder Society

    2015  Volume 30, Issue 6, Page(s) 787

    MeSH term(s) Female ; Humans ; Male ; Parkinson Disease/physiopathology ; Primary Health Care/statistics & numerical data ; Prodromal Symptoms
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.26234
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    Zs.MO 238: Show issues

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  8. Article ; Online: CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology.

    Herman, Shay / Djaldetti, Ruth / Mollenhauer, Brit / Offen, Daniel

    Brain : a journal of neurology

    2022  Volume 146, Issue 1, Page(s) 209–224

    Abstract: Parkinson's disease is characterized by the gradual appearance of intraneuronal inclusions that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and neural death. Recent in vitro and in vivo studies suggest that misfolded ... ...

    Abstract Parkinson's disease is characterized by the gradual appearance of intraneuronal inclusions that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and neural death. Recent in vitro and in vivo studies suggest that misfolded α-synuclein may spread transcellularly in a prion-like manner, inducing pathological aggregates in healthy neurons, and is disseminated via secretion of extracellular vesicles. Accordingly, extracellular vesicles derived from brain lysates and CSF of patients with Parkinson's disease were shown to facilitate α-synuclein aggregation in healthy cells. Prompted by the hypothesis of Braak and colleagues that the olfactory bulb is one of the primary propagation sites for the initiation of Parkinson's disease, we sought to investigate the role of extracellular vesicles in the spread of α-synuclein and progression of Parkinson's disease through the olfactory bulb. Extracellular vesicles derived from the CSF of patients diagnosed with Parkinson's disease or with a non-synucleinopathy neurodegenerative disorder were administered intranasally to healthy mice, once daily over 4 days. Three months later, mice were subjected to motor and non-motor tests. Functional impairments were elucidated by histochemical analysis of midbrain structures relevant to Parkinson's disease pathology, 8 months after EVs treatment. Mice treated with extracellular vesicles from the patients with Parkinson's disease displayed multiple symptoms consistent with prodromal and clinical-phase Parkinson's disease such as hyposmia, motor behaviour impairments and high anxiety levels. Furthermore, their midbrains showed widespread α-synuclein aggregations, dopaminergic neurodegeneration, neuroinflammation and altered autophagy activity. Several unconventional pathologies were also observed, such as α-synuclein aggregations in the red nucleus, growth of premature grey hair and astrogliosis. Collectively, these data indicate that intranasally administered extracellular vesicles derived from the CSF of patients with Parkinson's disease can propagate α-synuclein aggregation in vivo and trigger Parkinson's disease-like symptoms and pathology in healthy mice.
    MeSH term(s) Mice ; Animals ; Parkinson Disease/metabolism ; alpha-Synuclein/metabolism ; Neurons/metabolism ; Brain/pathology ; Extracellular Vesicles/metabolism
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2022-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac261
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  9. Article ; Online: Movement disorders in 2019: from antibodies to lifestyle interventions.

    Trenkwalder, Claudia / Mollenhauer, Brit

    The Lancet. Neurology

    2019  Volume 19, Issue 1, Page(s) 10–12

    MeSH term(s) Antibodies ; Humans ; Life Style ; Movement Disorders ; Neurology/trends
    Chemical Substances Antibodies
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(19)30438-7
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  10. Article ; Online: Levodopa Equivalent Dose Conversion Factors: An Updated Proposal Including Opicapone and Safinamide.

    Schade, Sebastian / Mollenhauer, Brit / Trenkwalder, Claudia

    Movement disorders clinical practice

    2020  Volume 7, Issue 3, Page(s) 343–345

    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.12921
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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