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  1. Article ; Online: Corrigendum to "A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia" [J. Theor. Biol. 545 (2022) 111104].

    Celora, Giulia L / Bader, Samuel B / Hammond, Ester M / Maini, Philip K / Pitt-Francis, Joe M / Byrne, Helen M

    Journal of theoretical biology

    2023  Volume 571, Page(s) 111507

    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2023.111507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 923: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Bacterial adaptation to cold: Conservation of a short J-domain co-chaperone and its protein partners in environmental proteobacteria.

    Weber, Lana / Gilat, Atar / Maillot, Nathanael / Byrne, Deborah / Arnoux, Pascal / Giudici-Orticoni, Marie-Thérèse / Méjean, Vincent / Ilbert, Marianne / Genest, Olivier / Rosenzweig, Rina / Dementin, Sébastien

    Environmental microbiology

    2023  Volume 25, Issue 11, Page(s) 2447–2464

    Abstract: Bacterial genomes are a huge reservoir of genes encoding J-domain protein co-chaperones ... AtcJ is a short J-domain protein that interacts with DnaK, but also with AtcC through its 21 amino acid ... represents a subfamily of short J-domain proteins that (i) are found in several environmental, mostly aquatic ...

    Abstract Bacterial genomes are a huge reservoir of genes encoding J-domain protein co-chaperones that recruit the molecular chaperone DnaK to assist protein substrates involved in survival, adaptation, or fitness. The atc operon of the aquatic mesophilic bacterium Shewanella oneidensis encodes the proteins AtcJ, AtcA, AtcB, and AtcC, and all of them, except AtcA, are required for growth at low temperatures. AtcJ is a short J-domain protein that interacts with DnaK, but also with AtcC through its 21 amino acid C-terminal domain. This interaction network is critical for cold growth. Here, we show that AtcJ represents a subfamily of short J-domain proteins that (i) are found in several environmental, mostly aquatic, β- or ɣ-proteobacteria and (ii) contain a conserved PX
    MeSH term(s) Proteobacteria/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Arginine ; Cold Temperature ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Escherichia coli Proteins/genetics
    Chemical Substances arginine thiazolidinecarboxylate (57631-15-9) ; Molecular Chaperones ; Arginine (94ZLA3W45F) ; Bacterial Proteins ; Escherichia coli Proteins
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.16478
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  3. Article ; Online: J-shaped relationship between serum zinc levels and the severity of hepatic necro-inflammation in patients with MAFLD.

    Chen, Sui-Dan / Zhang, Huai / Rios, Rafael S / Li, Yang-Yang / Zhu, Pei-Wu / Jin, Yi / Ma, Hong-Lei / Tang, Liang-Jie / Li, Gang / Huang, Ou-Yang / Zheng, Kenneth I / Byrne, Christopher D / Targher, Giovanni / Zheng, Ming-Hua

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2022  Volume 32, Issue 5, Page(s) 1259–1265

    Abstract: ... 1.97; p = 0.035).: Conclusions: There is a J-shaped relationship between serum zinc levels and ...

    Abstract Background and aims: Zinc is an essential trace element that plays an important role in maintaining health, and affecting gene expression, signal transduction and regulation of apoptosis. It is uncertain whether serum zinc levels are altered in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to investigate the association between serum zinc levels and the severity of hepatic necro-inflammation (HN) in patients with MAFLD.
    Methods and results: Liver disease severity was graded histologically using the NAFLD activity score. HN was defined as the sum of ballooning and lobular inflammation. We used a smooth function regression model to analyze the relationship between serum zinc levels and HN. A total of 561 (76.5% men) patients with biopsy-confirmed MAFLD were enrolled. They had a mean age of 41.3 years, and a mean serum zinc level of 17.0 ± 4.1 μmol/L. Compared to those with mild hepatic necro-inflammation (MHN, grades 0-2; n = 286), patients with severe hepatic necro-inflammation (SHN, grades 3-5; n = 275) had lower serum zinc concentrations (16.3 ± 4.2 vs. 17.6 ± 4.0 μmol/L; p < 0.001). However, a threshold saturation effect analysis showed that there was an inflection in serum zinc levels at 24 μmol/L. After adjustment for potential confounders, serum zinc levels <24 μmol/L were inversely associated with SHN (adjusted-odds ratio 0.88, 95%CI 0.83-0.93; p < 0.001), whereas serum zinc levels >24 μmol/L were positively associated with SHN (adjusted-odds ratio 1.42, 95%CI: 1.03-1.97; p = 0.035).
    Conclusions: There is a J-shaped relationship between serum zinc levels and the severity of hepatic necro-inflammation in patients with biopsy-proven MAFLD.
    MeSH term(s) Adult ; Female ; Humans ; Inflammation/diagnosis ; Liver Cirrhosis ; Male ; Non-alcoholic Fatty Liver Disease/complications ; Zinc
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-02-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.01.035
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    Zs.A 3149: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: J-shaped relationship between serum zinc levels and the severity of hepatic necro-inflammation in patients with MAFLD

    Chen, Sui-Dan / Zhang, Huai / Rios, Rafael S. / Li, Yang-Yang / Zhu, Pei-Wu / Jin, Yi / Ma, Hong-Lei / Tang, Liang-Jie / Li, Gang / Huang, Ou-Yang / Zheng, Kenneth I. / Byrne, Christopher D. / Targher, Giovanni / Zheng, Ming-Hua

    The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2022 Jan. 31,

    2022  

    Abstract: ... with SHN (adjusted-odds ratio 1.42, 95%CI: 1.03–1.97; p = 0.035). There is a J-shaped relationship between ...

    Abstract Zinc is an essential trace element that plays an important role in maintaining health, and affecting gene expression, signal transduction and regulation of apoptosis. It is uncertain whether serum zinc levels are altered in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to investigate the association between serum zinc levels and the severity of hepatic necro-inflammation (HN) in patients with MAFLD. Liver disease severity was graded histologically using the NAFLD activity score. HN was defined as the sum of ballooning and lobular inflammation. We used a smooth function regression model to analyze the relationship between serum zinc levels and HN. A total of 561 (76.5% men) patients with biopsy-confirmed MAFLD were enrolled. They had a mean age of 41.3 years, and a mean serum zinc level of 17.0 ± 4.1 μmol/L. Compared to those with mild hepatic necro-inflammation (MHN, grades 0–2; n = 286), patients with severe hepatic necro-inflammation (SHN, grades 3–5; n = 275) had lower serum zinc concentrations (16.3 ± 4.2 vs. 17.6 ± 4.0 μmol/L; p < 0.001). However, a threshold saturation effect analysis showed that there was an inflection in serum zinc levels at 24 μmol/L. After adjustment for potential confounders, serum zinc levels <24 μmol/L were inversely associated with SHN (adjusted-odds ratio 0.88, 95%CI 0.83–0.93; p < 0.001), whereas serum zinc levels >24 μmol/L were positively associated with SHN (adjusted-odds ratio 1.42, 95%CI: 1.03–1.97; p = 0.035). There is a J-shaped relationship between serum zinc levels and the severity of hepatic necro-inflammation in patients with biopsy-proven MAFLD.
    Keywords apoptosis ; blood serum ; disease severity ; fatty liver ; gene expression ; inflammation ; metabolism ; nutrition ; regression analysis ; signal transduction ; zinc
    Language English
    Dates of publication 2022-0131
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.01.035
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 3149: Show issues Location:
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  5. Article ; Online: An interview with William J. O'Byrne, executive director of NJ-HITEC. Interview by Carol V. Brown.

    O'Byrne, William J

    MD advisor : a journal for New Jersey medical community

    2011  Volume 4, Issue 1, Page(s) 30–36

    MeSH term(s) Electronic Health Records ; Humans ; Medical Informatics/trends ; Practice Patterns, Physicians'/organization & administration ; Quality Improvement
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Interview
    ISSN 1947-3613
    ISSN (online) 1947-3613
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  6. Article ; Online: Cold adaptation in the environmental bacterium Shewanella oneidensis is controlled by a J-domain co-chaperone protein network

    Nathanael Jean Maillot / Flora Ambre Honoré / Deborah Byrne / Vincent Méjean / Olivier Genest

    Communications Biology, Vol 2, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: ... a previously uncharacterized J‐ domain protein, AtcJ and that its interaction with the target protein AtcC is ...

    Abstract Maillot et al. demonstrate that the environmental bacterium Shewanella oneidensis possesses a previously uncharacterized J‐ domain protein, AtcJ and that its interaction with the target protein AtcC is important for this bacterial adaptation to the cold. This study identifies a protein network that allows bacteria to survive cold stress.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Assessment of abdominoperineal resection rate as a surrogate marker of hospital quality in rectal cancer surgery (Br J Surg 2013; 100: 1655-1663).

    Byrne, B / Bottle, A / Faiz, O

    The British journal of surgery

    2014  Volume 101, Issue 6, Page(s) 736

    MeSH term(s) Abdomen/surgery ; Female ; Hospitals, Private/standards ; Hospitals, Public/standards ; Humans ; Male ; Perineum/surgery ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.9505
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    Uk I Zs.66: Show issues Location:
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  8. Book: Anxiety in older people

    Byrne, Gerard / Pachana, Nancy A.

    clinical and research perspectives

    (Cambridge medicine)

    2021  

    Author's details edited by Gerard J. Byrne, Nancy A. Pachana
    Series title Cambridge medicine
    Keywords Anxiety in old age
    Subject code 618.97685223
    Language English
    Size vi, 253 Seiten, Illustrationen
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT020938625
    ISBN 978-1-108-82636-5 ; 9781009028707 ; 9781139087469 ; 1-108-82636-9 ; 1009028707 ; 1139087460
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 A 778 available for loan (reading room) Lesesaal EG

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  9. Article: Analysis of an 'Official Report to the Surgeon-General U. S. Army, on the Use of Large Doses of Sulphate of Quinine in Diseases of the South.

    Byrne, John

    Western journal of medicine and surgery

    2024  Volume 4, Issue 3, Page(s) 246–250

    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Clinical Notes on the Electric Cautery in Uterine Surgery.

    Byrne, J

    Buffalo medical and surgical journal

    2023  Volume 12, Issue 5, Page(s) 172–187

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426472-1
    ISSN 1040-3825
    ISSN 1040-3825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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