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  1. Book ; Online ; Thesis: Analyse von T-Zell-Subpopulationen hinsichtlich Frequenz und spezifischer Zytokinsekretion in HLA B27-positiven AS-Patienten und Kontrollen

    Kohler, Siegfried

    2006  

    Author's details vorgelegt von Siegfried Kohler
    Subject code 616.7
    Language German
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Berlin, Charité, Univ.-Med., Diss., 2006
    Note Dateiformat: zip, Dateien im PDF-Format
    HBZ-ID HT014878484
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; Thesis: Untersuchungen zur Pathophysiologie und zu experimentellen Therapieansätzen der Myasthenia Gravis

    Kohler, Siegfried [Verfasser]

    2021  

    Author's details Siegfried Kohler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Early recognition and treatment of pre-VITT syndrome after adenoviral vector-based SARS-CoV-2 vaccination may prevent from thrombotic complications: review of published cases and clinical pathway.

    Salih, Farid / Kohler, Siegfried / Schönborn, Linda / Thiele, Thomas / Greinacher, Andreas / Endres, Matthias

    European heart journal open

    2022  Volume 2, Issue 3, Page(s) oeac036

    Abstract: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but highly morbid complication after adenoviral vector-based SARS-CoV-2 vaccination. The pre-VITT syndrome is defined as vaccine-induced immune thrombocytopenia without thrombosis ... ...

    Abstract Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but highly morbid complication after adenoviral vector-based SARS-CoV-2 vaccination. The pre-VITT syndrome is defined as vaccine-induced immune thrombocytopenia without thrombosis typically presenting with new-onset headache. This review aims to identify at-risk patients before complications such as cerebral venous sinus thrombosis occur. We review previously published reports of 19 patients (median age 35 years, range 23-74; 16 females) who met the diagnostic criteria for a pre-VITT syndrome. Seven patients progressed to VITT, 12 patients did not. Patients who experienced VITT received delayed treatment. The median interval between the onset of headache and VITT-treatment (i.e. anticoagulation, immune globulins, or corticosteroids) was 5 days (range 1-8 days) compared with 2 days (0-5 days) in those without subsequent VITT (
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2752-4191
    ISSN (online) 2752-4191
    DOI 10.1093/ehjopen/oeac036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comment on: Temporal artery compression sonography for the diagnosis of giant cell arteritis in elderly patients with acute ocular arterial occlusions: reply.

    Czihal, Michael / Köhler, Anton / Lottspeich, Christian / Prearo, Ilaria / Hoffmann, Ulrich / Schulze-Koops, Hendrik / Priglinger, Siegfried / Mackert, Marc / Dechant, Claudia

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue 6, Page(s) e213–e214

    MeSH term(s) Aged ; Biopsy ; Giant Cell Arteritis/diagnostic imaging ; Humans ; Temporal Arteries/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 240: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  5. Article ; Online: Calprotectin as potential novel biomarker in myasthenia gravis.

    Stascheit, Frauke / Hotter, Benjamin / Hoffmann, Sarah / Kohler, Siegfried / Lehnerer, Sophie / Sputtek, Andreas / Meisel, Andreas

    Journal of translational autoimmunity

    2021  Volume 4, Page(s) 100111

    Abstract: Myasthenia gravis (MG) is the most common autoimmune disease affecting the neuromuscular junction by specific autoantibodies. The etiology of MG and its heterogeneity in clinical courses are poorly understood, although it was recently shown that gut ... ...

    Abstract Myasthenia gravis (MG) is the most common autoimmune disease affecting the neuromuscular junction by specific autoantibodies. The etiology of MG and its heterogeneity in clinical courses are poorly understood, although it was recently shown that gut microbial dysbiosis plays a critical role. Since levels of Calprotectin (CLP) seem to correlate with level of dysbiosis, we hypothesize that CLP may serve as potential disease activity biomarker in MG. Sera from 251 patients with MG and 90 controls were analyzed in an explorative, cross-sectional design. Prospectively, we tested CLP levels in MG patients up to 3 years. Association of CLP levels with socio-demographics, disease activity (quantitative myasthenia gravis (QMG) score, myasthenia gravis-specific Activities of Daily Living scale (MG-ADL)), antibody (Abs) status, history of myasthenic crisis, treatment regime, and history of thymectomy were investigated using univariate analysis. Mean baseline serum levels of CLP were significantly higher in MG patients compared to controls (4.3 μg/ml vs. 2.1 μg/ml;
    Language English
    Publishing date 2021-08-10
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2021.100111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quantitative normal values of helical flow, flow jets and wall shear stress of healthy volunteers in the ascending aorta.

    Ebel, Sebastian / Kühn, Alexander / Aggarwal, Abhinav / Köhler, Benjamin / Behrendt, Benjamin / Gohmann, Robin / Riekena, Boris / Lücke, Christian / Ziegert, Juliane / Vogtmann, Charlotte / Preim, Bernhard / Kropf, Siegfried / Jung, Bernd / Denecke, Timm / Grothoff, Matthias / Gutberlet, Matthias

    European radiology

    2022  Volume 32, Issue 12, Page(s) 8597–8607

    Abstract: Objectives: 4D flow MRI enables quantitative assessment of helical flow. We sought to generate normal values and elucidate changes of helical flow (duration, volume, length, velocities and rotational direction) and flow jet (displacement, flow angle) as ...

    Abstract Objectives: 4D flow MRI enables quantitative assessment of helical flow. We sought to generate normal values and elucidate changes of helical flow (duration, volume, length, velocities and rotational direction) and flow jet (displacement, flow angle) as well as wall shear stress (WSS).
    Methods: We assessed the temporal helical existence (TH
    Results: WSS decreased by 42.1% and maxV
    Conclusion: This study provides age-dependent normal values regarding WSS and maxV
    Key points: • 4D flow provides numerous new parameters; therefore, normal values are mandatory. • Wall shear stress decreases over age. • Maximum helical forward velocity decreases over age.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Blood Flow Velocity ; Reference Values ; Healthy Volunteers ; Aorta ; Stress, Mechanical ; Hemodynamics
    Language English
    Publishing date 2022-05-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-08866-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3300: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Hyperechogenic intimal lesions and wall thickness of the temporal and facial arteries in elderly patients with arterial occlusions of the eye

    Claudia Dechant / Siegfried G Priglinger / Marc J Mackert / Michael Czihal / Anton Köhler / Ilaria Prearo / Ulrich Hoffmann / Christian Lottspeich

    RMD Open, Vol 7, Iss

    2021  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Transocular sonography in acute arterial occlusions of the eye in elderly patients: Diagnostic value of the spot sign.

    Czihal, Michael / Lottspeich, Christian / Köhler, Anton / Prearo, Ilaria / Hoffmann, Ulrich / Priglinger, Siegfried G / Mackert, Marc J

    PloS one

    2021  Volume 16, Issue 2, Page(s) e0247072

    Abstract: Purpose: To characterize the diagnostic yield of the spot sign in the diagnostic workup of acute arterial occlusions of the eye in elderly patients.: Methods: Clinical characteristics of consecutive patients aged ≥ 50 years with acute central retinal ...

    Abstract Purpose: To characterize the diagnostic yield of the spot sign in the diagnostic workup of acute arterial occlusions of the eye in elderly patients.
    Methods: Clinical characteristics of consecutive patients aged ≥ 50 years with acute central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) or anterior ischemic optic neuropathy (AION) were recorded. Videos of transocular sonography were assessed for the presence of the spot sign by two blinded readers. Group comparisons were made between CRAO-patients with and without the spot sign. Two experienced cardiovascular physicians allocated CRAO-cases to a presumed aetiology, without and with knowledge on the presence/absence of the spot sign.
    Results: One-hundred-twenty-three patients were included, 46 of whom suffered from CRAO. A spot sign was seen in 32 of 46 of patients with CRAO and in 7 of 23 patients with BRAO. Interobserver agreement was excellent (Cohen`s kappa 0.98). CRAO-patients with the spot sign significantly more frequently had a medical history of cardiovascular disease (62.8 vs. 21.4%, p = 0.03) and left heart valve pathologies (51.9 vs. 10%, p = 0.03). The spot sign was not found in any of the three patients with CRAO secondary to cranial giant cell arteritis. The assumed CRAO aetiology differed in 37% of cases between two cardiovascular physicians, regardless whether transocular sonography findings were known or not.
    Conclusion: The spot sign is a simple sonographic finding with excellent interobserver agreement, which proofs the embolic nature of CRAO, but does not allow exact attribution of the underlying aetiology.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Observer Variation ; Optic Nerve Diseases/diagnostic imaging ; Retinal Artery Occlusion/diagnostic imaging ; Ultrasonography/methods ; Ultrasonography/standards
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0247072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hyperechogenic intimal lesions and wall thickness of the temporal and facial arteries in elderly patients with arterial occlusions of the eye.

    Czihal, Michael / Köhler, Anton / Prearo, Ilaria / Hoffmann, Ulrich / Schulze-Koops, Hendrik / Dechant, Claudia / Priglinger, Siegfried G / Mackert, Marc J / Lottspeich, Christian

    RMD open

    2021  Volume 7, Issue 3

    Abstract: Objective: To determine the association of arteriosclerosis, characterised by hyperechogenic intimal lesions (HIL), with wall thickness of the temporal and facial arteries in elderly patients with ocular arterial occlusions.: Methods: Patients ... ...

    Abstract Objective: To determine the association of arteriosclerosis, characterised by hyperechogenic intimal lesions (HIL), with wall thickness of the temporal and facial arteries in elderly patients with ocular arterial occlusions.
    Methods: Patients suffering from non-arteritic ocular perfusion disorders were included. High-resolution compression sonography (18 MHz) images of the temporal arteries (frontal and parietal branch at the upper margin of the auricle) and facial arteries (at the crossing point of the artery over the mandible) were analysed for the presence of HIL (grade 0: absent; grade 1: moderate; grade 2: severe). Characteristics of patients with and without evidence of HIL >grade 1 were compared.
    Results: In total, 330 cranial artery segments of 55 patients were analysed. HIL ≥grade 1 was present in 13.0% of all artery segments and in 38.1% of all patients. Patients with HIL ≥grade 1 in at least one arterial segment displayed significantly increased maximum wall thickness of the temporal arteries (0.62±0.23 mm vs 0.50±0.13 mm; p<0.01) and facial arteries (0.71±0.20 mm vs 0.54±0.19 mm; p=0.01). Patients with at least one temporal or facial artery segment with HIL were older, more often male and more frequently suffered from diabetes mellitus.
    Conclusion: The presence of HIL goes along with a significantly increased wall thickness of the temporal and facial arteries. These findings should be considered when interpreting the results of sonography of the cranial arteries in the diagnostic workup of suspected giant cell arteritis.
    MeSH term(s) Aged ; Arteries/diagnostic imaging ; Giant Cell Arteritis/diagnostic imaging ; Humans ; Male ; Temporal Arteries/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2021-001688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Accuracy of Repeated Sleep Studies in OSA: A Longitudinal Observational Study With 14 Nights of Oxygen Saturation Monitoring.

    Roeder, Maurice / Sievi, Noriane A / Bradicich, Matteo / Grewe, Fabian A / Siegfried, Sandra / Gaisl, Thomas / Kohler, Malcolm

    Chest

    2020  Volume 159, Issue 3, Page(s) 1222–1231

    Abstract: Background: Strong evidence exists for clinically relevant night-to-night variability of respiratory events in patients with suspected OSA.: Research question: How many sleep study nights are required to diagnose OSA accurately?: Study design and ... ...

    Abstract Background: Strong evidence exists for clinically relevant night-to-night variability of respiratory events in patients with suspected OSA.
    Research question: How many sleep study nights are required to diagnose OSA accurately?
    Study design and methods: Patients with suspected OSA underwent up to 14 nights of pulse oximetry (PO) at home and one night of in-hospital respiratory polygraphy (RP). The accuracy of each of the 13 sleep study nights was analyzed using the mean oxygen desaturation index 3% (ODI
    Results: One hundred three patients underwent in-hospital RP. Using only the results of the RP, 19.7% were misdiagnosed using an ODI
    Interpretation: One single night of in-hospital RP may miss relevant OSA. Multiple study nights, for example, using ambulatory oxygen saturation monitoring, increase accuracy for diagnosing moderate OSA.
    Trial registry: ClinicalTrials.gov; No.: NCT03819361; URL: www.clinicaltrials.gov.
    MeSH term(s) Diagnostic Errors/prevention & control ; Dimensional Measurement Accuracy ; Female ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/standards ; Monitoring, Physiologic/statistics & numerical data ; Oximetry/methods ; Oxygen/analysis ; Oxygen/blood ; Polysomnography/methods ; Prospective Studies ; Sleep Apnea, Obstructive/diagnosis
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.09.098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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