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  1. Article: Interview mit Ingrid Grummt

    Grummt, Ingrid

    Einblick

    2017  Volume 31, Issue 2, Page(s) 28

    Language German
    Document type Article
    ZDB-ID 639277-5
    ISSN 0933-128X
    Database Current Contents Medicine

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  2. Article ; Online: Stop-and-Go: Dynamics of Nucleolar Transcription During the Cell Cycle.

    Iyer-Bierhoff, Aishwarya / Grummt, Ingrid

    Epigenetics insights

    2019  Volume 12, Page(s) 2516865719849090

    Abstract: Entry into mitosis correlates with nucleolar disassembly and shutdown of ribosomal RNA (rRNA) gene (rDNA) transcription. In telophase, nucleoli reform and transcription is reactivated. The molecular mechanisms underlying the dynamics of nucleolar ... ...

    Abstract Entry into mitosis correlates with nucleolar disassembly and shutdown of ribosomal RNA (rRNA) gene (rDNA) transcription. In telophase, nucleoli reform and transcription is reactivated. The molecular mechanisms underlying the dynamics of nucleolar transcription during the cell cycle are manifold. Although mitotic inactivation of the RNA polymerase I (Pol I) transcription machinery by posttranslational modifications has been extensively studied, little is known about the structure of rDNA chromatin during progression through mitosis. Methylation of histone H2A at glutamine 104 (H2AQ104me), a dedicated nucleolar histone modification, is lost in prometaphase, leading to chromatin compaction, which enforces mitotic repression of rRNA genes. At telophase, restoration of H2AQ104me is required for the activation of transcription. H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD
    Language English
    Publishing date 2019-05-21
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2516-8657
    ISSN (online) 2516-8657
    DOI 10.1177/2516865719849090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Experimental Approaches to Investigate the Role of Helicase Acetylation in Regulating R-Loop Stability.

    Song, Chenlin / Grummt, Ingrid

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1983, Page(s) 237–253

    Abstract: R-loops are three-stranded nucleic acid structures composed of a DNA-RNA heteroduplex and a displaced single-stranded DNA. Although R-loops serve important roles in transcription and chromatin structure, they are also a major threat to genome stability. ... ...

    Abstract R-loops are three-stranded nucleic acid structures composed of a DNA-RNA heteroduplex and a displaced single-stranded DNA. Although R-loops serve important roles in transcription and chromatin structure, they are also a major threat to genome stability. Cells prevent accumulation of genomic R-loops by mechanisms that remove these structures, such as ribonucleases which digest DNA-RNA hybrids and helicases which unwind R-loops. Here we describe methods to monitor resolvement of R-loops by the helicase DDX21 focussing on the impact of acetylation on helicase activity.
    MeSH term(s) Acetylation ; Cell Line ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; DNA Helicases/metabolism ; Genomic Instability ; Humans ; Nucleic Acid Conformation ; R-Loop Structures ; RNA/chemistry ; RNA/genetics ; RNA/metabolism ; Substrate Specificity
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2) ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2019-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9434-2_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The nucleolus—guardian of cellular homeostasis and genome integrity.

    Grummt, Ingrid

    Chromosoma

    2013  Volume 122, Issue 6, Page(s) 487–497

    Abstract: All organisms sense and respond to conditions that stress their homeostasis by downregulating the synthesis of rRNA and ribosome biogenesis, thus designating the nucleolus as the central hub in coordinating the cellular stress response. One of the most ... ...

    Abstract All organisms sense and respond to conditions that stress their homeostasis by downregulating the synthesis of rRNA and ribosome biogenesis, thus designating the nucleolus as the central hub in coordinating the cellular stress response. One of the most intriguing roles of the nucleolus, long regarded as a mere ribosome-producing factory, is its participation in monitoring cellular stress signals and transmitting them to the RNA polymerase I (Pol I) transcription machinery. As rRNA synthesis is a most energy-consuming process, switching off transcription of rRNA genes is an effective way of saving the energy required to maintain cellular homeostasis during acute stress. The Pol I transcription machinery is the key convergence point that collects and integrates a vast array of information from cellular signaling cascades to regulate ribosome production which, in turn, guides cell growth and proliferation. This review focuses on the mechanisms that link cell physiology to rDNA silencing, a prerequisite for nucleolar integrity and cell survival.
    MeSH term(s) Animals ; Cell Nucleolus/genetics ; Cell Nucleolus/metabolism ; DNA, Ribosomal/genetics ; DNA, Ribosomal/metabolism ; Down-Regulation ; Epigenesis, Genetic ; Gene Silencing ; Genomic Instability ; Homeostasis/genetics ; Humans ; Protein Biosynthesis ; RNA Polymerase I/genetics ; RNA Polymerase I/metabolism ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; Signal Transduction ; Stress, Physiological ; Transcription, Genetic
    Chemical Substances DNA, Ribosomal ; RNA, Ribosomal ; RNA Polymerase I (EC 2.7.7.6)
    Language English
    Publishing date 2013-09-11
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-013-0430-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The seven faces of SIRT7.

    Blank, Maximilian F / Grummt, Ingrid

    Transcription

    2017  Volume 8, Issue 2, Page(s) 67–74

    Abstract: SIRT7, a member of the sirtuin family of ... ...

    Abstract SIRT7, a member of the sirtuin family of NAD
    Language English
    Publishing date 2017-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2646974-1
    ISSN 2154-1272 ; 2154-1264
    ISSN (online) 2154-1272
    ISSN 2154-1264
    DOI 10.1080/21541264.2016.1276658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Analysis of RNA-DNA Triplex Structures In Vitro and In Vivo.

    Postepska-Igielska, Anna / Blank-Giwojna, Alena / Grummt, Ingrid

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2161, Page(s) 229–246

    Abstract: RNA can bind within the major groove of purine-rich DNA via Hoogsteen base pairing and form a triple helical RNA-DNA structure that anchors the RNA to specific DNA sequences, thereby targeting RNA-associated regulatory proteins to distinct genomic sites. ...

    Abstract RNA can bind within the major groove of purine-rich DNA via Hoogsteen base pairing and form a triple helical RNA-DNA structure that anchors the RNA to specific DNA sequences, thereby targeting RNA-associated regulatory proteins to distinct genomic sites. Here we present methods to analyze the potential of a given RNA to form triplexes in vitro and to validate these structures in vivo.
    MeSH term(s) DNA/chemistry ; Electrophoretic Mobility Shift Assay/methods ; HeLa Cells ; Humans ; Nucleic Acid Conformation ; RNA/chemistry
    Chemical Substances triplex DNA ; RNA (63231-63-0) ; DNA (9007-49-2)
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0680-3_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dynamic regulation of nucleolar architecture.

    Németh, Attila / Grummt, Ingrid

    Current opinion in cell biology

    2018  Volume 52, Page(s) 105–111

    Abstract: The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an essential role in the assembly and function of non-ribosomal ribonucleoprotein (RNP) complexes, controls cell cycle ... ...

    Abstract The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an essential role in the assembly and function of non-ribosomal ribonucleoprotein (RNP) complexes, controls cell cycle progression and senses environmental stress. The spatial organization and dynamics of nucleolar proteins and RNA is regulated at different structural levels, which finally determine nucleolar architecture. The intimate link between nucleolar structure and function is reflected by transcription-dependent changes in nucleolus-associated chromatin, overall morphological alterations in response to external cues, and the liquid droplet-like behavior of nucleolar compartments. Here we provide a concise overview of the latest studies which integrate novel trends in nucleolar architecture research into the context of cell biology.
    MeSH term(s) Cell Nucleolus/genetics ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism
    Chemical Substances Nuclear Proteins
    Language English
    Publishing date 2018-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2018.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
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  8. Article: Ribosomes Dance to a Daily Rhythm.

    Iyer, Aishwarya / Grummt, Ingrid

    Trends in biochemical sciences

    2017  Volume 42, Issue 8, Page(s) 585–587

    Abstract: Sinturel et al. demonstrate that feeding-fasting rhythms and light-dark cycles direct daily changes in liver mass and cell size. These feeding-fasting- and light-dark-driven diurnal fluctuations are controlled by an unconventional mechanism that affects ... ...

    Abstract Sinturel et al. demonstrate that feeding-fasting rhythms and light-dark cycles direct daily changes in liver mass and cell size. These feeding-fasting- and light-dark-driven diurnal fluctuations are controlled by an unconventional mechanism that affects ribosome assembly and protein levels during the active phase.
    MeSH term(s) Circadian Rhythm ; Light ; Liver/physiology ; Photoperiod ; Ribosomes
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2017.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1207: Show issues Location:
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  9. Article ; Online: Wisely chosen paths--regulation of rRNA synthesis: delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden.

    Grummt, Ingrid

    The FEBS journal

    2010  Volume 277, Issue 22, Page(s) 4626–4639

    Abstract: All cells, from prokaryotes to vertebrates, synthesize enormous amounts of rRNA to produce 1-2 million ribosomes per cell cycle, which are required to maintain the protein synthesis capacity of the daughter cells. In recent years, considerable progress ... ...

    Abstract All cells, from prokaryotes to vertebrates, synthesize enormous amounts of rRNA to produce 1-2 million ribosomes per cell cycle, which are required to maintain the protein synthesis capacity of the daughter cells. In recent years, considerable progress has been made in the elucidation of the basic principles of transcriptional regulation and the pathways that adapt cellular rRNA synthesis to metabolic activity, a process that is essential for understanding the link between nucleolar activity, cell growth, proliferation, and apoptosis. I will survey our present knowledge of the highly coordinated networks that regulate transcription by RNA polymerase I, coordinating rRNA gene transcription and ribosome production with environmental cues. Moreover, I will discuss the epigenetic mechanisms that control the chromatin structure and transcriptional activity of rRNA genes, in particular the role of noncoding RNA in DNA methylation and transcriptional silencing.
    MeSH term(s) Animals ; Cell Cycle/physiology ; Chromatin/metabolism ; Congresses as Topic ; DNA Methylation ; Epigenesis, Genetic ; Gene Expression Regulation ; Genes, rRNA ; Pol1 Transcription Initiation Complex Proteins/metabolism ; RNA Polymerase I/metabolism ; RNA, Ribosomal/biosynthesis ; RNA, Untranslated/metabolism ; Signal Transduction/physiology ; Sweden ; Transcription, Genetic
    Chemical Substances Chromatin ; Pol1 Transcription Initiation Complex Proteins ; RNA, Ribosomal ; RNA, Untranslated ; RNA Polymerase I (EC 2.7.7.6)
    Language English
    Publishing date 2010-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/j.1742-4658.2010.07892.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: lncRNA KHPS1 Activates a Poised Enhancer by Triplex-Dependent Recruitment of Epigenomic Regulators.

    Blank-Giwojna, Alena / Postepska-Igielska, Anna / Grummt, Ingrid

    Cell reports

    2019  Volume 26, Issue 11, Page(s) 2904–2915.e4

    Abstract: Transcription of the proto-oncogene SPHK1 is regulated by KHPS1, an antisense RNA that activates SPHK1 expression by forming a triple-helical RNA-DNA-DNA structure at the SPHK1 enhancer. Triplex-mediated tethering of KHPS1 to its target gene is required ... ...

    Abstract Transcription of the proto-oncogene SPHK1 is regulated by KHPS1, an antisense RNA that activates SPHK1 expression by forming a triple-helical RNA-DNA-DNA structure at the SPHK1 enhancer. Triplex-mediated tethering of KHPS1 to its target gene is required for recruitment of E2F1 and p300 and transcription of the RNA derived from the SPHK1 enhancer (eRNA-Sphk1). eRNA-Sphk1 evicts CTCF, which insulates the enhancer from the SPHK1 promoter, thus facilitating SPHK1 expression. Genomic deletion of the triplex-forming sequence attenuates SPHK1 expression, leading to decreased cell migration and invasion. Replacement of the triplex-forming region (TFR) of KHPS1 by the TFR of the lncRNA MEG3 tethers KHPS1 to the MEG3 target gene TGFBR1, underscoring the interchangeability and anchoring function of sequences involved in triplex formation. Altogether, the results reveal a triplex-driven feedforward mechanism involving lncRNA-dependent induction of eRNA, which enhances expression of specific target genes.
    MeSH term(s) 3T3 Cells ; Animals ; Enhancer Elements, Genetic ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Humans ; Mice ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Receptor, Transforming Growth Factor-beta Type I/metabolism
    Chemical Substances Khps1 long noncoding RNA, human ; MEG3 non-coding RNA, human ; RNA, Long Noncoding ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-) ; Receptor, Transforming Growth Factor-beta Type I (EC 2.7.11.30) ; TGFBR1 protein, human (EC 2.7.11.30)
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.02.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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