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Article ; Online: Assessing the utility of retailer based on generalized costs of end-consumers

Halkin, Andrii

2020

Abstract: This paper gives a methodology to estimate the generalized costs of end-consumers visiting any retailer. The attractiveness and utility of retailers for end-consumers have been calculated based on their possible generalized costs according to their ... ...

Abstract	This paper gives a methodology to estimate the generalized costs of end-consumers visiting any retailer. The attractiveness and utility of retailers for end-consumers have been calculated based on their possible generalized costs according to their choice. According to the developed model, analysis of the consumer market visiting all shops in the described zone has been made. Research provides explanation of generalized costs of end-consumers. Generally, the utility function of end-consumers visiting retailers depends on the price and non-price factors. The regression models describing the time spent on transit to a retailer and inside of it provide monetary assessment of costs associated with the purchase process. The monetary level of fatigue was evaluated using the calories spent during the purchase process. The attractiveness of the retailer in an urban zone was assessed as an inverse function of the generalized costs.
Keywords	ddc:650 ; M30 ; M31 ; M39 ; L66 ; end-consumers ; zone ; non-linearity factor ; slope factor ; generalized costs
Subject code	303
Language	English
Publisher	Warsaw: De Gruyter
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Feasibility of Intravascular Lithotripsy for the Treatment of Calcified Supra-Aortic Vessels: A Case Report and Literature Review.

Bilman, Victor / Rosenthal, Eyal / Klemperer, Leigh / Rubinstein, Chen / Halkin, Amir / Sheick-Yousif, Basheer

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2023 , Page(s) 15266028231175604

Abstract: Purpose: To report a case of coronary-subclavian steal syndrome (CSSS) due to a history of a left internal mammary artery (LIMA) to left anterior descending (LAD) artery coronary bypass (CABG) and a heavily calcified ostial left subclavian artery (LSA) ... ...

Abstract	Purpose: To report a case of coronary-subclavian steal syndrome (CSSS) due to a history of a left internal mammary artery (LIMA) to left anterior descending (LAD) artery coronary bypass (CABG) and a heavily calcified ostial left subclavian artery (LSA) occlusion, that was treated with intravascular lithotripsy (IVL) technique and to summarize the current trends of IVL treatment for supra-aortic vessels. Case report: A 64-year-old woman with progressive intermittent angina pectoris and a history of LIMA to LAD bypass underwent coronary angiography which demonstrated complete ostial occlusion of the LSA. Via brachial access, the patient underwent Shockwave IVL balloon treatment of the LSA and stent-graft implantation. At 9 months follow-up, the patient showed symptoms resolution, and duplex ultrasound (DUS) demonstrated a patent LSA. Conclusions: The Shockwave IVL system was demonstrated to be a feasible treatment and justified for selective cases of highly calcified lesions in supra-aortic vessels. The present case report and the literature review, in a total of 47 patients resulted in a high technical procedural success rate, with a low rate of complications. Future studies with larger cohorts are warranted to confirm these findings and standardize this technology in this particular vascular field. Clinical impact: The present study exemplifies a case of recanalization of the left subclavian artery in a patient with coronary-subclavian steal syndrome with a heavily calcified ostial lesion treated with intravascular lithotripsy (IVL). In this paper, for the first time, a review of the contemporary literature on the use of IVL in supra-aortic vessels is reported, elucidating the feasibility of this technique in this vascular territory. Despite the heterogeneous features of the reported cases and the lack of a standardized protocol for the use of IVL in the management of highly calcified lesions of supra-aortic vessels, it was demonstrated to be a feasible technique, with a high technical success rate, being an advantageous tool for heavily calcified supra-aortic lesions.
Language	English
Publishing date	2023-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028231175604
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Zs.A 4547: Show issues

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Article ; Online: ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells.

Krasnytska, Daria A / Khita, Olena O / Viletska, Yuliia M / Minchenko, Dmytro O / Halkin, Oleh V / Rudnytska, Olha V / Hoian, Sofiia L / Minchenko, Oleksandr H

Endocrine regulations

2024 Volume 58, Issue 1, Page(s) 47–56

Abstract: Objective.: Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box ... ...

Abstract	Objective.: Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm associated antigen 4) and NKX3-1 (NK3 homeobox 1) in U87MG glioblastoma cells in response to inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of glioblastoma growth. Methods.: The expression level of homeobox genes was studied in control (transfected by vector) and ERN1 knockdown U87MG glioblastoma cells under hypoxia induced by dimethyloxalylglycine (0.5 mM for 4 h) by quantitative polymerase chain reaction and normalized to ACTB. Results.: It was found that hypoxia down-regulated the expression level of Conclusion.: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes
MeSH term(s)	Humans ; Glioblastoma/genetics ; Genes, Homeobox ; Protein Serine-Threonine Kinases/genetics ; LIM-Homeodomain Proteins/genetics ; Cell Hypoxia/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Hypoxia/genetics ; Transcription Factors/genetics ; Gene Expression ; Cell Line, Tumor ; Gene Knockdown Techniques ; Endoribonucleases/genetics
Chemical Substances	Protein Serine-Threonine Kinases (EC 2.7.11.1) ; LIM-Homeodomain Proteins ; Transcription Factors ; ERN1 protein, human (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
Language	English
Publishing date	2024-04-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1082213-6
ISSN	1336-0329 ; 0013-7200 ; 1210-0668
ISSN (online)	1336-0329
ISSN	0013-7200 ; 1210-0668
DOI	10.2478/enr-2024-0006
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Article ; Online: Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells.

Minchenko, Oleksandr H / Sliusar, Myroslava Y / Khita, Olena O / Minchenko, Dmytro O / Viletska, Yuliia M / Halkin, Oleh V / Levadna, Liudmyla O / Cherednychenko, Anastasiia A / Khikhlo, Yevgen P

Endocrine regulations

2024 Volume 58, Issue 1, Page(s) 91–100

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Serine/metabolism ; Serine/biosynthesis ; Glucose/metabolism ; Cell Line, Tumor ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Glutamine/metabolism ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Gene Expression Regulation, Neoplastic ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/metabolism ; Phosphoglycerate Dehydrogenase/genetics ; Phosphoglycerate Dehydrogenase/metabolism ; Signal Transduction ; Glycine Hydroxymethyltransferase/genetics ; Glycine Hydroxymethyltransferase/metabolism ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Endoplasmic Reticulum Stress/genetics ; Endoplasmic Reticulum Stress/drug effects ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Gene Knockdown Techniques ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Transaminases
Chemical Substances	ERN1 protein, human (EC 2.7.11.1) ; Serine (452VLY9402) ; Glucose (IY9XDZ35W2) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Glutamine (0RH81L854J) ; Endoribonucleases (EC 3.1.-) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Phosphoglycerate Dehydrogenase (EC 1.1.1.95) ; ATF4 protein, human ; Glycine Hydroxymethyltransferase (EC 2.1.2.1) ; SHMT protein, human (EC 2.1.2.1) ; phosphoserine aminotransferase (EC 2.6.1.52) ; Activating Transcription Factor 4 (145891-90-3) ; phosphoserine phosphatase (EC 3.1.3.3) ; Minor Histocompatibility Antigens ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2024-04-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1082213-6
ISSN	1336-0329 ; 0013-7200 ; 1210-0668
ISSN (online)	1336-0329
ISSN	0013-7200 ; 1210-0668
DOI	10.2478/enr-2024-0010
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Article ; Online: Heart Failure Due to High-Degree Atrioventricular Block: How Frequent Is It and What Is the Cause?

Viskin, Dana / Halkin, Amir / Sherez, Jack / Megidish, Ricki / Fourey, Dana / Keren, Gad / Topilsky, Yan

The Canadian journal of cardiology

2021 Volume 37, Issue 10, Page(s) 1562–1568

Abstract: Background: The causes of heart failure (HF) during high-grade atrioventricular block (AVB) are poorly understood. This study assessed the mechanisms of HF in patients with AVB.: Methods: We studied patients presenting (between 2012 and 2016) with ... ...

Abstract	Background: The causes of heart failure (HF) during high-grade atrioventricular block (AVB) are poorly understood. This study assessed the mechanisms of HF in patients with AVB. Methods: We studied patients presenting (between 2012 and 2016) with high-grade AVB not related to acute myocardial infarction. Patients with preexisting significant valvular heart disease were excluded. All patients underwent comprehensive echocardiographic evaluation during AVB, before pacemaker implantation. The diagnosis of HF was based on the Framingham criteria. Results: A total of 122 patients were included in the study, 50% male, average age 76 ± 13 years. Twenty-eight patients (23%) with AVB presented with HF. Univariate correlates associated with HF were decrease in cardiac output (CO) (odds ratio [OR] 0.68 [95% confidence interval 0.49-0.9] per L/min; P = 0.007), measures of impaired left ventricular (LV) compliance, and increase in diastolic mitral regurgitation (MR) volume (OR 1.04 [1.01-1.07] per cc; P = 0.0016). Ventricular rate during AVB and LV ejection fraction were not significantly associated with the presence of HF. By multivariate nominal logistic analysis, the best model associated with HF included diastolic MR volume (OR 1.04 [1.001-1.09]; P = 0.02), A-wave deceleration time (OR 0.96 [0.94-0.9]; P = 0.001), and CO (OR 0.92 [0.4-1.00]; P = 0.005) (χ Conclusions: In the setting of high-degree AVB, clinical HF occurrence correlates with impaired LV compliance and diastolic MR volume, but not with heart rate or LV ejection fraction. The cardiac performance of patients with poor LV compliance and high-volume diastolic MR may show maladjustment to slow heart rates, manifesting as low CO and HF.
MeSH term(s)	Aged ; Atrioventricular Block/complications ; Atrioventricular Block/diagnosis ; Atrioventricular Block/epidemiology ; Echocardiography ; Electrocardiography ; Female ; Follow-Up Studies ; Heart Failure/epidemiology ; Heart Failure/etiology ; Heart Failure/physiopathology ; Humans ; Incidence ; Israel/epidemiology ; Male ; Prognosis ; ROC Curve ; Retrospective Studies ; Survival Rate/trends ; Ventricular Function, Left/physiology
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2021.05.007
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Zs.A 2150: Show issues

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Article ; Online: Evaluation of coronary disease among patients undergoing transcatheter aortic valve implantation: propensity score matching analysis.

Berkovitch, Anat / Finkelstein, Ariel / Barbash, Israel M / Fefer, Paul / Maor, Elad / Banai, Shmuel / Brodov, Yafim / Goitein, Orly / Aviram, Galit / Halkin, Amir / Guetta, Victor / Steinvil, Arie / Segev, Amit

Clinical research in cardiology : official journal of the German Cardiac Society

2023 Volume 113, Issue 1, Page(s) 11–17

Abstract: Background: Chronic coronary syndrome (CCS) is common among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). Current guidelines recommend performance of percutaneous coronary intervention (PCI) of ... ...

Abstract	Background: Chronic coronary syndrome (CCS) is common among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). Current guidelines recommend performance of percutaneous coronary intervention (PCI) of any > 70% proximal coronary lesions prior to TAVI. Aims: To evaluate the outcomes of two diagnostic approaches for CCS clearance pre-TAVI and to determine the reduction in the need of invasive angiography (IA). Methods: We investigated 2219 patients undergoing TAVI for severe aortic stenosis at two large centers with different pre-procedural strategies for CCS assessment: pre-TAVI computed tomography angiography (CTA) with selective invasive angiography according to CTA results or mandatory IA. We preformed propensity score matching analysis using a 1:1 ratio. The final study cohort included 870 matched patients. Peri-procedural complications were documented according to the VARC-2 criteria. Mortality rates were prospectively documented. Results: Mean age of the study population was 82 ± 7, of whom 55% were female. Patients in the IA group had significantly higher rates of pre-TAVI PCI compared to the CTA group (39% vs. 22%, p < 0.001). Following TAVI, peri-procedural myocardial infarction (MI) rates were similar between the two groups (0.3% vs. 0.7%, p value = 0.41), but spontaneous MI were significantly lower among the IA group (0% vs. 1.3%, p value = 0.03). Kaplan-Meier's survival analysis found that the cumulative probability of 1-year morality was similar between the two groups (p value log rank = 0.65). Cox regression analysis did not find association between CCS clearance strategy and outcome. Conclusions: In elderly patients, CTA-driven approach for CCS evaluation pre-TAVI is a valid strategy with similar outcome as compared to invasive approach. CTA strategy significantly reduces invasive procedures rates without compromising patient's outcome.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Transcatheter Aortic Valve Replacement/methods ; Percutaneous Coronary Intervention/adverse effects ; Aortic Valve Stenosis/surgery ; Propensity Score ; Heart Valve Prosthesis Implantation/methods ; Treatment Outcome ; Coronary Artery Disease/surgery ; Myocardial Infarction/complications ; Aortic Valve/surgery ; Retrospective Studies
Language	English
Publishing date	2023-03-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-023-02175-7
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Article ; Online: Effects of imatinib on glycemic and lipid profiles: a retrospective cohort study.

Markovits, Noa / Kurnik, Daniel / Friedrich, Carmel / Gueta, Itai / Halkin, Hillel / David, Sara / Lomnicky, Yossi / Topol, Yael / Tirosh, Amir / Loebstein, Ronen

Leukemia & lymphoma

2022 Volume 63, Issue 9, Page(s) 2224–2232

Abstract: Despite a favorable effect of imatinib on glucose metabolism in animal models, human reports are inconsistent. We retrospectively studied the long-term effect of imatinib on fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), LDL-cholesterol (LDL), ...

Abstract	Despite a favorable effect of imatinib on glucose metabolism in animal models, human reports are inconsistent. We retrospectively studied the long-term effect of imatinib on fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), LDL-cholesterol (LDL), and triglycerides (TGs) in a large HMO cohort of patients initiating therapy. In patients with diabetes (n = 118), significant reductions in HbA1c (0.53%, IQR 0.09, 1.19; p < .001) and FPG (10.2 mg/dL, IQR -3.5, 32.2; p < .001), independent of demographics and of glucose-lowering drugs utilization, were observed during the first year of imatinib treatment. Significant reductions in LDL (17.8 mg/dL, IQR -1.3, 34.0; p < .001) and TG (25.0 mg/dL, IQR -2.3, 58.3; p < .001), also independent of demographics and of statin utilization, were evident in the entire cohort (n = 611) during the first imatinib year. All reductions persisted during the second treatment year. To conclude, imatinib is associated with durable metabolic benefits, which may guide TKI choice in patients with cardiovascular co-morbidities.
MeSH term(s)	Blood Glucose ; Cholesterol, LDL/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin A/analysis ; Glycated Hemoglobin A/metabolism ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Imatinib Mesylate/adverse effects ; Retrospective Studies ; Triglycerides/therapeutic use
Chemical Substances	Blood Glucose ; Cholesterol, LDL ; Glycated Hemoglobin A ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Triglycerides ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2022.2068003
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Article ; Online: Vascular Complications in Transcatheter Aortic Valve Replacement With Plug-Based vs Suture-Based Closure Devices.

Zornitzki, Lior / Zahler, David / Frydman, Shir / Itach, Tamar / Ben-Shoshan, Jeremy / Halkin, Amir / Bazan, Samuel / Arbel, Yaron / Konigstein, Maayan / Finkelstein, Ariel / Banai, Shmuel / Steinvil, Arie

The Canadian journal of cardiology

2023 Volume 39, Issue 11, Page(s) 1528–1534

Abstract: Background: There are conflicting data regarding the efficacy and safety of suture vs plug-based vascular closure devices (VCDs) for large-bore catheter management in patients undergoing transcatheter aortic valve replacement (TAVR). We compared the ... ...

Abstract	Background: There are conflicting data regarding the efficacy and safety of suture vs plug-based vascular closure devices (VCDs) for large-bore catheter management in patients undergoing transcatheter aortic valve replacement (TAVR). We compared the rates of vascular complications (VCs) associated with 2 commonly used VCDs in a large cohort of patients undergoing TAVR. Methods: We conducted a single-centre, all-comer, prospective registry study, enrolling patients undergoing TAVR for symptomatic severe aortic stenosis (AS) between the years 2009 and 2022. Clinical outcomes were compared between patients undergoing closure of the femoral access point using the MANTA VCD (M-VCD) (Teleflex, Wayne, PA) vs the ProGlide VCD (P-VCD) (Abbott Vascular, Abbott Park, IL). The main outcome measures were researcher adjudicated events of VARC-2 defined major and minor VCs. Results: Overall, 2368 patients were enrolled in the registry; 1315 (51.0% male, 81.0 ± 7.0 years) patients were included in the current analysis. P-VCD was used in 813 patients, whereas M-VCD was used in 502 patients. In-hospital VCs were more frequent in the M-VCD vs the P-VCD group (17.3% vs 9.8%; P < 0.001). This outcome was mainly driven by elevated rates of minor VCs in the M-VCD group, whereas no significant difference was observed for major VCs (15.1% vs 8.4%; P < 0.001 and 2.2% vs 1.5%; P = 0.33, respectively). Conclusions: In patients undergoing TAVR for severe AS, M-VCD was associated with higher rates of VCs. This outcome was mainly driven by minor VCs. The rate of major VCs was low in both groups.
MeSH term(s)	Humans ; Male ; Female ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome ; Femoral Artery/surgery ; Vascular Closure Devices/adverse effects ; Cardiovascular Diseases/etiology ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/etiology ; Aortic Valve/surgery ; Hemostatic Techniques/adverse effects
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2023.06.425
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Article ; Online: Excess of blood eosinophils prior to therapy correlates with worse prognosis in mesothelioma.

Willems, Mégane / Scherpereel, Arnaud / Wasielewski, Eric / Raskin, Jo / Brossel, Hélène / Fontaine, Alexis / Grégoire, Mélanie / Halkin, Louise / Jamakhani, Majeed / Heinen, Vincent / Louis, Renaud / Duysinx, Bernard / Hamaidia, Malik / Willems, Luc

Frontiers in immunology

2023 Volume 14, Page(s) 1148798

Abstract: Background: Only a fraction of patients with malignant pleural mesothelioma (MPM) will respond to chemo- or immunotherapy. For the majority, the condition will irremediably relapse after 13 to 18 months. In this study, we hypothesized that patients' ... ...

Abstract	Background: Only a fraction of patients with malignant pleural mesothelioma (MPM) will respond to chemo- or immunotherapy. For the majority, the condition will irremediably relapse after 13 to 18 months. In this study, we hypothesized that patients' outcome could be correlated to their immune cell profile. Focus was given to peripheral blood eosinophils that, paradoxically, can both promote or inhibit tumor growth depending on the cancer type. Methods: The characteristics of 242 patients with histologically proven MPM were retrospectively collected in three centers. Characteristics included overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and disease control rate (DCR). The mean absolute eosinophil counts (AEC) were determined by averaging AEC data sets of the last month preceding the administration of chemo- or immunotherapy. Results: An optimal cutoff of 220 eosinophils/µL of blood segregated the cohort into two groups with significantly different median OS after chemotherapy (14 and 29 months above and below the threshold, Conclusion: In conclusion, baseline AEC ≥ 220/µL preceding therapy is associated with worse outcome and quicker relapse in MPM.
MeSH term(s)	Humans ; Mesothelioma, Malignant/drug therapy ; Eosinophils/metabolism ; Retrospective Studies ; Pemetrexed ; Pleural Neoplasms/drug therapy ; Glutamates/therapeutic use ; Guanine/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Mesothelioma/drug therapy ; Prognosis
Chemical Substances	Pemetrexed (04Q9AIZ7NO) ; Glutamates ; Guanine (5Z93L87A1R)
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1148798
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Article ; Online: First-Phase Ejection Fraction and Long-Term Survival in Patients Who Underwent Transcatheter Aortic Valve Implantation.

Feder, Omri / Zahler, David / Szekely, Yishay / Gefen, Sheizaf / Amsterdam, Dana / Topilsky, Yan / Flint, Nir / Konigstein, Maayan / Halkin, Amir / Bazan, Samuel / Arbel, Yaron / Finkelstein, Ariel / Banai, Shmuel / Ben-Shoshan, Jeremy

The American journal of cardiology

2023 Volume 202, Page(s) 17–23

Abstract: Early recognition of deteriorating left ventricular function plays a key prognostic role in patients with aortic stenosis (AS). First-phase ejection fraction (EF1), the ejection fraction (EF) up to time of maximal contraction, has been suggested for ... ...

Abstract	Early recognition of deteriorating left ventricular function plays a key prognostic role in patients with aortic stenosis (AS). First-phase ejection fraction (EF1), the ejection fraction (EF) up to time of maximal contraction, has been suggested for detection of early left ventricular dysfunction in patients with AS with preserved EF. This work aims to evaluate the predictive value of EF1 for assessment of long-term survival in patients with symptomatic severe AS and preserved EF who undergo transcatheter aortic valve implantation (TAVI). We included 102 consecutive patients (median age 84 years [interquartile range 80 to 86 years]) who underwent TAVI between 2009 and 2011. Patients were retrospectively stratified into tertiles by EF1. Device success and procedural complications were defined according to the Valve Academic Research Consortium-3 criteria. Mortality data were retrieved from a computerized interface of the Israeli Ministry of Health. Baseline characteristics, co-morbidities, clinical presentation, and echocardiographic findings were similar among groups. The groups did not differ significantly regarding device success and in-hospital complications. During a potential follow-up period of >10 years, 88 patients died. Kaplan-Meier analysis (log-rank p = 0.017) followed by multivariable Cox regression analysis showed that EF1 predicted long-term mortality independently, either as continuous variable (hazard ratio 1.04, 95% confidence interval 1.01 to 1.07, p = 0.012) or for each decrease in tertile group (hazard ratio 1.40, 95% confidence interval 1.05 to 1.86, p = 0.023). In conclusion, low EF1 is associated with a significant decrease in adjusted hazard for long-term survival in patients with preserved EF who undergo TAVI. Low EF1 might delineate a population at great risk who would benefit from prompt intervention.
MeSH term(s)	Humans ; Aged, 80 and over ; Transcatheter Aortic Valve Replacement ; Stroke Volume ; Retrospective Studies ; Prognosis ; Ventricular Function, Left ; Aortic Valve Stenosis ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Treatment Outcome
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.06.038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ui IV Zs.73: Show issues

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