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  1. Article ; Online: Did the world overlook the media’s early warning of COVID-19?

    Fu, King-wa / Zhu, Yuner

    Journal of Risk Research

    2020  , Page(s) 1–5

    Keywords General Engineering ; Strategy and Management ; General Social Sciences ; Safety, Risk, Reliability and Quality ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2021006-1
    ISSN 1466-4461 ; 1366-9877
    ISSN (online) 1466-4461
    ISSN 1366-9877
    DOI 10.1080/13669877.2020.1756380
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: [The role of inflammation in heart failure with preserved ejection fraction].

    Zhang, Qi / Chen, Yun-Er / Zhu, Xin-Xin / Wang, Xia / Qu, Ai-Juan

    Sheng li xue bao : [Acta physiologica Sinica

    2023  Volume 75, Issue 3, Page(s) 390–402

    Abstract: Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure characterized by left ventricular diastolic dysfunction with preserved ejection fraction. With the aging of the population and the increasing prevalence of metabolic ... ...

    Abstract Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure characterized by left ventricular diastolic dysfunction with preserved ejection fraction. With the aging of the population and the increasing prevalence of metabolic diseases, such as hypertension, obesity and diabetes, the prevalence of HFpEF is increasing. Compared with heart failure with reduced ejection fraction (HFrEF), conventional anti-heart failure drugs failed to reduce the mortality in HFpEF due to the complex pathophysiological mechanism and multiple comorbidities of HFpEF. It is known that the main changes of cardiac structure of in HFpEF are cardiac hypertrophy, myocardial fibrosis and left ventricular hypertrophy, and HFpEF is commonly associated with obesity, diabetes, hypertension, renal dysfunction and other diseases, but how these comorbidities cause structural and functional damage to the heart is not completely clear. Recent studies have shown that immune inflammatory response plays a vital role in the progression of HFpEF. This review focuses on the latest research progress in the role of inflammation in the process of HFpEF and the potential application of anti-inflammatory therapy in HFpEF, hoping to provide new research ideas and theoretical basis for the clinical prevention and treatment in HFpEF.
    MeSH term(s) Humans ; Heart Failure ; Stroke Volume/physiology ; Hypertrophy, Left Ventricular/complications ; Hypertrophy, Left Ventricular/metabolism ; Ventricular Dysfunction, Left/drug therapy ; Ventricular Dysfunction, Left/metabolism ; Inflammation/complications ; Obesity ; Hypertension
    Language Chinese
    Publishing date 2023-02-21
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An overlooked source of nanosized lead particles in the atmosphere: Residential honeycomb briquette combustion

    Zhang, Yinxiao / Kong, Shaofei / Yan, Qin / Zhu, Kongyang / Jiang, Xiaotong / Liu, Lei / Xu, Liang / Wang, Yuanyuan / Pang, Yuner / Teng, Xiaomi / Zhu, Jihao / Li, Weijun

    Journal of hazardous materials. 2022 Aug. 15, v. 436

    2022  

    Abstract: Atmospheric lead (Pb) pollution has attracted long-term and widespread concerns due to its high toxicity. The definite source identification of atmospheric Pb is the key step to mitigate this pollution. Here, we first report an overlooked source of ... ...

    Abstract Atmospheric lead (Pb) pollution has attracted long-term and widespread concerns due to its high toxicity. The definite source identification of atmospheric Pb is the key step to mitigate this pollution. Here, we first report an overlooked source of atmospheric nanosized Pb particles using transmission electron microscopy and bulk sample analyses, finding that residential honeycomb briquette combustion emits large numbers of nanosized Pb-rich particles. We found that 33.7 ± 19.9 % of primary particles by number from residential honeycomb briquette combustion contains the crystalline Pb particles. These Pb-rich particles range in size from 14 to 956 nm with a mean diameter of 117 nm. Compared with raw coal chunks, honeycomb briquette combustion could emit less carbonaceous particles, but largely increase nanosized Pb particle emissions. This result is attributed to two key factors: (1) higher Pb content in honeycomb briquette (63.6 μg g⁻¹) than that in coal chunk (8.5 μg g⁻¹), and (2) higher Pb release rate for honeycomb briquette (62.3 %) caused by honeycomb structure than that for coal chunk (20.1 %). This study highlights that atmospheric and health implications of high emissions of toxic nanosized Pb from honeycomb briquette should be paid more attention in future research on ambient and indoor airs.
    Keywords coal ; combustion ; lead ; pollution ; toxicity ; transmission electron microscopy
    Language English
    Dates of publication 2022-0815
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.129289
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Limited Early Warnings and Public Attention to Coronavirus Disease 2019 in China, January-February, 2020: A Longitudinal Cohort of Randomly Sampled Weibo Users.

    Zhu, Yuner / Fu, King-Wa / Grépin, Karen A / Liang, Hai / Fung, Isaac Chun-Hai

    Disaster medicine and public health preparedness

    2020  Volume 14, Issue 5, Page(s) e24–e27

    Abstract: Objective: Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public's attention to an outbreak. To measure the attention of Chinese ... ...

    Abstract Objective: Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public's attention to an outbreak. To measure the attention of Chinese netizens to coronavirus disease 2019 (COVID-19), a pre-established nationally representative cohort of Weibo users was searched for COVID-19-related key words in their posts.
    Methods: COVID-19-related posts (N = 1101) were retrieved from a longitudinal cohort of 52 268 randomly sampled Weibo accounts (December 31, 2019-February 12, 2020).
    Results: Attention to COVID-19 was limited prior to China openly acknowledging human-to-human transmission on January 20. Following this date, attention quickly increased and has remained high over time. Particularly high levels of social media traffic appeared around when Wuhan was first placed in quarantine (January 23-24, 8-9% of the overall posts), when a scandal associated with the Red Cross Society of China occurred (February 1, 8%), and, following the death of Dr Li Wenliang (February 6-7, 11%), one of the whistleblowers who was reprimanded by the Chinese police in early January for discussing this outbreak online.
    Conclusion: Limited early warnings represent missed opportunities to engage citizens earlier in the outbreak. Governments should more proactively communicate early warnings to the public in a transparent manner.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; China/epidemiology ; Cohort Studies ; Humans ; Longitudinal Studies ; Quarantine/methods ; Quarantine/standards ; Quarantine/statistics & numerical data ; Social Media/instrumentation ; Social Media/trends
    Keywords covid19
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2020.68
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An overlooked source of nanosized lead particles in the atmosphere: Residential honeycomb briquette combustion.

    Zhang, Yinxiao / Kong, Shaofei / Yan, Qin / Zhu, Kongyang / Jiang, Xiaotong / Liu, Lei / Xu, Liang / Wang, Yuanyuan / Pang, Yuner / Teng, Xiaomi / Zhu, Jihao / Li, Weijun

    Journal of hazardous materials

    2022  Volume 436, Page(s) 129289

    Abstract: Atmospheric lead (Pb) pollution has attracted long-term and widespread concerns due to its high toxicity. The definite source identification of atmospheric Pb is the key step to mitigate this pollution. Here, we first report an overlooked source of ... ...

    Abstract Atmospheric lead (Pb) pollution has attracted long-term and widespread concerns due to its high toxicity. The definite source identification of atmospheric Pb is the key step to mitigate this pollution. Here, we first report an overlooked source of atmospheric nanosized Pb particles using transmission electron microscopy and bulk sample analyses, finding that residential honeycomb briquette combustion emits large numbers of nanosized Pb-rich particles. We found that 33.7 ± 19.9 % of primary particles by number from residential honeycomb briquette combustion contains the crystalline Pb particles. These Pb-rich particles range in size from 14 to 956 nm with a mean diameter of 117 nm. Compared with raw coal chunks, honeycomb briquette combustion could emit less carbonaceous particles, but largely increase nanosized Pb particle emissions. This result is attributed to two key factors: (1) higher Pb content in honeycomb briquette (63.6 μg g
    MeSH term(s) Air Pollutants/analysis ; Atmosphere/analysis ; China ; Coal/analysis ; Environmental Monitoring ; Lead/analysis ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Coal ; Particulate Matter ; Lead (2P299V784P)
    Language English
    Publishing date 2022-06-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.129289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Conversing or Diffusing Information?

    Lauren Bayliss / Yuner Zhu / King-Wa Fu / Lindsay A. Mullican / Ferdous Ahmed / Hai Liang / Zion Tsz Ho Tse / Nitin Saroha / Jingjing Yin / Isaac Chun-Hai Fung

    Journal of Public Interest Communications , Vol 5, Iss

    2021  Volume 2

    Abstract: This study examines the one-way information diffusion and two-way dialogic engagement present in public health Twitter chats. Network analysis assessed whether Twitter chats adhere to one of the key principles for online dialogic communication, the ... ...

    Abstract This study examines the one-way information diffusion and two-way dialogic engagement present in public health Twitter chats. Network analysis assessed whether Twitter chats adhere to one of the key principles for online dialogic communication, the dialogic loop (Kent & Taylor, 1998) for four public health-related chats hosted by CDC Twitter accounts. The features of the most retweeted accounts and the most retweeted tweets also were examined. The results indicate that very little dialogic engagement took place. Moreover, the chats seemed to function as pseudoevents primarily used by organizations as opportunities for creating content. However, events such as #PublicHealthChat may serve as important opportunities for gaining attention for issues on social media. Implications for using social media in public interest communications are discussed.
    Keywords Communication. Mass media ; P87-96 ; Social Sciences ; H
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher University of Florida, College of Journalism and Communications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Limited Early Warnings and Public Attention to Coronavirus Disease 2019 in China, January–February, 2020

    Zhu, Yuner / Fu, King-Wa / Grépin, Karen A. / Liang, Hai / Fung, Isaac Chun-Hai

    Disaster Medicine and Public Health Preparedness

    A Longitudinal Cohort of Randomly Sampled Weibo Users

    2020  , Page(s) 1–4

    Abstract: ABSTRACT Objective: Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public’s attention to an outbreak. To measure the attention of ... ...

    Abstract ABSTRACT Objective: Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public’s attention to an outbreak. To measure the attention of Chinese netizens to coronavirus disease 2019 (COVID-19), a pre-established nationally representative cohort of Weibo users was searched for COVID-19-related key words in their posts. Methods: COVID-19-related posts ( N = 1101) were retrieved from a longitudinal cohort of 52 268 randomly sampled Weibo accounts (December 31, 2019–February 12, 2020). Results: Attention to COVID-19 was limited prior to China openly acknowledging human-to-human transmission on January 20. Following this date, attention quickly increased and has remained high over time. Particularly high levels of social media traffic appeared around when Wuhan was first placed in quarantine (January 23–24, 8–9% of the overall posts), when a scandal associated with the Red Cross Society of China occurred (February 1, 8%), and, following the death of Dr Li Wenliang (February 6–7, 11%), one of the whistleblowers who was reprimanded by the Chinese police in early January for discussing this outbreak online. Conclusion: Limited early warnings represent missed opportunities to engage citizens earlier in the outbreak. Governments should more proactively communicate early warnings to the public in a transparent manner.
    Keywords Public Health, Environmental and Occupational Health ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2020.68
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Limited Early Warnings and Public Attention to Coronavirus Disease 2019 in China, January-February, 2020: A Longitudinal Cohort of Randomly Sampled Weibo Users

    Zhu, Yuner / Fu, King-Wa / Grépin, Karen A / Liang, Hai / Fung, Isaac Chun-Hai

    Disaster Med Public Health Prep

    Abstract: OBJECTIVE: Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public's attention to an outbreak. To measure the attention of Chinese ... ...

    Abstract OBJECTIVE: Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public's attention to an outbreak. To measure the attention of Chinese netizens to coronavirus disease 2019 (COVID-19), a pre-established nationally representative cohort of Weibo users was searched for COVID-19-related key words in their posts. METHODS: COVID-19-related posts (N = 1101) were retrieved from a longitudinal cohort of 52 268 randomly sampled Weibo accounts (December 31, 2019-February 12, 2020). RESULTS: Attention to COVID-19 was limited prior to China openly acknowledging human-to-human transmission on January 20. Following this date, attention quickly increased and has remained high over time. Particularly high levels of social media traffic appeared around when Wuhan was first placed in quarantine (January 23-24, 8-9% of the overall posts), when a scandal associated with the Red Cross Society of China occurred (February 1, 8%), and, following the death of Dr Li Wenliang (February 6-7, 11%), one of the whistleblowers who was reprimanded by the Chinese police in early January for discussing this outbreak online. CONCLUSION: Limited early warnings represent missed opportunities to engage citizens earlier in the outbreak. Governments should more proactively communicate early warnings to the public in a transparent manner.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32241328
    Database COVID19

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  9. Article ; Online: Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function.

    Zhu, Xin-Xin / Wang, Xia / Jiao, Shi-Yu / Liu, Ye / Shi, Li / Xu, Qing / Wang, Jing-Jing / Chen, Yun-Er / Zhang, Qi / Song, Yan-Ting / Wei, Ming / Yu, Bao-Qi / Fielitz, Jens / Gonzalez, Frank J / Du, Jie / Qu, Ai-Juan

    Acta pharmacologica Sinica

    2023  Volume 44, Issue 11, Page(s) 2184–2200

    Abstract: Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial dynamics enhances mitophagy and apoptosis. However, therapies targeted to ... ...

    Abstract Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial dynamics enhances mitophagy and apoptosis. However, therapies targeted to improve mitochondrial function in septic patients have not been explored. Transcriptomic data analysis revealed that the peroxisome proliferator-activated receptor (PPAR) signaling pathway in the heart was the most significantly decreased in the cecal ligation puncture-treated mouse heart model, and PPARα was the most notably decreased among the three PPAR family members. Male Ppara
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Myocytes, Cardiac/metabolism ; PPAR alpha/metabolism ; Lipopolysaccharides ; Cardiomyopathies/drug therapy ; Cardiomyopathies/prevention & control ; Cardiomyopathies/metabolism ; Mitochondria/metabolism ; Heart Diseases ; Mice, Knockout ; Disease Models, Animal ; Fatty Acids/metabolism
    Chemical Substances PPAR alpha ; Lipopolysaccharides ; Fatty Acids
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-023-01107-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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