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  1. Article ; Online: Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19.

    Salton, Francesco / Geri, Pietro / Confalonieri, Marco

    The European respiratory journal

    2020  Volume 56, Issue 5

    MeSH term(s) Betacoronavirus ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral ; Respiratory System ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.03383-2020
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    Zs.A 2322: Show issues Location:
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  2. Article: Response to: Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19

    Salton, Francesco / Geri, Pietro / Confalonieri, Marco

    The European respiratory journal

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #781429
    Database COVID19

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  3. Article ; Online: Response to

    Salton, Francesco / Geri, Pietro / Confalonieri, Marco

    Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19

    2020  

    Abstract: We thank Dr. Deepak and Dr. Varinder for their comments on our Research Letter [1], as they allow us to better highlight the main key points of our study, dismissing possible misinterpretation of its results. ...

    Abstract We thank Dr. Deepak and Dr. Varinder for their comments on our Research Letter [1], as they allow us to better highlight the main key points of our study, dismissing possible misinterpretation of its results.
    Keywords bronchoalveolar lavage ; sars-cov-2 ; COVID-19 ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Transbronchial lung cryobiopsy and pulmonary fibrosis: A never-ending story?

    Ruaro, Barbara / Tavano, Stefano / Confalonieri, Paola / Pozzan, Riccardo / Hughes, Michael / Braga, Luca / Volpe, Maria Concetta / Ligresti, Giovanni / Andrisano, Alessia Giovanna / Lerda, Selene / Geri, Pietro / Biolo, Marco / Baratella, Elisa / Confalonieri, Marco / Salton, Francesco

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e14768

    Abstract: Background: The diagnostic process of pulmonary fibrosis (PF) is often challenging, requires a collaborative effort of several experts, and often requires bioptic material, which can be difficult to obtain, both in terms of quality and technique. The ... ...

    Abstract Background: The diagnostic process of pulmonary fibrosis (PF) is often challenging, requires a collaborative effort of several experts, and often requires bioptic material, which can be difficult to obtain, both in terms of quality and technique. The main procedures available to obtain such samples are transbronchial lung cryobiopsy (TBLC) and surgical lung biopsy (SLB).
    Objective: The purpose of this paper is to review the evidence for the role of TBLC in the diagnostic-therapeutic process of PF.
    Methods: A comprehensive review was performed to identify articles to date that addressed the role of TBLC in the diagnostic-therapeutic process of PF using the PubMed® database.
    Results: The reasoned search identified 206 papers, including 21 manuscripts (three reviews, one systematic review, two guidelines, two prospective studies, three retrospective studies, one cross-sectional study, one original article, three editorials, three clinical trials, and two unclassifiable studies), which were included in the final review.
    Conclusions: TBLC is gaining increasing efficacy and improving safety profile; however, there are currently no clear data demonstrating its superiority over SLB. Therefore, the two techniques should be considered with careful rationalization on a case-by-case basis. Further research is needed to further optimize and standardize the procedure and to thoroughly study the histological and molecular characteristics of PF.
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14768
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  5. Article ; Online: Biomarkers in Systemic Sclerosis: An Overview.

    Di Maggio, Giuseppe / Confalonieri, Paola / Salton, Francesco / Trotta, Liliana / Ruggero, Luca / Kodric, Metka / Geri, Pietro / Hughes, Michael / Bellan, Mattia / Gilio, Michele / Lerda, Selene / Baratella, Elisa / Confalonieri, Marco / Mondini, Lucrezia / Ruaro, Barbara

    Current issues in molecular biology

    2023  Volume 45, Issue 10, Page(s) 7775–7802

    Abstract: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by significant fibrosis of the skin and internal organs, with the main involvement of the lungs, kidneys, heart, esophagus, and intestines. SSc is also characterized by macro- and ... ...

    Abstract Systemic sclerosis (SSc) is a complex autoimmune disease characterized by significant fibrosis of the skin and internal organs, with the main involvement of the lungs, kidneys, heart, esophagus, and intestines. SSc is also characterized by macro- and microvascular damage with reduced peripheral blood perfusion. Several studies have reported more than 240 pathways and numerous dysregulation proteins, giving insight into how the field of biomarkers in SSc is still extremely complex and evolving. Antinuclear antibodies (ANA) are present in more than 90% of SSc patients, and anti-centromere and anti-topoisomerase I antibodies are considered classic biomarkers with precise clinical features. Recent studies have reported that trans-forming growth factor β (TGF-β) plays a central role in the fibrotic process. In addition, interferon regulatory factor 5 (IRF5), interleukin receptor-associated kinase-1 (IRAK-1), connective tissue growth factor (CTGF), transducer and activator of transcription signal 4 (STAT4), pyrin-containing domain 1 (NLRP1), as well as genetic factors, including DRB1 alleles, are implicated in SSc damage. Several interleukins (e.g., IL-1, IL-6, IL-10, IL-17, IL-22, and IL-35) and chemokines (e.g., CCL 2, 5, 23, and CXC 9, 10, 16) are elevated in SSc. While adiponectin and maresin 1 are reduced in patients with SSc, biomarkers are important in research but will be increasingly so in the diagnosis and therapeutic approach to SSc. This review aims to present and highlight the various biomarker molecules, pathways, and receptors involved in the pathology of SSc.
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45100490
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Gastroesophageal Reflux Disease in Idiopathic Pulmonary Fibrosis: Viewer or Actor? To Treat or Not to Treat?

    Ruaro, Barbara / Pozzan, Riccardo / Confalonieri, Paola / Tavano, Stefano / Hughes, Michael / Matucci Cerinic, Marco / Baratella, Elisa / Zanatta, Elisabetta / Lerda, Selene / Geri, Pietro / Confalonieri, Marco / Salton, Francesco

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 8

    Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a rare and severe disease with a median survival of ∼3 years. Several risk factors have been identified, such as age, genetic predisposition, tobacco exposure, and gastro-oesophageal reflux disease ( ... ...

    Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a rare and severe disease with a median survival of ∼3 years. Several risk factors have been identified, such as age, genetic predisposition, tobacco exposure, and gastro-oesophageal reflux disease (GERD). Prevalence of GERD in IPF is high and may affect 87% of patients, of whom only half (47%) report symptoms.
    Language English
    Publishing date 2022-08-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15081033
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  7. Article: Laser Speckle Contrast Analysis: Functional Evaluation of Microvascular Damage in Connective Tissue Diseases. Is There Evidence of Correlations With Organ Involvement, Such as Pulmonary Damage?

    Ruaro, Barbara / Bruni, Cosimo / Wade, Barbara / Baratella, Elisa / Confalonieri, Paola / Antonaglia, Caterina / Geri, Pietro / Biolo, Marco / Confalonieri, Marco / Salton, Francesco

    Frontiers in physiology

    2021  Volume 12, Page(s) 710298

    Abstract: Laser speckle contrast analysis (LASCA) is a non-contact technique able to quantify peripheral blood perfusion (PBP) over large skin areas. LASCA has been used to study hand PBP in several clinical conditions. These include systemic sclerosis (SSc) and ... ...

    Abstract Laser speckle contrast analysis (LASCA) is a non-contact technique able to quantify peripheral blood perfusion (PBP) over large skin areas. LASCA has been used to study hand PBP in several clinical conditions. These include systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) and LASCA showed that PBP was significantly lower in these conditions than in healthy subjects (HS). Moreover, it has been demonstrated that LASCA is a safe technique also able to monitor digital ulcer perfusion and their evolution in SSc patients, during systemic and local treatment. The use of LASCA, coupled with reactivity tests is commonplace in the field of microvascular function research. Post-occlusive hyperemia reactivity (POHR) and local thermal hyperemia, associated with laser techniques are reliable tests in the evaluation of perfusion in SSc patients. Other studies used laser speckled techniques, together with acetylcholine and sodium nitroprusside iontophoresis, as specific tests of endothelium function. In conclusion, LASCA is a safe, non-contact reliable instrument for the quantification of PBP at skin level and can also be associated with reactivity tests to monitor disease progression and response to treatment in different connective tissue diseases.
    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.710298
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  8. Article: The Relationship between Pulmonary Damage and Peripheral Vascular Manifestations in Systemic Sclerosis Patients.

    Ruaro, Barbara / Confalonieri, Marco / Salton, Francesco / Wade, Barbara / Baratella, Elisa / Geri, Pietro / Confalonieri, Paola / Kodric, Metka / Biolo, Marco / Bruni, Cosimo

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 5

    Abstract: Systemic sclerosis (SSc) is an autoimmune disease, characterized by the presence of generalized vasculopathy and tissue fibrosis. Collagen vascular disorder in SSc is due to fibroblast and endothelial cell dysfunctions. This leads to collagen ... ...

    Abstract Systemic sclerosis (SSc) is an autoimmune disease, characterized by the presence of generalized vasculopathy and tissue fibrosis. Collagen vascular disorder in SSc is due to fibroblast and endothelial cell dysfunctions. This leads to collagen overproduction, vascular impairment and immune system abnormalities and, in the last stage, multi-organ damage. Thus, to avoid organ damage, which has a poor prognosis, all patients should be carefully evaluated and followed. This is particularly important in the initial disease phase, so as to facilitate early identification of any organ involvement and to allow for appropriate therapy. Pulmonary disease in SSc mainly involves interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH). High-resolution computed tomography (HRCT) and pulmonary function tests (PFT) have been proposed to monitor parenchymal damage. Although transthoracic echocardiography is the most commonly used screening tool for PAH in SSc patients, definitive diagnosis necessitates confirmation by right heart catheterization (RHC). Moreover, some studies have demonstrated that nailfold videocapillaroscopy (NVC) provides an accurate evaluation of the microvascular damage in SSc and is able to predict internal organ involvement, such as lung impairment. This review provides an overview of the correlation between lung damage and microvascular involvement in SSc patients.
    Language English
    Publishing date 2021-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14050403
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  9. Article ; Online: Transbronchial lung cryobiopsy and pulmonary fibrosis

    Barbara Ruaro / Stefano Tavano / Paola Confalonieri / Riccardo Pozzan / Michael Hughes / Luca Braga / Maria Concetta Volpe / Giovanni Ligresti / Alessia Giovanna Andrisano / Selene Lerda / Pietro Geri / Marco Biolo / Elisa Baratella / Marco Confalonieri / Francesco Salton

    Heliyon, Vol 9, Iss 4, Pp e14768- (2023)

    A never-ending story?

    2023  

    Abstract: Background: The diagnostic process of pulmonary fibrosis (PF) is often challenging, requires a collaborative effort of several experts, and often requires bioptic material, which can be difficult to obtain, both in terms of quality and technique. The ... ...

    Abstract Background: The diagnostic process of pulmonary fibrosis (PF) is often challenging, requires a collaborative effort of several experts, and often requires bioptic material, which can be difficult to obtain, both in terms of quality and technique. The main procedures available to obtain such samples are transbronchial lung cryobiopsy (TBLC) and surgical lung biopsy (SLB). Objective: The purpose of this paper is to review the evidence for the role of TBLC in the diagnostic-therapeutic process of PF. Methods: A comprehensive review was performed to identify articles to date that addressed the role of TBLC in the diagnostic-therapeutic process of PF using the PubMed® database. Results: The reasoned search identified 206 papers, including 21 manuscripts (three reviews, one systematic review, two guidelines, two prospective studies, three retrospective studies, one cross-sectional study, one original article, three editorials, three clinical trials, and two unclassifiable studies), which were included in the final review. Conclusions: TBLC is gaining increasing efficacy and improving safety profile; however, there are currently no clear data demonstrating its superiority over SLB. Therefore, the two techniques should be considered with careful rationalization on a case-by-case basis. Further research is needed to further optimize and standardize the procedure and to thoroughly study the histological and molecular characteristics of PF.
    Keywords Pulmonary fibrosis (PF) ; Idiopathic pulmonary fibrosis (IPF) ; Interstitial lung disease (ILD) ; Transbronchial lung cryobiopsy (TBLC) ; Surgical lung biopsy (SLB) ; Bronchoscopy ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Chronic Thromboembolic Pulmonary Hypertension: An Update.

    Ruaro, Barbara / Baratella, Elisa / Caforio, Gaetano / Confalonieri, Paola / Wade, Barbara / Marrocchio, Cristina / Geri, Pietro / Pozzan, Riccardo / Andrisano, Alessia Giovanna / Cova, Maria Assunta / Cortale, Maurizio / Confalonieri, Marco / Salton, Francesco

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease observed in a small proportion of patients after acute pulmonary embolism (PE). CTEPH has a high morbidity and mortality rate, related to the PH severity, and a poor prognosis, which ...

    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease observed in a small proportion of patients after acute pulmonary embolism (PE). CTEPH has a high morbidity and mortality rate, related to the PH severity, and a poor prognosis, which mirrors the right ventricular dysfunction involvement. Pulmonary endarterectomy (PEA) reduces pulmonary vascular resistance, making it the treatment of choice and should be offered to operable CTEPH patients, as significant symptomatic and prognostic improvement has been observed. Moreover, these patients may also benefit from the advances made in surgical techniques and pulmonary hypertension-specific medication. However, not all patients are eligible for PEA surgery, as some have either distal pulmonary vascular obstruction and/or significant comorbidities. Therefore, surgical candidates should be carefully selected by an interprofessional team in expert centers. This review aims at making an overview of the risk factors and latest developments in diagnostic tools and treatment options for CTEPH.
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12020235
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