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  1. Article ; Online: Long-term remission of candidiasis with fermented lingonberry mouth rinse in an adult patient with APECED.

    Pärnänen, Pirjo / Suojanen, Juho / Laine, Mikael / Sorsa, Timo / Ranki, Annamari

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  , Page(s) 107066

    Abstract: We report a long-term remission in candidiasis in a 57-year-old Finnish female with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) suffering from recurrent oral, esophageal, gastric, vaginal, and anal candidiasis since childhood. ...

    Abstract We report a long-term remission in candidiasis in a 57-year-old Finnish female with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) suffering from recurrent oral, esophageal, gastric, vaginal, and anal candidiasis since childhood. Candidiasis treatment with antifungal medicines fluconazole, itraconazole, posaconazole, voriconazole, caspofungin, nystatin or amphotericin-B during 2008-2021 had variable effects and intermittent development of antifungal resistance and hospital periods. The patient started using fermented lingonberry juice (FLJ) as a mouth rinse daily in April 2021. No symptoms or mucosal signs of candidiasis in any part of the digestive system or vaginal area have been noticed during this exceptionally long-term 2 ½ year remission in candidiasis without no antifungal medications.
    Language English
    Publishing date 2024-04-20
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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  2. Article: Antimicrobial and Anti-Inflammatory Oral Effects of Fermented Lingonberry Juice-A One-Year Prospective Human Intervention Study.

    Pärnänen, Pirjo / Lomu, Sari / Räisänen, Ismo T / Tervahartiala, Taina / Sorsa, Timo

    European journal of dentistry

    2023  Volume 17, Issue 4, Page(s) 1235–1240

    Abstract: Objectives:  A 1-year prospective human intervention study was performed to examine the anticaries, anti-inflammatory, antiproteolytic, and antimicrobial effects of fermented lingonberry juice (FLJ), used as a mouthwash for a period of 6 months, ... ...

    Abstract Objectives:  A 1-year prospective human intervention study was performed to examine the anticaries, anti-inflammatory, antiproteolytic, and antimicrobial effects of fermented lingonberry juice (FLJ), used as a mouthwash for a period of 6 months, followed by a 6-month washout period.
    Materials and methods:  Twenty-five adults were recruited from private dental clinics in Helsinki and Joensuu (Finland). Standard oral examinations and sample gatherings were performed at base level, 6 months, and 1 year for oral
    Statistical analysis:  Statistical analyses were performed with nonparametric Friedman's test and pairwise post-hoc analysis with Dunn-Bonferroni test, SPSS (version 27; IBM) and
    Results:  The levels of
    Conclusions:  The specially formulated FLJ may have a positive decreasing effect on
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2491711-4
    ISSN 1305-7464 ; 1305-7456
    ISSN (online) 1305-7464
    ISSN 1305-7456
    DOI 10.1055/s-0042-1759619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antimicrobial and Anti-inflammatory Lingonberry Mouthwash - A Clinical Pilot Study in the Oral Cavity.

    Pärnänen, Pirjo / Nikula-Ijäs, Pirjo / Sorsa, Timo

    Microorganisms

    2019  Volume 7, Issue 9

    Abstract: Fermented lingonberry juice was designed to be used as a mouthwash. Our aim was to study the antimicrobial and anti-inflammatory effects of the mouthwash in the oral cavity. A clinical study of 30 adult participants was performed. A total of 20 ... ...

    Abstract Fermented lingonberry juice was designed to be used as a mouthwash. Our aim was to study the antimicrobial and anti-inflammatory effects of the mouthwash in the oral cavity. A clinical study of 30 adult participants was performed. A total of 20 participants used 10 mL of the mouthwash twice daily for two weeks and 10 participants used 20 mL twice daily for one week. Streptococcus mutans, Candida and Lactobacilli were cultivated at the beginning, after the mouthwash period and after a washout period. At the same timepoints an additional oral mouthrinse was collected for chair-side/point-of-care (POC)-PerioSafe
    Language English
    Publishing date 2019-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7090331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lingonberry polyphenols: Potential SARS-CoV-2 inhibitors as nutraceutical tools?

    Pärnänen, Pirjo / Lähteenmäki, Hanna / Räisänen, Ismo / Tervahartiala, Taina / Sorsa, Timo

    Physiological reports

    2021  Volume 9, Issue 3, Page(s) e14741

    Abstract: Proposed pathway of the effect of lingonberry polyphenols on oral microbial (viral) load reduction and consequent beneficial local and systemic (respiratory tract) anti-inflammatory and antimicrobial/antiviral effects. ...

    Abstract Proposed pathway of the effect of lingonberry polyphenols on oral microbial (viral) load reduction and consequent beneficial local and systemic (respiratory tract) anti-inflammatory and antimicrobial/antiviral effects.
    MeSH term(s) COVID-19 ; Dietary Supplements ; Humans ; Oral Hygiene ; Polyphenols/pharmacology ; SARS-CoV-2 ; Vaccinium vitis-idaea
    Chemical Substances Polyphenols
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Isolation, characterization and regulation of moonlighting proteases from Candida glabrata cell wall.

    Pärnänen, Pirjo / Sorsa, Timo / Tervahartiala, Taina / Nikula-Ijäs, Pirjo

    Microbial pathogenesis

    2020  Volume 149, Page(s) 104547

    Abstract: Candida glabrata (C. glabrata) cell wall proteins play a role in virulence and in initial host immune recognition and responses. We isolated and characterized C. glabrata cell wall proteases from a clinical hospital C. glabrata T-1638 blood isolate and ... ...

    Abstract Candida glabrata (C. glabrata) cell wall proteins play a role in virulence and in initial host immune recognition and responses. We isolated and characterized C. glabrata cell wall proteases from a clinical hospital C. glabrata T-1638 blood isolate and estimated the enzymatic activities and their ability to degrade gelatin and processing proMMP-8 and assess the regulation of these proteases with salt treatment, mercaptoethanol and fermented lingonberry juice from Vaccinium vitis idaea L. The cell wall proteases were enzymatically released from the cell wall and beta- 1,3- bonded proteases were fractioned into 10-50 kDa and >50 kDa fractions with anionic DEAE-sepharose ion-exchange chromatography and gel filtration. Proteins were monitored and analyzed with MDPF- zymography, and five gelatinolytic bands were cut out from a parallel silver-stained gel for the LC- MS/MS analysis. The proteases lacked a signal sequence, indicating that they are moonlighting proteases. Human proMMP-8 activation assays were performed with both fractions and verified by western-immunoblot using aMMP-8 specific antibody. Inhibition of proMMP-8 conversion to the lower molecular active enzyme species were demonstrated with fermented lingonberry juice. The results indicate that moonlighting proteases may play a role in the virulence of C. glabrata.
    MeSH term(s) Candida glabrata ; Cell Wall ; Chromatography, High Pressure Liquid ; Humans ; Peptide Hydrolases ; Tandem Mass Spectrometry
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2020.104547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Antimicrobial and Anti-Inflammatory Lingonberry Mouthwash—A Clinical Pilot Study in the Oral Cavity

    Pärnänen, Pirjo / Nikula-Ijäs, Pirjo / Sorsa, Timo

    Microorganisms. 2019 Sept. 08, v. 7, no. 9

    2019  

    Abstract: Fermented lingonberry juice was designed to be used as a mouthwash. Our aim was to study the antimicrobial and anti-inflammatory effects of the mouthwash in the oral cavity. A clinical study of 30 adult participants was performed. A total of 20 ... ...

    Abstract Fermented lingonberry juice was designed to be used as a mouthwash. Our aim was to study the antimicrobial and anti-inflammatory effects of the mouthwash in the oral cavity. A clinical study of 30 adult participants was performed. A total of 20 participants used 10 mL of the mouthwash twice daily for two weeks and 10 participants used 20 mL twice daily for one week. Streptococcus mutans, Candida and Lactobacilli were cultivated at the beginning, after the mouthwash period and after a washout period. At the same timepoints an additional oral mouthrinse was collected for chair-side/point-of-care (POC)-PerioSafe®/OraLyzer® aMMP-8 quantitative on-line evaluation, and an oral clinical investigation was performed. Mean Streptococcus mutans and Candida counts, visible plaque index (VPI) and bleeding on probing (BOP) were reduced, and Lactobacilli counts increased during the lingonberry mouthwash period. The aMMP-8 mouthrinses showed reduced values in both test groups when compared to the startpoint. The mouthrinse aMMP-8 reduction correlated with the reductions in microbial counts, VPI and BOP. Based on the results, fermented lingonberry juice seems a promising aid in oral homecare, diminishing the microbial and related proinflammatory burden by balancing the oral microbial flora and gradually lowering the inflammatory load in the oral cavity.
    Keywords Candida ; Lactobacillus ; Streptococcus mutans ; Vaccinium vitis-idaea ; adults ; anti-inflammatory activity ; fruit juices ; hemorrhage ; microorganisms ; mouth ; point-of-care systems
    Language English
    Dates of publication 2019-0908
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7090331
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters-A One-Year Prospective Human Intervention Study.

    Pärnänen, Pirjo / Lomu, Sari / Räisänen, Ismo T / Tervahartiala, Taina / Sorsa, Timo

    Dentistry journal

    2022  Volume 10, Issue 4

    Abstract: A one-year prospective human intervention study was performed to examine the effects of fermented lingonberry juice (FLJ), used as a mouthwash for six months, on salivary parameters. A total of 25 adult participants used 10 mL of FLJ as mouthwash 30 s ... ...

    Abstract A one-year prospective human intervention study was performed to examine the effects of fermented lingonberry juice (FLJ), used as a mouthwash for six months, on salivary parameters. A total of 25 adult participants used 10 mL of FLJ as mouthwash 30 s daily for 6 months in addition to their normal oral homecare routines. Standard oral examinations and gathering of samples were performed at the beginning of the study and after six months and one year. Resting and stimulated saliva secretion rates, resting saliva pH, and stimulated saliva buffering capacity were determined. A questionnaire of participants' subjective sensations of mouth dryness was also recorded at each timepoint. Fermented lingonberry juice mouthwash had positive effect to all five salivary parameters and were, according to the omnibus test, statistically significant during the study period. Analysis of the subjective dry mouth sensation questionnaires revealed that symptoms of xerostomia decreased due to the use of FLJ. This study revealed that the once-a-day use of FLJ mouthwash had a beneficial, increasing effect on salivary flow rates, buffering capacity, and salivary pH. FLJ thus can be safely used as an adjunctive and beneficial therapy in oral homecare, protecting teeth and oral mucosa, including periodontium, and also relieving dry mouth symptoms.
    Language English
    Publishing date 2022-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681351-8
    ISSN 2304-6767 ; 2304-6767
    ISSN (online) 2304-6767
    ISSN 2304-6767
    DOI 10.3390/dj10040069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review.

    Grigoriadis, Andreas / Räisänen, Ismo T / Pärnänen, Pirjo / Tervahartiala, Taina / Sorsa, Timo / Sakellari, Dimitra

    European journal of dentistry

    2022  Volume 16, Issue 3, Page(s) 514–520

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic greatly affected human well-being, social behavior, global economy, and healthcare systems. Everyday clinical practice in dentistry has been adjusted to the increased hazards of aerosol production by ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic greatly affected human well-being, social behavior, global economy, and healthcare systems. Everyday clinical practice in dentistry has been adjusted to the increased hazards of aerosol production by routine dental procedures. The objective of this study was to assess the existing literature to determine possible mechanisms of a relationship between COVID-19 and periodontitis, as well as describe findings from relevant epidemiological studies.Scarce data exist in the literature that directly addresses the relationship between the two diseases. However, several data describe the role of the oral cavity and periodontal tissues as portals of entry of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), and the contribution of cytokines known to be produced in periodontal disease to severe forms of COVID-19. It is also suggested from the current literature that periodontal disease, shown to be associated with systemic diseases such as diabetes mellitus, cardiovascular and respiratory diseases, shares common risk factors with-especially-severe forms of COVID-19.Further clinical studies are required to establish the relationship between these diseases. Oral hygiene performance and intact periodontal tissues can assist in mitigating the pandemic, and it is suggested that dental practitioners can contribute to identifying at-risk patients.
    Language English
    Publishing date 2022-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2491711-4
    ISSN 1305-7464 ; 1305-7456
    ISSN (online) 1305-7464
    ISSN 1305-7456
    DOI 10.1055/s-0041-1740223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lingonberries-General and Oral Effects on the Microbiome and Inflammation.

    Pärnänen, Pirjo / Lähteenmäki, Hanna / Tervahartiala, Taina / Räisänen, Ismo T / Sorsa, Timo

    Nutrients

    2021  Volume 13, Issue 11

    Abstract: Lingonberry ( ...

    Abstract Lingonberry (
    MeSH term(s) Administration, Oral ; Animals ; Dysbiosis/microbiology ; Fruit/chemistry ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Microbiota ; Vaccinium vitis-idaea/chemistry
    Language English
    Publishing date 2021-10-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13113738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis.

    Lähteenmäki, Hanna / Pätilä, Tommi / Pärnänen, C Pirjo / Räisänen, Ismo / Tervahartiala, Taina / Gupta, Shipra / Sorsa, Timo

    Expert opinion on therapeutic targets

    2023  Volume 27, Issue 7, Page(s) 627–637

    Abstract: Introduction: When collected in a standardized fashion, oral fluid analysis can refine the diagnosis of periodontal and peri-implant disease. In practice, dental professionals can perform active matrix metalloproteinase (aMMP-8) analysis chairside.: ... ...

    Abstract Introduction: When collected in a standardized fashion, oral fluid analysis can refine the diagnosis of periodontal and peri-implant disease. In practice, dental professionals can perform active matrix metalloproteinase (aMMP-8) analysis chairside.
    Areas covered: Periodontal tissues are mainly made up of type I collagen, and collagen breakdown is one of the main events in periodontal and peri-implantitis destructive lesions. In addition to traditional measurements, their diagnosis can be refined with tests utilizing oral fluids. The active matrix metalloproteinase-8 (aMMP-8) is possible to be determined from the gingival crevicular fluid (GCF), peri-implant sulcus fluid (PISF), and other oral fluids such as mouth rinse and saliva. We also investigated the applicability of aMMP-8 chair-side test kits in the evaluation of oral health benefits of different adjunctive host-modulating periodontal therapies including fermented lingonberry mouthwash (FLJ) and antibacterial photodynamic therapy (aPDT).
    Expert opinion: The aMMP-8 levels can more reliably detect early activation of periodontal and peri-implant disease as compared to traditional diagnostic methods that assess the experienced health status or past disease, rather than the present or future pathology. Novel therapies like, fermented lingonberry juice as a mouthrinse or aPDT, are potential host-modulating adjunctive treatments to reduce the signs of oral inflammation and infection.
    MeSH term(s) Humans ; Peri-Implantitis/diagnosis ; Peri-Implantitis/therapy ; Peri-Implantitis/microbiology ; Point-of-Care Systems ; Periodontitis/diagnosis ; Periodontitis/drug therapy ; Gingival Crevicular Fluid/metabolism
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2240014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
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