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  1. Book: In honor of Professor Jens Christian Djurhuus

    Frøkiaer, Jørgen / Munch JøRgensen, Troels / Rittig, SøRen / Djurhuus, Jens C.

    Institute of Experimental Clinical Research, University of Aarhus, Denmark

    (Acta pathologica, microbiologica et immunologica Scandinavica : Supplementum ; 109)

    2003  

    Author's details by Jørgen Frøkiaer, Troels Munch Jørgensen and Søren Rittig
    Series title Acta pathologica, microbiologica et immunologica Scandinavica : Supplementum ; 109
    Acta pathologica, microbiologica et immunologica Scandinavica
    Acta pathologica, microbiologica et immunologica Scandinavica ; Supplementum
    Collection Acta pathologica, microbiologica et immunologica Scandinavica
    Acta pathologica, microbiologica et immunologica Scandinavica ; Supplementum
    Language English
    Size 153 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT013710212
    ISBN 1-4051-1876-8 ; 978-1-4051-1876-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Ud II Zs 73 -Suppl.109- verfügbar in Königswinter Königswinter

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  2. Article: [No title information]

    Jorgensen, Christian

    Journal international de bioethique et d'ethique des sciences

    2023  Volume 34, Issue 2, Page(s) 165–171

    Abstract: Cell therapy is becoming established in many fields, including oncology with CAR-Ts or in regenerative medicine for cardiovascular diseases, diabetes or musculoskeletal disorders with mesenchymal stromal cells. These therapeutic cells are called advanced ...

    Title translation Chapitre 12. Impact sociétal et éthique de la thérapie cellulaire et des biotechnologies.
    Abstract Cell therapy is becoming established in many fields, including oncology with CAR-Ts or in regenerative medicine for cardiovascular diseases, diabetes or musculoskeletal disorders with mesenchymal stromal cells. These therapeutic cells are called advanced therapy medicinal products (ATMPs) and include all processes including cells manipulated to obtain reprogramming (iPS), to induce gene expression or by genome editing to modify the expression of a gene. The development of new biomaterial supports that can be 3D printed and take the desired shape of the target tissue before being colonised by the cellular elements necessary for their biological functions and replace the failing organ. All of these new technologies are driving innovation and the development of tomorrow’s bio-medicines. These new biotherapies will profoundly modify patient care in all areas, changing medical practices but with a considerable societal impact. Thus, the development and clinical research on cellular biotherapies are essential health issues but with a major ethical, societal and economic impact.
    MeSH term(s) Humans ; Cell- and Tissue-Based Therapy ; Regenerative Medicine ; Biotechnology ; Medical Oncology
    Language French
    Publishing date 2023-05-26
    Publishing country France
    Document type English Abstract ; Journal Article
    ISSN 2608-1008
    ISSN 2608-1008
    DOI 10.3917/jibes.342.0165
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  3. Article ; Online: Preoperative hemoglobin thresholds for increased risk of "medical" complications in fast-track total hip and knee arthroplasty, a secondary analysis of a machine-learning algorithm.

    Jørgensen, Christoffer C / Michelsen, Christian / Petersen, Troels / Kehlet, Henrik

    Transfusion

    2024  Volume 64, Issue 3, Page(s) 438–442

    Abstract: Background: There is increasing evidence that gender-specific hemoglobin thresholds may not be ideal in the surgical population. Thus, preoperative anemia defined as a hemoglobin of <13.0 g/dL is a well-established risk factor in elective surgery. ... ...

    Abstract Background: There is increasing evidence that gender-specific hemoglobin thresholds may not be ideal in the surgical population. Thus, preoperative anemia defined as a hemoglobin of <13.0 g/dL is a well-established risk factor in elective surgery. However, few studies have investigated the specific influence of preoperative hemoglobin within a machine-learning model using data from an optimized fast-track surgical setup.
    Study design and methods: A secondary analysis on the specific influence of preoperative hemoglobin level on a machine-learning model developed for identifying patients at increased risk of a length of stay (LOS) of >4 day or readmissions due to medical complications in fast-track total hip and knee arthroplasty within a well-defined fast-track protocol. To evaluate the effect of hemoglobin on the model we calculated SHaply Additive Explanation (SHAP) values for the 3913 patients from our previous test-dataset and stratified by gender and total hip and knee arthroplasty, respectively.
    Results: The study period ran from January 2017 to August 2017. Median LOS was 1 day and mean preoperative Hb was 15.5 g/dL (SD:1.5), lower in women (14.9 vs. 16.2 g/dL) and with 30.5% of women versus 12.0% of men having a Hb of <13.0 g/dL. There was a steep increase in SHAP value with a preoperative Hb < 14.8 g/dL, and irrespective of gender age and procedure type.
    Discussion: A machine-learning model found a hemoglobin threshold of <14.8 g/dL for increased risk of impaired recovery, regardless of gender or age, supporting reevaluation of preoperative anemia thresholds in the elective surgical setting.
    MeSH term(s) Male ; Humans ; Female ; Arthroplasty, Replacement, Knee/adverse effects ; Hemoglobins/analysis ; Anemia/etiology ; Arthroplasty, Replacement, Hip/adverse effects ; Preoperative Care ; Length of Stay ; Retrospective Studies
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17735
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    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Handheld FTIR outperforms total organic carbon swab in pharmaceutical cleaning validation.

    Jul-Jørgensen, Isabella / Gernaey, Krist V / Hundahl, Christian A

    The Analyst

    2023  Volume 148, Issue 16, Page(s) 3835–3842

    Abstract: Cleaning Validation is a crucial process in pharmaceutical manufacturing, as it verifies that cross-contamination levels are below acceptable limits. The use of Mid-Infrared (IR) spectroscopy has long been proposed as a rapid method enabling real-time ... ...

    Abstract Cleaning Validation is a crucial process in pharmaceutical manufacturing, as it verifies that cross-contamination levels are below acceptable limits. The use of Mid-Infrared (IR) spectroscopy has long been proposed as a rapid method enabling real-time release, but only with the recent emergence of a handheld Fourier-Transform IR (FTIR) does a feasible solution exist for practical implementation in pharmaceutical manufacturing plants. This paper address the model development challenges for multi-product plants without complete traceability of production equipment and produced product. This is done by developing a partial least squares discriminant analysis model determining if the sample is clean or not clean compared to a residual acceptance limit, based on total organic carbon (TOC) measurements. The model is built and tested on artificial samples printed with a chemical printer for multiple products with different spectral peaks based on 91 samples in the calibration set and tested on 30 samples in the validation set. Furthermore, the model also incorporates spectra from surfaces with different surface roughness. The evaluation of the model is based on sensitivity, specificity and class error. The model outperforms or performs equally well as TOC swab with sampling error, dependent on the sampling error distribution for the TOC swab.
    MeSH term(s) Spectroscopy, Fourier Transform Infrared ; Discriminant Analysis ; Least-Squares Analysis ; Carbon ; Pharmaceutical Preparations
    Chemical Substances Carbon (7440-44-0) ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an00167a
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    Zs.A 2423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Author Correction: Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells.

    Bertolino, Giuliana Minani / Maumus, Marie / Jorgensen, Christian / Noël, Danièle

    Nature reviews. Rheumatology

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-024-01114-8
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    Zs.A 6338: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Evidence of 11-Hydroxy-hexahydrocannabinol and 11-Nor-9-carboxy-hexahydrocannabinol as Novel Human Metabolites of Δ

    Falck Jørgensen, Christian / Schou Rasmussen, Brian / Linnet, Kristian / Thomsen, Ragnar

    Metabolites

    2023  Volume 13, Issue 12

    Abstract: ...

    Abstract (-)-
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13121169
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  7. Book ; Online: A Modifiable Architectural Design for Commercial Greenhouses Energy Economic Dispatch Testbed

    Clausen, Christian Skafte Beck / Jørgensen, Bo Nørregaard / Ma, Zheng Grace

    2024  

    Abstract: Facing economic challenges due to the diverse objectives of businesses, and consumers, commercial greenhouses strive to minimize energy costs while addressing CO2 emissions. This scenario is intensified by rising energy costs and the global imperative to ...

    Abstract Facing economic challenges due to the diverse objectives of businesses, and consumers, commercial greenhouses strive to minimize energy costs while addressing CO2 emissions. This scenario is intensified by rising energy costs and the global imperative to curtail CO2 emissions. To address these dynamic economic challenges, this paper proposes an architectural design for an energy economic dispatch testbed for commercial greenhouses. Utilizing the Attribute-Driven De-sign method, core architectural components of a software-in-the-loop testbed are proposed which emphasizes modularity and careful consideration of the multi-objective optimization problem. This approach extends prior research by implementing a modular multi-objective optimization framework in Java. The results demonstrate the successful integration of the CO2 reduction objective within the modular architecture with minimal effort. The multi-objective optimization output can also be employed to examine cost and CO2 objectives, ultimately serving as a valuable decision-support tool. The novel testbed architecture and a modular approach can tackle the multi-objective optimization problem and enable commercial greenhouses to navigate the intricate landscape of energy cost and CO2 emissions management.

    Comment: 19 pages
    Keywords Computer Science - Software Engineering ; Electrical Engineering and Systems Science - Systems and Control
    Subject code 006
    Publishing date 2024-01-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Redefining stem cells through their use in musculoskeletal tissue preservation, regeneration, and cancer metastases to bone.

    Drissi, Hicham / Taipaleenmäki, Hanna / Jorgensen, Christian

    Bone reports

    2023  Volume 19, Page(s) 101678

    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 2821774-3
    ISSN 2352-1872
    ISSN 2352-1872
    DOI 10.1016/j.bonr.2023.101678
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  9. Book ; Online ; Thesis: Advancing individual-based models of Antarctic krill (Euphausia superba, Dana 1850)

    Bahlburg, Dominik [Verfasser] / Berger, Uta [Gutachter] / Grimm, Volker [Gutachter] / Jørgensen, Christian [Gutachter]

    2024  

    Author's details Dominik Bahlburg ; Gutachter: Uta Berger, Volker Grimm, Christian Jørgensen
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Early Switch From Intravenous to Oral Antibiotics for Patients With Uncomplicated Gram-Negative Bacteremia.

    Tingsgård, Sandra / Bastrup Israelsen, Simone / Jørgensen, Henrik Løvendahl / Østergaard, Christian / Benfield, Thomas

    JAMA network open

    2024  Volume 7, Issue 1, Page(s) e2352314

    Abstract: Importance: Gram-negative bacteremia is a global health concern, and optimizing the transition from intravenous (IV) to oral antibiotics is a critical step in improving patient treatment and resource utilization.: Objective: To assess the association ...

    Abstract Importance: Gram-negative bacteremia is a global health concern, and optimizing the transition from intravenous (IV) to oral antibiotics is a critical step in improving patient treatment and resource utilization.
    Objective: To assess the association of switching to oral antibiotics within 4 days after initial blood culture with 90-day all-cause mortality compared with prolonged IV antibiotic treatment for patients with uncomplicated gram-negative bacteremia.
    Design, setting, and participants: This cohort study conducted using the target trial emulation framework included observational data from adults with uncomplicated gram-negative bacteremia in 4 hospitals in Copenhagen, Denmark, from January 1, 2018, through December 31, 2021. The duration of follow-up was 90 days. Eligibility criteria included a blood culture positive for growth of gram-negative bacteria, clinical stability within 4 days of initial blood culture, an available susceptibility report on day 4, and initiation of appropriate empirical IV antibiotic treatment within 24 hours of blood culture.
    Exposure: Switching to oral antibiotics within 4 days after initial blood culture compared with continuing IV antibiotic treatment for at least 5 days after initial blood culture.
    Main outcomes and measures: The main outcome was 90-day all-cause mortality. Inverse probability of treatment weighting was applied to adjust for confounding. Intention-to-treat and per-protocol analyses were performed using pooled logistic regression to estimate absolute risk, risk difference (RD), and risk ratio (RR); 95% CIs were computed using bootstrapping.
    Results: A total of 914 individuals were included in the target trial emulation analysis (512 [56.0%] male; median age, 74.5 years [IQR, 63.3-83.2 years]); 433 (47.4%) transitioned early to oral antibiotic treatment, and 481 (52.6%) received prolonged IV treatment. Ninety-nine individuals (10.8%) died during follow-up. The proportion of individuals who died was higher in the group receiving prolonged IV treatment (69 [14.3%] vs 30 [6.9%]). In the intention-to-treat analysis, 90-day all-cause mortality risk was 9.1% (95% CI, 6.7%-11.6%) for the early-switch group and 11.7% (95% CI, 9.6%-13.8%) for the group receiving prolonged IV treatment; the RD was -2.5% (95% CI, -5.7% to 0.7%) and RR was 0.78 (95% CI, 0.60-1.10). In the per-protocol analysis, the RD was -0.1% (95% CI, -3.4% to 3.1%) and RR was 0.99 (95% CI, 0.70-1.40).
    Conclusions and relevance: In this cohort study of uncomplicated gram-negative bacteremia, early transition to oral antibiotics within 4 days of initial blood culture was associated with 90-day all-cause mortality risk comparable to that of continuing IV antibiotic treatment and may be an effective alternative to prolonged IV treatment.
    MeSH term(s) Adult ; Humans ; Male ; Aged ; Female ; Cohort Studies ; Administration, Intravenous ; Patients ; Death ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Observational Study ; Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.52314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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