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Article: Toward three-dimensionally ordered nanoporous graphene materials: template synthesis, structure, and applications.

Yamamoto, Masanori / Goto, Shunsuke / Tang, Rui / Yamazaki, Kaoru

2023 Volume 15, Issue 6, Page(s) 1953–1965

Abstract: Precise template synthesis will realize three-dimensionally ordered nanoporous graphenes (NPGs) with a spatially controlled seamless graphene structure and fewer edges. These structural features result in superelastic nature, high electrochemical ... ...

Abstract	Precise template synthesis will realize three-dimensionally ordered nanoporous graphenes (NPGs) with a spatially controlled seamless graphene structure and fewer edges. These structural features result in superelastic nature, high electrochemical stability, high electrical conductivity, and fast diffusion of gases and ions at the same time. Such innovative 3D graphene materials are conducive to solving energy-related issues for a better future. To further improve the attractive properties of NPGs, we review the template synthesis and its mechanism by chemical vapor deposition of hydrocarbons, analysis of the nanoporous graphene structure, and applications in electrochemical and mechanical devices.
Language	English
Publishing date	2023-12-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc05022j
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Article: Diacylglycerol Kinase ε in Adipose Tissues: A Crosstalk Between Signal Transduction and Energy Metabolism.

Nakano, Tomoyuki / Goto, Kaoru

Frontiers in physiology

2022 Volume 13, Page(s) 815085

Abstract: Diacylglycerol (DG) is unique in lipid metabolism because it serves not only as an intermediate product for triglyceride synthesis, but also as a signaling molecule that activates proteins containing DG-responsive elements, such as protein kinase C. ... ...

Abstract	Diacylglycerol (DG) is unique in lipid metabolism because it serves not only as an intermediate product for triglyceride synthesis, but also as a signaling molecule that activates proteins containing DG-responsive elements, such as protein kinase C. Consequently, DG acts as a hub between energy metabolism and intracellular signaling. Of DG metabolizing pathways, DG kinase (DGK) phosphorylates DG to produce phosphatidic acid, which also serves as a second messenger. Several lines of evidence suggest that DGK is deeply involved in metabolic diseases such as obesity and insulin resistance. Of DGK isozymes, DGKε is simplest in terms of structure, but it is characterized by substrate specificity toward arachidonoyl-DG. Recently, we have reported that DGKε deficiency promotes adipose tissue remodeling in mice during the course of high fat diet (HFD) feeding regimen including obesity, insulin resistance, and beige adipogenesis. DGKε ablation engenders altered expression of other lipid metabolizing enzymes, including adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and diacylglycerol acyltransferase (DGAT). Subcellular localization of DGKε in the endoplasmic reticulum suggests involvement of this isozyme in lipid energy homeostasis. This review presents current findings of DGKε in lipid-orchestrated pathophysiology, especially unique phenotypes of DGKε-knockout mice in the early and late stages of obesogenic conditions.
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.815085
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Article ; Online: Ablation of diacylglycerol kinase ε promotes whitening of brown adipose tissue under high fat diet feeding.

Nakano, Tomoyuki / Suzuki, Ayako / Goto, Kaoru

Advances in biological regulation

2023 Volume 91, Page(s) 100994

Abstract: Adipose tissue (AT) comprises distinct fat depots such as white AT and brown AT. White and brown adipocytes exhibit different morphological and physiological properties. White adipocytes containing large single lipid droplet (LD) provide energy on demand ...

Abstract	Adipose tissue (AT) comprises distinct fat depots such as white AT and brown AT. White and brown adipocytes exhibit different morphological and physiological properties. White adipocytes containing large single lipid droplet (LD) provide energy on demand whereas brown adipocytes loaded with multilocular LDs consume energy to generate heat or dissipate excess energy. Recent studies have shown that multilocular brown-like cells emerge in white AT under certain conditions. These cells termed beige adipocytes participate in energy expenditure and heat generation. In the process of lipolysis, TG is broken down into free fatty acid and diacylglycerol (DG). In this regard, DG also serves as a signaling molecule activating some proteins such as protein kinase C. Therefore, DG kinase (DGK), an enzyme which phosphorylates DG into phosphatidic acid (PA), plays a pivotal role in integrating energy homeostasis and intracellular signaling. Recently, we described that DGKε-KO mice exhibit increased adiposity in visceral white AT accompanied with impaired glucose tolerance early (40 days) in the course of high fat diet (HFD) feeding, although these mice exhibit "browning or beiging" in visceral white AT associated with improved glucose tolerance after longer term HFD feeding (180 days). This study was conducted to understand the overall features of adipose tissues and investigate changes in subcutaneous (inguinal) white AT and interscapular brown AT of DGKε-KO mice during the course of HFD feeding. Results demonstrated that fat accumulation is promoted in all fat depots under 40 days of HFD feeding conditions. Remarkably, "whitening" of brown adipocytes was identified in DGKε-deficient brown AT during the course of HFD feeding, suggesting brown adipocyte dysfunction. In addition, insulin levels were considerably elevated in DGKε-KO mice under 180 days of HFD feeding conditions. Collectively, these findings suggest that brown adipocytes are dysfunctional in DGKε-KO mice, which promotes browning or beiging in visceral white AT. Beige adipocytes may take over energy disposal and contribute to improving glucose tolerance with the aid of high levels of insulin in DGKε-KO mice upon excess feeding.
MeSH term(s)	Mice ; Animals ; Adipose Tissue, Brown/metabolism ; Diacylglycerol Kinase/genetics ; Diacylglycerol Kinase/metabolism ; Diet, High-Fat ; Glucose/metabolism ; Insulins/metabolism
Chemical Substances	Diacylglycerol Kinase (EC 2.7.1.107) ; Glucose (IY9XDZ35W2) ; Insulins
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2667413-0
ISSN	2212-4934 ; 2212-4926
ISSN (online)	2212-4934
ISSN	2212-4926
DOI	10.1016/j.jbior.2023.100994
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Article ; Online: Surface defect healing in annealing from nanoporous carbons to nanoporous graphenes.

Yamazaki, Kaoru / Goto, Shunsuke / Yoshino, Shunya / Gubarevich, Anna / Yoshida, Katsumi / Kato, Hideki / Yamamoto, Masanori

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 48, Page(s) 32972–32978

Abstract: Nanoporous graphene (NPG) materials have the pronounced electrochemical stability of the seamless graphene structures developed over the 3D space. We revisited the Raman spectra of nanoporous carbons (NPCs) synthesized using θ-/γ- ... ...

Abstract	Nanoporous graphene (NPG) materials have the pronounced electrochemical stability of the seamless graphene structures developed over the 3D space. We revisited the Raman spectra of nanoporous carbons (NPCs) synthesized using θ-/γ-Al
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp04921c
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Article: Associations Between Internet Addiction, Psychiatric Comorbidity, and Maternal Depression and Anxiety: Potential Underlying Mechanisms [Response to Letter].

Sakamoto, Shoko / Miyawaki, Dai / Goto, Ayako / Hirai, Kaoru / Hama, Hiroki / Kadono, Shin / Nishiura, Sayaka / Inoue, Koki

Neuropsychiatric disease and treatment

2023 Volume 19, Page(s) 949–950

Language	English
Publishing date	2023-04-18
Publishing country	New Zealand
Document type	Journal Article ; Comment
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S415170
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Article ; Online: Multi-institutional study of osimertinib dose-optimization in non-small cell lung cancer patients with EGFR activating mutation aged 70 years or older ('MONEY' trial).

Tsukita, Yoko / Taguri, Masataka / Goto, Yasushi / Hosomi, Yukio / Mizutani, Tomonori / Watanabe, Kageaki / Yoh, Kiyotaka / Takahashi, Satoshi / Kubota, Kaoru / Kunitoh, Hideo

Japanese journal of clinical oncology

2024

Abstract: Osimertinib is the standard of care for patients with epidermal growth factor receptor-activating mutation-positive non-small cell lung cancer. Dose-toxicity has been previously reported, but no dose-response data within the range of 20-240 mg daily (mg/ ... ...

Abstract	Osimertinib is the standard of care for patients with epidermal growth factor receptor-activating mutation-positive non-small cell lung cancer. Dose-toxicity has been previously reported, but no dose-response data within the range of 20-240 mg daily (mg/d). Thus, the current 80 mg/d dosing might be too high for elderly Japanese patients with an average body weight of only 50 kg, resulting in excessive toxicity and cost. We therefore initiated a study to investigate whether osimertinib at 40 mg/d is non-inferior to 80 mg/d in patients with advanced or recurrent epidermal growth factor receptor-activating mutation-positive non-small cell lung cancer aged ≥70 years, using a regression discontinuity design. Osimertinib is administered at 40 mg/d for body weight ≤50 kg, and 80 mg/d for body weight >50 kg. The primary endpoint is progression-free survival. Sample size is 550 patients, based on a non-inferiority margin of the progression-free survival hazard ratio 1.333, 0.10 one-sided type I error and 80% power.
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyae032
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Article ; Online: Cellular expression and subcellular localization of diacylglycerol kinase γ in rat brain.

Hozumi, Yasukazu / Nakano, Tomoyuki / Goto, Kaoru

Biomedical research (Tokyo, Japan)

2021 Volume 42, Issue 1, Page(s) 33–42

Abstract: Gq protein-coupled receptors lead to activation of phospholipase C, which triggers phosphoinositide signaling. Diacylglycerol (DG) is one of the phosphoinositide metabolites and serves as a second messenger. Diacylglycerol kinase (DGK) phosphorylates DG ... ...

Abstract	Gq protein-coupled receptors lead to activation of phospholipase C, which triggers phosphoinositide signaling. Diacylglycerol (DG) is one of the phosphoinositide metabolites and serves as a second messenger. Diacylglycerol kinase (DGK) phosphorylates DG to produce another second messenger phosphatidic acid. Of the DGK family, DGKγ is predominantly expressed in the brain at the mRNA level. Recent studies have shown the expression of DGKγ in vascular endothelial cells and adrenal medullary cells at the protein level, although its detailed cellular expression pattern and subcellular localization in the brain remain to be determined. In the present study, we addressed this point using specific DGKγ antibody. DGKγ was expressed in both projection neurons and interneurons in the cerebral cortex, hippocampal formation, and cerebellum. In cerebellar Purkinje cells, DGKγ was distributed to the soma and dendrites. Fractionation study revealed that DGKγ was enriched in the internal membranes containing the endoplasmic reticulum and Golgi complex. In immunoelectron microscopy, DGKγ was localized throughout the smooth endoplasmic reticulum system. These findings suggest that DGKγ shows unique cellular expression pattern in the brain and distinct subcellular localization different from other DGK isozymes.
MeSH term(s)	Animals ; Brain/enzymology ; Brain/metabolism ; Cerebral Cortex/metabolism ; Diacylglycerol Kinase/metabolism ; Diglycerides ; Endoplasmic Reticulum/metabolism ; Endothelial Cells/metabolism ; Gene Expression Regulation, Enzymologic ; Golgi Apparatus/metabolism ; Isoenzymes ; Neurons/metabolism ; Phosphorylation ; Purkinje Cells/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Signal Transduction
Chemical Substances	1,2-diacylglycerol ; Diglycerides ; Isoenzymes ; RNA, Messenger ; Diacylglycerol Kinase (EC 2.7.1.107)
Language	English
Publishing date	2021-02-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604561-3
ISSN	1880-313X ; 0388-6107
ISSN (online)	1880-313X
ISSN	0388-6107
DOI	10.2220/biomedres.42.33
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Article ; Online: Proposal of a novel subspecies:

Goto, Keiichi / Fujii, Taichi / Yasui, Kazuki / Mochida, Kaoru / Kato-Tanaka, Yuko / Morohoshi, Sho / An, Sun-Young / Kasai, Hiroaki / Yokota, Akira

International journal of systematic and evolutionary microbiology

2023 Volume 73, Issue 10

Abstract: ... ...

Abstract	Alicyclobacillus
MeSH term(s)	Alicyclobacillus ; Aegle/genetics ; Fatty Acids/chemistry ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Phylogeny ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Base Composition ; Guaiacol ; Nucleic Acid Hybridization
Chemical Substances	Fatty Acids ; RNA, Ribosomal, 16S ; DNA, Bacterial ; Guaiacol (6JKA7MAH9C)
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006067
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Article ; Online: Moyamoya Disease Complicating Ebstein's Anomaly.

Goto, Itaru / Okamoto, Ryuji / Sato, Yu / Tsuji, Akihiro / Tanigawa, Takashi / Dohi, Kaoru

Internal medicine (Tokyo, Japan)

2022 Volume 61, Issue 24, Page(s) 3683–3686

Abstract: Ebstein's anomaly is an uncommon congenital disorder affecting the tricuspid valve. We herein report a 38-year-old woman who experienced consciousness and sensory disturbance during treatment for heart failure caused by Ebstein's anomaly. Urgent magnetic ...

Abstract	Ebstein's anomaly is an uncommon congenital disorder affecting the tricuspid valve. We herein report a 38-year-old woman who experienced consciousness and sensory disturbance during treatment for heart failure caused by Ebstein's anomaly. Urgent magnetic resonance imaging and cerebral angiography demonstrated acute cerebral infarction and internal carotid artery obstruction with the development of collateral arteries. We diagnosed her with multiple cerebral infarctions due to moyamoya disease. Ebstein's anomaly concomitant with moyamoya disease is extremely rare. However, we should consider the possibility of this rare but important concurrence when treating patients with heart failure due to Ebstein's anomaly to avoid excessive diuresis and vasodilation and irreversible brain injury.
MeSH term(s)	Female ; Humans ; Adult ; Ebstein Anomaly/complications ; Ebstein Anomaly/diagnostic imaging ; Moyamoya Disease/complications ; Moyamoya Disease/diagnostic imaging ; Tricuspid Valve ; Heart Failure/complications
Language	English
Publishing date	2022-05-14
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9516-22
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Article ; Online: Clinicopathologic, immunohistochemical, and ultrastructural features of histiocytic sarcoma in a chinchilla (Chinchilla lanigera).

Enomoto, Kaoru / Tsutsumitani, Chihiro / Asakawa, Midori Goto

Veterinary medicine and science

2021 Volume 8, Issue 1, Page(s) 302–308

Abstract: A 9-year-old intact female chinchilla (Chinchilla lanigera) was presented to a referring veterinarian due to small, multiple cervical nodules that had been rapidly increasing in size and number. Cytology of the nodules revealed sheets of pleomorphic ... ...

Abstract	A 9-year-old intact female chinchilla (Chinchilla lanigera) was presented to a referring veterinarian due to small, multiple cervical nodules that had been rapidly increasing in size and number. Cytology of the nodules revealed sheets of pleomorphic round cells that were morphologically most compatible with histiocytic sarcoma. Histologically, the nodules were fairly demarcated, partially infiltrative, densely cellular neoplasm, and was composed of pleomorphic large round cells arranged in sheets. Special stains for bacteria (Gram stain and Ziehl-Neelsen stain) and fungi (periodic acid-Schiff stain) were all negative. On immunohistochemistry, the neoplastic cells showed strong cytoplasmic positivity for Iba-1 and CD204, but were negative for CD3 and CD20. Transmission electron microscopy failed to detect Birbeck's granules in the cytoplasm of the neoplastic histiocytes. The chinchilla received chemotherapy with lomustine but died spontaneously on day 62 despite treatment. Autopsy with histopathologic examination revealed disseminated histiocytic sarcoma involving the bone marrow, bronchial lymph nodes, nasal cavity, lung, heart, stomach, pancreas, pancreatic lymph nodes, liver, spleen, and kidney. To the best of our knowledge, this is the first report of disseminated histiocytic sarcoma in chinchillas.
MeSH term(s)	Animals ; Chinchilla ; Female ; Histiocytic Sarcoma/diagnosis ; Histiocytic Sarcoma/pathology ; Histiocytic Sarcoma/veterinary ; Immunohistochemistry ; Kidney ; Rodent Diseases ; Spleen/pathology
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Case Reports
ZDB-ID	2819409-3
ISSN	2053-1095 ; 2053-1095
ISSN (online)	2053-1095
ISSN	2053-1095
DOI	10.1002/vms3.645
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