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  1. Book ; Online ; E-Book: Bioactive sphingolipids in cancer biology and therapy

    Hannun, Yusuf A.

    2015  

    Author's details Yusuf A. Hannun ... ed
    Keywords Sphingolipids / metabolism ; Sphingolipids / therapeutic use ; Chemotherapy, Adjuvant ; Antineoplastic Agents ; Medicine ; Oncology ; Medical laboratories ; Biochemistry
    Subject code 614.5999
    Language English
    Size XI, 490 S. : zahlr. Ill.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018823803
    ISBN 978-3-319-20750-6 ; 978-3-319-20749-0 ; 3-319-20750-4 ; 3-319-20749-0
    DOI 10.1007/978-3-319-20750-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Build a registry of results that students can replicate.

    Hannun, Yusuf A

    Nature

    2021  Volume 600, Issue 7890, Page(s) 571

    MeSH term(s) Authorship ; Education, Graduate ; Goals ; Registries ; Reproducibility of Results ; Research/standards ; Research Design ; Research Personnel/education ; Research Personnel/standards ; Students
    Language English
    Publishing date 2021-12-18
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-021-03707-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Biological function, topology, and quantification of plasma membrane Ceramide.

    Canals, Daniel / Hannun, Yusuf A

    Advances in biological regulation

    2023  Volume 91, Page(s) 101009

    Abstract: Over the past 30 years, a growing body of evidence has revealed the regulatory role of the lipid ceramide in various cellular functions. The structural diversity of ceramide, resulting in numerous species, and its distinct distribution within subcellular ...

    Abstract Over the past 30 years, a growing body of evidence has revealed the regulatory role of the lipid ceramide in various cellular functions. The structural diversity of ceramide, resulting in numerous species, and its distinct distribution within subcellular compartments may account for its wide range of functions. However, our ability to study the potential role of ceramide in specific subcellular membranes has been limited. Several works have shown mitochondrial, Golgi, and plasma membrane ceramide to mediate signaling pathways independently. These results have started to shift the focus on ceramide signaling research toward specific membrane pools. Nonetheless, the challenge arises from the substantial intracellular ceramide content, hindering efforts to quantify its presence in particular membranes. Recently, we have developed the first method capable of detecting and quantifying ceramide in the plasma membrane, leading to unexpected results such as detecting different pools of ceramide responding to drug concentration or time. This review summarizes the historical context that defined the idea of pools of ceramide, the studies on plasma membrane ceramide as a bioactive entity, and the tools available for its study, especially the new method to detect and, for the first time, quantify plasma membrane ceramide. We believe this method will open new avenues for researching sphingolipid signaling and metabolism.
    MeSH term(s) Humans ; Ceramides/metabolism ; Cell Membrane/metabolism ; Golgi Apparatus/metabolism ; Signal Transduction ; Mitochondria/metabolism ; Sphingolipids/metabolism
    Chemical Substances Ceramides ; Sphingolipids
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2023.101009
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  4. Article ; Online: Differentiate and switch, a tale of two heads of a lipid.

    Hannun, Yusuf A

    The EMBO journal

    2018  Volume 37, Issue 7

    MeSH term(s) Glycosphingolipids ; Lipids
    Chemical Substances Glycosphingolipids ; Lipids
    Language English
    Publishing date 2018-03-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.201899221
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  5. Book: Apoptosis in neurobiology

    Hannun, Yusuf A.

    (CRC methods in neuroscience series)

    1999  

    Author's details ed. by Yusuf A. Hannun
    Series title CRC methods in neuroscience series
    Keywords Apoptosis ; Nervenzelle
    Subject Ganglienzelle ; Neurozyt ; Neuron ; Apoptose ; Programmierter Zelltod
    Language English
    Size 278 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT011121763
    ISBN 0-8493-3352-0 ; 978-0-8493-3352-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 6692 order for loan Magazin

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  6. Book: Sphingolipid mediated signal transduction

    Hannun, Yusuf A.

    (Molecular biology intelligence unit)

    1997  

    Title variant Sphingolipid-mediated
    Author's details Yusuf A. Hannun
    Series title Molecular biology intelligence unit
    Keywords Sphingolipids / physiology ; Signal Transduction / physiology ; Signaltransduktion ; Sphingolipide
    Subject Signalübertragung ; Signalvermittlung
    Language English
    Size 188 S. : graph. Darst.
    Publisher Springer u.a.
    Publishing place New York u.a.
    Document type Book
    HBZ-ID HT007815440
    ISBN 3-540-62714-6 ; 978-3-540-62714-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1997 A 7721 order for loan Magazin

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  7. Article ; Online: Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail.

    Bonica, Joseph / Clarke, Christopher J / Obeid, Lina M / Luberto, Chiara / Hannun, Yusuf A

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Volume 37, Issue 3, Page(s) e22787

    Abstract: Sphingosine kinase 1 (SK1) converts the pro-death lipid sphingosine to the pro-survival sphingosine-1-phosphate (S1P) and is upregulated in several cancers. DNA damaging agents, such as the chemotherapeutic doxorubicin (Dox), have been shown to degrade ... ...

    Abstract Sphingosine kinase 1 (SK1) converts the pro-death lipid sphingosine to the pro-survival sphingosine-1-phosphate (S1P) and is upregulated in several cancers. DNA damaging agents, such as the chemotherapeutic doxorubicin (Dox), have been shown to degrade SK1 protein in cancer cells, a process dependent on wild-type p53. As mutations in p53 are very common across several types of cancer, we evaluated the effects of Dox on SK1 in p53 mutant cancer cells. In the p53 mutant breast cancer cell line MDA-MB-231, we show that Dox treatment significantly increases SK1 protein and S1P. Using MDA-MB-231 cells with CRISPR-mediated knockout of SK1 or the selective SK1 inhibitor PF-543, we implicated SK1 in both Dox-induced migration and in a newly uncovered proangiogenic program induced by Dox. Mechanistically, inhibition of SK1 suppressed the induction of the cytokine BMP4 and of the EMT transcription factor Snail in response to Dox. Interestingly, induction of BMP4 by SK1 increased Snail levels following Dox treatment by stabilizing Snail protein. Furthermore, we found that SK1 was required for Dox-induced p38 MAP kinase phosphorylation and that active p38 MAPK in turn upregulated BMP4 and Snail, positioning p38 downstream of SK1 and upstream of BMP4/Snail. Modulating production of S1P by inhibition of de novo sphingolipid synthesis or knockdown of the S1P-degrading enzyme S1P lyase identified S1P as the sphingolipid activator of p38 in this model. This work establishes a novel angiogenic pathway in response to a commonly utilized chemotherapeutic and highlights the potential of SK1 as a secondary drug target for patients with p53 mutant cancer.
    MeSH term(s) Humans ; Up-Regulation ; Tumor Suppressor Protein p53/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Neoplasms ; Sphingolipids ; Doxorubicin/pharmacology ; Sphingosine/pharmacology ; Sphingosine/metabolism ; Lysophospholipids/pharmacology
    Chemical Substances sphingosine kinase (EC 2.7.1.-) ; Tumor Suppressor Protein p53 ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; Sphingolipids ; Doxorubicin (80168379AG) ; Sphingosine (NGZ37HRE42) ; Lysophospholipids
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202201066R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer.

    Sadeghi, Mohammad Mojtaba / Salama, Mohamed F / Hannun, Yusuf A

    International journal of molecular sciences

    2021  Volume 22, Issue 11

    Abstract: Driver-directed therapeutics have revolutionized cancer treatment, presenting similar or better efficacy compared to traditional chemotherapy and substantially improving quality of life. Despite significant advances, targeted therapy is greatly limited ... ...

    Abstract Driver-directed therapeutics have revolutionized cancer treatment, presenting similar or better efficacy compared to traditional chemotherapy and substantially improving quality of life. Despite significant advances, targeted therapy is greatly limited by resistance acquisition, which emerges in nearly all patients receiving treatment. As a result, identifying the molecular modulators of resistance is of great interest. Recent work has implicated protein kinase C (PKC) isozymes as mediators of drug resistance in non-small cell lung cancer (NSCLC). Importantly, previous findings on PKC have implicated this family of enzymes in both tumor-promotive and tumor-suppressive biology in various tissues. Here, we review the biological role of PKC isozymes in NSCLC through extensive analysis of cell-line-based studies to better understand the rationale for PKC inhibition. PKC isoforms α, ε, η, ι, ζ upregulation has been reported in lung cancer, and overexpression correlates with worse prognosis in NSCLC patients. Most importantly, PKC isozymes have been established as mediators of resistance to tyrosine kinase inhibitors in NSCLC. Unfortunately, however, PKC-directed therapeutics have yielded unsatisfactory results, likely due to a lack of specific evaluation for PKC. To achieve satisfactory results in clinical trials, predictive biomarkers of PKC activity must be established and screened for prior to patient enrollment. Furthermore, tandem inhibition of PKC and molecular drivers may be a potential therapeutic strategy to prevent the emergence of resistance in NSCLC.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Drug Resistance, Neoplasm ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Humans ; Indoles/pharmacology ; Lung Neoplasms/drug therapy ; Prognosis ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism
    Chemical Substances Indoles ; KRAS protein, human ; Protein Isoforms ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase C (EC 2.7.11.13) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; enzastaurin (UC96G28EQF)
    Language English
    Publishing date 2021-05-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22115527
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  9. Article ; Online: Author Correction: Sphingolipids and their metabolism in physiology and disease.

    Hannun, Yusuf A / Obeid, Lina M

    Nature reviews. Molecular cell biology

    2018  Volume 19, Issue 10, Page(s) 673

    Abstract: In the original Figure 2, sphingolipids on the endosomal and lysosomal membranes are facing the outside of these organelles. The correct orientation of these species should be towards the lumen, as shown in the corrected figure. ...

    Abstract In the original Figure 2, sphingolipids on the endosomal and lysosomal membranes are facing the outside of these organelles. The correct orientation of these species should be towards the lumen, as shown in the corrected figure.
    Language English
    Publishing date 2018-08-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-018-0046-6
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  10. Article ; Online: Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.

    Coant, Nicolas / Hannun, Yusuf A

    Advances in biological regulation

    2018  Volume 71, Page(s) 141–146

    Abstract: Extensive research conducted in the last three decades has identified the roles for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) as key regulators of cellular homeostasis, growth and death. One of the ... ...

    Abstract Extensive research conducted in the last three decades has identified the roles for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) as key regulators of cellular homeostasis, growth and death. One of the major groups of enzymes in the ceramide pathway, ceramidases, converts ceramide into sphingosine and fatty acids, with sphingosine being further metabolized to S1P. Thus, these enzymes play important roles in the network controlling the functions associated with these bioactive sphingolipids. Among the family of ceramidases, neutral ceramidase (nCDase), which is named according to its optimal pH for catalytic activity, has received increased attention in the last decade. The goal of this review is to provide a brief background on bioactive sphingolipids and the ceramidases. We then describe more recent advances on nCDase, specifically the resolution of its crystal structure and understanding its roles in cell biology and physiology.
    MeSH term(s) Animals ; Humans ; Lysophospholipids/metabolism ; Neoplasm Proteins/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Neutral Ceramidase/metabolism ; Signal Transduction ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism
    Chemical Substances Lysophospholipids ; Neoplasm Proteins ; sphingosine 1-phosphate (26993-30-6) ; ASAH2 protein, human (EC 3.5.1.23) ; Neutral Ceramidase (EC 3.5.1.23) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2018-10-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2018.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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