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  1. Article ; Online: The complete mitochondrial genome of

    Tang, Shaobo / Zhang, Xiaoyun / Du, Chunhong / Jiang, Dandan / Yang, Xing

    Mitochondrial DNA. Part B, Resources

    2024  Volume 9, Issue 4, Page(s) 551–556

    Abstract: We conducted an analysis of the complete mitochondrial genome ... ...

    Abstract We conducted an analysis of the complete mitochondrial genome of
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2024.2345136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of liver enzymes in the association between ozone exposure and diabetes risk: a cross-sectional study of Zhuang adults in China.

    Ma, Xiaoyun / Wu, Han / Huang, Huishen / Tang, Peng / Zeng, Xiaoyun / Huang, Dongping / Liu, Shun / Qiu, Xiaoqiang

    Environmental science. Processes & impacts

    2024  Volume 26, Issue 4, Page(s) 765–777

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Ozone/adverse effects ; Ozone/analysis ; Cross-Sectional Studies ; China/epidemiology ; Male ; Female ; Adult ; Diabetes Mellitus/epidemiology ; Middle Aged ; Environmental Exposure/statistics & numerical data ; Environmental Exposure/adverse effects ; Air Pollutants/analysis ; Air Pollutants/adverse effects ; Liver/enzymology ; Prevalence ; Blood Glucose/analysis
    Chemical Substances Ozone (66H7ZZK23N) ; Air Pollutants ; Blood Glucose
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703814-2
    ISSN 2050-7895 ; 2050-7887
    ISSN (online) 2050-7895
    ISSN 2050-7887
    DOI 10.1039/d3em00463e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7401: Show issues

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  3. Article ; Online: One Small Step for Neurotechnology, One Giant Leap for an In-Depth Understanding of the Brain.

    Qiu, Xiaoyun / Sun, Minjuan / Xu, Cenglin / Tang, Yingying / Chen, Zhong

    Neuroscience bulletin

    2023  Volume 39, Issue 6, Page(s) 1034–1036

    MeSH term(s) Brain/diagnostic imaging ; Head
    Language English
    Publishing date 2023-01-31
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-023-01027-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6734: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article ; Online: A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker.

    Zhang, Xiaoyun / Tang, Chaogui / Lian, Jianchun / Jiang, Yuzhang

    Canadian journal of gastroenterology & hepatology

    2023  Volume 2023, Page(s) 5557546

    Abstract: Studies have established a correlation ... ...

    Abstract Studies have established a correlation between
    MeSH term(s) Animals ; Mice ; Humans ; Esophageal Squamous Cell Carcinoma ; Esophageal Neoplasms/pathology ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Prognosis ; Cell Line, Tumor ; Biomarkers, Tumor/analysis ; alpha-Macroglobulins
    Chemical Substances Biomarkers, Tumor ; A2ML1 protein, human ; alpha-Macroglobulins
    Language English
    Publishing date 2023-11-03
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2762182-0
    ISSN 2291-2797 ; 1916-7237 ; 0835-7900
    ISSN (online) 2291-2797 ; 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2023/5557546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Multicomponent reactions to access

    Tang, Yisong / Cai, Yougen / Xie, Zhiwei / Gao, Zishan / Chen, Xiaoyun / Yi, Jun

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 7, Page(s) 1378–1385

    Abstract: A simple and efficient transition-metal/photocatalyst-free visible-light-driven one-pot three-component reaction between thianthrenium salts, carbon disulfide and amines under an air atmosphere for the preparation of biologically ... ...

    Abstract A simple and efficient transition-metal/photocatalyst-free visible-light-driven one-pot three-component reaction between thianthrenium salts, carbon disulfide and amines under an air atmosphere for the preparation of biologically relevant
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01935g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Analysis of Cell Proliferation by Three-Dimensional Culture.

    Tang, Xiaoyun / Brindley, David N

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2579, Page(s) 197–207

    Abstract: Three-dimensional (3D) cell culture technology is a powerful tool in cancer research and drug development. It retains several critical components of the in vivo environment, including cell-cell and cell-extracellular matrix (ECM) interactions in a 3D ... ...

    Abstract Three-dimensional (3D) cell culture technology is a powerful tool in cancer research and drug development. It retains several critical components of the in vivo environment, including cell-cell and cell-extracellular matrix (ECM) interactions in a 3D fashion, gradients of oxygen, nutrients and metabolic waste, and it is thus more physiologically relevant than traditional two-dimensional (2D) cell culture. Here, we describe a simple and versatile method using commercially available chamber slides and Matrigel, a surrogate ECM hydrogel, to set up a 3D culture model for breast cancer cells. In this 3D culture model, cells form aggregates or spheroids on top of a thin layer of Matrigel, which can be fixed directly onto the chamber slides for cell imaging and immunofluorescence staining. Alternatively, RNA and protein can be extracted from the cells for further investigation. This 3D cell culture model provides a useful platform for cancer research and drug development, in which the effects of novel compounds or genetic modifications can be tested.
    MeSH term(s) Cell Culture Techniques/methods ; Cell Proliferation ; Extracellular Matrix/metabolism ; Hydrogels/metabolism ; Spheroids, Cellular
    Chemical Substances Hydrogels
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2736-5_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer.

    Benesch, Matthew G K / Tang, Xiaoyun / Brindley, David N / Takabe, Kazuaki

    World journal of oncology

    2024  Volume 15, Issue 1, Page(s) 1–13

    Abstract: Overcoming and preventing cancer therapy resistance is the most pressing challenge in modern breast cancer management. Consequently, most modern breast cancer research is aimed at understanding and blocking these therapy resistance mechanisms. One ... ...

    Abstract Overcoming and preventing cancer therapy resistance is the most pressing challenge in modern breast cancer management. Consequently, most modern breast cancer research is aimed at understanding and blocking these therapy resistance mechanisms. One increasingly promising therapeutic target is the autotaxin (ATX)-lysophosphatidate (LPA)-lipid phosphate phosphatase (LPP) axis. Extracellular LPA, produced from albumin-bound lysophosphatidylcholine by ATX and degraded by the ecto-activity of the LPPs, is a potent cell-signaling mediator of tumor growth, invasion, angiogenesis, immune evasion, and resistance to cancer treatment modalities. LPA signaling in the post-natal organism has central roles in physiological wound healing, but these mechanisms are subverted to fuel pathogenesis in diseases that arise from chronic inflammatory processes, including cancer. Over the last 10 years, our understanding of the role of LPA signaling in the breast tumor microenvironment has begun to mature. Tumor-promoting inflammation in breast cancer leads to increased ATX production within the tumor microenvironment. This results in increased local concentrations of LPA that are maintained in part by decreased overall cancer cell LPP expression that would otherwise more rapidly break it down. LPA signaling through six G-protein-coupled LPA receptors expressed by cancer cells can then activate virtually every known tumorigenic pathway. Consequently, to target therapy resistance and tumor growth mediated by LPA signaling, multiple inhibitors against the LPA signaling axis are entering clinical trials. In this review, we summarize recent developments in LPA breast cancer biology, and illustrate how these novel therapeutics against the LPA signaling pathway may be excellent adjuncts to extend the efficacy of evolving breast cancer treatments.
    Language English
    Publishing date 2024-01-20
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1762
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  8. Article ; Online: Financial market sentiment and stock return during the COVID-19 pandemic.

    Bai, Chenjiang / Duan, Yuejiao / Fan, Xiaoyun / Tang, Shuai

    Finance research letters

    2023  Volume 54, Page(s) 103709

    Abstract: Using 1,287,932 pieces of textual data from news media, we measure the financial market sentiment worldwide. We conduct the first international study of the effect of the financial market sentiment on stock return during the COVID-19 pandemic. Results ... ...

    Abstract Using 1,287,932 pieces of textual data from news media, we measure the financial market sentiment worldwide. We conduct the first international study of the effect of the financial market sentiment on stock return during the COVID-19 pandemic. Results show that the intensification of the epidemic adversely affects the stock market, but the increasing financial market sentiment increases the stock market return, even during the worst of the pandemic. Our results remain robust using alternative proxies. Additional analysis suggests that negative sentiment has a more significant impact on stock market returns than positive sentiment. Taken together, our findings confirm that negative financial market sentiment amplifies the impact of the crisis on the stock market, and positive financial market sentiment can help mitigate the losses caused by the shock.
    Language English
    Publishing date 2023-02-17
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1544-6131
    ISSN (online) 1544-6131
    DOI 10.1016/j.frl.2023.103709
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  9. Article ; Online: Primary care team and its association with quality of care for people with multimorbidity: a systematic review.

    Li, Mingyue / Tang, Haoqing / Liu, Xiaoyun

    BMC primary care

    2023  Volume 24, Issue 1, Page(s) 20

    Abstract: Background: Multimorbidity is posing an enormous burden to health systems, especially for primary healthcare system. While primary care teams (PCTs) are believed to have potentials to improve quality of primary health care (PHC), less is known about ... ...

    Abstract Background: Multimorbidity is posing an enormous burden to health systems, especially for primary healthcare system. While primary care teams (PCTs) are believed to have potentials to improve quality of primary health care (PHC), less is known about their impact on the quality of care for people with multimorbidity. We assessed the characteristics of PCTs and their impact on the quality of care for people with multimorbidity and the mechanisms.  METHODS: We searched PubMed, MEDLINE, EMBASE, ProQuest for published studies from January 2000 to October 2021 for studies in English. Following through PRISMA guidelines, two reviewers independently abstracted data and reconciled by consensus with a third reviewer. Titles, abstracts, and full texts were evaluated to identify relevant studies. Studies were categorized by types of interventions, the impact of interventions on outcome measures, and mechanisms of interventions.  RESULTS: Seventeen studies (13 RCT, 3 cohort studies, and 1 non-randomized trial) were identified. PCTs were summarized into three types-upward PCTs, downward PCTs and traditional PCTs according to the skill mix. The upward PCTs included primary care workers and specialists from upper-level hospitals, downward PCTs involving primary care workers and lay health workers, and traditional PCTs involving physicians and care managers. PCTs improved patients' mental and psychological health outcomes greatly, and also improved patients' perceptions towards care including satisfaction with care, sense of improvement, and patient-centeredness. PCTs also improved the process of care and changed providers' behaviors. However, PCTs showed mixed effects on clinical outcome measures.
    Conclusions: PCTs have improved mental and psychological health outcomes, the process of care, patients' care experiences, and satisfaction towards care for patients with multimorbidity. The effect of PCTs on clinical outcomes and changes in patient behaviors need to be further explored.
    MeSH term(s) Humans ; Multimorbidity ; Health Personnel ; Outcome Assessment, Health Care ; Text Messaging ; Primary Health Care
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2731-4553
    ISSN (online) 2731-4553
    DOI 10.1186/s12875-023-01968-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acetylation of the polysaccharide from Houttuynia cordata rhizome and their α-glucosidase inhibition mechanism.

    He, Mengyao / Tang, Shuxin / Xu, Tingting / Yuan, Yanan / Wu, Ting / Pan, Siyi / Xu, Xiaoyun

    Journal of food science

    2024  

    Abstract: In this study, the polysaccharide (RHCP) extracted from Houttuynia cordata rhizome was acetylated through the acetic anhydride method. The physicochemical properties of RHCP and its acetylated derivatives (Ac-RHCP) were determined by infrared spectra, ... ...

    Abstract In this study, the polysaccharide (RHCP) extracted from Houttuynia cordata rhizome was acetylated through the acetic anhydride method. The physicochemical properties of RHCP and its acetylated derivatives (Ac-RHCP) were determined by infrared spectra, scanning electron microscopy, and Congo red test. Meanwhile, the α-glucosidase inhibition mechanism of RHCP and Ac-RHCP was analyzed by inhibition kinetics, and circular dichroism and fluorescence spectroscopy. Ac-RHCP resulted in a more porous surface structure and 1.83-fold higher solubility compared with RHCP. At a concentration of 6 mg/mL, the α-glucosidase inhibition rate of Ac-RHCP was 75.40%, while that of RHCP was 44.68%. RHCP and Ac-RHCP inhibited α-glucosidase in a mixed-type manner, reduced the endogenous fluorescence of α-glucosidase, affected the microenvironment of amino acid residues, and changed the conformation of α-glucosidase. The study indicates that Ac-RHCP exhibits a certain level of α-glucosidase inhibition, demonstrating its potential as a functional food for glycemic control.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    DOI 10.1111/1750-3841.17000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1001: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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