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Article ; Online: "Indole-gence" for the mind.

Mayneris-Perxachs, Jordi / Castells-Nobau, Anna / Fernández-Real, José Manuel

2024 Volume 32, Issue 2, Page(s) 151–153

Abstract: Surging depression rates highlight the need for innovative strategies beyond the traditional focus on the brain. In this issue of Cell Host & Microbe, Cheng et al. uncover a role for the gut microbiota in depression through the intestinal receptor Grp35 ... ...

Abstract	Surging depression rates highlight the need for innovative strategies beyond the traditional focus on the brain. In this issue of Cell Host & Microbe, Cheng et al. uncover a role for the gut microbiota in depression through the intestinal receptor Grp35 and indole pathway, offering hope in fighting against depression.
MeSH term(s)	Microbiota ; Intestines ; Gastrointestinal Microbiome ; Indoles/pharmacology ; Indoles/metabolism
Chemical Substances	Indoles
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2024.01.006
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Article ; Online: Proline-related metabolites: Towards biological diagnosis of depression.

Mayneris-Perxachs, Jordi / Fernández-Real, José Manuel

Psychiatry and clinical neurosciences

2023 Volume 77, Issue 4, Page(s) 195

MeSH term(s)	Humans ; Proline ; Depression/diagnosis
Chemical Substances	Proline (9DLQ4CIU6V)
Language	English
Publishing date	2023-04-01
Publishing country	Australia
Document type	Editorial
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13535
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Article ; Online: The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism.

Mayneris-Perxachs, Jordi / Moreno-Navarrete, José María / Fernández-Real, José Manuel

Nature reviews. Endocrinology

2022 Volume 18, Issue 11, Page(s) 683–698

Abstract: Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms compete or cooperate for iron acquisition, demonstrating the importance of this essential element for the biological and physiological processes that are key for ... ...

Abstract	Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms compete or cooperate for iron acquisition, demonstrating the importance of this essential element for the biological and physiological processes that are key for the preservation of metabolic homeostasis. In humans and other mammals, the bidirectional interactions between the bacterial component of the gut microbiota and the host for iron acquisition shape both host and microbiota metabolism. Bacterial functions influence host iron absorption, whereas the intake of iron, iron deficiency and iron excess in the host affect bacterial biodiversity, taxonomy and function, resulting in changes in bacterial virulence. These consequences of the host-microbial crosstalk affect systemic levels of iron, its storage in different tissues and host glucose metabolism. At the interface between the host and the microbiota, alterations in the host innate immune system and in circulating soluble factors that regulate iron (that is, hepcidin, lipocalin 2 and lactoferrin) are associated with metabolic disease. In fact, patients with obesity-associated metabolic dysfunction and insulin resistance exhibit dysregulation in iron homeostasis and alterations in their gut microbiota profile. From an evolutionary point of view, the pursuit of two important nutrients - glucose and iron - has probably driven human evolution towards the most efficient pathways and genes for human survival and health.
MeSH term(s)	Animals ; Bacteria/metabolism ; Glucose/metabolism ; Hepcidins/metabolism ; Humans ; Iron/metabolism ; Lactoferrin/metabolism ; Lipocalin-2/metabolism ; Microbiota
Chemical Substances	Hepcidins ; Lipocalin-2 ; Iron (E1UOL152H7) ; Lactoferrin (EC 3.4.21.-) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-022-00721-3
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Article ; Online: Is the jejunum the fulcrum of glucose metabolism?

Fernández-Real, Jose Manuel / Mayneris-Perxachs, Jordi

Gut

2020 Volume 70, Issue 6, Page(s) 1005–1006

MeSH term(s)	Carbohydrate Metabolism ; Glucose/metabolism ; Humans ; Ileum ; Jejunum/metabolism ; Obesity/metabolism
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2020-322662
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Article: Exploration of the microbiota and metabolites within body fluids could pinpoint novel disease mechanisms

Mayneris‐Perxachs, Jordi / Fernández‐Real, José‐Manuel

FEBS journal. 2020 Mar., v. 287, no. 5

2020

Abstract: Thanks to the emergence and recent advances in high‐throughput sequencing technologies, it is becoming more evident every day that changes in the microbiome composition are linked to a myriad of health conditions. Despite this, the mechanisms of host– ... ...

Abstract	Thanks to the emergence and recent advances in high‐throughput sequencing technologies, it is becoming more evident every day that changes in the microbiome composition are linked to a myriad of health conditions. Despite this, the mechanisms of host–microbiota signalling remain largely unknown. The microbiome has an extensive metabolic activity that leads to the generation of a large number of compounds that are likely to influence host health. Therefore, the microbiome–host cross‐talk is in part mediated by microbial‐derived metabolites. Unlike metagenomics, which only provides information about microbial genes and thus the microbiome functional potential, metabolic phenotyping is well suited to capture their actual metabolic activity. Here, we provide an overview of these approaches and propose an integration of metagenomics, as a microbiome compositional readout, with faecal and plasma/urine metabolomics, as a functional readout, to unravel novel mechanisms linking the microbiome to host health and disease.
Keywords	biochemical pathways ; metabolites ; metabolomics ; metagenomics ; microbiome ; microorganisms ; phenotype ; urine
Language	English
Dates of publication	2020-03
Size	p. 856-865.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; REVIEW
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.15130
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Article ; Online: Bidirectional relationships between the gut microbiome and sexual traits.

Del Castillo-Izquierdo, Angela / Mayneris-Perxachs, Jordi / Fernández-Real, José Manuel

American journal of physiology. Cell physiology

2022

Abstract: The human gut microbiota is known to be shaped by a variety of environmental factors (diet, drugs, geography and sanitation) and host intrinsic factors (age and sexual development). The differences in gut microbiota between sexes are minimal before ... ...

Abstract	The human gut microbiota is known to be shaped by a variety of environmental factors (diet, drugs, geography and sanitation) and host intrinsic factors (age and sexual development). The differences in gut microbiota between sexes are minimal before adulthood and late adulthood, and marked during adulthood. For instance, consistent higher abundances of Akkermansia and Ruminococcus have been observed in adult women compared to men and most studies have found higher abundances of Prevotella and Fusobacterium (linked to a diet rich in animal proteins) in adult men compared to women. The gut microbiota taxonomy and functionality present in women is more similar to men once reached the menopause. In fact, specific taxa have been associated with the levels of different sexual hormones and their precursors in blood. The gut microbiota composition and circulating testosterone levels are also tightly linked to the extent that microbial signatures can predict its levels in blood. Not only sexual hormones seem to influence the gut microbiome, but also the latter participates in the metabolism of these hormones, with some bacteria being able to metabolize gonadal steroid hormones (one example is 3β-hydroxysteroid dehydrogenase, a testosterone degrading enzyme). In summary, the relationships between the gut microbiome and sexual traits are bidirectional. In addition, other phenotypes and cultural gender-related factors could drive sex-related differences. It is important to note that other members of the microbiome (Archeae, viruses and fungi) have been largely unexplored in relation to this sexual dimorphism. More research is needed on this topic.
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00116.2022
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Article ; Online: Brain N-Glycosylation and Lipidomic Profile Changes Induced by a High-Fat Diet in Dyslipidemic Hamsters.

Paton, Beatrix / Foguet-Romero, Elisabet / Suarez, Manuel / Mayneris-Perxachs, Jordi / Boqué, Noemí / Caimari, Antoni / Canela, Núria / Herrero, Pol

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: The consumption of diets rich in saturated fats is known to be associated with higher mortality. The adoption of healthy habits, for instance adhering to a Mediterranean diet, has proved to exert a preventive effect towards cardiovascular diseases and ... ...

Abstract	The consumption of diets rich in saturated fats is known to be associated with higher mortality. The adoption of healthy habits, for instance adhering to a Mediterranean diet, has proved to exert a preventive effect towards cardiovascular diseases and dyslipidemia. Little is known about how a suboptimal diet can affect brain function, structure, and the mechanisms involved. The aims of this study were to examine how a high-fat diet can alter the brain N-glycan and lipid profile in male Golden Syrian hamsters and to evaluate the potential of a Mediterranean-like diet to reverse this situation. During twelve weeks, hamsters were fed a normal fat diet (CTRL group), a high-fat diet (HFD group), and a high-fat diet followed by a Mediterranean-like diet (MED group). Out of seventy-two identified N-glycans, fourteen were significant (
MeSH term(s)	Cricetinae ; Animals ; Male ; Diet, High-Fat/adverse effects ; Dietary Fats/adverse effects ; Dietary Fats/metabolism ; Lipidomics ; Glycosylation ; Mesocricetus ; Dyslipidemias/etiology ; Dyslipidemias/metabolism ; Brain ; Liver/metabolism
Chemical Substances	Dietary Fats
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032883
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Article ; Online: Exploration of the microbiota and metabolites within body fluids could pinpoint novel disease mechanisms.

Mayneris-Perxachs, Jordi / Fernández-Real, José-Manuel

The FEBS journal

2019 Volume 287, Issue 5, Page(s) 856–865

Abstract: Thanks to the emergence and recent advances in high-throughput sequencing technologies, it is becoming more evident every day that changes in the microbiome composition are linked to a myriad of health conditions. Despite this, the mechanisms of host- ... ...

Abstract	Thanks to the emergence and recent advances in high-throughput sequencing technologies, it is becoming more evident every day that changes in the microbiome composition are linked to a myriad of health conditions. Despite this, the mechanisms of host-microbiota signalling remain largely unknown. The microbiome has an extensive metabolic activity that leads to the generation of a large number of compounds that are likely to influence host health. Therefore, the microbiome-host cross-talk is in part mediated by microbial-derived metabolites. Unlike metagenomics, which only provides information about microbial genes and thus the microbiome functional potential, metabolic phenotyping is well suited to capture their actual metabolic activity. Here, we provide an overview of these approaches and propose an integration of metagenomics, as a microbiome compositional readout, with faecal and plasma/urine metabolomics, as a functional readout, to unravel novel mechanisms linking the microbiome to host health and disease.
MeSH term(s)	Humans ; Metabolomics/methods ; Metagenomics/methods ; Microbiota/physiology ; Phenotype
Language	English
Publishing date	2019-11-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.15130
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Article: Metabolic phenotyping of malnutrition during the first 1000 days of life

Mayneris-Perxachs, Jordi / Swann, Jonathan R

European journal of nutrition. 2019 Apr., v. 58, no. 3

2019

Abstract: Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously ... ...

Abstract	Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight metabolites in a sample providing a comprehensive assessment of the individual’s biochemical status. There are a growing number of studies applying such approaches to characterize the metabolic derangements induced by various forms of early-life malnutrition. This includes acute and chronic undernutrition and specific micronutrient deficiencies. Collectively, these studies highlight the diverse and dynamic metabolic disruptions resulting from various forms of nutritional deficiencies. Perturbations were observed in many pathways including those involved in energy, amino acid, and bile acid metabolism, the metabolic interactions between the gut microbiota and the host, and changes in metabolites associated with gut health. The information gleaned from such studies provides novel insights into the mechanisms linking malnutrition with developmental impairments and assists in the elucidation of candidate biomarkers to identify individuals at risk of developmental shortfalls. As the metabolic profile represents a snapshot of the biochemical status of an individual at a given time, there is great potential to use this information to tailor interventional strategies specifically to the metabolic needs of the individual.
Keywords	amino acids ; at-risk population ; bile acids ; biomarkers ; cognitive development ; digestive system ; energy metabolism ; intestinal microorganisms ; malnutrition ; metabolites ; metabolomics ; molecular weight ; nutrient deficiencies ; phenotype
Language	English
Dates of publication	2019-04
Size	p. 909-930.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-018-1679-0
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Article ; Online: Metabolic phenotyping of malnutrition during the first 1000 days of life.

Mayneris-Perxachs, Jordi / Swann, Jonathan R

European journal of nutrition

2018 Volume 58, Issue 3, Page(s) 909–930

Abstract	Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight metabolites in a sample providing a comprehensive assessment of the individual's biochemical status. There are a growing number of studies applying such approaches to characterize the metabolic derangements induced by various forms of early-life malnutrition. This includes acute and chronic undernutrition and specific micronutrient deficiencies. Collectively, these studies highlight the diverse and dynamic metabolic disruptions resulting from various forms of nutritional deficiencies. Perturbations were observed in many pathways including those involved in energy, amino acid, and bile acid metabolism, the metabolic interactions between the gut microbiota and the host, and changes in metabolites associated with gut health. The information gleaned from such studies provides novel insights into the mechanisms linking malnutrition with developmental impairments and assists in the elucidation of candidate biomarkers to identify individuals at risk of developmental shortfalls. As the metabolic profile represents a snapshot of the biochemical status of an individual at a given time, there is great potential to use this information to tailor interventional strategies specifically to the metabolic needs of the individual.
MeSH term(s)	Child, Preschool ; Female ; Gastrointestinal Microbiome/physiology ; Humans ; Infant ; Infant, Newborn ; Male ; Malnutrition/diagnosis ; Malnutrition/microbiology ; Metabolome/physiology ; Metabolomics/methods ; Phenotype
Language	English
Publishing date	2018-04-11
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-018-1679-0
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