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  1. Article: Selbstverständnis und Verstehen Anderer in der hermeneutischen Phänomenologie Martin Heideggers

    Thurnher, Rainer

    Daseinsanalyse

    2003  Volume 19, Issue 1, Page(s) 116

    Language German
    Document type Article
    ZDB-ID 605641-6
    ISSN 0254-6221
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1922: Show issues Location:
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  2. Article ; Online: P2Y

    Klaver, Dominik / Thurnher, Martin

    Purinergic signalling

    2023  Volume 19, Issue 3, Page(s) 501–511

    Abstract: Although first cloning of the human ATP receptor ... ...

    Abstract Although first cloning of the human ATP receptor P2Y
    MeSH term(s) Humans ; Anti-Inflammatory Agents/pharmacology ; Cell Movement ; Inflammation/metabolism ; Macrophages/metabolism ; Signal Transduction ; Interleukin-1
    Chemical Substances Anti-Inflammatory Agents ; P2RY11 protein, human ; Interleukin-1
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-023-09932-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Crosstalk between purinergic receptor P2Y

    Klaver, Dominik / Gander, Hubert / Frena, Beatrice / Amato, Marco / Thurnher, Martin

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 132

    Abstract: ... ...

    Abstract P2Y
    MeSH term(s) Humans ; Cell Line ; Chemokine CXCL12/genetics ; Chemokine CXCL12/metabolism ; Chemokine CXCL12/pharmacology ; Cyclic AMP/metabolism ; Macrophages/metabolism ; Receptors, CXCR4/genetics ; Receptors, Purinergic/metabolism ; Signal Transduction
    Chemical Substances Chemokine CXCL12 ; CXCR4 protein, human ; Cyclic AMP (E0399OZS9N) ; Receptors, CXCR4 ; Receptors, Purinergic ; P2RY11 protein, human ; ACKR3 protein, human
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05158-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Manual für die Behandlung von Kopf-/Hals-Tumoren

    Burian, Martin / Kornek, Gabriela / Selzer, Edgar / Thurnher, Dietmar

    (UNI-MED science)

    2015  

    Title variant Manual für die Behandlung von Kopf-Hals-Tumoren
    Author's details Prim. Univ.-Prof. Dr. Martin Burian, a.o. Univ.-Prof. Dr. Gabriela Kornek, a.o. Univ.-Prof. Dr. Edgar Selzer, a.o. Univ.-Prof. Dr. Dietmar Thurnher [und 12 andere]
    Series title UNI-MED science
    Keywords Hals-Nasen-Ohren-Tumor ; Therapieplan ; Mind mapping
    Subject Gedankenlandkarte ; Mind map ; Mindmapping ; Behandlungsplan ; Heilplan ; Algorithmus ; Entscheidungsfindung ; Entscheidungsprozess ; Clinical reasoning ; Kopf-Hals-Tumor ; HNO-Tumor
    Subject code 616.99491
    Language German
    Size 48 Seiten, Illustrationen, 25 cm
    Edition 2. Auflage
    Publisher UNI-MED Verlag AG
    Publishing place Bremen
    Publishing country Germany
    Document type Book
    HBZ-ID HT018909713
    ISBN 978-3-8374-1482-0 ; 3-8374-1482-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 607 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Control of Macrophage Inflammation by P2Y Purinergic Receptors.

    Klaver, Dominik / Thurnher, Martin

    Cells

    2021  Volume 10, Issue 5

    Abstract: Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To perform tissue stress surveillance, macrophages express many different stress- ... ...

    Abstract Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To perform tissue stress surveillance, macrophages express many different stress-sensing receptors, including purinergic P2X and P2Y receptors that respond to extracellular nucleotides and their sugar derivatives. Activation of G protein-coupled P2Y receptors can be both pro- and anti-inflammatory. Current examples include the observation that P2Y
    MeSH term(s) Animals ; COVID-19/blood ; COVID-19/immunology ; Humans ; Immunologic Surveillance/drug effects ; Immunologic Surveillance/immunology ; Inflammation/blood ; Inflammation/drug therapy ; Inflammation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/immunology ; Purinergic P2Y Receptor Agonists/pharmacology ; Purinergic P2Y Receptor Agonists/therapeutic use ; Purinergic P2Y Receptor Antagonists/pharmacology ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Receptors, Purinergic P2Y/metabolism ; Receptors, Tumor Necrosis Factor/metabolism ; STAT1 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Stress, Physiological/immunology ; Tumor Necrosis Factor-alpha/metabolism ; COVID-19 Drug Treatment
    Chemical Substances Purinergic P2Y Receptor Agonists ; Purinergic P2Y Receptor Antagonists ; Receptors, Purinergic P2Y ; Receptors, Tumor Necrosis Factor ; STAT1 Transcription Factor ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-05-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10051098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Small Drops Get Fat: Unexpected Fatty Acid in Cytoplasmic Lipid Droplets.

    Thurnher, Martin

    Cell chemical biology

    2016  Volume 23, Issue 6, Page(s) 637–638

    Abstract: In a model of transcellular lipid biosynthesis, Guijas et al. (2016), in this issue of Cell Chemical Biology, demonstrate that lipid droplet-containing "foamy" monocytes unexpectedly accumulate 16:1n9-palmitoleic acid, which has anti-inflammatory ... ...

    Abstract In a model of transcellular lipid biosynthesis, Guijas et al. (2016), in this issue of Cell Chemical Biology, demonstrate that lipid droplet-containing "foamy" monocytes unexpectedly accumulate 16:1n9-palmitoleic acid, which has anti-inflammatory function in vitro and in vivo. This uncommon positional isomer of 16:1n7-palmitoleic acid represents a candidate biomarker for early cardiovascular disease detection.
    MeSH term(s) Biomarkers ; Cardiovascular Diseases ; Fatty Acids ; Humans ; Lipid Droplets ; Lipids ; Monocytes
    Chemical Substances Biomarkers ; Fatty Acids ; Lipids
    Language English
    Publishing date 2016-06-23
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2016.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance.

    Nussbaumer, Oliver / Thurnher, Martin

    Cells

    2020  Volume 9, Issue 3

    Abstract: Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in human peripheral ... ...

    Abstract Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in human peripheral blood. Vγ9Vδ2 T cells, which cannot be studied easily in vivo because they do not exist in rodents, are often referred to as innate-like T cells. The genetically recombined γδ T cell receptor (TCR) that responds to isoprenoid-derived pyrophosphates (phosphoantigens) produced by infected and malignant cells in a butyrophilin-dependent manner qualifies them as therapeutically relevant components of the adaptive immune system. On the other hand, cell-surface proteins such as the C-type lectin CD161 mark a functional phenotype of Vγ9Vδ2 T cells that mediates TCR-independent innate-like responses. Moreover, CD56 (neural cell adhesion molecule, NCAM) and the G protein-coupled receptor GPR56 define Vγ9Vδ2 T cells with increased cytolytic potential and, like CD161, may also be expressed by dendritic cells, principally facilitating the generation of an innate-like immunological synapse. In this review, we summarise current knowledge of Vγ9Vδ2 T cell functional phenotypes that are critical to lymphoid stress surveillance.
    MeSH term(s) Humans ; Immunity, Innate ; Lymphocytes/immunology ; Phenotype ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Stress, Physiological ; T-Lymphocytes/immunology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2020-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9030772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Control of Macrophage Inflammation by P2Y Purinergic Receptors

    Dominik Klaver / Martin Thurnher

    Cells, Vol 10, Iss 1098, p

    2021  Volume 1098

    Abstract: Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To perform tissue stress surveillance, macrophages express many different stress- ... ...

    Abstract Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To perform tissue stress surveillance, macrophages express many different stress-sensing receptors, including purinergic P2X and P2Y receptors that respond to extracellular nucleotides and their sugar derivatives. Activation of G protein-coupled P2Y receptors can be both pro- and anti-inflammatory. Current examples include the observation that P2Y 14 receptor promotes STAT1-mediated inflammation in pro-inflammatory M1 macrophages as well as the demonstration that P2Y 11 receptor suppresses the secretion of tumor necrosis factor (TNF)-α and concomitantly promotes the release of soluble TNF receptors from anti-inflammatory M2 macrophages. Here, we review macrophage regulation by P2Y purinergic receptors, both in physiological and disease-associated inflammation. Therapeutic targeting of anti-inflammatory P2Y receptor signaling is desirable to attenuate excessive inflammation in infectious diseases such as COVID-19. Conversely, anti-inflammatory P2Y receptor signaling must be suppressed during cancer therapy to preserve its efficacy.
    Keywords P2Y receptor ; G protein ; P2Y 11 ; P2Y 14 ; ATP ; UDP-glucose ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The P2Y

    Klaver, Dominik / Gander, Hubert / Dobler, Gabriele / Rahm, Andrea / Thurnher, Martin

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 10, Page(s) 519

    Abstract: The cytoprotective ATP receptor ... ...

    Abstract The cytoprotective ATP receptor P2Y
    MeSH term(s) Adenosine Triphosphate/metabolism ; Anti-Inflammatory Agents/metabolism ; Calcium/metabolism ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Humans ; Inflammasomes/metabolism ; Interleukin-1/metabolism ; Macrophages/metabolism ; Protein Kinase C/metabolism ; RNA, Messenger/genetics ; Receptors, Interleukin-1 ; Receptors, Purinergic P2/genetics ; Receptors, Purinergic P2/metabolism ; Receptors, Tumor Necrosis Factor, Type II/metabolism ; Suppressor of Cytokine Signaling Proteins/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Inflammasomes ; Interleukin-1 ; P2RY11 protein, human ; RNA, Messenger ; Receptors, Interleukin-1 ; Receptors, Purinergic P2 ; Receptors, Tumor Necrosis Factor, Type II ; Suppressor of Cytokine Signaling Proteins ; Vascular Endothelial Growth Factor A ; Adenosine Triphosphate (8L70Q75FXE) ; Cyclic AMP (E0399OZS9N) ; Protein Kinase C (EC 2.7.11.13) ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04548-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Targeting c-Met to Improve Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma.

    Lindner, Andrea Katharina / Pichler, Martin / Thurnher, Martin / Pichler, Renate

    European urology

    2021  Volume 81, Issue 1, Page(s) 1–2

    Abstract: c-Met inhibition has direct antitumor effects on proliferation, angiogenesis, and metastasis, and indirect antitumor effects via prevention of the induction of immunosuppressive mechanisms (PD-L1, TGFβ, IDO1). c-Met inhibition is key to overcome ... ...

    Abstract c-Met inhibition has direct antitumor effects on proliferation, angiogenesis, and metastasis, and indirect antitumor effects via prevention of the induction of immunosuppressive mechanisms (PD-L1, TGFβ, IDO1). c-Met inhibition is key to overcome resistance to immune checkpoint inhibition and to maximize the efficacy of immunotherapy.
    MeSH term(s) Carcinoma, Renal Cell/pathology ; Female ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Kidney Neoplasms/pathology ; Male ; Neovascularization, Pathologic
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.10.025
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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