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  1. Article ; Online: Phospholipid biosynthetic pathways and lipodystrophies: a novel syndrome due to PLAAT3 deficiency.

    Agarwal, Anil K / Garg, Abhimanyu

    Nature reviews. Endocrinology

    2024  Volume 20, Issue 3, Page(s) 128–129

    MeSH term(s) Humans ; Biosynthetic Pathways ; Lipodystrophy/metabolism ; Syndrome
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00950-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6336: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 93: Show issues

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  2. Book: Obesity

    Garg, Abhimanyu

    epidemiology, etiology, morbidity, and management

    (The journal of clinical endocrinology & metabolism ; 93, Suppl.1)

    2008  

    Author's details guest ed. Abhimanyu Garg
    Series title The journal of clinical endocrinology & metabolism ; 93, Suppl.1
    Collection
    Language English
    Size S96, 9A S. : graph. Darst., Kt.
    Publisher Endocrine Soc
    Publishing place Chevy Chase, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT015750734
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 134 -93,Suppl.1- verfügbar in Königswinter Königswinter

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  3. Article ; Online: A Novel Subtype of Acquired Generalized Lipodystrophy Associated With Subcutaneous Panniculitis-Like T-cell Lymphoma.

    Hoff, Fieke W / Xing, Chao / Garg, Abhimanyu

    JCEM case reports

    2024  Volume 2, Issue 5, Page(s) luae069

    Abstract: Acquired generalized lipodystrophy (AGL) is an extremely rare disease that is characterized by loss of body fat affecting nearly all parts of the body. It is often associated with autoimmune diseases or panniculitis, whereas in other patients the ... ...

    Abstract Acquired generalized lipodystrophy (AGL) is an extremely rare disease that is characterized by loss of body fat affecting nearly all parts of the body. It is often associated with autoimmune diseases or panniculitis, whereas in other patients the underlying etiology is unclear. We report a 52-year-old male individual who was diagnosed with subcutaneous panniculitis-like T-cell lymphoma (SPTCL) that spontaneously went into remission. Years later he developed new subcutaneous nodules most concerning for relapse SPTCL or lupus panniculitis, followed by onset of hemophagocytic lymphohistiocytosis (HLH) that was treated with allogeneic stem cell transplantation. Notably, around the same time, he also developed generalized subcutaneous fat loss of both upper and lower extremities, chest, abdomen, and face that persisted after treatment of the HLH. Whole exome sequencing was performed to search for pathogenic variants that are associated with SPTCL, including those in hepatitis A virus cellular receptor 2 (
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luae069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Regulated regeneration of adipose tissue in lipodystrophic

    Agarwal, Anil K / Tunison, Katie / Horton, Jay D / Garg, Abhimanyu

    iScience

    2024  Volume 27, Issue 4, Page(s) 109517

    Abstract: Both humans and mice with congenital generalized lipodystrophy due to AGPAT2 deficiency develop diabetes mellitus, insulin resistance, and hepatic steatosis, which have been attributed to the near total loss of adipose tissue (AT). Here, we show that ... ...

    Abstract Both humans and mice with congenital generalized lipodystrophy due to AGPAT2 deficiency develop diabetes mellitus, insulin resistance, and hepatic steatosis, which have been attributed to the near total loss of adipose tissue (AT). Here, we show that regulated AT regeneration in doxycycline (dox)-fed Tg
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lipodystrophy for the Diabetologist-What to Look For.

    Patni, Nivedita / Garg, Abhimanyu

    Current diabetes reports

    2022  Volume 22, Issue 9, Page(s) 461–470

    Abstract: Purpose of review: Genetic or acquired lipodystrophies are characterized by selective loss of body fat along with predisposition towards metabolic complications of insulin resistance, such as diabetes mellitus, hypertriglyceridemia, hepatic steatosis, ... ...

    Abstract Purpose of review: Genetic or acquired lipodystrophies are characterized by selective loss of body fat along with predisposition towards metabolic complications of insulin resistance, such as diabetes mellitus, hypertriglyceridemia, hepatic steatosis, polycystic ovarian syndrome, and acanthosis nigricans. In this review, we discuss the various subtypes and when to suspect and how to diagnose lipodystrophy.
    Recent findings: The four major subtypes are autosomal recessive, congenital generalized lipodystrophy (CGL); acquired generalized lipodystrophy (AGL), mostly an autoimmune disorder; autosomal dominant or recessive familial partial lipodystrophy (FPLD); and acquired partial lipodystrophy (APL), an autoimmune disorder. Diagnosis of lipodystrophy is mainly based upon physical examination findings of loss of body fat and can be supported by body composition analysis by skinfold measurements, dual-energy x-ray absorptiometry, and whole-body magnetic resonance imaging. Confirmatory genetic testing is helpful in the proband and at-risk family members with suspected genetic lipodystrophies. The treatment is directed towards the specific comorbidities and metabolic complications, and there is no treatment to reverse body fat loss. Metreleptin should be considered as the first-line therapy for metabolic complications in patients with generalized lipodystrophy and for prevention of comorbidities in children. Metformin and insulin therapy are the best options for treating hyperglycemia and fibrates and/or fish oil for hypertriglyceridemia. Lipodystrophy should be suspected in lean and muscular subjects presenting with diabetes mellitus, hypertriglyceridemia, non-alcoholic fatty liver disease, polycystic ovarian syndrome, or amenorrhea. Diabetologists should be aware of lipodystrophies and consider genetic varieties as an important subtype of monogenic diabetes.
    MeSH term(s) Diabetes Mellitus/diagnosis ; Diabetes Mellitus/genetics ; Female ; Humans ; Hypertriglyceridemia ; Lipodystrophy/diagnosis ; Lipodystrophy/genetics ; Lipodystrophy, Congenital Generalized/complications ; Magnetic Resonance Imaging/adverse effects ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/genetics ; Whole Body Imaging/adverse effects
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-022-01485-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5628: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Caveolar dysfunction and lipodystrophies.

    Patni, Nivedita / Hegele, Robert A / Garg, Abhimanyu

    European journal of endocrinology

    2022  Volume 186, Issue 3, Page(s) C1–C4

    MeSH term(s) Caveolae/metabolism ; Caveolin 1/genetics ; Caveolin 2/genetics ; Caveolins/genetics ; Female ; Humans ; Lipodystrophy, Congenital Generalized/genetics ; Male ; RNA-Binding Proteins/genetics ; Young Adult
    Chemical Substances CAV1 protein, human ; CAV2 protein, human ; CAVIN1 protein, human ; Caveolin 1 ; Caveolin 2 ; Caveolins ; RNA-Binding Proteins
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-21-1243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.147: Show issues Location:
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  7. Article ; Online: Severe Liver Injury Associated With High-Dose Atorvastatin Therapy.

    Saha, Amit / Garg, Abhimanyu

    Journal of investigative medicine high impact case reports

    2021  Volume 9, Page(s) 23247096211014050

    Abstract: Statins are recommended for first-line management of elevated cholesterol in the primary and secondary prevention of atherosclerotic cardiovascular disease. Statins may occasionally be associated with mild transaminase elevations but can also result in ... ...

    Abstract Statins are recommended for first-line management of elevated cholesterol in the primary and secondary prevention of atherosclerotic cardiovascular disease. Statins may occasionally be associated with mild transaminase elevations but can also result in life-threatening liver injury. Atorvastatin is the most common cause of clinically significant liver injury in this drug class. We report a case of severe, asymptomatic liver injury in a hepatocellular pattern in a 71-year-old man occurring within 3 months of switching from simvastatin to high-intensity atorvastatin therapy. Hepatitis improved rapidly with cessation of atorvastatin and did not recur after resuming simvastatin.
    MeSH term(s) Aged ; Atorvastatin/adverse effects ; Chemical and Drug Induced Liver Injury ; Heptanoic Acids ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Liver/drug effects ; Liver/injuries ; Male ; Pyrroles/adverse effects ; Simvastatin/adverse effects
    Chemical Substances Heptanoic Acids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pyrroles ; Atorvastatin (A0JWA85V8F) ; Simvastatin (AGG2FN16EV)
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096211014050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Regulated adipose tissue-specific expression of human

    Agarwal, Anil K / Tunison, Katie / Vale, Goncalo / McDonald, Jeffrey G / Li, Xilong / Scherer, Philipp E / Horton, Jay D / Garg, Abhimanyu

    iScience

    2023  Volume 26, Issue 10, Page(s) 107806

    Abstract: Genetic loss ... ...

    Abstract Genetic loss of
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Dyslipidemias

    Garg, Abhimanyu

    pathophysiology, evaluation and management

    (Contemporary endocrinology)

    2015  

    Author's details Abhimanyu Garg, editor
    Series title Contemporary endocrinology
    MeSH term(s) Dyslipidemias/physiopathology ; Dyslipidemias/therapy
    Language English
    Size xvi, 525 pages :, illustrations
    Document type Book
    ISBN 9781607614234 ; 9781607614241 ; 1607614235 ; 1607614243
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction

    Anil K. Agarwal / Katie Tunison / Goncalo Vale / Jeffrey G. McDonald / Xilong Li / Jay D. Horton / Abhimanyu Garg

    iScience, Vol 27, Iss 1, Pp 108653- (2024)

    2024  

    Abstract: Summary: AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased TAG synthesis (obesity) and its ... ...

    Abstract Summary: AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased TAG synthesis (obesity) and its metabolic complications remains unknown. We overexpressed human AGPAT2 specifically in AT using the adiponectin promoter and report increased mass of subcutaneous, gonadal, and brown AT in wild-type mice. Unexpectedly, overexpression of hAGPAT2 did not change the pattern of phospholipid or TAG concentration of the AT depots. Although there is an increase in liver weight, plasma aspartate aminotransferase, and plasma insulin at various time points of the study, it did not result in significant liver dysfunction. Despite increased adiposity in the Tg-AT-hAGPAT2;mAgpat2+/+ mice, there was no significant increase in TAG concentration of AT. Therefore, this study suggests a role of AGPAT2 in the generation of AT, but not for adipocyte TAG synthesis.
    Keywords Physiology ; Cellular physiology ; Cell biology ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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