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  1. Article ; Online: Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor.

    Aguiniga, Lizath M / Yang, Wenbin / Yaggie, Ryan E / Schaeffer, Anthony J / Klumpp, David J

    American journal of physiology. Regulatory, integrative and comparative physiology

    2019  Volume 317, Issue 2, Page(s) R289–R300

    Abstract: Corticotropin-releasing factor (CRF) regulates stress responses, and aberrant CRF signals are associated with depressive disorders. ...

    Abstract Corticotropin-releasing factor (CRF) regulates stress responses, and aberrant CRF signals are associated with depressive disorders.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carboxylic Ester Hydrolases/metabolism ; Corticosterone/blood ; Corticotropin-Releasing Hormone/metabolism ; Female ; Gene Expression Regulation/physiology ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Mice, Transgenic ; Paraventricular Hypothalamic Nucleus/metabolism ; Pituitary-Adrenal System/metabolism ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Receptors, Aryl Hydrocarbon/metabolism ; Stress, Psychological/metabolism
    Chemical Substances AHR protein, human ; Basic Helix-Loop-Helix Transcription Factors ; Receptors, Aryl Hydrocarbon ; Corticotropin-Releasing Hormone (9015-71-8) ; Carboxylic Ester Hydrolases (EC 3.1.1.-) ; acyloxyacyl hydrolase (EC 3.1.1.-) ; Corticosterone (W980KJ009P)
    Language English
    Publishing date 2019-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00029.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Acyloxyacyl hydrolase regulates voiding activity.

    Aguiniga, Lizath M / Searl, Timothy J / Rahman-Enyart, Afrida / Yaggie, Ryan E / Yang, Wenbin / Schaeffer, Anthony J / Klumpp, David J

    American journal of physiology. Renal physiology

    2020  Volume 318, Issue 4, Page(s) F1006–F1016

    Abstract: Corticotropin-releasing factor (CRF) regulates diverse physiological functions, including bladder control. We recently reported ... ...

    Abstract Corticotropin-releasing factor (CRF) regulates diverse physiological functions, including bladder control. We recently reported that
    MeSH term(s) Animals ; Azo Compounds/pharmacology ; Barrington's Nucleus/metabolism ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carboxylic Ester Hydrolases/deficiency ; Carboxylic Ester Hydrolases/genetics ; Carboxylic Ester Hydrolases/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Female ; Male ; Mice, Inbred C57BL ; Muscle Contraction ; Neurons/drug effects ; Neurons/enzymology ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Pressure ; Pyrazoles/pharmacology ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Urinary Bladder/drug effects ; Urinary Bladder/innervation ; Urination/drug effects ; Urination Disorders/drug therapy ; Urination Disorders/enzymology ; Urination Disorders/genetics ; Urination Disorders/physiopathology ; Urodynamics/drug effects
    Chemical Substances 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide ; Ahr protein, mouse ; Azo Compounds ; Basic Helix-Loop-Helix Transcription Factors ; PPAR gamma ; Pparg protein, mouse ; Pyrazoles ; Receptors, Aryl Hydrocarbon ; Corticotropin-Releasing Hormone (9015-71-8) ; Carboxylic Ester Hydrolases (EC 3.1.1.-) ; acyloxyacyl hydrolase (EC 3.1.1.-)
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00442.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Lipopolysaccharide Domains Modulate Urovirulence.

    Aguiniga, Lizath M / Yaggie, Ryan E / Schaeffer, Anthony J / Klumpp, David J

    Infection and immunity

    2016  Volume 84, Issue 11, Page(s) 3131–3140

    Abstract: Uropathogenic Escherichia coli (UPEC) accounts for 80 to 90% of urinary tract infections (UTI), and the increasing rate of antibiotic resistance among UPEC isolates reinforces the need for vaccines to prevent UTIs and recurrent infections. Previous ... ...

    Abstract Uropathogenic Escherichia coli (UPEC) accounts for 80 to 90% of urinary tract infections (UTI), and the increasing rate of antibiotic resistance among UPEC isolates reinforces the need for vaccines to prevent UTIs and recurrent infections. Previous studies have shown that UPEC isolate NU14 suppresses proinflammatory NF-κB-dependent cytokines (D. J. Klumpp, A. C. Weiser, S. Sengupta, S. G. Forrestal, R. A. Batler, and A. J. Schaeffer, Infect Immun 69:6689-6695, 2001, http://dx.doi.org/10.1128/IAI.69.11.6689-6695.2001; B. K. Billips, A. J. Schaeffer, and D. J. Klumpp, Infect Immun 76:3891-3900, 2008, http://dx.doi.org/10.1128/IAI.00069-08). However, modification of lipopolysaccharide (LPS) structure by deleting the O-antigen ligase gene (waaL) enhanced proinflammatory cytokine secretion. Vaccination with the ΔwaaL mutant diminished NU14 reservoirs and protected against subsequent infections. Therefore, we hypothesized that LPS structural determinants shape immune responses. We evaluated the contribution of LPS domains to urovirulence corresponding to the inner core (waaP, waaY, and rfaQ), outer core (rfaG), and O-antigen (waaL, wzzE, and wzyE). Deletion of waaP, waaY, and rfaG attenuated adherence to urothelial cells in vitro In a murine UTI model, the ΔrfaG mutant had the most severe defect in colonization. The mutation of rfaG, waaL, wzzE, and wzyE resulted in an inability to form reservoirs in mouse bladders. Infection with the LPS mutant panel resulted in various levels of urinary myeloperoxidase. Since the ΔwaaL mutant promoted Th
    MeSH term(s) Adaptive Immunity/physiology ; Animals ; Disease Models, Animal ; Escherichia coli Infections/immunology ; Female ; Immunity, Innate/physiology ; Lipopolysaccharides/physiology ; Mice ; Mice, Inbred C57BL ; Neutrophils/metabolism ; O Antigens/immunology ; Peroxidase/metabolism ; Urinary Tract Infections/immunology ; Urinary Tract Infections/microbiology ; Uropathogenic Escherichia coli/genetics ; Uropathogenic Escherichia coli/pathogenicity ; Virulence/physiology
    Chemical Substances Lipopolysaccharides ; O Antigens ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00315-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 684: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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