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  1. Book ; Online ; E-Book: Medical immunology

    Virella, Gabriel

    2020  

    Author's details edited by Dr. Gabriel Virella
    Keywords Electronic books ; Immune System Phenomena ; Immune System Diseases
    Language English
    Size 1 Online-Ressource (xvi, 462 Seiten)
    Edition Seventh edition
    Publisher CRC Press LLC
    Publishing place Milton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020364148
    ISBN 978-1-00-053713-0 ; 9780367224882 ; 1-00-053713-7 ; 0367224887
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Medical immunology

    Virella, Gabriel

    2007  

    Author's details ed. by Gabriel Virella
    Keywords Immunity ; Immune System Diseases
    Language English
    Size IX, 465 S. : Ill., graph. Darst.
    Edition 6. ed.
    Publisher Informa Healthcare
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015020046
    ISBN 0-8493-9696-4 ; 978-0-8493-9696-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 4298 order for loan Magazin

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  3. Book ; Online: The role of the immune system in the pathogenesis of diabetic complications

    Lopes-Virella, Maria / Virella, Gabriel

    2014  

    Abstract: The main causes of morbidity and mortality in diabetes are macrovasular and microvascular complications, including atherosclerosis, nephropathy, and retinopathy. As the definition of atherosclerosis as a chronic, smoldering, inflammatory disease has ... ...

    Abstract The main causes of morbidity and mortality in diabetes are macrovasular and microvascular complications, including atherosclerosis, nephropathy, and retinopathy. As the definition of atherosclerosis as a chronic, smoldering, inflammatory disease has gained general acceptance, the attention of researchers has focused on the triggers of chronic vascular inflammation. The oxidation and other forms of modification of lipids and lipoproteins have emerged as a major pathogenic factor in atherosclerosis, with a significant interaction with the immune system. Modified lipoproteins by themselves are proinflammatory through the activation of the innate immune system as a consequence of the interaction with scavenger receptors and/or toll-like receptors expressed by a variety of cell types, including phagocytic cells and dendritic cells.-

    A variety of modified forms of LDL (mLDL), including oxidized, malondialdehyde-modified, and Advanced Glycation End-product-modified LDL induce autoimmune responses in humans. Those modifications seem enhanced in diabetes, and the progression of atherosclerosis is accelerated in diabetic patients. The immune response to all forms of mLDL results in both activation of T cells in the arterial wall and in an autoimmune response characterized by the formation of IgG antibodies. Both arms of the immune response are believed to play a role in vascular inflammation. While the cell response is likely to activate resident macrophages, the humoral immune response results in the production of IgG antibodies that bind to specific epitopes in modified forms of LDL, generate immune complexes both intra- and extravascularly, and those complexes are able to activate the classical pathway of the complement system as well as phagocytic cells via Fc? receptors.-

    In vitro studies suggest that the pro-inflammatory activity of immune complexes containing mLDL is several-fold higher than that of the modified LDL molecules by themselves. Clinical studies have provided significant support to the pathogenic role of immune complexes containing modified LDL in the development of atherosclerotic complications in patients with both type 1 and type 2 diabetes. At the same time, there is increasing evidence that the formation of immune complexes containing modified forms of LDL may also be involved in the pathogenesis of diabetic nephropathy and retinopathy. These are areas in which more research is needed to fully understand the pathogenic mechanisms activated by those immune complexes. Of interest is the fact that animal models have suggested the possibility of modifying the adaptive humoral immune response in ways that would result in slowing down, and perhaps prevent, the atherosclerotic process.-
    Keywords Nutrition. Foods and food supply ; Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General) ; Public aspects of medicine ; Diseases of the endocrine glands. Clinical endocrinology ; Medicine (General)
    Size 1 electronic resource (95 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091000
    ISBN 9782889193523 ; 2889193527
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Introduction to medical immunology

    Virella, Gabriel

    (Immunology series ; 58)

    1993  

    Author's details ed. by Gabriel Virella
    Series title Immunology series ; 58
    Collection
    Keywords Immunity ; Immunologic Diseases ; Immunologie ; Immunkrankheit
    Subject Immunopathie ; Immunologische Krankheit ; Immunologische Erkrankung ; Klinische Immunologie
    Size XIII, 595 S. : Ill., graph. Darst.
    Edition 3. ed., 1. print.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004508424
    ISBN 0-8247-8835-4 ; 978-0-8247-8835-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 1470 order for loan Magazin

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  5. Book: Introduction to medical immunology

    Virella, Gabriel

    (Immunology series ; 50)

    1990  

    Title variant Medical immunology
    Author's details ed. by Gabriel Virella
    Series title Immunology series ; 50
    Collection
    Keywords Immunity ; Immunologic Diseases ; Immunologie
    Subject Klinische Immunologie
    Size XVI, 612 S. : Ill., graph. Darst.
    Edition 2. ed., 1. print.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003579209
    ISBN 0-8247-8229-1 ; 978-0-8247-8229-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 4597 order for loan Magazin

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  6. Article ; Online: Modified LDL Immune Complexes and Cardiovascular Disease.

    Lopes-Virella, Maria F / Virella, Gabriel

    Current medicinal chemistry

    2018  Volume 26, Issue 9, Page(s) 1680–1692

    Abstract: Modified forms of LDL, both spontaneously formed in the organism or prepared in the laboratory, are immunogenic. As a consequence, antigen-antibody complexes (immune complexes, IC) formed in vivo can be measured in the peripheral blood, and their levels ... ...

    Abstract Modified forms of LDL, both spontaneously formed in the organism or prepared in the laboratory, are immunogenic. As a consequence, antigen-antibody complexes (immune complexes, IC) formed in vivo can be measured in the peripheral blood, and their levels are strong predictors of cardiovascular disease (CVD). It has been possible to generate antibodies that recognize different LDL modifications, allowing the analysis of circulating IC constitution. Clinical studies showed that the antigenic constitution of the IC has a modulating effect on the development of CVD. Patients whose IC react strongly with antibodies to copper oxidized LDL (oxLDL) show progressive development of atherosclerosis as demonstrated by increased intima-media thickness and increased coronary calcification scores. In contrast, patients whose IC react strongly with antibodies to the heavily oxidized malondialdehyde LDL prepared in vitro (MDA-LDL) are at a high risk of acute vascular events, mainly myocardial infarction. In vitro studies have shown that while oxLDL IC induce both cell proliferation and mild to moderate macrophage apoptosis, MDA-LDL IC induce a more marked macrophage apoptosis but not cell proliferation. In addition, MDA-LDL IC induce the release of higher levels of matrix metalloproteinases and TNF than oxLDL IC. High levels of TNF are likely to be a major factor leading to apoptosis and high levels of metalloproteinases are likely to play a role in the thinning of the fibrous cap of the atheromatous plaque. The combination of apoptosis and fibrous cap thinning is a well-known characteristic of vulnerable plaques, which are more prone to rupture and responsible for the majority of acute cardiovascular events.
    MeSH term(s) Animals ; Cardiovascular Diseases/immunology ; Humans ; Lipoproteins, LDL/immunology
    Chemical Substances Lipoproteins, LDL
    Language English
    Publishing date 2018-05-20
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867325666180524114429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Immunology of cardiovascular disease.

    Virella, Gabriel

    Clinical immunology (Orlando, Fla.)

    2010  Volume 134, Issue 1, Page(s) 1–4

    MeSH term(s) Allergy and Immunology/trends ; Animals ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/therapy ; Humans
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2009.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The role of the immune system in the pathogenesis of diabetic complications.

    Virella, Gabriel / Lopes-Virella, Maria F

    Frontiers in endocrinology

    2014  Volume 5, Page(s) 126

    Language English
    Publishing date 2014-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2014.00126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The role of the immune system in the pathogenesis of diabetic complications

    GabrielVirella

    Frontiers in Endocrinology, Vol

    2014  Volume 5

    Keywords Diabetes Complications ; Immune System ; Pathogenesis ; diabetic complications ; Editorial ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Book: Introduction to medical immunology

    Boackle, Robert J. / Virella, Gabriel

    (Immunology series ; 28)

    1986  

    Author's details ed. by Gabriel Virella ... With contrib. by Robert J. Boackle
    Series title Immunology series ; 28
    Collection
    Keywords Immunity ; Immunologic Diseases ; Immunologie
    Subject Klinische Immunologie
    Size XII, 540 S. : Ill., graph. Darst.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002823160
    ISBN 0-8247-7599-6 ; 978-0-8247-7599-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 2974 order for loan Magazin

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