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  1. Book: A Clinician's Guide to Statistics in Mental Health

    Ghaemi, S. Nassir

    2023  

    Author's details S. Nassir Ghaemi is a Professor of Psychiatry and Pharmacology at Tufts University School of Medicine, Tufts Medical Center and is also a Lecturer in Psychiatry at Harvard Medical School in Boston, Massachusetts. He is an associate editor of Acta Psychiatrica Scandinavica, a Life Distinguished Fellow of the American Psychiatric Association, and an Overseas Fellow of the Royal Society of Medicine (UK)
    Size 174 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_20
    Format 156 x 233 x 12
    ISBN 9781108814966 ; 1108814964
    Database PDA

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  2. Book ; Online ; E-Book: Clinical psychopharmacology

    Ghaemi, S. Nassir

    principles and practice

    2019  

    Author's details S. Nassir Ghaemi
    Keywords Psychotropic Drugs / pharmacology ; Psychopharmacology / methods ; Mental Disorders / drug therapy
    Language English
    Size 1 Online-Ressource (xviii, 580 Seiten), Illustrationen
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020067861
    ISBN 978-0-19-999549-3 ; 9780199995486 ; 0-19-999549-4 ; 0199995486
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Book: On depression

    Ghaemi, S. Nassir

    drugs, diagnosis, and despair in the modern world

    2013  

    Author's details Nassir Ghaemi
    Keywords Depression / psychology ; Depressive Disorder / drug therapy ; Depressive Disorder / diagnosis ; Antidepressive Agents ; Diagnostic Errors ; Existentialism
    Language English
    Size 215 S.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore, Md
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017536279
    ISBN 978-1-4214-0933-7 ; 1-4214-0933-X ; 1421409348 ; 9781421409344
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1566 available for loan (reading room) Lesesaal EG

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  4. Book: The rise and fall of the biopsychosocial model

    Ghaemi, S. Nassir

    reconciling art and science in psychiatry

    2010  

    Author's details S. Nassir Ghaemi
    Keywords Psychiatry / methods ; Psychological Theory ; Models, Psychological ; Models, Biological ; Mental Disorders / therapy
    Language English
    Size XII, 253 S. : Ill.
    Publisher The Johns Hopkins Univ. Press
    Publishing place Baltimore, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT016030597
    ISBN 978-0-8018-9390-2 ; 0-8018-9390-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 510 order for loan Magazin

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  5. Article ; Online: Drug Discovery in Psychiatry: Rethinking Conventional Wisdom.

    Ghaemi, S Nassir

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2022  Volume 68, Issue 2, Page(s) 81–85

    MeSH term(s) Humans ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Psychiatry ; Drug Discovery ; Psychopharmacology
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0008-4824 ; 0706-7437
    ISSN (online) 1497-0015
    ISSN 0008-4824 ; 0706-7437
    DOI 10.1177/07067437221112907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 110: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: A clinician's guide to statistics and epidemiology in mental health

    Ghaemi, S. Nassir

    measuring truth and uncertainty

    2009  

    Author's details S. Nassir Ghaemi
    Keywords Psychiatry / methods ; Statistics as Topic ; Mental Disorders / epidemiology
    Language English
    Size XII, 151 S. : graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes references and index
    HBZ-ID HT016001468
    ISBN 978-0-521-70958-3 ; 0-521-70958-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 3343 order for loan Magazin

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  7. Article ; Online: The Need for Non-profit Psychiatric Drug Discovery and Development.

    Ghaemi, S Nassir

    Journal of clinical psychopharmacology

    2022  Volume 42, Issue 6, Page(s) 518–522

    Abstract: Background: Current psychiatric drug discovery and development has not produced very effective medications in the past few decades. Conventional wisdom provides reasons for failure that do not address major structural obstacles to true innovation for ... ...

    Abstract Background: Current psychiatric drug discovery and development has not produced very effective medications in the past few decades. Conventional wisdom provides reasons for failure that do not address major structural obstacles to true innovation for psychiatric drugs.
    Method: Narrative review based on analysis of the scientific literature augmented by personal experience in academic clinical research as well as in the pharmaceutical industry.
    Results: The largest obstacles to drug discovery and development are the biological invalidity of most DSM diagnoses, the economic incentives to produce short-term symptomatic treatments with blockbuster profit potential, and very low thresholds set by the FDA for ending drug discovery due to toxicity. Since these larger structural socio-economic obstacles to drug development will be difficult to change, a new proposal is made for a parallel non-profit drug discovery paradigm, to be funded by governments, akin to the development of vaccines for the Covid-19 pandemic. The key public health implications are highlighted in the example of developing new drugs for Alzheimer dementia, and the potential utility of an anti-tau agent like lithium, currently ignored in drug development in favor of much more expensive and questionably effective amyloid-reducing agents.
    Conclusions: Given the key structural problems of psychiatric drug discovery and development, a parallel non-profit drug discovery paradigm is needed to meet all public health needs, as well as to reinvigorate truly innovative and transformative research.
    MeSH term(s) Humans ; COVID-19 Vaccines ; COVID-19 ; Drug Discovery ; Drug Industry ; Drug Development
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1664: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Symptomatic versus disease-modifying effects of psychiatric drugs.

    Ghaemi, S Nassir

    Acta psychiatrica Scandinavica

    2022  Volume 146, Issue 3, Page(s) 251–257

    Abstract: Objective: Drugs can be divided into two major categories, symptomatic and disease modifying. This review explores whether and how psychiatric drugs fall into one or the other of those categories, and the implications of those results for clinical ... ...

    Abstract Objective: Drugs can be divided into two major categories, symptomatic and disease modifying. This review explores whether and how psychiatric drugs fall into one or the other of those categories, and the implications of those results for clinical practice and research in psychopharmacology.
    Method: Narrative review.
    Results: Most psychiatric drugs have only short-term effects of improving active symptoms. They do not show long-term benefits for the underlying disease, such as improving the course of illness and improving mortality. Evidence is provided for this claim in the treatment literature of antidepressants for depressive illness and antipsychotics for schizophrenia. Developing truly beneficial drugs for disease modification also is limited by the poor clinical and biological validity of Diagnostic and Statistical Manual diagnoses as well as the use of invalid falsely positive maintenance efficacy randomized discontinuation trial designs.
    Conclusions: Current psychopharmacology is limited mostly to symptomatic effects, not transformative treatments for the diseases underlying those symptoms. A change in approach is needed in psychopharmacology practice and research, focusing on long-term disease modification rather than short-term symptom improvement.
    MeSH term(s) Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Diagnostic and Statistical Manual of Mental Disorders ; Humans
    Chemical Substances Antidepressive Agents ; Antipsychotic Agents
    Language English
    Publishing date 2022-06-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.141: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Antidepressants Added Nothing to Mood Stabilizers Alone: Reply to Terao.

    Ghaemi, S Nassir

    The Journal of clinical psychiatry

    2021  Volume 82, Issue 4

    MeSH term(s) Anticonvulsants/therapeutic use ; Antidepressive Agents ; Antimanic Agents ; Humans
    Chemical Substances Anticonvulsants ; Antidepressive Agents ; Antimanic Agents
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.21lr13919a
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 108: Show issues Location:
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    Zs.MO 247: Show issues

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  10. Article ; Online: Perspective: Aristotle on manic-depressive illness and greatness.

    Ghaemi, S Nassir

    Bipolar disorders

    2020  Volume 22, Issue 6, Page(s) 633–635

    Language English
    Publishing date 2020-04-23
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.12910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5604: Show issues Location:
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