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Article ; Online: Vitamin D Receptor Mediates Attenuating Effect of Lithocholic Acid on Dextran Sulfate Sodium Induced Colitis in Mice.

Kubota, Hitomi / Ishizawa, Michiyasu / Kodama, Makoto / Nagase, Yoshihiro / Kato, Shigeaki / Makishima, Makoto / Sakurai, Kenichi

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Bile acids are major components of bile; they emulsify dietary lipids for efficient digestion and absorption and act as signaling molecules that activate nuclear and membrane receptors. The vitamin D receptor (VDR) is a receptor for the active form of ... ...

Abstract	Bile acids are major components of bile; they emulsify dietary lipids for efficient digestion and absorption and act as signaling molecules that activate nuclear and membrane receptors. The vitamin D receptor (VDR) is a receptor for the active form of vitamin D and lithocholic acid (LCA), a secondary bile acid produced by the intestinal microflora. Unlike other bile acids that enter the enterohepatic circulation, LCA is poorly absorbed in the intestine. Although vitamin D signaling regulates various physiological functions, including calcium metabolism and inflammation/immunity, LCA signaling remains largely unknown. In this study, we investigated the effect of the oral administration of LCA on colitis in a mouse model using dextran sulfate sodium (DSS). Oral LCA decreased the disease activity of colitis in the early phase, which is a phenotype associated with the suppression of histological injury, such as inflammatory cell infiltration and goblet cell loss. These protective effects of LCA were abolished in VDR-deleted mice. LCA decreased the expression of inflammatory cytokine genes, but this effect was at least partly observed in VDR-deleted mice. The pharmacological effect of LCA on colitis was not associated with hypercalcemia, an adverse effect induced by vitamin D compounds. Therefore, LCA suppresses DSS-induced intestinal injury in its action as a VDR ligand.
MeSH term(s)	Animals ; Mice ; Bile Acids and Salts/metabolism ; Colitis/chemically induced ; Dextran Sulfate ; Lithocholic Acid/metabolism ; Mice, Inbred C57BL ; Receptors, Calcitriol/metabolism
Chemical Substances	Bile Acids and Salts ; Dextran Sulfate (9042-14-2) ; Lithocholic Acid (5QU0I8393U) ; Receptors, Calcitriol
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043517
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D

Maekawa, Kazuki / Ishizawa, Michiyasu / Ikawa, Takashi / Sajiki, Hironao / Matsumoto, Taro / Tokiwa, Hiroaki / Makishima, Makoto / Yamada, Sachiko

Biomolecules

2023 Volume 13, Issue 7

Abstract: The active form of vitamin ... ...

Abstract	The active form of vitamin D
MeSH term(s)	Humans ; Vitamin D/pharmacology ; Cholecalciferol/pharmacology ; Gene Expression Regulation ; Cell Differentiation
Chemical Substances	1,25-dihydroxyvitamin D (66772-14-3) ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13071082
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Article ; Online: Zinc Inhibits Cadherin 1 Expression Induced by 1α,25-Dihydroxyvitamin D

Ishizawa, Michiyasu / Hirayu, Ayako / Makishima, Makoto

Anticancer research

2021 Volume 41, Issue 11, Page(s) 5453–5459

Abstract: Background: Zinc is a mineral that is essential for biological molecules, such as transcription factors, and is involved in the maintenance of intestinal homeostasis. Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1α,25- ... ...

Abstract	Background: Zinc is a mineral that is essential for biological molecules, such as transcription factors, and is involved in the maintenance of intestinal homeostasis. Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1α,25-dihydroxyvitamin D Materials and methods: Colon cancer SW480 and HCT116 cells were treated with zinc chloride (ZnCl Results: Treatment of cells with ZnCl Conclusion: Zinc signaling suppresses VDR-induced expression of CDH1.
MeSH term(s)	Antigens, CD/genetics ; Antigens, CD/metabolism ; Cadherins/genetics ; Cadherins/metabolism ; Calcitriol/pharmacology ; Chlorides/pharmacology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Metallothionein/genetics ; Metallothionein/metabolism ; Receptors, Calcitriol/agonists ; Receptors, Calcitriol/metabolism ; Signal Transduction ; Zinc Compounds/pharmacology
Chemical Substances	Antigens, CD ; CDH1 protein, human ; Cadherins ; Chlorides ; MT1A protein, human ; MT2A protein, human ; Receptors, Calcitriol ; VDR protein, human ; Zinc Compounds ; zinc chloride (86Q357L16B) ; Metallothionein (9038-94-2) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2021-10-31
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.15357
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Article ; Online: Vitamin D Receptor Deletion Changes Bile Acid Composition in Mice Orally Administered Chenodeoxycholic Acid.

Nishida, Shigeru / Ishizawa, Michiyasu / Kato, Shigeaki / Makishima, Makoto

Journal of nutritional science and vitaminology

2020 Volume 66, Issue 4, Page(s) 370–374

Abstract: The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin ... ...

Abstract	The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D
MeSH term(s)	Animals ; Bile Acids and Salts/blood ; Bile Acids and Salts/chemistry ; Bile Acids and Salts/metabolism ; Chenodeoxycholic Acid/administration & dosage ; Dietary Supplements ; Feces/chemistry ; Lithocholic Acid/metabolism ; Liver/metabolism ; Mice ; Mice, Knockout ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism
Chemical Substances	Bile Acids and Salts ; Receptors, Calcitriol ; Vdr protein, mouse ; Chenodeoxycholic Acid (0GEI24LG0J) ; Lithocholic Acid (5QU0I8393U)
Language	English
Publishing date	2020-08-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.66.370
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Article ; Online: Effects of pre-bedtime blue-light exposure on ratio of deep sleep in healthy young men.

Ishizawa, Masao / Uchiumi, Takuya / Takahata, Miki / Yamaki, Michiyasu / Sato, Toshiaki

Sleep medicine

2021 Volume 84, Page(s) 303–307

Abstract: This study aimed to investigate the effects of pre-bedtime blue-light exposure on ratio of deep sleep and sleep quality. In this study, 11 healthy young men were exposed to three conditions for 1 h before bedtime: 1) incandescent light, 2) blue-light, or ...

Abstract	This study aimed to investigate the effects of pre-bedtime blue-light exposure on ratio of deep sleep and sleep quality. In this study, 11 healthy young men were exposed to three conditions for 1 h before bedtime: 1) incandescent light, 2) blue-light, or 3) blue light-blocking glasses on. The following morning, subjective sleep quality was measured using the Oguri-Shirakawa-Azumi Sleep Inventory. Sleep time, ratio of sleep, ratio of deep sleep, and body movements during sleep were measured using a mat sleep-scan (sleep scan, SL- 504; TANITA Corp., Japan) and an ambulatory portable sleep study system (LS-140; Fukuda Denshi Co. Ltd., Japan). Ratio of deep sleep was significantly decreased in the blue-light exposure group compared to the groups with incandescent light and blue light-blocking glasses (p < 0.01), There were no differences noted in sleep time or body movements among the three groups. These results suggest that blue-light exposure to affects sleep quality by reducing the ratio of deep sleep.
MeSH term(s)	Circadian Rhythm ; Humans ; Light ; Male ; Sleep ; Sleep Disorders, Circadian Rhythm ; Sleep, Slow-Wave
Language	English
Publishing date	2021-06-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2021.05.046
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of maneuver of hair-washing motion and gender on oxygen uptake and ventilation in healthy people.

Takahata, Miki / Ishizawa, Masao / Uchiumi, Takuya / Yamaki, Michiyasu / Sato, Toshiaki

Scientific reports

2020 Volume 10, Issue 1, Page(s) 13142

Abstract: It is known that patients with chronic obstructive pulmonary disease experience dyspnea during unsupported arm exercise (UAE). We examined the respiratory variables in during a hair-washing motion for healthy young people requiring the UAE to find the ... ...

Abstract	It is known that patients with chronic obstructive pulmonary disease experience dyspnea during unsupported arm exercise (UAE). We examined the respiratory variables in during a hair-washing motion for healthy young people requiring the UAE to find the effects across gender, motion, and speed. In this study, 33 healthy young people were enrolled. Participants performed the following four types of hair-washing motions: both hands with fast speed, both hands with slow speed, one hand with fast speed, and one hand with slow speed. The respiratory variables such as oxygen uptake ([Formula: see text]O
MeSH term(s)	Activities of Daily Living ; Adult ; Exercise Therapy ; Female ; Humans ; Lung/physiopathology ; Male ; Motion ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/therapy ; Pulmonary Gas Exchange
Language	English
Publishing date	2020-08-04
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-69945-5
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Article ; Online: Oral benzo[a]pyrene administration attenuates dextran sulfate sodium-induced colitis in mice.

Adachi, Keita / Ishizawa, Michiyasu / Uno, Shigeyuki / Kubota, Hitomi / Henmi, Takuo / Koshinaga, Tsugumichi / Makishima, Makoto / Sakurai, Kenichi

Chemico-biological interactions

2022 Volume 353, Page(s) 109802

Abstract: Benzo[a]pyrene (BaP) is an environmental pollutant produced by combustion processes and is present in grilled foods as well as in tobacco smoke. BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes. ... ...

Abstract	Benzo[a]pyrene (BaP) is an environmental pollutant produced by combustion processes and is present in grilled foods as well as in tobacco smoke. BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes. BaP metabolism can result in either detoxification or metabolic activation, the latter leads to an increased risk of disease, particularly lung cancer and cardiovascular disease, in a context-dependent manner. Although AHR activation has been thought to protect against inflammatory bowel disease, it remains unknown whether BaP exerts a protective or deleterious effect on colitis. In this study, we examined the effect of oral BaP administration on colitis induced by dextran sulfate sodium (DSS) in mice, an animal model of inflammatory bowel disease. BaP administration attenuated weight loss, shortening of the colon, disease activity index scores, and histological damage in DSS-induced colitis mice. BaP also suppressed colonic expression of inflammation-associated genes and plasma interleukin-6 secretion induced by DSS treatment. BaP-DNA adduct formation, a marker of BaP metabolic activation, was not enhanced in the colon after DSS treatment. Thus, oral BaP exerts an anti-inflammatory effect on DSS-induced colitis, without the toxicity associated with metabolic activation. The results provide insights into the disease-specific roles of BaP.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Inflammatory Agents/therapeutic use ; Benzo(a)pyrene/therapeutic use ; Colitis/chemically induced ; Colitis/drug therapy ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Interleukin-6/blood ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Interleukin-6 ; Receptors, Aryl Hydrocarbon ; Benzo(a)pyrene (3417WMA06D) ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2022-01-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2022.109802
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Zs.A 686: Show issues

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Article ; Online: Effects of maneuver of hair-washing motion and gender on oxygen uptake and ventilation in healthy people

Miki Takahata / Masao Ishizawa / Takuya Uchiumi / Michiyasu Yamaki / Toshiaki Sato

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 7

Abstract: Abstract It is known that patients with chronic obstructive pulmonary disease experience dyspnea during unsupported arm exercise (UAE). We examined the respiratory variables in during a hair-washing motion for healthy young people requiring the UAE to ... ...

Abstract	Abstract It is known that patients with chronic obstructive pulmonary disease experience dyspnea during unsupported arm exercise (UAE). We examined the respiratory variables in during a hair-washing motion for healthy young people requiring the UAE to find the effects across gender, motion, and speed. In this study, 33 healthy young people were enrolled. Participants performed the following four types of hair-washing motions: both hands with fast speed, both hands with slow speed, one hand with fast speed, and one hand with slow speed. The respiratory variables such as oxygen uptake ($${\dot{\text{V}}}$$ V˙ O2), carbon dioxide output ($${\dot{\text{V}}}$$ V˙ CO2), and respiratory rate (RR), or minute ventilation ($${\dot{\text{V}}}$$ V˙ E) were measured. Regarding $${\dot{\text{V}}}$$ V˙ O2, $${\dot{\text{V}}}$$ V˙ CO2, and RR during the rest period and in each motion, $${\dot{\text{V}}}$$ V˙ O2 and $${\dot{\text{V}}}$$ V˙ CO2 in males were significantly greater than those in females. RR in the female participants had greater value than that in males. Among the maneuvers, $${\dot{\text{V}}}$$ V˙ O2, $${\dot{\text{V}}}$$ V˙ CO2 or $${\dot{\text{V}}}$$ V˙ E during a hair-washing motion with both hands were greater than those during hair-washing motion with one hand. $${\dot{\text{V}}}$$ V˙ O2, $${\dot{\text{V}}}$$ V˙ CO2, RR, or $${\dot{\text{V}}}$$ V˙ E during a hair-washing motion with both hands fast speed was greater than those during a hair-washing motion with slow speed. In conclusion, this study showed the effects owing to the differences in motion maneuvers and gender during UAE in healthy young people. These suggest a need to consider motion maneuver or gender when teaching motion methods of activities of daily living on the patients.
Keywords	Medicine ; R ; Science ; Q
Subject code	629
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists.

Yoshihara, Ayana / Kawasaki, Haru / Masuno, Hiroyuki / Takada, Koki / Numoto, Nobutaka / Ito, Nobutoshi / Hirata, Naoya / Kanda, Yasunari / Ishizawa, Michiyasu / Makishima, Makoto / Kagechika, Hiroyuki / Tanatani, Aya

Biomolecules

2022 Volume 12, Issue 1

Abstract: 1α,25-Dihydroxyvitamin ... ...

Abstract	1α,25-Dihydroxyvitamin D
MeSH term(s)	Amides/pharmacology ; Cholecalciferol ; Humans ; Lithocholic Acid/metabolism ; Lithocholic Acid/pharmacology ; Protein Binding ; Receptors, Calcitriol/metabolism
Chemical Substances	Amides ; Receptors, Calcitriol ; Cholecalciferol (1C6V77QF41) ; Lithocholic Acid (5QU0I8393U)
Language	English
Publishing date	2022-01-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12010130
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Article ; Online: Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum.

Ishizawa, Michiyasu / Akagi, Daisuke / Makishima, Makoto

International journal of molecular sciences

2018 Volume 19, Issue 7

Abstract: The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1α,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], and regulates calcium and bone metabolism. Lithocholic acid (LCA), which is a secondary bile ... ...

Abstract	The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1α,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], and regulates calcium and bone metabolism. Lithocholic acid (LCA), which is a secondary bile acid produced by intestinal bacteria, acts as an additional physiological VDR ligand. Despite recent progress, however, the physiological function of the LCA−VDR axis remains unclear. In this study, in order to elucidate the differences in VDR action induced by 1,25(OH)₂D₃ and LCA, we compared their effect on the VDR target gene induction in the intestine of mice. While the oral administration of 1,25(OH)₂D₃ induced the
MeSH term(s)	24,25-Dihydroxyvitamin D 3/administration & dosage ; 24,25-Dihydroxyvitamin D 3/metabolism ; Administration, Oral ; Animals ; Bone and Bones/metabolism ; Calcium/blood ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Corn Oil/administration & dosage ; Humans ; Ileum/metabolism ; Ligands ; Lithocholic Acid/administration & dosage ; Lithocholic Acid/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Calcitriol/drug effects ; Receptors, Calcitriol/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism
Chemical Substances	Calcium Channels ; Ligands ; Receptors, Calcitriol ; TRPV Cation Channels ; Trpv6 protein, mouse ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; Lithocholic Acid (5QU0I8393U) ; Corn Oil (8001-30-7) ; Cyp24a1 protein, mouse (EC 1.14.15.16) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19071975
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