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Article ; Online: Assembly and comparative analysis of the first complete mitochondrial genome of a traditional Chinese medicine Angelica biserrata (Shan et Yuan) Yuan et Shan.

Wang, Le / Liu, Xue / Xu, Yuanjiang / Zhang, Zhiwei / Wei, Yongsheng / Hu, Ying / Zheng, Changbing / Qu, Xianyou

International journal of biological macromolecules

2023 Volume 257, Issue Pt 1, Page(s) 128571

Abstract: Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has ... ...

Abstract	Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has revealed. Nevertheless, the mtDNA of Angelica species remains relatively unexplored. To address this gap, we sequenced and assembled the mtDNA of A. biserrata to shed light on its genetic mechanisms and evolutionary pathways. Our investigation indicated a distinctive multi-branched conformation in the A. biserrata mtDNA. A comprehensive analysis of protein-coding sequences (PCGs) across six closely related species revealed the presence of 11 shared genes in their mitochondrial genomes. Intriguingly, positive selection emerged as a significant factor in the evolution of the atp4, matR, nad3, and nad7 genes. In addition, our data highlighted a recurring trend of homologous fragment migration between chloroplast and mitochondrial organelles. We identified 13 homologous fragments spanning both chloroplast and mitochondrial genomes. The phylogenetic tree established a close relationship between A. biserrata and Saposhnikovia divaricata. To sum up, our research would contribute to the application of population genetics and evolutionary studies in the genus Acanthopanax and other genera in the Araliaceae family.
MeSH term(s)	Medicine, Chinese Traditional ; Angelica/genetics ; Phylogeny ; Genome, Mitochondrial/genetics ; DNA, Mitochondrial
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2023-12-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128571
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Article: Traditional Chinese Medicine Shen-Yuan-Dan (SYD) Improves Hypoxia-Induced Cardiomyocyte Apoptosis in Neonatal Rats by Upregulating miR-24/Bim Pathway.

Chu, Fuyong / Yan, Xue / Xiong, Xingjiang / Zhou, Mingxue / Tan, Yupei / Li, Yixuan / Liu, Wei / Liu, Hongxu

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 5804187

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/5804187
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Article ; Online: Traditional Chinese Medicine Shen-Yuan-Dan (SYD) Improves Hypoxia-Induced Cardiomyocyte Apoptosis in Neonatal Rats by Upregulating miR-24/Bim Pathway

Fuyong Chu / Xue Yan / Xingjiang Xiong / Mingxue Zhou / Yupei Tan / Yixuan Li / Wei Liu / Hongxu Liu

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: ... to date. The present study aimed to investigate the role of traditional Chinese medicine shen-yuan-dan ...

Abstract	Background: Acute myocardial infarction (AMI) is the leading cause of malignant arrhythmia, heart failure, and sudden death. However, safe and effective drugs for the treatment of AMI are unavailable to date. The present study aimed to investigate the role of traditional Chinese medicine shen-yuan-dan (SYD) in hypoxia-induced cardiomyocyte apoptosis in neonatal rats. In addition, the study explored the possible mechanism through which SYD could reduce myocardial ischemia apoptosis and regulate the expression of the miR-24/Bim pathway. Methods: Hypoxia-induced neonatal rat cardiomyocytes were used for the experiments. These cardiomyocytes were transfected with an miR-24 mimic and an miR-24 inhibitor and then cocultured with SYD-containing serum. MTT and lactate dehydrogenase (LDH) assays, AnnexinV/PI double staining, flow cytometry, and TUNEL staining were used to determine the cell viability and apoptosis under hypoxic conditions. Furthermore, the expression level of Bim in the hypoxia-induced cardiomyocytes was determined through western blotting and quantitative real-time polymerase chain reaction. Results: After 48 h of hypoxia, LDH and creatine phosphokinase (CPK) activities increased, cell viability decreased, and miR-24 expression upregulated in the cardiomyocytes. SYD alleviated hypoxia-induced cardiomyocyte injury, decreased LDH and CPK activities, increased cell viability, and reduced apoptosis in the neonatal rat cardiomyocytes. Moreover, SYD could upregulate miR-24 expression and downregulate Bim expression. Upregulation of miR-24 expression significantly enhanced the effect of SYD, thereby improving myocardial cell apoptosis. Dual-luciferase reporter assay and western blot analysis confirmed that Bim was a direct target of miR-24. Conclusion: SYD treatment reduces hypoxia-induced myocardial apoptosis by upregulating miR-24 expression. This study provides new insights into the molecular mechanism underlying the therapeutic potential of SYD in promoting the recovery of myocardial function and delaying ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Adapting the operation of cascaded reservoirs on Yuan River for fish habitat conservation

Wen, Xin / Guo-hua Fang / Lei Zhou / Yu-xue Guo

Ecological modelling. 2016 Oct. 10, v. 337

2016

Abstract: To alleviate the negative impacts on ecosystem caused by cascaded development of Yuan River ...

Abstract	To alleviate the negative impacts on ecosystem caused by cascaded development of Yuan River, this study quantified the ecological requirements and incorporated them into the cascaded reservoir operating schemes to provide the streamflow that balances fish habitat protection and hydropower generation. Physical habitat simulation model is proposed to simulate the relationship between streamflow and physical habitat for various life stages of Cyprinus rubrofuscus Lacépède and Bagarius rutilus Ng & Kottelat, and to determine the ecological requirement as a discharge range associated with the upper area of a certain proportion of maximum Weighted Usable Areas (WUA). Then the optimal operation model of cascaded reservoirs is established. Maintaining over 70% of maximum WUA as an example, the optimization technique could increase the hydropower generation of cascaded reservoirs by 3.60%, 1.93% and 4.19%, and also improve the ecological conditions by increasing the WUAs by 11.3%, 17.9% and 16.2% for Section A and 7.4%, 12.4% and 14.4% for Section B under wet, normal and dry conditions, respectively. Furthermore, the trade-offs between hydropower production and fish habitat conservation are discussed. The optimal compromises were identified at the knick points in the established relations where 50%–70% of maximum WUA are conserved at a cost of 11.72–52.11 billion kWh (1.8%–8.4%) power generation loss.
Keywords	Bagarius ; Cyprinus ; environmental impact ; fish ; fish production ; habitat conservation ; habitats ; power generation ; rivers ; simulation models ; stream flow ; water power
Language	English
Dates of publication	2016-1010
Size	p. 221-230.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	191971-4
ISSN	0304-3800
ISSN	0304-3800
DOI	10.1016/j.ecolmodel.2016.06.018
Database	NAL-Catalogue (AGRICOLA)

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Article: Efficacy and safety of Shen-Yuan-Dan capsules for peri-procedural myocardial injury following percutaneous coronary intervention: study protocol for a randomized, double-blind, placebo-controlled trial.

Li, Xiang / Lai, Xiao-Lei / Fei, Yu-Tong / Shang, Ju-Ju / Zhou, Qi / Sun, Xue-Yan / Xing, Wen-Long / Jia, Si-Han / Liu, Hong-Xu

Annals of translational medicine

2019 Volume 7, Issue 6, Page(s) 119

Abstract: ... treatment measures. Shen-Yuan-Dan (SYD) capsules are a traditional Chinese medicine (TCM) preparation ...

Abstract	Background: Peri-procedural myocardial injury (PMI) during percutaneous coronary intervention (PCI) will result in an unfavorable clinical prognosis in patients, thus urgently necessitating effective drug treatment measures. Shen-Yuan-Dan (SYD) capsules are a traditional Chinese medicine (TCM) preparation that have been found to have potential myocardial protection effects during the peri-procedural phase of PCI in previous clinical and basic research; however, there is a lack of rigorous, randomized, and controlled studies. The aim of this study is to evaluate the efficacy and safety of SYD in decreasing PMI. Methods: This is a randomized, double-blind, placebo-controlled clinical trial. A total of 284 patients with unstable angina will be randomized into test and control groups. The two groups will be given SYD or a placebo (three times each day, four capsules each time) 3 days before PCI on the basis of conventional treatment. Twelve hours before PCI, an additional 4 capsules will be given, and drug treatment is planned to be maintained for 1 month after surgery. Dynamic changes in the myocardial enzyme in four time-points (before PCI, and 4, 24, 48 hours after PCI) in both groups of patients that will be observed. The follow-up period will be 1 month. The primary observation markers are planned to evaluate the efficacy and safety of SYD in decreasing PMI. The secondary observation markers will be to evaluate the major adverse cardiovascular events (MACEs) status at day 30 after PCI, (all-cause mortality, non-fatal myocardial infarction, repeated revascularization of target blood vessel) and Seattle Angina Questionnaire scores. GRACE scores will be used for risk stratification, and the intervention efficacy of SYD on PMI patients with different risks will be retrospectively evaluated. Discussion: This study will provide a rigorous clinical evidence to evaluate the efficacy and safety of SYD in decreasing PMI and the results are worth anticipating. Trial registration: The design of this trial has been registered with the Chinese Clinical Trial Registry (No. ChiCTR-IPR-17011069).
Language	English
Publishing date	2019-04-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2018.09.44
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Article: [Nondestructive analysis of some ancient glass in Jin and Yuan dynasty, by EDXRF probe].

Li, Qing-lin / Xu, Cheng-tai / Ling, Xue / Yao, Zheng-quan

Guang pu xue yu guang pu fen xi = Guang pu

2011 Volume 31, Issue 7, Page(s) 1960–1963

Abstract: The chemical composition of some glass samples in Jin and Yuan Dynasty were analyzed by EDXRF ...

Abstract	The chemical composition of some glass samples in Jin and Yuan Dynasty were analyzed by EDXRF, to discuss the technological character of these glass samples. The result shows that the chemical composition of these glass samples is very complex. According to the chemical composition, these glass samples include K2-O-CaO-SiO2, Na2O-CaO-SiO2 and K2O-CaO-PbO-SiO2 glass, and a crystal SiO2 sample which was once considered a glass sample. The reason for the color of all blue glass samples is the existence of CuO, but not CoO.
Language	Chinese
Publishing date	2011-07
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1000-0593
ISSN	1000-0593
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Book ; Online: Supply Chain 4.0: New Generation of Supply Chain Management

Yuan, Xue-Ming / Xue, Anrong / Xue, Anrong

2023

Keywords	Industry 4.0 ; supply chain management and optimization ; Supply Chain 4.0 ; supply chain analytics ; supply chain visibility and connectivity ; supply chain synchronization and coordination ; sustainable supply chain management
Language	English
Size	1 electronic resource (192 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030376776
ISBN	9783036567594 ; 3036567593
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A study on Fu-Yuan Pellet, a traditional chinese medicine formula for detoxification of heroin addictions.

Wang, Xue / Li, Jing / Huang, Mingsheng / Kang, Lin / Hu, Min

The American journal of drug and alcohol abuse

2009 Volume 35, Issue 6, Page(s) 408–411

Abstract: ... to opiate addiction.: Objectives: The objective is to investigate the efficacy and safety of Fu-Yuan ...

Abstract	Background: Efforts toward researching effective and safe therapies for the treatment of drug addiction and acute heroin withdrawal syndrome remain important objectives in the field of drug addiction. Traditional Chinese medicine (TCM) is viewed as a potential approach to the treatment of drug addiction, and especially to opiate addiction. Objectives: The objective is to investigate the efficacy and safety of Fu-Yuan Pellet (FYP), a Chinese traditional medicine formula, for the treatment of acute heroin withdrawal syndrome. Methods: A multicenter, randomized, double-blind, double-dummy, and positive-controlled trial was conducted at 3 drug abuse treatment centers in China. Patients (n = 225) who met a diagnosis of opiate dependence based on DSM IV classification were recruited for this study, ranging in age from 18 to 55 years. Inclusion criteria included a heroin-positive urinalysis, as measured between 8 to 36 hours from last use of heroin, and total withdrawal syndrome scores above 50 before treatment (actual range 65-140). These patients were treated with either FYP or lofexidine in a fixed schedule of doses for 10 days. The total withdrawal syndrome scores and the daily reduction rate were used to measure the effect of FYP vs. lofexidine. Results: Both treatments significantly reduced withdrawal symptoms by day 3, but there was no significant difference overall between lofexidine and FYP in efficacy or safety. Conclusions and scientific significance: This clinical trial has shown that FYP is effective in the treatment of moderate-to-severe acute heroin withdrawal and has few adverse effects compared to lofexidine. Further study is warranted to determine whether FYP is similar to lofexidine in its potential for reducing stress induced opiate relapse.
MeSH term(s)	Adolescent ; Adrenergic alpha-Agonists/therapeutic use ; Adult ; Clonidine/analogs & derivatives ; Clonidine/therapeutic use ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Female ; Heroin Dependence/drug therapy ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Narcotic Antagonists/therapeutic use ; Substance Withdrawal Syndrome/drug therapy ; Treatment Outcome
Chemical Substances	Adrenergic alpha-Agonists ; Drugs, Chinese Herbal ; Narcotic Antagonists ; fu-yuan ; Clonidine (MN3L5RMN02) ; lofexidine (UI82K0T627)
Language	English
Publishing date	2009
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	193086-2
ISSN	1097-9891 ; 0095-2990
ISSN (online)	1097-9891
ISSN	0095-2990
DOI	10.3109/00952990903377146
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Article: [Comparative study on infrared radiation spectrum of yuan point and Xiahe point of the large intestine channel in the patient of ulcerative colitis].

Wu, Huan-gan / Yao, Yi / Shen, Xue-yong / Tan, Lin-ying / Shi, Yin / Yang, Yun / Liu, Hui-rong / Zheng, Shi

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2008 Volume 28, Issue 1, Page(s) 49–55

Abstract: Objective: To probe the diagnostic value of the infrared radiation spectrum of acupoint for ulcerative colitis (UC).: Methods: A high sensitivity PHE 201 infrared spectrum instrument was used to determine the infrared radiation spectrum of Hegu (LI 4) ...

Abstract	Objective: To probe the diagnostic value of the infrared radiation spectrum of acupoint for ulcerative colitis (UC). Methods: A high sensitivity PHE 201 infrared spectrum instrument was used to determine the infrared radiation spectrum of Hegu (LI 4) and Shangjuxu (ST 37) in 34 cases of UC. Results: Of 59 waves detected, there were significant differences in infrared radiation intensity of 28 different waves between the healthy people and the patients with UC in right Hegu (LI 4) (P < 0.05 or P < 0.01) and 13 waves in left Hegu (LI 4) (P < 0.05); there were significant differences in 16 different waves in right Shangjuxu (ST 37) (P < 0.05 or P < 0.01) and in 17 waves in left Shangjuxu (ST 37) (P < 0.05 or P < 0.01); there was a significant difference in 18 waves between right and left Hegu (LI 4) of the patients (P < 0.05 or P < 0.01) and 7 waves between right and left Hegu (LI 4) of the healthy people (P < 0.05). There was a significant difference in 4 waves between right and left Shangjuxu (ST 37) of the patients and one wave between right and left Shangjuxu (ST 37) of the healthy people (P < 0.01). Conclusion: Both Hegu (LI 4) and Shangjuxu (ST 37) show changes of infrared radiation spectrum when the intestine gets lesion, and Hegu (LI 4) can better show the change.
MeSH term(s)	Acupuncture Points ; Acupuncture Therapy ; Adult ; Colitis, Ulcerative/therapy ; Female ; Humans ; Infrared Rays ; Intestine, Large/anatomy & histology ; Male ; Middle Aged
Language	Chinese
Publishing date	2008-01
Publishing country	China
Document type	Comparative Study ; English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0255-2930
ISSN	0255-2930
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Article: [Volt-ampere characteristics of Yuan points of three yin channels of hand in women before, during and after menstruation].

Wei, Jian-Zi / Zhang, Ai-Mei / Shen, Xue-Yong / Zhou, Yu / Zhao, Ling

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine

2006 Volume 4, Issue 3, Page(s) 260–264

Abstract: Objective: To observe the changes of volt-ampere characteristics of Yuan-Primary acupoints ...

Abstract	Objective: To observe the changes of volt-ampere characteristics of Yuan-Primary acupoints in women before, during and after menstruation, and to find out the relationships between Qi-blood in human body and volt-ampere characteristics of acupoints, so as to develop a new method for quantitative analysis on changes of Qi-blood. Methods: A high-sensitive detection system of volt-ampere characteristics of acupoint was applied to detecting the volt-ampere characteristics of Taiyuan (LU 9), Daling (PC 7) and Shenmen (HT 7) in healthy women before, during and after menstruation. Results: The resistances on LU 9, PC 7 and HT 7 with some certain scan currents were quite different among the women before, during and after menstruation. For such changes, PC 7 was of the most obvious change, LU 9 was of the less and HT 7 was of the least. The total ratio of the scanning spots with significantly increasing changes of resistances on these three acupoints along with the menstrual process was 70.6%. Conclusion: The volt-ampere characteristics of acupoints vary with the menstrual process, which is of the acupoint specificity. The resistances on the acupoints increase with the menstrual process, and such results may be due to the blood loss during menstruation. The volt-ampere characteristics can be used as a quantitative index to study on the change of Qi and blood.
MeSH term(s)	Acupuncture Points ; Adult ; Electric Impedance ; Electrophysiology ; Female ; Humans ; Menstruation/physiology ; Meridians
Language	Chinese
Publishing date	2006-04-03
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2229154-4
ISSN	1672-1977
ISSN	1672-1977
DOI	10.3736/jcim20060308
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