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Article: Instant

Clack, Kimberley / Sallam, Mohamed / Muyldermans, Serge / Sambasivam, Prabhakaran / Nguyen, Cong Minh / Nguyen, Nam-Trung

Micromachines

2024 Volume 15, Issue 2

Abstract: Fungal pathogens such ... ...

Abstract	Fungal pathogens such as
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi15020216
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Article ; Online: Implementation of full-length 16S nanopore sequencing for bacterial identification in a clinical diagnostic setting.

Vanhee, Merijn / Floré, Katelijne / Vanthourenhout, Sanne / Hellemans, Jorn / Muyldermans, Astrid / Reynders, Marijke

Diagnostic microbiology and infectious disease

2023 Volume 108, Issue 2, Page(s) 116156

Abstract: This study describes the implementation of 16S nanopore sequencing in a diagnostic lab for pathogen identification without prior enrichment. First, the universality of the test and taxonomic resolution was evaluated for 78 clinically relevant bacteria ( ... ...

Abstract	This study describes the implementation of 16S nanopore sequencing in a diagnostic lab for pathogen identification without prior enrichment. First, the universality of the test and taxonomic resolution was evaluated for 78 clinically relevant bacteria (69 known and 9 unknown bacterial cultures). Next, the diagnostic value of the test was evaluated based on clinical samples. It was shown that 16S sequencing can be used both for identification of unknown cultures and to find bacteria directly in the clinical sample without cultivation. All culture-positive samples (n=11) tested positive with 16S sequencing directly performed on the sample, but bacteria were found as well in 15/30 culture-negative samples. Pathogenic bacteria were found in a background of commensal flora, and even complex polymicrobial infections could be unraveled. This study demonstrates the feasibility of implementing 16S nanopore sequencing in a clinical diagnostic setting and demonstrates its value for the diagnosis of culture-negative and polymicrobial infections.
MeSH term(s)	Humans ; Nanopore Sequencing ; Coinfection ; Bacteria/genetics ; RNA, Ribosomal, 16S/genetics ; High-Throughput Nucleotide Sequencing
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2023.116156
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Article ; Online: Camel-Derived Nanobodies as Potent Inhibitors of New Delhi Metallo-β-Lactamase-1 Enzyme.

Ben Abderrazek, Rahma / Hamdi, Emna / Piccirilli, Alessandra / Dhaouadi, Sayda / Muyldermans, Serge / Perilli, Mariagrazia / Bouhaouala-Zahar, Balkiss

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 7

Abstract: ... and Nb17NDM-1 behaved as uncompetitive inhibitors against NDM-1 with K ...

Abstract	The injudicious usage of antibiotics during infections caused by Gram-negative bacteria leads to the emergence of β-lactamases. Among them, the NDM-1 enzyme poses a serious threat to human health. Developing new antibiotics or inhibiting β-lactamases might become essential to reduce and prevent bacterial infections. Nanobodies (Nbs), the smallest antigen-binding single-domain fragments derived from Camelidae heavy-chain-only antibodies, targeting enzymes, are innovative alternatives to develop effective inhibitors. The biopanning of an immune VHH library after phage display has helped to retrieve recombinant antibody fragments with high inhibitory activity against recombinant-NDM-1 enzyme. Nb02NDM-1, Nb12NDM-1, and Nb17NDM-1 behaved as uncompetitive inhibitors against NDM-1 with K
MeSH term(s)	Humans ; Animals ; Camelus ; Single-Domain Antibodies/pharmacology ; beta-Lactamases ; Anti-Bacterial Agents/pharmacology ; Immunoglobulin Heavy Chains
Chemical Substances	beta-lactamase NDM-1 (EC 3.5.2.6) ; Single-Domain Antibodies ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Immunoglobulin Heavy Chains
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29071431
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Article ; Online: The Effects of COVID-19 Vaccination on Lactating Women: A Systematic Review of the Literature.

Muyldermans, Joke / De Weerdt, Louise / De Brabandere, Larissa / Maertens, Kirsten / Tommelein, Eline

Frontiers in immunology

2022 Volume 13, Page(s) 852928

Abstract: Objectives: The availability of new vaccines against COVID-19 urges for guidance about vaccination during lactation. We aimed to review the literature to get an insight into the effects of COVID-19 vaccination on lactating women.: Design: Systematic ... ...

Abstract	Objectives: The availability of new vaccines against COVID-19 urges for guidance about vaccination during lactation. We aimed to review the literature to get an insight into the effects of COVID-19 vaccination on lactating women. Design: Systematic review. Data sources: We searched Ovid Embase Classic+Embase, PubMed and BioMed Central for articles published between December 1 Review methods: The search strategy contained terms and combinations related to COVID-19 vaccination during lactation, including the MeSH terms "COVID-19", "COVID-19 Vaccines", "SARS-CoV-2", "Lactation", "Breast Feeding", "Pregnancy" and "Postpartum period". The database search was completed with a manual search of the reference lists of included articles. Data concerning country, study period, number of participants, type of applied vaccine, time points of sampling and outcome measures were collected from the selected manuscripts. The data are summarized and synthesized in a descriptive way. Results: 30 manuscripts were included in this review. Data on safety of COVID-19 vaccination during lactation indicate no severe vaccine-related local and systemic reactions, both after first and second dose, neither in the mother nor the nursing child. No significant amount of vaccine components seems to appear in breast milk. Milk supply data after vaccination are inconclusive as there are no quantitative data available. Some women however observe a temporary increase or reduction in milk supply, without long-term effects. All prospective cohort studies demonstrated the presence of SARS-CoV-2-specific antibodies in breast milk of nursing mothers vaccinated against SARS-CoV-2. Nearly all studies were conducted with mRNA vaccines. Conclusion: There is evidence that the administration of a COVID-19 vaccine is safe and poses no additional risk to the breastfeeding woman or the breastfed baby. After vaccination of the mother during the lactation period, antibodies appear in the milk, which could protect the infant against COVID-19. Professional associations and government health authorities should therefore recommend offering COVID-19 vaccines to breastfeeding women, as the potential benefits of maternal vaccination while breastfeeding outweigh the risks.
MeSH term(s)	Antibodies, Viral ; Breast Feeding ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Infant ; Lactation ; Mothers ; Prospective Studies ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.852928
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Article ; Online: Health Care Providers' Perspective and Knowledge about Peri-Surgical Medication and Practices in Breastfeeding Women.

De Hondt, Lena / Gorsen, Santina Lisa / Verburgh, Patrick / De Paepe, Kristien / Muyldermans, Joke / Tommelein, Eline

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: Many guidelines offer recommendations to support the continuation of breastfeeding and the choice of medication when a mother undergoes a surgical procedure. The aim of this study is to investigate health care providers' (HCPs) current practices and ... ...

Abstract	Many guidelines offer recommendations to support the continuation of breastfeeding and the choice of medication when a mother undergoes a surgical procedure. The aim of this study is to investigate health care providers' (HCPs) current practices and knowledge about peri-surgical medication and practices in breastfeeding women. We performed a cross-sectional study in Flanders (Belgium) assessing demographics, beliefs about breastfeeding and its health benefits, current practices concerning breastfeeding women undergoing (surgical) procedures and specific knowledge about the use of medication during breastfeeding. Two hundred and ninety-one (291) participants completed the online questionnaire. Many participants considered their knowledge about breastfeeding to be good, and almost all participants acknowledged the superiority of breastfeeding and the importance of its continuation. Very few participants were, however, familiar with the available protocols concerning surgical procedures in breastfeeding women. Less than half of the participants routinely advised the recommended practices to protect breastfeeding. For most of the peri-surgical medication, participants needed to look-up information about the compatibility with breastfeeding. We conclude that there is a knowledge gap and recommend the development of a comprehensive guideline as well as implementation of this information in basic and post-academic training.
MeSH term(s)	Humans ; Female ; Breast Feeding ; Cross-Sectional Studies ; Health Personnel ; Mothers ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043379
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Article: Exercise-induced effects on inflammatory markers and brain-derived neurotrophic factor in patients with knee osteoarthritis. A systematic review with meta-analysis.

Puts, Sofie / Liberman, Keliane / Leysen, Laurence / Forti, Louis / Muyldermans, Eveline / Vaes, Peter / Nijs, Jo / Beckwée, David / Bautmans, Ivan

Exercise immunology review

2023 Volume 29, Page(s) 22–53

Abstract: Background: In the pathogenesis of knee osteoarthritis (KOA), inflammatory mediators play an important role. However, the precise underlying mechanism by which regular exercise therapy (ET) exert effects on the immune system in KOA patients is unknown.!# ...

Abstract	Background: In the pathogenesis of knee osteoarthritis (KOA), inflammatory mediators play an important role. However, the precise underlying mechanism by which regular exercise therapy (ET) exert effects on the immune system in KOA patients is unknown. Objectives: The aim of this systematic review was to investigate the basal and acute effects of ET on inflammatory biomarkers and brain derived neurotrophic factor (BDNF) in KOA patients. Methods: PubMed, Web Of Science and PEDro were systematically searched for appropriate studies. If possible, a meta-analysis was performed or an approximation of the effect size (ES) was calculated. Risk of bias was scored using the Cochrane ROB 2.0 or ROBINS-tools. Results: Twenty-one studies involving 1374 participants were included. Fifteen articles focused on basal exercise effects, four on acute effects, and two on both. Biomarker analysis (n=18) was performed in synovial fluid (n=4) or serum/plasma (n=17). A meta-analysis demonstrated that basal CRP was reduced in KOA patients 6-18 weeks weeks after ET (MD: -0.17;95%CI[-0.31;-0.03]), while IL-6 (MD: 0.21;95%CI[-0.44;0.85]), and TNF-α (MD: -0.57;95%CI[-1.47;0.32]), levels did not significantly change. Also, sTNFR1/2 did not change significantly after ET. For other biomarkers, insufficient data were available to perform a meta-analysis. Nevertheless, a low degree of evidence was found for a decrease in IL-6 (ES:-0.596 & -0.259 & -0.513), an increase in sTNFR1 (ES:2.325), a decrease in sTNFR2 (ES:-0.997) and an increase in BDNF (ES:1.412). Locally, intra-articular IL-10 (ES:9.163) increased, and IL1β (ES:-6.199) and TNF-α decreased (ES:-2.322) after ET. An acute exercise session elicited a myokine response (ES IL-6:0.314), and an increase in BDNF (no ES-data). No inflammatory effect (ES CRP:0.052; ES TNF-α:-0.019 & 0.081) following an acute bout of training was found. However, a single bout of exercise elicited a decrease in intra-articular IL-10 (no ES-data). Conclusion: ET can induce circulatory and intra-articular anti-inflammatory effects in patients with KOA. The antiinflammatory properties have important implications for informing these patients and clinicians about the underlying effects of ET.
MeSH term(s)	Humans ; Osteoarthritis, Knee/therapy ; Brain-Derived Neurotrophic Factor ; Interleukin-10 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Biomarkers
Chemical Substances	Brain-Derived Neurotrophic Factor ; Interleukin-10 (130068-27-8) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Biomarkers
Language	English
Publishing date	2023-06-09
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1240985-6
ISSN	1077-5552
ISSN	1077-5552
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Article ; Online: The complementarity of green supply chain management practices and the impact on environmental performance.

Al-Sheyadi, Anwar / Muyldermans, Luc / Kauppi, Katri

Journal of environmental management

2019 Volume 242, Page(s) 186–198

Abstract: Although the importance of integrating different Green Supply Chain Management (GSCM) activities has been highlighted in the literature, the potential interdependencies between these practices and their performance impacts have not been investigated. The ...

Abstract	Although the importance of integrating different Green Supply Chain Management (GSCM) activities has been highlighted in the literature, the potential interdependencies between these practices and their performance impacts have not been investigated. The purpose of this study is to examine the collective impact of internal and external GSCM practices on two aspects of environmental performance: environmental impact and environmental cost savings. GSCM is proposed as a collective competency, combining four distinct, but interrelated, sets of practices: environmental management systems, eco design, source reduction and external environmental practices. Using survey data from 138 Omani manufacturing firms and Structural Equation Modelling, we find strong empirical support for the complementarity of GSCM practices. We find a strong positive relationship between the level of collective GSCM competency and the environmental impact achieved. Our findings support the belief that complementarities between GSCM practices lead to better performance. Managers should therefore focus on implementing bundles of GSCM practices rather than searching for individual best practices. We find an indirect, mediated influence on environmental cost savings, which is consistent with previous results in other emerging market contexts.
MeSH term(s)	Commerce ; Conservation of Natural Resources
Language	English
Publishing date	2019-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2019.04.078
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Article ; Online: Novel

Steyaert, Stephanie / Peeters, Charlotte / Wieme, Anneleen D / Muyldermans, Astrid / Vandoorslaer, Kristof / Spilker, Theodore / Wybo, Ingrid / Piérard, Denis / LiPuma, John J / Vandamme, Peter

Microbiology spectrum

2024 , Page(s) e0402123

Abstract: A collection of ... ...

Abstract	A collection of 161
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04021-23
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Article ; Online: Validation of the Colibrí Instrument for Automated Preparation of MALDI-TOF MS Targets for Yeast Identification.

Heestermans, Robbe / Herroelen, Pauline / Emmerechts, Kristof / Vandoorslaer, Kristof / De Geyter, Deborah / Demuyser, Thomas / Wybo, Ingrid / Piérard, Denis / Muyldermans, Astrid

Journal of clinical microbiology

2022 Volume 60, Issue 7, Page(s) e0023722

Abstract: Recently, Copan (Italy) introduced the Colibrí instrument for automated colony picking and preparation of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) target plates. Our study aimed to validate this system for yeasts as such ... ...

Abstract	Recently, Copan (Italy) introduced the Colibrí instrument for automated colony picking and preparation of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) target plates. Our study aimed to validate this system for yeasts as such testing has not been performed yet and is a missing link needed to implement the system for routine use. Fifty-five
MeSH term(s)	Agar ; Culture Media ; Reproducibility of Results ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Yeasts
Chemical Substances	Culture Media ; Agar (9002-18-0)
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.00237-22
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Article ; Online: Correction to: Validation of Rapid Antimicrobial Susceptibility Testing directly from blood cultures using WASPLab®, including Colibrí™ and Radian® in-Line Carousel.

Herroelen, Pauline Hilda / Heestermans, Robbe / Emmerechts, Kristof / Vandoorslaer, Kristof / Wybo, Ingrid / Piérard, Denis / Muyldermans, Astrid

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2022 Volume 41, Issue 6, Page(s) 1001

Language	English
Publishing date	2022-05-05
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-022-04451-2
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