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  1. Article ; Online: Fatty liver disease that is neither metabolic nor alcoholic.

    Allende, Daniela S / Kleiner, David E

    Human pathology

    2023  Volume 141, Page(s) 212–221

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. This article aims to summary less common etiologies of fatty liver and their key clinicopathological features. ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. This article aims to summary less common etiologies of fatty liver and their key clinicopathological features.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/pathology ; Liver/pathology
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 722: Show issues Location:
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  2. Article ; Online: Liver Biopsy Shines a Light on COVID-19-Related Liver Injury.

    Kleiner, David E

    Cellular and molecular gastroenterology and hepatology

    2020  Volume 11, Issue 3, Page(s) 881–882

    MeSH term(s) Biopsy ; COVID-19 ; Humans ; Liver Diseases ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2352-345X
    ISSN (online) 2352-345X
    DOI 10.1016/j.jcmgh.2020.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Digital pathology for nonalcoholic steatohepatitis assessment.

    Sanyal, Arun J / Jha, Prakash / Kleiner, David E

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 21, Issue 1, Page(s) 57–69

    Abstract: Histological assessment of nonalcoholic fatty liver disease (NAFLD) has anchored knowledge development about the phenotypes of the condition, their natural history and their clinical course. This fact has led to the use of histological assessment as a ... ...

    Abstract Histological assessment of nonalcoholic fatty liver disease (NAFLD) has anchored knowledge development about the phenotypes of the condition, their natural history and their clinical course. This fact has led to the use of histological assessment as a reference standard for the evaluation of efficacy of drug interventions for nonalcoholic steatohepatitis (NASH) - the more histologically active form of NAFLD. However, certain limitations of conventional histological assessment systems pose challenges in drug development. These limitations have spurred intense scientific and commercial development of machine learning and digital approaches towards the assessment of liver histology in patients with NAFLD. This research field remains an area in rapid evolution. In this Perspective article, we summarize the current conventional assessment of NASH and its limitations, the use of specific digital approaches for histological assessment, and their application to the study of NASH and its response to therapy. Although this is not a comprehensive review, the leading tools currently used to assess therapeutic efficacy in drug development are specifically discussed. The potential translation of these approaches to support routine clinical assessment of NAFLD and an agenda for future research are also discussed.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Liver/pathology
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00843-7
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  4. Article ; Online: Hepatocellular carcinoma: Liver biopsy in the balance.

    Kleiner, David E

    Hepatology (Baltimore, Md.)

    2018  Volume 68, Issue 1, Page(s) 13–15

    MeSH term(s) Biopsy ; Carcinoma, Hepatocellular ; Digestive System Surgical Procedures ; Humans ; Liver ; Liver Neoplasms
    Language English
    Publishing date 2018-02-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29831
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    Zs.A 1660: Show issues Location:
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  6. Article ; Online: Liver Biopsy Shines a Light on COVID-19-Related Liver Injury

    Kleiner, David E.

    Cellular and Molecular Gastroenterology and Hepatology ; ISSN 2352-345X

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.jcmgh.2020.10.003
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Recent Advances in the Histopathology of Drug-Induced Liver Injury.

    Kleiner, David E

    Surgical pathology clinics

    2018  Volume 11, Issue 2, Page(s) 297–311

    Abstract: Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic ...

    Abstract Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic findings considering patients' medical history and drug exposure. The liver biopsy findings may suggest alternative explanations of the injury and additional testing that should be performed to exclude non-DILI causes. Recent reports of iatrogenic liver injury are reviewed with attention to immunomodulatory and antineoplastic agents as well as reports of injury associated with HDS use.
    MeSH term(s) Antineoplastic Agents, Alkylating/adverse effects ; Biopsy ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/pathology ; Dacarbazine/adverse effects ; Dacarbazine/analogs & derivatives ; Diagnosis, Differential ; Dietary Supplements/adverse effects ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/pathology ; Humans ; Immunosuppressive Agents/adverse effects ; Liver/pathology ; Phytotherapy/adverse effects ; Temozolomide
    Chemical Substances Antineoplastic Agents, Alkylating ; Immunosuppressive Agents ; Dacarbazine (7GR28W0FJI) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2018-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2018.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Role of the Hepatopathologist in the Assessment of Drug-induced Liver Injury.

    Kleiner, David E

    Clinical liver disease

    2017  Volume 9, Issue 2, Page(s) 34–37

    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: On beyond staging and grading: Liver biopsy evaluation in a posttreatment world.

    Kleiner, David E

    Hepatology (Baltimore, Md.)

    2017  Volume 65, Issue 5, Page(s) 1432–1434

    MeSH term(s) Biopsy ; Humans ; Liver
    Language English
    Publishing date 2017-03-30
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29111
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  10. Article ; Online: Histopathological challenges in suspected drug-induced liver injury.

    Kleiner, David E

    Liver international : official journal of the International Association for the Study of the Liver

    2017  Volume 38, Issue 2, Page(s) 198–209

    Abstract: When a patient with suspected drug-induced liver injury (DILI) undergoes liver biopsy, the pathologist is confronted with two major challenges. The first and most important is to establish the pattern(s) of injury which are present. Patterns of injury ... ...

    Abstract When a patient with suspected drug-induced liver injury (DILI) undergoes liver biopsy, the pathologist is confronted with two major challenges. The first and most important is to establish the pattern(s) of injury which are present. Patterns of injury represent stereotypical responses of an organ to injury and relate to specific aetiologies of liver damage. The pattern of injury and the histological details of that injury can then be analysed with respect to the patient's intercurrent diseases and medication history. The specific expertise of the pathologist can be used to weigh the prospect of DILI against the likelihood of other explanations of injury. The second challenge is to characterize specific types of injury and the severity of injury, both of which may have importance for clinical decision-making and prognosis. The pathologist's report should convey both an accurate description of the pathology as well its interpretation.
    MeSH term(s) Biopsy ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/therapy ; Clinical Competence ; Clinical Decision-Making ; Diagnosis, Differential ; Humans ; Liver/drug effects ; Liver/pathology ; Pathologists ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2017-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13584
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