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  1. AU=Pathanki Adithya M
  2. AU="Armando Vilchis-Ordoñez"
  3. AU="Zhongfu Lu"
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  5. AU="Ziman Xiong"
  6. AU="Oakes, Allison H"
  7. AU="Ma, Shaotong"
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  9. AU="Adams Brian D"
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  11. AU="Kollia, Georgia"
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  13. AU="Guzmán, Luis"
  14. AU="Alipour, Elnaz"
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  17. AU="Xueying Huang"
  18. AU="Cromwell, Howard C"
  19. AU="Spence, John C H"
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  1. Artikel: Liver Transplantation During the COVID-19 Pandemic: Viruses, Vaccines and Beyond.

    Pathanki, Adithya M / Mirza, Darius F

    Journal of clinical and experimental hepatology

    2021  Band 11, Heft 4, Seite(n) 411–413

    Sprache Englisch
    Erscheinungsdatum 2021-05-04
    Erscheinungsland India
    Dokumenttyp Editorial
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2021.04.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Comparative study of operative expenses: robotic vs. laparoscopic vs. open liver resections at a university hospital in the UK.

    Elshaer, Mohamed / Askari, Alan / Pathanki, Adithya / Rajani, Jaimini / Ahmad, Jawad

    Journal of robotic surgery

    2024  Band 18, Heft 1, Seite(n) 12

    Abstract: Robotic liver resections (RLR) are increasingly being performed and has previously been considered more costly. The aim is to explore the cost of RLR compared with laparoscopic and open liver resection in a single National Health Service (NHS) hospital. ... ...

    Abstract Robotic liver resections (RLR) are increasingly being performed and has previously been considered more costly. The aim is to explore the cost of RLR compared with laparoscopic and open liver resection in a single National Health Service (NHS) hospital. A retrospective review of patients who underwent RLR, LLR, and OLR from April 2014 to December 2022 was conducted. The primary outcomes were the cost of consumables and median income, and the secondary outcomes were the overall length of stay and mortality at 90 days. Overall, 332 patients underwent liver resections. There were 204 males (61.4%) and 128 females (38.6%), with a median age of 62 years (IQR: 51-77 years). Of these, 60 patients (18.1%) underwent RLR, 21 patients (6.3%) underwent LLR, and 251 patients (75.6%) underwent OLR. Median consumables cost per case was £3863 (IQR: £3458-£5061) for RLR, £4326 (IQR: £4273-£4473) for LLR, and £4,084 (IQR: £3799-£5549) for the OLR cohort (p = 0.140). Median income per case was £7999 (IQR: £4509-£10,777) for RLR, £7497 (IQR: £2407-£14,576) for LLR, and £7493 (IQR: £2542-£14,121) for OLR. The median length of stay (LOS) for RLR was 3 days (IQR: 2-4.7 days) compared to 5 days for LLR (IQR: 4.5-7 days) and 6 days for OLR (IQR: 5-8 days, p < 0.001). Within the NHS, RLR has consumable costs comparable to OLR and LLR. It is also linked with a shorter LOS and generates similar income for patients undergoing OLR and LLR.
    Mesh-Begriff(e) Male ; Female ; Humans ; Middle Aged ; Aged ; Liver Neoplasms/surgery ; Robotic Surgical Procedures/methods ; State Medicine ; Laparoscopy ; Hepatectomy ; Length of Stay ; Retrospective Studies ; Hospitals ; United Kingdom ; Carcinoma, Hepatocellular/surgery ; Postoperative Complications/surgery
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-023-01778-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Meta-analysis and trial sequential analysis of pancreatic stump closure using a hand-sewn or stapler technique in distal pancreatectomy.

    Hajibandeh, Shahin / Hajibandeh, Shahab / Hablus, Mohammed Abdallah / Bari, Hassaan / Pathanki, Adithya Malolan / Ali, Majid / Ahmad, Jawad / Marangoni, Gabriele / Khan, Saboor / Lam, For Tai

    Annals of hepato-biliary-pancreatic surgery

    2024  

    Abstract: This study aimed to compare outcomes of hand-sewn and stapler closure techniques of pancreatic stump in patients undergoing distal pancreatectomy (DP). Impact of stapler closure reinforcement using mesh on outcomes was also evaluated. Literature search ... ...

    Abstract This study aimed to compare outcomes of hand-sewn and stapler closure techniques of pancreatic stump in patients undergoing distal pancreatectomy (DP). Impact of stapler closure reinforcement using mesh on outcomes was also evaluated. Literature search was carried out using multiple data sources to identify studies that compared hand-sewn and stapler closure techniques in management of pancreatic stump following DP. Odds ratio (OR) was determined for clinically relevant postoperative pancreatic fistula (POPF) via random-effects modelling. Subsequently, trial sequential analysis was performed. Thirty-two studies with a total of 4,022 patients undergoing DP with hand-sewn (n = 1,184) or stapler (n = 2,838) closure technique of pancreatic stump were analyzed. Hand-sewn closure significantly increased the risk of clinically relevant POPF compared to stapler closure (OR: 1.56,
    Sprache Englisch
    Erscheinungsdatum 2024-03-25
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3012179-6
    ISSN 2508-5859 ; 2508-5778
    ISSN (online) 2508-5859
    ISSN 2508-5778
    DOI 10.14701/ahbps.24-015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management.

    Pathanki, Adithya M / Attard, Joseph A / Bradley, Elizabeth / Powell-Brett, Sarah / Dasari, Bobby V M / Isaac, John R / Roberts, Keith J / Chatzizacharias, Nikolaos A

    World journal of gastrointestinal pathophysiology

    2020  Band 11, Heft 2, Seite(n) 20–31

    Abstract: Pancreaticoduodenectomy (PD) is the commonest procedure performed for pancreatic cancer. Pancreatic exocrine insufficiency (PEI) may be caused or exacerbated by surgery and remains underdiagnosed and undertreated. The aim of this review was to ascertain ... ...

    Abstract Pancreaticoduodenectomy (PD) is the commonest procedure performed for pancreatic cancer. Pancreatic exocrine insufficiency (PEI) may be caused or exacerbated by surgery and remains underdiagnosed and undertreated. The aim of this review was to ascertain the incidence of PEI, its consequences and management in the setting of PD for indications other than chronic pancreatitis. A literature search of databases (MEDLINE, EMBASE, Cochrane and Scopus) was carried out with the MeSH terms "pancreatic exocrine insufficiency" and "Pancreaticoduodenectomy". Studies that analysed PEI and its complications in the setting of PD for malignant and benign disease were included. Studies reporting PEI in the setting of PD for chronic pancreatitis, conference abstracts and reviews were excluded. The incidence of PEI approached 100% following PD in some series. The pre-operative incidence varied depending on the characteristics of the patient cohort and it was higher (46%-93%) in series where pancreatic cancer was the predominant indication for surgery. Variability was also recorded with regards to the method used for the diagnosis and evaluation of pancreatic function and malabsorption. Pancreatic enzyme replacement therapy is the mainstay of the management. PEI is common and remains undertreated after PD. Future studies are required for the identification of a well-tolerated, reliable and reproducible diagnostic test in this setting.
    Sprache Englisch
    Erscheinungsdatum 2020-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2583474-5
    ISSN 2150-5330
    ISSN 2150-5330
    DOI 10.4291/wjgp.v11.i2.20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The effects of resection margin and KRAS status on outcomes after resection of colorectal liver metastases.

    Hatta, Ayiesha Ahmad Zalmani / Pathanki, Adithya M / Hodson, James / Sutcliffe, Robert P / Marudanayagam, Ravi / Roberts, Keith J / Chatzizacharias, Nikolaos / Isaac, John / Muiesan, Paolo / Taniere, Phillipe / Mirza, Darius F / Dasari, Bobby V M

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2020  Band 23, Heft 1, Seite(n) 90–98

    Abstract: Background: The aim of this study was to investigate the influence of resection margin status in patients with KRAS mutations (mt-KRAS) when compared to those with wild-type KRAS (wt-KRAS) on long-term outcomes in patients with resected CRLM.: Methods! ...

    Abstract Background: The aim of this study was to investigate the influence of resection margin status in patients with KRAS mutations (mt-KRAS) when compared to those with wild-type KRAS (wt-KRAS) on long-term outcomes in patients with resected CRLM.
    Methods: All patients who underwent resection of CRLM with curative intent between January 2011 and December 2016 and had a KRAS type recorded were included in the study. Overall survival (OS), as well as death-censored overall (RFS) and liver-specific (LS-RFS) recurrence-free survival between KRAS types and the margin status within KRAS subgroups were compared using Cox regression models.
    Results: Data were available for N = 500 patients (30.4% mt-KRAS). mt-KRAS status was independently associated with significantly shorter OS. Within the wt-KRAS subgroup, smaller margins were found to be associated with significantly shorter death-censored LS-RFS (p < 0.001), with HRs of 1.93 (p = 0.005) for 1-4 mm margins and 2.83 (p < 0.001) for <1 mm margins, relative to those with clear margins. No such association was observed in the mt-KRAS subgroup (p = 0.721).
    Conclusion: The resection margin status is of greater importance in patients with wt-KRAS. Such information could be useful in the operative planning, especially for those with multiple metastatic deposits, and also in the post-operative counselling and surveillance based on the margin and KRAS status.
    Mesh-Begriff(e) Colorectal Neoplasms/genetics ; Colorectal Neoplasms/surgery ; Hepatectomy/adverse effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/surgery ; Margins of Excision ; Mutation ; Prognosis ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemische Substanzen KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Sprache Englisch
    Erscheinungsdatum 2020-05-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2020.04.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6326: Hefte anzeigen Standort:
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  6. Artikel ; Online: Addressing extreme size mismatch in pediatric intestinal transplantation: Outcomes of intestinal length reduction.

    Hann, Angus / Gupte, Girish L / Pathanki, Adithya / Coelho, Maria / Beath, Sue / Hartley, Jane / Kelly, Deirdre / De Ville De Goyet, Jean / Oo, Ye H / Hartog, Hermien / Perera, Thamara P R / Sharif, Khalid / Mirza, Darius F

    Pediatric transplantation

    2023  Band 27, Heft 5, Seite(n) e14528

    Abstract: Background: Bench liver reduction, with or without intestinal length reduction (LR) (coupled with delayed closure and abdominal wall prostheses), has been a strategy adopted by our program for small children due to the limited availability of size- ... ...

    Abstract Background: Bench liver reduction, with or without intestinal length reduction (LR) (coupled with delayed closure and abdominal wall prostheses), has been a strategy adopted by our program for small children due to the limited availability of size-matched donors. This report describes the short, medium, and long-term outcomes of this graft reduction strategy.
    Methods: A single-center, retrospective analysis of children that underwent intestinal transplantation (April 1993 to December 2020) was performed. Patients were grouped according to whether they received an intestinal graft of full length (FL) or following LR.
    Results: Overall, 105 intestinal transplants were performed. The LR group (n = 10) was younger (14.5 months vs. 40.0 months, p = .012) and smaller (8.7 kg vs. 13.0 kg, p = .032) compared to the FL group (n = 95). Similar abdominal closure rates were achieved after LR, without any increase in abdominal compartment syndrome (1/10 vs. 7/95, p = .806). The 90-day graft and patient survival were similar (9/10, 90% vs. 83/95, 86%; p = .810). Medium and long-term graft survival at 1 year (8/10, 80% vs. 65/90, 71%; p = .599), and 5 years (5/10, 50% vs. 42/84, 50%; p = 1.00) was similar.
    Conclusion: LR of intestinal grafts appears to be a safe strategy for infants and small children requiring intestinal transplantation. This technique should be considered in the situation of significant size mismatch of intestine containing grafts.
    Mesh-Begriff(e) Infant ; Child ; Humans ; Liver Transplantation/methods ; Retrospective Studies ; Intestines/transplantation ; Liver ; Tissue Donors ; Graft Survival
    Sprache Englisch
    Erscheinungsdatum 2023-06-19
    Erscheinungsland Denmark
    Dokumenttyp Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14528
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