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Article ; Online: From pandemic to endemic: learning from the past and preparing for the future.

Bilodeau, Marc

Health promotion and chronic disease prevention in Canada : research, policy and practice

2022 Volume 42, Issue 3, Page(s) 95

Title translation	De la pandémie à l’endémie : tirer les leçons du passé et préparer l’avenir.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Pandemics/prevention & control
Language	French
Publishing date	2022-02-07
Publishing country	Canada
Document type	Editorial
ISSN	2368-738X
ISSN (online)	2368-738X
DOI	10.24095/hpcdp.42.3.01
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: From pandemic to endemic

Marc Bilodeau

Health Promotion and Chronic Disease Prevention in Canada, Vol 42, Iss 3, Pp 95-

learning from the past and preparing for the future

2022 Volume 95

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Public Health Agency of Canada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: De la pandémie à l’endémie

Marc Bilodeau

Promotion de la santé et prévention des maladies chroniques au Canada, Vol 42, Iss 3, Pp 107-

tirer les leçons du passé et préparer l’avenir

2022 Volume 108

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Agence de la santé publique du Canada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The golden age of hepatology.

Bilodeau, Marc

Canadian liver journal

2019 Volume 2, Issue 2, Page(s) 1–2

Language	English
Publishing date	2019-05-22
Publishing country	Canada
Document type	Editorial
ISSN	2561-4444
ISSN (online)	2561-4444
DOI	10.3138/canlivj.2019-0008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Laboratory Study of the Effects of the Mixer Type and Mixing Time on the Volumetric Properties and Performance of a HMA with 30 Percent Reclaimed Asphalt Pavement.

Bérubé, Marc-André / Lamothe, Sébastien / Bilodeau, Kevin / Carter, Alan

Materials (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: This study examined the effects of the laboratory mixer type and mixing time on a hot-mix asphalt (HMA) using three different types of mixers and four different mixing times. The asphalt mix used is a semi-open graded mix (ESG-10) with 30% reclaimed ... ...

Abstract	This study examined the effects of the laboratory mixer type and mixing time on a hot-mix asphalt (HMA) using three different types of mixers and four different mixing times. The asphalt mix used is a semi-open graded mix (ESG-10) with 30% reclaimed asphalt pavement (RAP), and a range of tests were conducted including bitumen extraction by ignition, particle size distribution, maximum specific gravity (G
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16031300
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Article ; Online: Immune-Mediated Hepatitis During Immune Checkpoint Inhibitor cancer Immunotherapy: Lessons From Autoimmune Hepatitis and Liver Immunology.

Hercun, Julian / Vincent, Catherine / Bilodeau, Marc / Lapierre, Pascal

Frontiers in immunology

2022 Volume 13, Page(s) 907591

Abstract: Immune checkpoint inhibitors (ICI) are being increasingly used to successfully treat several types of cancer. However, due to their mode of action, these treatments are associated with several immune-related adverse events (irAEs), including immune- ... ...

Abstract	Immune checkpoint inhibitors (ICI) are being increasingly used to successfully treat several types of cancer. However, due to their mode of action, these treatments are associated with several immune-related adverse events (irAEs), including immune-mediated autoimmune-like hepatitis in 5 to 10% of cases. The specific immune mechanism responsible for the development of immune-mediated liver injury caused by immune checkpoint inhibitors (ILICI) is currently unknown. This review summarizes the current knowledge on hepatic irAEs during cancer immunotherapy. It also addresses the clinical management of ILICI and how it is becoming an increasingly important clinical issue. Clinical, histological, and laboratory features of autoimmune hepatitis (AIH) and ILICI are compared, and their shared and distinctive traits are discussed in an effort to better understand the development of hepatic irAEs. Finally, based on the current knowledge of liver immunology and AIH pathogenesis, we propose a series of events that could trigger the observed liver injury in ICI-treated patients. This model could be useful in the design of future studies aiming to identify the specific immune mechanism(s) at play in ILICI and improve immune checkpoint inhibitor cancer immunotherapy.
MeSH term(s)	Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/therapy ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunotherapy/adverse effects ; Neoplasms/pathology
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.907591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolomics-Guided Identification of a Distinctive Hepatocellular Carcinoma Signature.

Tambay, Vincent / Raymond, Valérie-Ann / Goossens, Corentine / Rousseau, Louise / Turcotte, Simon / Bilodeau, Marc

Cancers

2023 Volume 15, Issue 12

Abstract: Background: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related morbidity and mortality burdens globally. Given the fundamental metabolic activity of hepatocytes within the liver, hepatocarcinogenesis is bound to be characterized by ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related morbidity and mortality burdens globally. Given the fundamental metabolic activity of hepatocytes within the liver, hepatocarcinogenesis is bound to be characterized by alterations in metabolite profiles as a manifestation of metabolic reprogramming. Methods: HCC and adjacent non-tumoral liver specimens were obtained from patients after HCC resection. Global patterns in tissue metabolites were identified using non-targeted Results: Principal component analysis (PCA) within our Conclusions: Together,
Language	English
Publishing date	2023-06-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15123232
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Article ; Online: Enhanced Bioaccumulation and Transfer of Monomethylmercury through Periphytic Biofilms in Benthic Food Webs of a River Affected by Run-of-River Dams.

Leclerc, Maxime / Ponton, Dominic E / Bilodeau, François / Planas, Dolors / Amyot, Marc

Environmental science & technology

2023 Volume 57, Issue 49, Page(s) 20792–20801

Abstract: Run-of-river (ROR) power plants impound limited terrestrial areas compared to traditional hydropower plants with large reservoirs and are assumed to have reduced impacts on mercury cycling. We conducted a study on periphyton and benthic communities from ... ...

Abstract	Run-of-river (ROR) power plants impound limited terrestrial areas compared to traditional hydropower plants with large reservoirs and are assumed to have reduced impacts on mercury cycling. We conducted a study on periphyton and benthic communities from different habitats of the St. Maurice River (Québec, Canada) affected by two ROR power plants and their effect on the bioaccumulation and biomagnification of monomethylmercury (MMHg). Proportion of total mercury as MMHg reached maximum values about 2.9 times higher in flooded sites compared to unflooded sites. Impoundment by ROR would therefore provide favorable environments for the growth of periphyton, which can produce and accumulate MMHg. Periphyton MMHg concentrations significantly explained concentrations in some benthic macroinvertebrates, reflecting a local transfer. Through the analysis of δ
MeSH term(s)	Animals ; Food Chain ; Bioaccumulation ; Rivers ; Mercury/analysis ; Biofilms ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Fishes ; Methylmercury Compounds/analysis
Chemical Substances	Mercury (FXS1BY2PGL) ; Water Pollutants, Chemical ; Methylmercury Compounds
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c05585
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Article: MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype.

Tambay, Vincent / Raymond, Valérie-Ann / Bilodeau, Marc

Cancers

2021 Volume 13, Issue 17

Abstract: Metabolic reprogramming and deregulated cellular energetics are hallmarks of cancer. The aberrant ...

Abstract	Metabolic reprogramming and deregulated cellular energetics are hallmarks of cancer. The aberrant metabolism of cancer cells is thought to be the product of differential oncogene activation and tumor suppressor gene inactivation. MYC is one of the most important oncogenic drivers, its activation being reported in a variety of cancer types and sub-types, among which are the most prevalent and aggressive of all malignancies. This review aims to offer a comprehensive overview and highlight the importance of the c-Myc transcription factor on the regulation of metabolic pathways, in particular that of glutamine and glutaminolysis. Glutamine can be extensively metabolized into a variety of substrates and be integrated in a complex metabolic network inside the cell, from energy metabolism to nucleotide and non-essential amino acid synthesis. Together, understanding metabolic reprogramming and its underlying genetic makeup, such as MYC activation, allows for a better understanding of the cancer cell phenotype and thus of the potential vulnerabilities of cancers from a metabolic standpoint.
Language	English
Publishing date	2021-09-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13174484
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Article ; Online: Long-Term Follow-Up into Adulthood of Pediatric-Onset Primary Sclerosing Cholangitis and Autoimmune Sclerosing Cholangitis.

Hercun, Julian / Willems, Philippe / Bilodeau, Marc / Vincent, Catherine / Alvarez, Fernando

JPGN reports

2022 Volume 3, Issue 3, Page(s) e220

Abstract: Studies on pediatric patients with primary sclerosing cholangitis (PSC) have been limited by short follow-up and inconsistent classification of pediatric patients with autoimmune hepatitis-sclerosing cholangitis overlap (AIC). We conducted a ... ...

Abstract	Studies on pediatric patients with primary sclerosing cholangitis (PSC) have been limited by short follow-up and inconsistent classification of pediatric patients with autoimmune hepatitis-sclerosing cholangitis overlap (AIC). We conducted a retrospective study of patients diagnosed with AIC or PSC during childhood with extension of follow-up into adulthood. Methods: We reviewed records of patients followed for PSC or AIC between 1998 and 2019 at a pediatric referral center. Features at diagnosis, biochemical and liver-related outcomes (cholangitis, liver transplant, and cirrhosis) were compared. Results: Forty patients (27 PSC, 13 AIC) were followed for 92 months on average (standard deviation 79 months) with extension into adulthood in 52.5%; 70% had associated inflammatory bowel disease (IBD). The proportion of patients with significant fibrosis and abnormal baseline liver tests (serum bilirubin and transaminase levels) were similar in both groups. One year postdiagnosis, 55% (15/27) of PSC patients had normal liver tests versus only 15% (2/13) in the AIC group ( Conclusions: Pediatric patients with AIC and PSC presented at a similar fibrosis stage, however, with a more severe hepatitis in AIC. In this cohort, AIC was associated with more liver-related events, primarily driven by a higher rate of cirrhosis compared with PSC; transplant rates were similar.
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000220
Database	MEDical Literature Analysis and Retrieval System OnLINE

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