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Article: Applications and Perspectives of Artificial Intelligence, Machine Learning and "Dentronics" in Dentistry: A Literature Review.

Mayta-Tovalino, Frank / Munive-Degregori, Arnaldo / Luza, Silvia / Cárdenas-Mariño, Flor C / Guerrero, Maria Eugenia / Barja-Ore, John

Journal of International Society of Preventive & Community Dentistry

2023 Volume 13, Issue 1, Page(s) 1–8

Abstract: Objective: The aim of this study was to describe artificial intelligence, machine learning, and "Dentronics" applications and perspectives in dentistry.: Materials and methods: A literature review was carried out to identify the applications of ... ...

Abstract	Objective: The aim of this study was to describe artificial intelligence, machine learning, and "Dentronics" applications and perspectives in dentistry. Materials and methods: A literature review was carried out to identify the applications of artificial intelligence in the field of dentistry. A specialized search for information was carried out in three databases such as Scopus, PubMed, and Web of Science. Manuscripts published from January 1988 to November 2021 were analyzed. Articles were included without any restriction by language or country. Results: Scopus, PubMed, and Web of Science were found to have 215, 1023, and 98 registered manuscripts, respectively. Duplicates (191 manuscripts) were eliminated. Finally, 4 letters, 12 editorials, 5 books, 1 erratum, 54 conference papers, 3 conference reviews, and 222 reviews were excluded. Conclusions: Artificial intelligence has revolutionized prediction, diagnosis, and therapeutic management in modern dentistry. Finally, artificial intelligence is a potential complement to managing future data in this area.
Language	English
Publishing date	2023-02-27
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2734043-0
ISSN	2250-1002 ; 2231-0762
ISSN (online)	2250-1002
ISSN	2231-0762
DOI	10.4103/jispcd.JISPCD_35_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inclusion of fibroblasts and collagen fibrils in the cytologic grading of canine cutaneous mast cell tumors.

Paes, Paulo R O / Horta, Rodrigo S / Luza, Ludimila C / Pierezan, Felipe / Costa, Mariana P / Lavalle, Gleidice E

Veterinary clinical pathology

2022 Volume 51, Issue 3, Page(s) 339–348

Abstract: Background: Fibroblasts and/or collagen fibrils have not been included in previous cytologic grading schemes of canine mast cell tumors (MCTs), and their association with biological behavior is broadly debated.: Objectives: This study aimed to ... ...

Abstract	Background: Fibroblasts and/or collagen fibrils have not been included in previous cytologic grading schemes of canine mast cell tumors (MCTs), and their association with biological behavior is broadly debated. Objectives: This study aimed to evaluate the cytologic findings of canine MCT, with emphasis on the microenvironment, and propose a novel cytologic grading system correlated with mortality and histologic grade. Material and methods: Cytology smears of canine cutaneous MCTs were retrospectively reviewed and compared with their histopathologic counterparts using Cohen´s Kappa test. One-year survival rates were also compared with the cytologic and histopathologic variables using Pearson´s correlation test. Results: From 92 first-occurrence canine cutaneous MCTs, the five features most associated with mortality were selected for a new grading system. The five features were cytoplasmic granulation, fibroblast and/or collagen fibril concentrations, and the presence of mitotic figures, multinucleation, and karyomegaly. Among concordant histopathologic and cytologic cases (ie, the same grades using both systems), mortality rates were 2.6% (1/38) for low-grade and 71.4% (10/14) for high-grade cases (P < 0.001, chi-square). For false-negative and false-positive results, mortality rates were 33% (1/3) and 45% (5/11), respectively (P = 0.707). Conclusions: Unlike the Camus cytologic grading system, the present amendment excluded binucleation and included fibroblasts and/ or collagen fibrils, which in higher concentrations were associated with increased survival and a low histopathologic grade. Cytologic grading with the inclusion of fibroblast and collagen fibril concentrations correlated with survival, as did the Camus cytologic and Kiupel histopathologic grades; however, further studies are needed to confirm the prognostic value of this novel cytologic grading scheme.
MeSH term(s)	Animals ; Collagen ; Dog Diseases/diagnosis ; Dog Diseases/pathology ; Dogs ; Fibroblasts/pathology ; Mast Cells/pathology ; Mastocytoma, Skin/pathology ; Mastocytoma, Skin/veterinary ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Skin Neoplasms/veterinary ; Tumor Microenvironment
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2114702-4
ISSN	1939-165X ; 0275-6382
ISSN (online)	1939-165X
ISSN	0275-6382
DOI	10.1111/vcp.13098
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Article ; Online: Perturbed iron biology in the prefrontal cortex of people with schizophrenia.

Lotan, Amit / Luza, Sandra / Opazo, Carlos M / Ayton, Scott / Lane, Darius J R / Mancuso, Serafino / Pereira, Avril / Sundram, Suresh / Weickert, Cynthia Shannon / Bousman, Chad / Pantelis, Christos / Everall, Ian P / Bush, Ashley I

Molecular psychiatry

2023 Volume 28, Issue 5, Page(s) 2058–2070

Abstract: Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for schizophrenia do not target disruptions in late maturational reshaping of the prefrontal cortex. Iron, ... ...

Abstract	Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for schizophrenia do not target disruptions in late maturational reshaping of the prefrontal cortex. Iron, the most abundant transition metal in the brain, is essential to brain development and function, but in excess, it can impair major neurotransmission systems and lead to lipid peroxidation, neuroinflammation and accelerated aging. However, analysis of cortical iron biology in schizophrenia has not been reported in modern literature. Using a combination of inductively coupled plasma-mass spectrometry and western blots, we quantified iron and its major-storage protein, ferritin, in post-mortem prefrontal cortex specimens obtained from three independent, well-characterised brain tissue resources. Compared to matched controls (n = 85), among schizophrenia cases (n = 86) we found elevated tissue iron, unlikely to be confounded by demographic and lifestyle variables, by duration, dose and type of antipsychotic medications used or by copper and zinc levels. We further observed a loss of physiologic age-dependent iron accumulation among people with schizophrenia, in that the iron level among cases was already high in young adulthood. Ferritin, which stores iron in a redox-inactive form, was paradoxically decreased in individuals with the disorder. Such iron-ferritin uncoupling could alter free, chemically reactive, tissue iron in key reasoning and planning areas of the young-adult schizophrenia cortex. Using a prediction model based on iron and ferritin, our data provide a pathophysiologic link between perturbed cortical iron biology and schizophrenia and indicate that achievement of optimal cortical iron homeostasis could offer a new therapeutic target.
MeSH term(s)	Young Adult ; Humans ; Adult ; Schizophrenia ; Iron ; Prefrontal Cortex ; Ferritins ; Biology
Chemical Substances	Iron (E1UOL152H7) ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-01979-3
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Article ; Online: The ubiquitin proteasome system and schizophrenia.

Luza, Sandra / Opazo, Carlos M / Bousman, Chad A / Pantelis, Christos / Bush, Ashley I / Everall, Ian P

The lancet. Psychiatry

2020 Volume 7, Issue 6, Page(s) 528–537

Abstract: The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover ... ...

Abstract	The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover, ubiquitin-proteasome system signalling transduces epigenetic changes in neurons independently of protein degradation and, as such, dysfunction of components and substrates of this system has been linked to a broad range of brain conditions. Although links between ubiquitin-proteasome system dysfunction and neurodegenerative disorders have been known for some time, only recently have similar links emerged for neurodevelopmental disorders, such as schizophrenia. Here, we review the components of the ubiquitin-proteasome system that are reported to be dysregulated in schizophrenia, and discuss specific molecular changes to these components that might, in part, explain the complex causes of this mental disorder.
MeSH term(s)	Animals ; Humans ; Models, Animal ; Neurodegenerative Diseases/metabolism ; Neurodevelopmental Disorders/metabolism ; Neurogenesis/physiology ; Neurons/metabolism ; Presynaptic Terminals/physiology ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Endopeptidase Complex/physiology ; Schizophrenia/drug therapy ; Schizophrenia/metabolism ; Schizophrenia/physiopathology ; Synaptic Transmission/physiology ; Ubiquitin/metabolism ; Ubiquitin/physiology ; Ubiquitin-Protein Ligases/antagonists & inhibitors ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/therapeutic use
Chemical Substances	Ubiquitin ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2020-02-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2215-0374
ISSN (online)	2215-0374
DOI	10.1016/S2215-0366(19)30520-6
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Article ; Online: A Global Systematic Literature Review of Ecosystem Services in Reef Environments.

Giglio, Vinicius J / Aued, Anaide W / Cordeiro, Cesar A M M / Eggertsen, Linda / S Ferrari, Débora / Gonçalves, Leandra R / Hanazaki, Natalia / Luiz, Osmar J / Luza, André L / Mendes, Thiago C / Pinheiro, Hudson T / Segal, Bárbara / Waechter, Luiza S / Bender, Mariana G

Environmental management

2023 Volume 73, Issue 3, Page(s) 634–645

Abstract: Ecosystem services (ES) embrace contributions of nature to human livelihood and well-being. Reef environments provide a range of ES with direct and indirect contributions to people. However, the health of reef environments is declining globally due to ... ...

Abstract	Ecosystem services (ES) embrace contributions of nature to human livelihood and well-being. Reef environments provide a range of ES with direct and indirect contributions to people. However, the health of reef environments is declining globally due to local and large-scale threats, affecting ES delivery in different ways. Mapping scientific knowledge and identifying research gaps on reefs' ES is critical to guide their management and conservation. We conducted a systematic assessment of peer-reviewed articles published between 2007 and 2022 to build an overview of ES research on reef environments. We analyzed the geographical distribution, reef types, approaches used to assess ES, and the potential drivers of change in ES delivery reported across these studies. Based on 115 articles, our results revealed that coral and oyster reefs are the most studied reef ecosystems. Cultural ES (e.g., subcategories recreation and tourism) was the most studied ES in high-income countries, while regulating and maintenance ES (e.g., subcategory life cycle maintenance) prevailed in low and middle-income countries. Research efforts on reef ES are biased toward the Global North, mainly North America and Oceania. Studies predominantly used observational approaches to assess ES, with a marked increase in the number of studies using statistical modeling during 2021 and 2022. The scale of studies was mostly local and regional, and the studies addressed mainly one or two subcategories of reefs' ES. Overexploitation, reef degradation, and pollution were the most commonly cited drivers affecting the delivery of provisioning, regulating and maintenance, and cultural ES. With increasing threats to reef environments, the growing demand for assessing the contributions to humans provided by reefs will benefit the projections on how these ES will be impacted by anthropogenic pressures. The incorporation of multiple and synergistic ecosystem mechanisms is paramount to providing a comprehensive ES assessment, and improving the understanding of functions, services, and benefits.
MeSH term(s)	Animals ; Humans ; Ecosystem ; Coral Reefs ; Conservation of Natural Resources/methods ; Anthozoa/physiology ; Models, Statistical
Language	English
Publishing date	2023-11-25
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-023-01912-y
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Article: Management of Peri-implant Mucositis of Multiple Osseointegrated Implants Using a Modified Free Gingival Graft "Punch Technique" in the Total Edentulous Area: A Case Report.

Mayta-Tovalino, Frank / Rosas, José / Mauricio, Franco / Luza, Silvia / Alvitez-Temoche, Daniel / Mauricio-Vilchez, Cesar

Journal of International Society of Preventive & Community Dentistry

2021 Volume 11, Issue 1, Page(s) 109–113

Abstract: The purpose of this case report was to describe a technique to modify the free gingival graft by perforations within the graft to guarantee a horizontal increase in the keratinized mucosa in the anteroinferior sector of a total edentulous mandible after ... ...

Abstract	The purpose of this case report was to describe a technique to modify the free gingival graft by perforations within the graft to guarantee a horizontal increase in the keratinized mucosa in the anteroinferior sector of a total edentulous mandible after osseointegration of previously placed dental implants in a hybrid prosthesis protocol. A 71-year-old male underwent free modified gingival graft surgery with perforations at the level of each implant. At 3 months, the mucosa appeared to be healthy and keratinized, especially at a horizontal level around the implants previously diagnosed with mucositis, providing the patient with satisfactory results. Finally, the hybrid prosthesis was cleaned and polished due to the presentation of a hard plate at the level of the abutments. Within the limitations of this case report, further research is needed to evaluate the long-term efficacy of this modification to the free gingival graft.
Language	English
Publishing date	2021-01-30
Publishing country	India
Document type	Case Reports
ZDB-ID	2734043-0
ISSN	2250-1002 ; 2231-0762
ISSN (online)	2250-1002
ISSN	2231-0762
DOI	10.4103/jispcd.JISPCD_292_20
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Article ; Online: Going across taxa in functional ecology: Review and perspectives of an emerging field

Luza, André L. / Barneche, Diego R. / Cordeiro, Cesar A. M. M. / Dambros, Cristian S. / Ferreira, Carlos E. L. / Floeter, Sergio R. / Giglio, Vinicius J. / Luiz, Osmar J. / Mendes, Thiago C. / Picolotto, Vitor A. P. / Quimbayo, Juan P. / Silva, Fernanda C. / Waechter, Luiza / Longo, Guilherme O. / Bender, Mariana G.

Functional Ecology. 2023 Dec., v. 37, no. 12 p.3091-3110

2023

Abstract: The emergence of functional ecology has changed the focus of ecological research from investigating patterns of species diversity to understanding how species traits relate to specific ecological processes generating these patterns. Traits, ecological ... ...

Abstract	The emergence of functional ecology has changed the focus of ecological research from investigating patterns of species diversity to understanding how species traits relate to specific ecological processes generating these patterns. Traits, ecological patterns and processes can be shared and driven by species from distantly related taxonomic groups. Crossing the boundaries among distantly related taxonomic groups is still a challenge and a critical knowledge frontier in functional ecology. A cross‐taxa approach, merging trait data across distantly related taxonomic groups, could fill this gap. In this context, functionally analogous traits, that is traits that may have distinct ontogenetic origins yet represent similar processes, comprise an important recent advance in functional ecology. However, which taxa and traits (be them analogous or not) have been used in research with multiple taxa, and whether (and how) these data have been combined, still needs to be elucidated. We reviewed articles published in the last 75 years to investigate the use of traits in functional research involving multiple taxa. Our search returned 1006 articles, and a subset of 96 was filtered for data extraction. Studies covered a total of 134 taxa and 491 different traits; they were predominantly observational, and focussed on community ecology and ecosystem monitoring. Our review showed that current knowledge in this field relies on a limited number of response variables, particularly taxonomic diversity (e.g. species richness and abundance within functional groups). Also, the field relies on a limited number of taxa (e.g. plants, birds and mammals) and trait types (diet, size, habitat and dispersal). Two‐thirds of the articles (n = 72) used functionally analogous traits, and one‐third of them (n = 32) employed a cross‐taxa approach. We mapped the limitations of current research in functional ecology involving multiple taxa, presented ecological questions to a functional cross‐taxa research and showed directions to pushing the limits of this research field. Our review aimed to encourage researchers in the field of functional ecology to move beyond single taxa and traits, and to integrate more branches and dimensions of the Tree of Life in their research. Read the free Plain Language Summary for this article on the Journal blog.
Keywords	diet ; ecosystems ; habitats ; ontogeny ; species richness
Language	English
Dates of publication	2023-12
Size	p. 3091-3110.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	2020307-X
ISSN	1365-2435 ; 0269-8463
ISSN (online)	1365-2435
ISSN	0269-8463
DOI	10.1111/1365-2435.14442
Database	NAL-Catalogue (AGRICOLA)

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Article: Management of Postsurgical Complication in Multiple Implant-Infected Postextraction Sites in the Lower Arch.

Mayta-Tovalino, Frank / Rosas, José / Mauricio-Vilchez, Cesar / Luza, Silvia / Alvitez-Temoche, Daniel / Mauricio, Franco

International journal of dentistry

2020 Volume 2020, Page(s) 8869046

Abstract: Currently, dental implants are a very frequent therapeutic alternative for replacing missing teeth. However, they are not exempt from developing complications of infectious origin. Therefore, this case report describes a 67-year-old female patient ... ...

Abstract	Currently, dental implants are a very frequent therapeutic alternative for replacing missing teeth. However, they are not exempt from developing complications of infectious origin. Therefore, this case report describes a 67-year-old female patient presenting infectious complications caused by suture rupture. Surgery combined with therapeutic management with antibiotics was performed, allowing preservation of the osseointegration of the implants in the lower arch. Within the limitations of this study, it was shown that more research is needed to determine the success and survival of implants presenting complications due to infections during the osseointegration process.
Language	English
Publishing date	2020-09-29
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2546524-7
ISSN	1687-8736 ; 1687-8728
ISSN (online)	1687-8736
ISSN	1687-8728
DOI	10.1155/2020/8869046
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Article ; Online: Burden of Stroke and Population-Attributable Fractions of Risk Factors in Latin America and the Caribbean.

Pacheco-Barrios, Kevin / Giannoni-Luza, Stefano / Navarro-Flores, Alba / Rebello-Sanchez, Ingrid / Parente, Joao / Balbuena, Ana / de Melo, Paulo S / Otiniano-Sifuentes, Ricardo / Rivera-Torrejón, Oscar / Abanto, Carlos / Alva-Diaz, Carlos / Musolino, Patricia L / Fregni, Felipe

Journal of the American Heart Association

2022 Volume 11, Issue 21, Page(s) e027044

Abstract: Background Stroke burden characterization studies in low- and middle-income countries are scarce. We estimated the burden of stroke and its risk factors in Latin America and the Caribbean (LAC). Methods and Results We extracted GBD (Global Burden of ... ...

Abstract	Background Stroke burden characterization studies in low- and middle-income countries are scarce. We estimated the burden of stroke and its risk factors in Latin America and the Caribbean (LAC). Methods and Results We extracted GBD (Global Burden of Disease) study 2019 data on overall stroke and 3 subtypes (ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage) for 20 LAC countries. We estimated absolute and age-standardized rates of disability-adjusted life years, years of life lost, years lived with disability, and deaths. The population-attributable fractions of 17 risk factors were estimated. All analyses were performed at regional and national levels by stroke subtype, sex, and age subgroups. In 2019, the LAC region had the fourth largest stroke burden worldwide (6.8 million disability-adjusted life years), predominantly attributable to premature deaths (89.5% of disability-adjusted life years). Intracerebral hemorrhage was the primary cause of the overall stroke burden (42% of disability-adjusted life years), but ischemic stroke was the leading cause of disability (69% of total years lived with disability). Haiti and Honduras had the highest age-standardized rates. Older adults and men had the largest burdens, although women had the highest rate of disability. Socioeconomic development level did not influence the burden. The major risk factor clusters were metabolic (high systolic blood pressure [population-attributable fraction=53%] and high body mass index [population-attributable fraction=37%]), which were more influential in hemorrhagic events, women, and older adults. Household air pollution was an important risk factor in low-income countries in LAC. Conclusions The stroke burden and stroke-related mortality in LAC are higher than the worldwide averages. However, stroke is a highly preventable disease in this region. Up to 90% of the burden could be reduced by targeting 2 modifiable factors: blood pressure and body mass index. Further research and implementation of primary and secondary prevention interventions are needed, as well as integrated national stroke care programs for acute, subacute, and rehabilitation management in LAC.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Global Burden of Disease ; Quality-Adjusted Life Years ; Latin America/epidemiology ; Global Health ; Risk Factors ; Stroke/epidemiology ; Cerebral Hemorrhage
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.027044
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Article ; Online: Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial.

Gunduz, Muhammed Enes / Pacheco-Barrios, Kevin / Bonin Pinto, Camila / Duarte, Dante / Vélez, Faddi Ghassan Saleh / Gianlorenco, Anna Carolyna Lepesteur / Teixeira, Paulo Eduardo Portes / Giannoni-Luza, Stefano / Crandell, David / Battistella, Linamara Rizzo / Simis, Marcel / Fregni, Felipe

Neurorehabilitation and neural repair

2021 Volume 35, Issue 8, Page(s) 704–716

Abstract: Phantom limb pain (PLP) is a frequent complication in amputees, which is often refractory to treatments. We aim to assess in a factorial trial the effects of transcranial direct current stimulation (tDCS) and mirror therapy (MT) in patients with ... ...

Abstract	Phantom limb pain (PLP) is a frequent complication in amputees, which is often refractory to treatments. We aim to assess in a factorial trial the effects of transcranial direct current stimulation (tDCS) and mirror therapy (MT) in patients with traumatic lower limb amputation; and whether the motor cortex plasticity changes drive these results. In this large randomized, blinded, 2-site, sham-controlled, 2 × 2 factorial trial, 112 participants with traumatic lower limb amputation were randomized into treatment groups. The interventions were active or covered MT for 4 weeks (20 sessions, 15 minutes each) combined with 2 weeks of either active or sham tDCS (10 sessions, 20 minutes each) applied to the contralateral primary motor cortex. The primary outcome was PLP changes on the visual analogue scale at the end of interventions (4 weeks). Motor cortex excitability and cortical mapping were assessed by transcranial magnetic stimulation (TMS). We found no interaction between tDCS and MT groups (
MeSH term(s)	Adult ; Combined Modality Therapy ; Double-Blind Method ; Evoked Potentials, Motor/physiology ; Female ; Humans ; Male ; Middle Aged ; Mirror Movement Therapy/methods ; Motor Cortex/physiopathology ; Phantom Limb/physiopathology ; Phantom Limb/therapy ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1491637-x
ISSN	1552-6844 ; 1545-9683 ; 0888-4390
ISSN (online)	1552-6844
ISSN	1545-9683 ; 0888-4390
DOI	10.1177/15459683211017509
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