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  1. Book: Paul Lauterbur and the invention of MRI

    Dawson, M. Joan

    2013  

    Author's details M. Joan Dawson
    MeSH term(s) Magnetic Resonance Imaging/history ; Magnetic Resonance Spectroscopy/instrumentation ; Inventors ; Nobel Prize
    Language English
    Size xv, 273 p. :, ill., ports.
    Publisher MIT Press
    Publishing place Cambridge, Mass
    Document type Book
    ISBN 9780262019217 ; 0262019213
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book ; Online: Routledge Companion to Narrative Theory

    Dawson, Paul / Mäkelä, Maria

    2023  

    Keywords Literature: history & criticism ; Narrative Theory, Literary Criticism
    Language English
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030382586
    ISBN 9781003100157 ; 1003100155
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Effect of Freezing on the Shelf Life of Salmon

    Dawson, Paul

    International journal of food science, 2018:1686121

    2018  

    Abstract: Food shelf-life extension is important not only to food manufacturers, but also to home refrigeration/freezing appliance companies, whose products affect food quality and food waste. While freezing and refrigerating both extend the shelf life of foods, ... ...

    Abstract Food shelf-life extension is important not only to food manufacturers, but also to home refrigeration/freezing appliance companies, whose products affect food quality and food waste. While freezing and refrigerating both extend the shelf life of foods, food quality deterioration continues regardless of the preservation method. This review article discusses the global fish market, the composition of fish meat, and the effects of freezing and thawing on salmon quality.
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Article: Modified turbidometric microassay for the measurement of sulfate in plasma and urine.

    Vijayakumar, Prasidhee / McWhinney, Avis / Eiby, Yvonne A / Dawson, Paul A

    MethodsX

    2024  Volume 12, Page(s) 102712

    Abstract: Sulfate is the fourth most abundant anion in circulation. Despite being an essential nutrient for healthy growth and development, sulfate is not routinely measured in clinical settings. In research settings, animal studies have shown that hyposulfatemia ... ...

    Abstract Sulfate is the fourth most abundant anion in circulation. Despite being an essential nutrient for healthy growth and development, sulfate is not routinely measured in clinical settings. In research settings, animal studies have shown that hyposulfatemia and hypersulfaturia are associated with adverse developmental outcomes. Those findings have increased interest in measuring plasma and urine sulfate levels. In this study, we describe a modified assay to measure sulfate in low volumes of plasma and urine. •A streamlined microassay to measure sulfate levels using a microtiter plate format was developed.•To determine the robustness of the assay, this method assessed reagent stability and concentrations, as well as absorbance at different wavelengths and following a range of incubation times.•The optimized microassay was used to measure sulfate level in pig plasma and urine samples, which were compared to a validated ion chromatography method.
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2024.102712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Substance use during hospitalisation requiring an urgent clinical response: an opportunity for intervention.

    Nash, Emily / Dawson, Andrew H / Haber, Paul / Gribble, Robert / Volovets, Anastasia

    Internal medicine journal

    2024  

    Abstract: Background: There are few reports on drug use in patients while hospitalised and none regarding management or clinical outcomes.: Aims: To describe cases of drug use by inpatients requiring an urgent clinical response.: Methods: We retrospectively ...

    Abstract Background: There are few reports on drug use in patients while hospitalised and none regarding management or clinical outcomes.
    Aims: To describe cases of drug use by inpatients requiring an urgent clinical response.
    Methods: We retrospectively reviewed cases at a teaching hospital in Sydney, Australia, from February 2019 to March 2021.
    Results: Thirty cases were identified, with no deaths. Two patient groups were identified: (i) substance use disorders, using illicit drugs and (ii) self-harm history, using prescribed or over-the-counter drugs. Management involved cardiac monitoring (40%), intensive care (30%), charcoal (20%), antidotes (20%) and intubation (13%). Discharge was planned in 22 of 30 patients, against medical advice in four and directed by medical staff in four.
    Conclusions: Inpatient drug use requiring an urgent clinical response was infrequently recognised but presents a risk of harm to patients and staff and increases service utilisation and costs. Both harm reduction and systematic approaches guided by institutional policy are recommended. Using these events as reachable moments to address driving factors may modify patients' risk from future events.
    Language English
    Publishing date 2024-01-23
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.16336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling.

    Dawson, Paul A

    Hepatology (Baltimore, Md.)

    2017  Volume 66, Issue 5, Page(s) 1384–1386

    MeSH term(s) Animals ; Bile Acids and Salts ; Biological Transport ; Humans ; Liver ; Mice ; Signal Transduction
    Chemical Substances Bile Acids and Salts
    Language English
    Publishing date 2017-09-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sulfation Pathways During Neurodevelopment.

    Clarke, Taylor / Fernandez, Francesca E / Dawson, Paul A

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 866196

    Abstract: Sulfate is an important nutrient that modulates a diverse range of molecular and cellular functions in mammalian physiology. Over the past 2 decades, animal studies have linked numerous sulfate maintenance genes with neurological phenotypes, including ... ...

    Abstract Sulfate is an important nutrient that modulates a diverse range of molecular and cellular functions in mammalian physiology. Over the past 2 decades, animal studies have linked numerous sulfate maintenance genes with neurological phenotypes, including seizures, impaired neurodevelopment, and behavioral abnormalities. Despite sulfation pathways being highly conserved between humans and animals, less than one third of all known sulfate maintenance genes are clinically reportable. In this review, we curated the temporal and spatial expression of 91 sulfate maintenance genes in human fetal brain from 4 to 17 weeks post conception using the online Human Developmental Biology Resource Expression. In addition, we performed a systematic search of PubMed and Embase, identifying those sulfate maintenance genes linked to atypical neurological phenotypes in humans and animals. Those findings, together with a search of the Online Mendelian Inheritance in Man database, identified a total of 18 candidate neurological dysfunction genes that are not yet considered in clinical settings. Collectively, this article provides an overview of sulfate biology genes to inform future investigations of perturbed sulfate homeostasis associated with neurological conditions.
    Language English
    Publishing date 2022-04-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.866196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effects of DNA extraction methods on the real time PCR quantification of Campylobacter jejuni, Campylobacter coli, and Campylobacter lari in chicken feces and ceca contents.

    Dawson, Paul / Buyukyavuz, Ahmet / Ionita, Claudia / Northcutt, Julie

    Poultry science

    2022  Volume 102, Issue 2, Page(s) 102369

    Abstract: Polymerase chain reaction (PCR) method was coupled with a DNA extraction to enumerate Campylobacter spp. from poultry gastrointestinal tract samples. Three experiments were conducted that included: 1) Development of a DNA standard curve related to ... ...

    Abstract Polymerase chain reaction (PCR) method was coupled with a DNA extraction to enumerate Campylobacter spp. from poultry gastrointestinal tract samples. Three experiments were conducted that included: 1) Development of a DNA standard curve related to bacterial DNA primers; 2) Design of a cell/genomic DNA extraction protocol to isolate Campylobacter spp. DNA from complex samples such as poultry feces; and 3) Comparison of PCR quantification to standard plate count methodology. The standard curve using primers for Campylobacter spp. was created for DNA extracted from environmental isolates with a linear range (R
    MeSH term(s) Animals ; Swine ; Campylobacter jejuni/genetics ; Campylobacter coli/genetics ; Campylobacter lari/genetics ; Chickens/genetics ; Real-Time Polymerase Chain Reaction/veterinary ; DNA, Bacterial/genetics ; DNA, Bacterial/analysis ; Campylobacter ; Campylobacter Infections/veterinary ; Campylobacter Infections/microbiology ; Poultry/genetics ; DNA Primers/genetics ; Feces/chemistry ; Swine Diseases
    Chemical Substances DNA, Bacterial ; DNA Primers
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2022.102369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Serum sulfate level and Slc13a1 mRNA expression remain unaltered in a mouse model of moderate vitamin D deficiency.

    Atcheson, Ranita J / Burne, Thomas H J / Dawson, Paul A

    Molecular and cellular biochemistry

    2022  Volume 478, Issue 8, Page(s) 1771–1777

    Abstract: Sulfate is essential for healthy foetal growth and neurodevelopment. The SLC13A1 sulfate transporter is primarily expressed in the kidney where it mediates sulfate reabsorption and maintains circulating sulfate levels. To meet foetal demands, maternal ... ...

    Abstract Sulfate is essential for healthy foetal growth and neurodevelopment. The SLC13A1 sulfate transporter is primarily expressed in the kidney where it mediates sulfate reabsorption and maintains circulating sulfate levels. To meet foetal demands, maternal sulfate levels increase by twofold in pregnancy via upregulated SLC13A1 expression. Previous studies found hyposulfataemia and reduced renal Slc13a1 mRNA expression in rodent models with either severe vitamin D deficiency or perturbed vitamin D signalling. Here we investigated a mouse model of moderate vitamin D deficiency. However, serum sulfate level and renal Slc13a1 mRNA expression was not decreased by a moderate reduction in circulating vitamin D level. We confirmed that the mouse Slc13a1 5'-flanking region was upregulated by 1,25(OH)
    MeSH term(s) Pregnancy ; Female ; Child ; Humans ; Mice ; Animals ; Vitamin D ; Gene Expression Regulation ; Vitamin D Deficiency/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sulfates/metabolism
    Chemical Substances Vitamin D (1406-16-2) ; RNA, Messenger ; Sulfates
    Language English
    Publishing date 2022-12-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-022-04634-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Roles of Ileal ASBT and OSTα-OSTβ in Regulating Bile Acid Signaling.

    Dawson, Paul A

    Digestive diseases (Basel, Switzerland)

    2017  Volume 35, Issue 3, Page(s) 261–266

    Abstract: Background: In addition to their classical role as detergents, bile acids function as signaling molecules to regulate gastrointestinal physiology, carbohydrate and lipid metabolism, and energy expenditure. The pharmacodynamic potential of bile acids is ... ...

    Abstract Background: In addition to their classical role as detergents, bile acids function as signaling molecules to regulate gastrointestinal physiology, carbohydrate and lipid metabolism, and energy expenditure. The pharmacodynamic potential of bile acids is dependent in part on the tight pharmacokinetic control of their concentration and metabolism, properties governed by their hepatic synthesis, enterohepatic cycling, and biotransformation via host and gut microbiota-catalyzed pathways. Key Messages: By altering the normal cycling and compartmentalization of bile acids, changes in hepatobiliary or intestinal transport can affect signaling and lead to the retention of cytotoxic hydrophobic bile acids and cell injury. This review discusses advances in our understanding of the intestinal transporters that maintain the enterohepatic cycling of bile acids, signaling via bile acid-activated nuclear and G protein receptors, and mechanisms of bile acid-induced cell injury.
    Conclusions: Dysregulated expression of the Asbt and Ostα-Ostβ alters bile acid signaling via the gut-liver farnesoid X receptor-fibroblast growth factor 15/19 axis and may contribute to other bile acid-regulated metabolic and cell injury pathways.
    MeSH term(s) Animals ; Bile Acids and Salts/metabolism ; Cytoprotection ; Enterohepatic Circulation ; Feedback, Physiological ; Humans ; Ileum/metabolism ; Membrane Transport Proteins/metabolism ; Signal Transduction
    Chemical Substances Bile Acids and Salts ; Membrane Transport Proteins
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000450987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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