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Article ; Online: Liver histopathology in COVID 19 infection is suggestive of vascular alteration

sonzogni, aurelio

medRxiv

Abstract: COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection very few information are available about liver involvement in COVID-19 infection, ...

Abstract	COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection very few information are available about liver involvement in COVID-19 infection, that could possibly evocate a systemic disease targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease. Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease or signs of liver failure before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation, partial or complete recent luminal thrombosis of portal and sinusoidal vessels, fibrosis of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection confirm the clinical impression that liver failure is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood vessels.
Keywords	covid19
Language	English
Publishing date	2020-05-11
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.05.06.20092718
Database	COVID19

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Article ; Online: Treatment with an ileal bile acid transporter inhibitor in patients with TJP2 deficiency.

Di Giorgio, Angelo / Sciveres, Marco / Fuoti, Maurizio / Sonzogni, Aurelio / Mandato, Claudia / D'Antiga, Lorenzo

Clinics and research in hepatology and gastroenterology

2023 Volume 47, Issue 8, Page(s) 102185

Abstract: There are no published data on the use of odevixibat, a selective ileal bile acid transporter (IBAT) inhibitor, in children with tight junction protein 2 (TJP2) deficiency (also named as PFIC-4). We describe a case series of five children treated with ... ...

Abstract	There are no published data on the use of odevixibat, a selective ileal bile acid transporter (IBAT) inhibitor, in children with tight junction protein 2 (TJP2) deficiency (also named as PFIC-4). We describe a case series of five children treated with odevixibat. After treatment, serum bile acids (sBA) decreased compared to baseline [mean value: 244 (±125), vs 38 (±34) µmol/L; p = 0.007]; reduction in sBA was >70% from baseline (or <70 µmol/L) in all. Improvements in pruritus were reported in all patients. The drug was well tolerated. IBAT inhibitors should be considered a valuable treatment option in patients with TJP2 deficiency.
MeSH term(s)	Child ; Humans ; Carrier Proteins ; Membrane Glycoproteins ; Benzodiazepines ; Cholestasis, Intrahepatic ; Bile Acids and Salts ; Zonula Occludens-2 Protein/metabolism
Chemical Substances	bile acid binding proteins ; odevixibat (2W150K0UUC) ; Carrier Proteins ; Membrane Glycoproteins ; Benzodiazepines (12794-10-4) ; Bile Acids and Salts ; TJP2 protein, human ; Zonula Occludens-2 Protein
Language	English
Publishing date	2023-07-26
Publishing country	France
Document type	Case Reports
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2023.102185
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Article ; Online: Acute Neurological Involvement after Donor Lymphocyte Infusion for Post-Transplant Viral Infection: The Same Pattern of Novel Cancer Immunotherapy-Related CNS Toxicity?

Marcuzzi, Annalisa / Rimondi, Erika / Melloni, Elisabetta / Zennaro, Floriana / Sonzogni, Aurelio / Leo, Sara / Maximova, Natalia

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Early post-transplant is the critical phase for the success of hematopoietic stem cell transplantation (HSCT). New viral infections and the reactivations associated with complete ablation of the recipient's T-cell immunity and inefficient reconstitution ... ...

Abstract	Early post-transplant is the critical phase for the success of hematopoietic stem cell transplantation (HSCT). New viral infections and the reactivations associated with complete ablation of the recipient's T-cell immunity and inefficient reconstitution of the donor-derived system represent the main risks of HSCT. To date, the pharmacological treatments for post-HSCT viral infection-related complications have many limitations. Adoptive cell therapy (ACT) represents a new pharmacological strategy, allowing us to reconstitute the immune response to infectious agents in the post-HSC period. To demonstrate the potential advantage of this novel immunotherapy strategy, we report three cases of pediatric patients and the respective central nervous system complications after donor lymphocyte infusion.
MeSH term(s)	Cell- and Tissue-Based Therapy/adverse effects ; Child ; Communicable Diseases/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immunotherapy/adverse effects ; Immunotherapy, Adoptive/adverse effects ; Lymphocytes ; Neoplasms/etiology ; Virus Diseases/etiology ; Virus Diseases/therapy
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073553
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Article: Use of oral vancomycin in children with autoimmune liver disease: A single centre experience.

Di Giorgio, Angelo / Tulone, Anna / Nicastro, Emanuele / Norsa, Lorenzo / Sonzogni, Aurelio / D'Antiga, Lorenzo

World journal of hepatology

2022 Volume 13, Issue 12, Page(s) 2113–2127

Abstract: Background: Previous reports showed some beneficial effect of oral vancomycin treatment (OVT) in children with primary sclerosing cholangitis; conversely, the experience in patients with other autoimmune liver diseases (AILD), including autoimmune ... ...

Abstract	Background: Previous reports showed some beneficial effect of oral vancomycin treatment (OVT) in children with primary sclerosing cholangitis; conversely, the experience in patients with other autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (ASC), is scant. Aim: To assess the response to immunosuppressive treatment (IS) and to OVT in children diagnosed with AILD. Methods: Retrospective study of children diagnosed with AIH (normal biliary tree at cholangiography) and ASC (abnormal biliary tree at cholangiography) in the last 10 years. All underwent standard immunosuppressive therapy (IS), but non-responders received also OVT. Biochemical remission [normal aspartate aminotransferase (AST)] and immunological remission (normal IgG and negative autoantibodies) rates and Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index were assessed and compared during the follow up. Results: 75 children were included [69% female, median age 10.5 years (5.6-13.4 years), AIH = 54, ASC= 21]. Sixty-three patients (84%, AIH = 52, ASC = 11) were treated with standard IS and 61 achieved biochemical remission, whereas 12 not responding to IS [16%, F = 75%, median age 13.5 years, (12.2-15.7), 10 with ASC] required OVT and 8 achieved biochemical remission. Overall OVT increased the biochemical remission rate of the whole group of AILD patients from 81% (61/75) to 92% (69/75). Median values of AST, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) decreased significantly after OVT start ( Conclusion: Children with AIH and ASC respond well to IS treatment. OVT may represent a valuable treatment option to achieve biochemical remission in patients not responding to standard IS. These promising preliminary results suggest that a prospective study is indicated to define the efficacy of OVT in AILD.
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v13.i12.2113
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Article ; Online: Disseminated Gastrointestinal and Hepatosplenic Epstein-Barr Virus-related Smooth Muscle Tumors in a Young Heart-transplant Recipient.

Bramuzzo, Matteo / Sonzogni, Aurelio / Gregori, Massimo / Maximova, Natalia

Journal of pediatric gastroenterology and nutrition

2019 Volume 69, Issue 6, Page(s) e158

MeSH term(s)	Adolescent ; Epstein-Barr Virus Infections/complications ; Fatal Outcome ; Female ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/etiology ; Gastrointestinal Neoplasms/pathology ; Humans ; Immunosuppression/adverse effects ; Liver Neoplasms/diagnosis ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Smooth Muscle Tumor/diagnosis ; Smooth Muscle Tumor/etiology ; Smooth Muscle Tumor/pathology ; Transplant Recipients
Language	English
Publishing date	2019-11-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000002315
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Article ; Online: Acute Neurological Involvement after Donor Lymphocyte Infusion for Post-Transplant Viral Infection

Annalisa Marcuzzi / Erika Rimondi / Elisabetta Melloni / Floriana Zennaro / Aurelio Sonzogni / Sara Leo / Natalia Maximova

International Journal of Molecular Sciences, Vol 23, Iss 3553, p

The Same Pattern of Novel Cancer Immunotherapy-Related CNS Toxicity?

2022 Volume 3553

Abstract: Early post-transplant is the critical phase for the success of hematopoietic stem cell transplantation (HSCT). New viral infections and the reactivations associated with complete ablation of the recipient’s T-cell immunity and inefficient reconstitution ... ...

Abstract	Early post-transplant is the critical phase for the success of hematopoietic stem cell transplantation (HSCT). New viral infections and the reactivations associated with complete ablation of the recipient’s T-cell immunity and inefficient reconstitution of the donor-derived system represent the main risks of HSCT. To date, the pharmacological treatments for post-HSCT viral infection-related complications have many limitations. Adoptive cell therapy (ACT) represents a new pharmacological strategy, allowing us to reconstitute the immune response to infectious agents in the post-HSC period. To demonstrate the potential advantage of this novel immunotherapy strategy, we report three cases of pediatric patients and the respective central nervous system complications after donor lymphocyte infusion.
Keywords	stem cell ; transplantation ; immunotherapy ; viral infection ; cytokines ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1

Fabris, Luca / Milani, Chiara / Fiorotto, Romina / Mariotti, Valeria / Kaffe, Eleanna / Seller, Barbara / Sonzogni, Aurelio / Strazzabosco, Mario / Cadamuro, Massimiliano

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2022 Volume 36, Issue 6, Page(s) e22364

Abstract: Congenital hepatic fibrosis (CHF), a genetic cholangiopathy characterized by fibropolycystic changes in the biliary tree, is caused by mutations in the PKHD1 gene, leading to defective fibrocystin (FPC), changes in planar cell polarity (PCP) and ... ...

Abstract	Congenital hepatic fibrosis (CHF), a genetic cholangiopathy characterized by fibropolycystic changes in the biliary tree, is caused by mutations in the PKHD1 gene, leading to defective fibrocystin (FPC), changes in planar cell polarity (PCP) and increased β-catenin-dependent chemokine secretion. In this study, we aimed at understanding the role of Scribble (a protein involved in PCP), Yes-associated protein (YAP), and β-catenin in the regulation of the fibroinflammatory phenotype of FPC-defective cholangiocytes. Immunohistochemistry showed that compared with wild type (WT) mice, in FPC-defective (Pkhd1
MeSH term(s)	Animals ; Cysts ; Disease Models, Animal ; Genetic Diseases, Inborn ; Intracellular Signaling Peptides and Proteins ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Mice ; RNA, Small Interfering ; Receptors, Cell Surface ; Transcription Factors/genetics ; Transcription Factors/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Pkhd1 protein, mouse ; RNA, Small Interfering ; Receptors, Cell Surface ; Transcription Factors ; beta Catenin ; scribble protein, mouse
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202101924R
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Article ; Online: Poor Outcome of Intestinal Ischemic Manifestations of COVID-19.

Norsa, Lorenzo / Bonaffini, Pietro Andrea / Indriolo, Amedeo / Valle, Clarissa / Sonzogni, Aurelio / Sironi, Sandro

Gastroenterology

2020 Volume 159, Issue 4, Page(s) 1595–1597.e1

MeSH term(s)	Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Humans ; Intestines/blood supply ; Ischemia/blood ; Ischemia/virology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Thromboembolism/virology ; Thrombophilia/blood ; Thrombophilia/virology
Chemical Substances	Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Keywords	covid19
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2020.06.041
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Article ; Online: Microthrombi and ST-Segment-Elevation Myocardial Infarction in COVID-19.

Guagliumi, Giulio / Sonzogni, Aurelio / Pescetelli, Irene / Pellegrini, Dario / Finn, Aloke V

Circulation

2020 Volume 142, Issue 8, Page(s) 804–809

MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Betacoronavirus/isolation & purification ; C-Reactive Protein/analysis ; COVID-19 ; Cobicistat/therapeutic use ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Darunavir/therapeutic use ; Electrocardiography ; Female ; Humans ; Hypokinesia/diagnosis ; Hypokinesia/etiology ; Hypotension/complications ; Hypotension/pathology ; International Normalized Ratio ; Myocardium/pathology ; Nasopharynx/virology ; Pandemics ; Platelet Count ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/diagnosis ; Thrombosis/complications ; Thrombosis/diagnosis ; Troponin I/analysis ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/diagnosis
Chemical Substances	Antiviral Agents ; Troponin I ; C-Reactive Protein (9007-41-4) ; Cobicistat (LW2E03M5PG) ; Darunavir (YO603Y8113)
Keywords	covid19
Language	English
Publishing date	2020-07-17
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.120.049294
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Article ; Online: Intestinal ischemia in the COVID-19 era.

Norsa, Lorenzo / Valle, Clarissa / Morotti, Denise / Bonaffini, Pietro Andrea / Indriolo, Amedeo / Sonzogni, Aurelio

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2020 Volume 52, Issue 10, Page(s) 1090–1091

MeSH term(s)	Betacoronavirus/genetics ; Betacoronavirus/metabolism ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/pathology ; Endarteritis/etiology ; Endarteritis/pathology ; Fatal Outcome ; Humans ; Infarction/diagnosis ; Infarction/etiology ; Infarction/pathology ; Infarction/surgery ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/virology ; Intestine, Small/blood supply ; Intestine, Small/metabolism ; Intestine, Small/surgery ; Male ; Mesenteric Ischemia/diagnosis ; Mesenteric Ischemia/etiology ; Mesenteric Ischemia/pathology ; Mesenteric Ischemia/surgery ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/pathology ; RNA, Messenger/metabolism ; SARS-CoV-2 ; Shock, Septic/etiology ; Spike Glycoprotein, Coronavirus/genetics ; Thrombosis/etiology ; Thrombosis/pathology ; Tomography, X-Ray Computed
Chemical Substances	RNA, Messenger ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2020.05.030
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