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Article ; Online: Inotropes administration in patients with acute infective endocarditis and indication for urgent cardiac surgery.

Bertolino, Lorenzo / Marrazzo, Tommaso / Boccia, Filomena / Zampino, Rosa / Durante-Mangoni, Emanuele

2023 Volume 116, Page(s) 146–148

Language	English
Publishing date	2023-07-18
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2023.07.011
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Article ; Online: Guillain-Barré syndrome as clinical presentation of a recently acquired hepatitis C.

Boccia, Filomena / Florio, Letizia Lucia / Durante-Mangoni, Emanuele / Zampino, Rosa

Journal of neurovirology

2023 Volume 29, Issue 5, Page(s) 640–643

Abstract: About 40% of the Guillain-Barré syndrome (GBS) cases are associated with prodromal infections; occasionally, it has been associated to chronic hepatitis C or its reactivation. A 38-year-old man came to our attention after transaminase elevation occurred ... ...

Abstract	About 40% of the Guillain-Barré syndrome (GBS) cases are associated with prodromal infections; occasionally, it has been associated to chronic hepatitis C or its reactivation. A 38-year-old man came to our attention after transaminase elevation occurred during recovery from GBS. All the possible causes of acute hepatitis were excluded except for the positivity of HCVRNA, and a diagnosis of new onset hepatitis C was made. Recalling patient history, we observed that (i) anti-HCV antibodies were negative and liver enzymes were normal 7 weeks before GBS onset; (ii) in the early stages of ICU admission, liver enzymes started to rise, but the elevation remained mild under steroid treatment; (iii) serum aminotransferase peak occurred 11 weeks after GBS onset; and (iv) HCV RNA was already significantly high when anti-HCV antibodies became positive, consistent with an acute hepatitis. Furthermore, anti-HCV seroconversion was likely delayed or blurred by steroids and immunoglobulin infusions. The interval of time between GBS onset and transaminase elevation compared with the patient clinical history allows us to establish a cause-effect relationship between the two diseases. All patients with GBS should be tested for hepatitis C, or its reactivation if already present, and followed up for an early diagnosis and treatment.
MeSH term(s)	Male ; Humans ; Adult ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/drug therapy ; Guillain-Barre Syndrome/etiology ; Hepatitis C Antibodies/therapeutic use ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Acute Disease ; Hepacivirus/genetics ; Hepatitis C, Chronic/complications ; Transaminases/therapeutic use
Chemical Substances	Hepatitis C Antibodies ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283265-0
ISSN	1538-2443 ; 1355-0284
ISSN (online)	1538-2443
ISSN	1355-0284
DOI	10.1007/s13365-023-01167-7
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Zs.A 4426: Show issues

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Article ; Online: Infective endocarditis involving MitraClip

Bertolino, Lorenzo / Ramadan, Mohammad Said / Zampino, Rosa / Durante-Mangoni, Emanuele

Infection

2023 Volume 51, Issue 5, Page(s) 1241–1248

Abstract: Purpose: Progress of interventional cardiology has boosted the use of newer cardiac devices. These devices are perceived to be less prone to infections compared to traditional surgical prostheses, but little data are currently available. In this ... ...

Abstract	Purpose: Progress of interventional cardiology has boosted the use of newer cardiac devices. These devices are perceived to be less prone to infections compared to traditional surgical prostheses, but little data are currently available. In this systematic review (SR), we summarize current literature regarding the clinical characteristics, management, and outcomes of patients with MitraClip-related infective endocarditis (IE). Methods: We conducted a SR of PubMed, Google Scholar, Embase, and Scopus between January 2003 and March 2022. MitraClip-related IE was defined according to 2015 ESC criteria whereas MitraClip involvement as vegetation on the device or on the mitral valve. Risk of bias was assessed through standardized checklist and potential bias of underestimation cannot be excluded. Data regarding clinical presentation, echocardiography, management, and outcome were collected. Results: Twenty-six cases of MitraClip-related IE were retrieved. The median age of patients was 76 [61-83] years with a median EuroScore of 41%. Fever was present in 65.8% of patients followed by signs and symptoms of heart failure (42.3%). IE occurred early in 20 (76.9%) cases with a median time between MitraClip implantation and IE symptom onset of 5 [2-16] months. Staphylococcus aureus was the major causative microorganism (46%). Surgical mitral valve replacement was needed in 50% of patients. A conservative medical approach was considered in the remainder. The overall in-hospital mortality rate was 50% (surgical group: 38.4%; medical group: 58.3%; p = 0.433). Conclusion: Our results suggest that MitraClip-related IE affects elderly, comorbid patients, is mostly due to Staphylococcus aureus, and has a poor prognosis irrespective of the therapeutic approach. Clinicians must be aware of the features of this new entity among cardiovascular infections.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Aged, 80 and over ; Heart Valve Prosthesis/adverse effects ; Treatment Outcome ; Endocarditis, Bacterial ; Endocarditis/diagnosis ; Endocarditis/etiology ; Mitral Valve ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology
Language	English
Publishing date	2023-06-29
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-023-02067-y
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Risk of long Covid in children infected with Omicron or pre-Omicron SARS-CoV-2 variants.

Buonsenso, Danilo / Morello, Rosa / Mariani, Francesco / De Rose, Cristina / Mastrantoni, Luca / Zampino, Giuseppe / Valentini, Piero

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 6, Page(s) 1284–1286

MeSH term(s)	Child ; Humans ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; COVID-19
Language	English
Publishing date	2023-03-30
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16764
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Article: Case report: Post-COVID new-onset neurocognitive decline with bilateral mesial-temporal hypometabolism in two previously healthy sisters.

Cocciolillo, Fabrizio / Chieffo, Daniela Pia Rosaria / Giordano, Alessandro / Arcangeli, Valentina / Lazzareschi, Ilaria / Morello, Rosa / Zampino, Giuseppe / Valentini, Piero / Buonsenso, Danilo

Frontiers in pediatrics

2023 Volume 11, Page(s) 1165072

Abstract: Background: Long coronavirus disease (COVID) is increasingly recognized in adults and children; however, it is still poorly characterized from a clinical and diagnostic perspective, particularly in the younger populations.: Case presentation: We ... ...

Abstract	Background: Long coronavirus disease (COVID) is increasingly recognized in adults and children; however, it is still poorly characterized from a clinical and diagnostic perspective, particularly in the younger populations. Case presentation: We described the story of two sisters-with high social and academic performance before their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-who reported severe neurocognitive problems, initially classified as psychologic pandemic distress and eventually found to have significant brain hypometabolism. Conclusions: We provided a detailed clinical presentation of neurocognitive symptoms in two sisters with long COVID associated with brain hypometabolism documented in both sisters. We believe that the evidence of objective findings in these children further supports the hypothesis that organic events cause persisting symptoms in a cohort of children after SARS-CoV-2 infection. Such findings highlight the importance of discovering diagnostics and therapeutics.
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1165072
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Article ; Online: Admissions for acute cardiac inflammatory events or chest pain before and after the severe acute respiratory syndrome coronavirus 2 was in circulation.

Sodero, Giorgio / Mariani, Francesco / Proli, Francesco / Lazzareschi, Ilaria / Bersani, Giulia / Delogu, Angelica Bibiana / De Rosa, Gabriella / Zampino, Giuseppe / Valentini, Piero / Buonsenso, Danilo

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 5, Page(s) 1038–1040

MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Hospitalization ; Chest Pain/etiology
Language	English
Publishing date	2023-02-25
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16712
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Article ; Online: Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory? - Authors' reply.

Bertolino, Lorenzo / Ursi, Maria Paola / Zampino, Rosa / Durante-Mangoni, Emanuele

European journal of internal medicine

2020 Volume 85, Page(s) 114–115

MeSH term(s)	Bacterial Infections ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Endocarditis, Bacterial/diagnosis ; Humans
Language	English
Publishing date	2020-12-31
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2020.12.016
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Zs.A 2608: Show issues

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Article: Incidence, Risk Factors and Clinical Implications of Glucose Metabolic Changes after Heart Transplant.

Durante-Mangoni, Emanuele / Iossa, Domenico / Iorio, Valeria / Mattucci, Irene / Malgeri, Umberto / Pinto, Daniela / Andini, Roberto / Maiello, Ciro / Zampino, Rosa

Biomedicines

2022 Volume 10, Issue 11

Abstract: Diabetes mellitus (DM) ... ...

Abstract	Diabetes mellitus (DM) arising
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10112704
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Article ; Online: Clinical efficacy and safety of cefiderocol for resistant Gram-negative infections: a real-life, single-centre experience.

Karruli, Arta / Massa, Alessia / Andini, Roberto / Marrazzo, Tommaso / Ruocco, Giuseppe / Zampino, Rosa / Durante-Mangoni, Emanuele

International journal of antimicrobial agents

2023 Volume 61, Issue 2, Page(s) 106723

Abstract: Objectives: Cefiderocol is a 'siderophore' cephalosporin active against Gram-negative bacteria, including carbapenem-resistant strains. Data on the use of cefiderocol in real life are limited. We evaluated the efficacy and safety of cefiderocol in the ... ...

Abstract	Objectives: Cefiderocol is a 'siderophore' cephalosporin active against Gram-negative bacteria, including carbapenem-resistant strains. Data on the use of cefiderocol in real life are limited. We evaluated the efficacy and safety of cefiderocol in the context of our hospital clinical practice. Methods: This was a single-centre, observational, retrospective clinical study. We collected data for all patients who received cefiderocol therapy in our hospital, with a focus on clinical outcomes and adverse events. Results: The study cohort included 28 patients, with a median age of 73 years (25-83 years) and a high burden of co-morbidities. Up to 45 Gram-negative isolates were cultured from the study patients, the most common pathogen being Acinetobacter baumannii (31.1%). Cefiderocol was mostly prescribed for pneumonia (37.8% of cases), bloodstream infection (24.4%), urinary tract infection (22.2%) and intra-abdominal infection (20%), and largely as salvage therapy (92.8%). Of the 18 patients for whom follow-up cultures were available, 14 (77.8%) achieved eradication of the causative micro-organism. Therapeutic success (improvement/resolution of infection) occurred in 64.3% of cases at 7 days and 50% at 14 days from treatment start. Treatment failed in 9 cases (32.1%). No effects on kidney, liver or bone marrow function were observed. Conclusions: Cefiderocol showed fair efficacy and excellent tolerability in highly co-morbid patients with a range of multiresistant infections. It may be an option for infections due to colistin-resistant pathogens, when other regimens fail or in cases at risk of kidney dysfunction.
MeSH term(s)	Humans ; Aged ; Anti-Bacterial Agents/adverse effects ; Retrospective Studies ; Drug Resistance, Multiple, Bacterial ; Cephalosporins/adverse effects ; Gram-Negative Bacteria ; Treatment Outcome ; Microbial Sensitivity Tests ; Cefiderocol
Chemical Substances	Anti-Bacterial Agents ; Cephalosporins
Language	English
Publishing date	2023-01-12
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106723
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cardiac sequelae after coronavirus disease 2019 recovery: a systematic review.

Ramadan, Mohammad Said / Bertolino, Lorenzo / Zampino, Rosa / Durante-Mangoni, Emanuele

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2021 Volume 27, Issue 9, Page(s) 1250–1261

Abstract: Background: Coronavirus disease 2019 (COVID-19) has been implicated in a wide spectrum of cardiac manifestations following the acute phase of the disease.: Objectives: To assess the range of cardiac sequelae after COVID-19 recovery.: Data sources: ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) has been implicated in a wide spectrum of cardiac manifestations following the acute phase of the disease. Objectives: To assess the range of cardiac sequelae after COVID-19 recovery. Data sources: PubMed, Embase, Scopus (inception through 17 February 2021) and Google scholar (2019 through 17 February 2021). Study eligibility criteria: Prospective and retrospective studies, case reports and case series. Participants: Adult patients assessed for cardiac manifestations after COVID-19 recovery. Exposure: Severe acute respiratory syndrome coronavirus 2 infection diagnosed by PCR. Methods: Systematic review. Results: Thirty-five studies (fifteen prospective cohort, seven case reports, five cross-sectional, four case series, three retrospective cohort and one ambidirectional cohort) evaluating cardiac sequelae in 52 609 patients were included. Twenty-nine studies used objective cardiac assessments, mostly cardiac magnetic resonance imaging (CMR) in 16 studies, echocardiography in 15, electrocardiography (ECG) in 16 and cardiac biomarkers in 18. Most studies had a fair risk of bias. The median time from diagnosis/recovery to cardiac assessment was 48 days (1-180 days). Common short-term cardiac abnormalities (<3 months) included increased T1 (proportion: 30%), T2 (16%), pericardial effusion (15%) and late gadolinium enhancement (11%) on CMR, with symptoms such as chest pain (25%) and dyspnoea (36%). In the medium term (3-6 months), common changes included reduced left ventricular global longitudinal strain (30%) and late gadolinium enhancement (10%) on CMR, diastolic dysfunction (40%) on echocardiography and elevated N-terminal proB-type natriuretic peptide (18%). In addition, COVID-19 survivors had higher risk (risk ratio 3; 95% CI 2.7-3.2) of developing heart failure, arrythmias and myocardial infarction. Conclusions: COVID-19 appears to be associated with persistent/de novo cardiac injury after recovery, particularly subclinical myocardial injury in the earlier phase and diastolic dysfunction later. Larger well-designed and controlled studies with baseline assessments are needed to better measure the extent of cardiac injury and its clinical impact.
MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Echocardiography ; Electrocardiography ; Heart Diseases/epidemiology ; Heart Diseases/etiology ; Humans ; Magnetic Resonance Imaging, Cine ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2021.06.015
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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