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  1. Article ; Online: Investigation of structural brain changes in Charles Bonnet Syndrome.

    Firbank, Michael J / daSilva Morgan, Katrina / Collerton, Daniel / Elder, Greg J / Parikh, Jehill / Olsen, Kirsty / Schumacher, Julia / Ffytche, Dominic / Taylor, John-Paul

    NeuroImage. Clinical

    2022  Volume 35, Page(s) 103041

    Abstract: Background and objectives: In Charles Bonnet Syndrome (CBS), visual hallucinations (VH) are ...

    Abstract Background and objectives: In Charles Bonnet Syndrome (CBS), visual hallucinations (VH) are experienced by people with sight loss due to eye disease or lesional damage to early visual pathways. The aim of this cross-sectional study was to investigate structural brain changes using magnetic resonance imaging (MRI) in CBS.
    Methods: Sixteen CBS patients, 17 with eye disease but no VH, and 19 normally sighted people took part. Participants were imaged on a 3T scanner, with 1 mm resolution T1 weighted structural imaging, and diffusion tensor imaging with 64 diffusion directions.
    Results: The three groups were well matched for age, sex and cognitive scores (MMSE). The two eye disease groups were matched on visual acuity. Compared to the sighted controls, we found reduced grey matter in the occipital cortex in both eye disease groups. We also found reductions of fractional anisotropy and increased diffusivity in widespread areas, including occipital tracts, the corpus callosum, and the anterior thalamic radiation. We did not find any significant differences between the eye disease participants with VH versus without VH, but did observe a negative association between hippocampal volume and VH severity in the CBS group.
    Discussion: Our findings suggest that although there are cortical and subcortical effects associated with sight loss, structural changes do not explain the occurrence of VHs. CBS may relate instead to connectivity or excitability changes in brain networks linked to vision.
    MeSH term(s) Blindness ; Brain/diagnostic imaging ; Charles Bonnet Syndrome/complications ; Charles Bonnet Syndrome/diagnostic imaging ; Cross-Sectional Studies ; Diffusion Tensor Imaging ; Eye Diseases/complications ; Hallucinations/diagnostic imaging ; Humans
    Language English
    Publishing date 2022-05-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2022.103041
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  2. Article ; Online: Failing Up: Charles Dotter, the Father of Interventional Medicine.

    Taylor, Clayton P / Gunderman, Richard B

    Journal of the American College of Radiology : JACR

    2021  Volume 18, Issue 3 Pt B, Page(s) 522–523

    MeSH term(s) Medicine ; Radiology, Interventional ; Research
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2020.09.033
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  3. Article ; Online: Investigation of structural brain changes in Charles Bonnet Syndrome

    Michael J. Firbank / Katrina daSilva Morgan / Daniel Collerton / Greg J. Elder / Jehill Parikh / Kirsty Olsen / Julia Schumacher / Dominic ffytche / John-Paul Taylor

    NeuroImage: Clinical, Vol 35, Iss , Pp 103041- (2022)

    2022  

    Abstract: Background and objectives: In Charles Bonnet Syndrome (CBS), visual hallucinations (VH) are ...

    Abstract Background and objectives: In Charles Bonnet Syndrome (CBS), visual hallucinations (VH) are experienced by people with sight loss due to eye disease or lesional damage to early visual pathways. The aim of this cross-sectional study was to investigate structural brain changes using magnetic resonance imaging (MRI) in CBS. Methods: Sixteen CBS patients, 17 with eye disease but no VH, and 19 normally sighted people took part. Participants were imaged on a 3T scanner, with 1 mm resolution T1 weighted structural imaging, and diffusion tensor imaging with 64 diffusion directions. Results: The three groups were well matched for age, sex and cognitive scores (MMSE). The two eye disease groups were matched on visual acuity. Compared to the sighted controls, we found reduced grey matter in the occipital cortex in both eye disease groups. We also found reductions of fractional anisotropy and increased diffusivity in widespread areas, including occipital tracts, the corpus callosum, and the anterior thalamic radiation. We did not find any significant differences between the eye disease participants with VH versus without VH, but did observe a negative association between hippocampal volume and VH severity in the CBS group. Discussion: Our findings suggest that although there are cortical and subcortical effects associated with sight loss, structural changes do not explain the occurrence of VHs. CBS may relate instead to connectivity or excitability changes in brain networks linked to vision.
    Keywords Charles Bonnet Syndrome ; Visual hallucinations ; Eye disease ; MRI ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Transcranial Direct Current Stimulation in the Treatment of Visual Hallucinations in Charles Bonnet Syndrome: A Randomized Placebo-Controlled Crossover Trial.

    daSilva Morgan, Katrina / Schumacher, Julia / Collerton, Daniel / Colloby, Sean / Elder, Greg J / Olsen, Kirsty / Ffytche, Dominic H / Taylor, John-Paul

    Ophthalmology

    2022  Volume 129, Issue 12, Page(s) 1368–1379

    Abstract: ... transcranial direct current stimulation (tDCS) on the remediation of visual hallucinations in Charles Bonnet ...

    Abstract Objective: To investigate the potential therapeutic benefits and tolerability of inhibitory transcranial direct current stimulation (tDCS) on the remediation of visual hallucinations in Charles Bonnet syndrome (CBS).
    Design: Randomized, double-masked, placebo-controlled crossover trial.
    Participants: Sixteen individuals diagnosed with CBS secondary to visual impairment caused by eye disease experiencing recurrent visual hallucinations.
    Intervention: All participants received 4 consecutive days of active and placebo cathodal stimulation (current density: 0.29 mA/cm
    Main outcome measures: Ratings of visual hallucination frequency and duration following active and placebo stimulation, accounting for treatment order, using a 2 × 2 repeated-measures model. Secondary outcomes included impact ratings of visual hallucinations and electrophysiological measures.
    Results: When compared with placebo treatment, active inhibitory stimulation of visual cortex resulted in a significant reduction in the frequency of visual hallucinations measured by the North East Visual Hallucinations Interview, with a moderate-to-large effect size. Impact measures of visual hallucinations improved in both placebo and active conditions, suggesting support and education for CBS may have therapeutic benefits. Participants who demonstrated greater occipital excitability on electroencephalography assessment at the start of treatment were more likely to report a positive treatment response. Stimulation was found to be tolerable in all participants, with no significant adverse effects reported, including no deterioration in preexisting visual impairment.
    Conclusions: Findings indicate that inhibitory tDCS of visual cortex may reduce the frequency of visual hallucinations in people with CBS, particularly individuals who demonstrate greater occipital excitability prior to stimulation. tDCS may offer a feasible intervention option for CBS with no significant side effects, warranting larger-scale clinical trials to further characterize its efficacy.
    MeSH term(s) Humans ; Charles Bonnet Syndrome/complications ; Charles Bonnet Syndrome/therapy ; Transcranial Direct Current Stimulation/adverse effects ; Transcranial Direct Current Stimulation/methods ; Cross-Over Studies ; Hallucinations/therapy ; Hallucinations/diagnosis ; Hallucinations/etiology ; Vision, Low/etiology
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2022.06.041
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    Zs.MO 533: Show issues

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  5. Article ; Online: Toward a hermeneutical conception of medicine: a conversation with Charles Taylor.

    Taylor, Charles

    The Journal of medicine and philosophy

    2011  Volume 36, Issue 4, Page(s) 436–445

    MeSH term(s) Communication ; Humans ; Medicine ; Research ; Science ; Social Sciences
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Interview
    ZDB-ID 197282-0
    ISSN 1744-5019 ; 0360-5310
    ISSN (online) 1744-5019
    ISSN 0360-5310
    DOI 10.1093/jmp/jhr033
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  6. Article: 'Where is the damned collection?' Charles Davies Sherborn's listing of named natural science collections and its successors.

    Taylor, Michael A

    ZooKeys

    2016  , Issue 550, Page(s) 83–106

    Abstract: C. D. Sherborn published in 1940, under the imprint of Cambridge University Press but at his own expense, Where is the - Collection? This idiosyncratic listing of named natural science collections, and their fates, was useful, but incomplete, and uneven ... ...

    Abstract C. D. Sherborn published in 1940, under the imprint of Cambridge University Press but at his own expense, Where is the - Collection? This idiosyncratic listing of named natural science collections, and their fates, was useful, but incomplete, and uneven in its accuracy. It is argued that those defects were inevitable, given Sherborn's age and wartime conditions, and that what might seem one of Sherborn's less impressive works was in fact a pioneering work highly influential in stimulating the production of successor works now much used in curation, and in systematic and descriptive biology and palaeontology. The book also contributed to the development of collections research in the natural sciences, and the history of collections and of museums.
    Language English
    Publishing date 2016-01-07
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.550.10073
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  7. Article ; Online: ‘Where is the damned collection?’ Charles Davies Sherborn’s listing of named natural science collections and its successors

    Taylor, Michael A.

    ZooKeys. 2016 Jan. 7, v. 550, p. 83-106

    2016  , Page(s) 83–106

    Abstract: C. D. Sherborn published in 1940, under the imprint of Cambridge University Press but at his own expense, Where is the – Collection? This idiosyncratic listing of named natural science collections, and their fates, was useful, but incomplete, and uneven ... ...

    Abstract C. D. Sherborn published in 1940, under the imprint of Cambridge University Press but at his own expense, Where is the – Collection? This idiosyncratic listing of named natural science collections, and their fates, was useful, but incomplete, and uneven in its accuracy. It is argued that those defects were inevitable, given Sherborn’s age and wartime conditions, and that what might seem one of Sherborn’s less impressive works was in fact a pioneering work highly influential in stimulating the production of successor works now much used in curation, and in systematic and descriptive biology and palaeontology. The book also contributed to the development of collections research in the natural sciences, and the history of collections and of museums.
    Keywords museums ; paleontology ; research and development
    Language English
    Dates of publication 2016-0107
    Size p. 83-106.
    Publishing place Pensoft Publishers
    Document type Article ; Online
    Note NALT-AP-4-rerunAP2-fuzzy
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.550.10073
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: The Charles Bernard Lecture.

    Taylor, R

    Journal of the Royal Naval Medical Service

    2001  Volume 87, Issue 2, Page(s) 96–97

    MeSH term(s) England ; General Surgery/history ; History, 18th Century ; Naval Medicine/history
    Language English
    Publishing date 2001-09-28
    Publishing country England
    Document type Address ; Biography ; Historical Article
    ZDB-ID 764213-1
    ISSN 0035-9033
    ISSN 0035-9033
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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.287: Show issues Location:
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  9. Article ; Online: Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development

    Jay A. Berzofsky / Lauren Gerard Koch / Steven L. Britton / Shaochen Chen / Wei Zhu / Xuanyi Ma / Anthony G. Comuzzie / Laetitia Devy-Dimanche / Ryan Feaver / Jan Grimm / Christoph Hock / Roger M. Nitsch / James B. Hoying / Aldons J. Lusis / Francesco Marincola / Josue Samayoa / Tolga Turan / David A. Pearce / Antti Nurmi /
    Tuulia Huhtala / Artem Shatillo / Jukka Puoliväli / Taneli Heikkinen / Timo Bragge / Kimmo Lehtimäki / Arun J. Sanyal / Kevin Strange / D. Lansing Taylor / Mark Miedel / Shanhang Jia / Alex Soto-Guterriez / Andrew Stern / Albert Gough

    Journal of Translational Medicine, Vol 15, Iss S3, Pp 1-

    2017  Volume 7

    Keywords Medicine ; R
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: "Received, a blank child": John Brownlow, Charles Dickens, and the London Foundling Hospital - archives and fictions.

    Taylor, J B

    Nineteenth-century literature

    2010  Volume 56, Issue 3, Page(s) 293–363

    MeSH term(s) Authorship ; Child ; Child Health Services/economics ; Child Health Services/history ; Child Health Services/legislation & jurisprudence ; Child Welfare/economics ; Child Welfare/ethnology ; Child Welfare/history ; Child Welfare/legislation & jurisprudence ; Child Welfare/psychology ; Child, Preschool ; History, 18th Century ; History, 19th Century ; Hospitals/history ; Humans ; Literature/history ; London/ethnology ; Parent-Child Relations/ethnology ; Parent-Child Relations/legislation & jurisprudence ; Publications/economics ; Publications/history ; Social Change/history ; Social Conditions/economics ; Social Conditions/history ; Social Conditions/legislation & jurisprudence ; Women's Health/economics ; Women's Health/ethnology ; Women's Health/history ; Women's Health/legislation & jurisprudence ; Women, Working/education ; Women, Working/history ; Women, Working/legislation & jurisprudence ; Women, Working/psychology
    Language English
    Publishing date 2010-02-03
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2010833-3
    ISSN 1067-8352 ; 0891-9356
    ISSN (online) 1067-8352
    ISSN 0891-9356
    DOI 10.1525/ncl.2001.56.3.293
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