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Book: Breast pathology

O'Malley, Frances P.

(Foundations in diagnostic pathology ; Expert consult)

2011

Author's details	ed. by Frances O'Malley
Series title	Foundations in diagnostic pathology Expert consult
Keywords	Breast / pathology ; Breast Diseases
Language	English
Size	XVI, 377 S. : zahlr. Ill., graph. Darst.
Edition	2. ed.
Publisher	Elsevier Saunders
Publishing place	Philadelphia, Pa
Publishing country	United States
Document type	Book
Accompanying material	Zugang zur Internetausgabe über Code
HBZ-ID	HT016922412
ISBN	978-1-4377-1757-0 ; 1-4377-1757-8
Database	Catalogue ZB MED Medicine, Health

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2011 A 3149	order for loan	Magazin
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Book: Breast pathology

O'Malley, Frances P.

(Foundations in diagnostic pathology)

2006

Author's details	ed. by Frances O'Malley
Series title	Foundations in diagnostic pathology
Language	English
Size	XVII, 328 S. : überw. Ill.
Publisher	Churchill Livingstone
Publishing place	Philadelphia, Pa
Publishing country	United States
Document type	Book
HBZ-ID	HT014681077
ISBN	0-443066-80-9 ; 0-443-06680-9 ; 978-0-443-06680-1 ; 978-0-443066-80-1
Database	Catalogue ZB MED Medicine, Health

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2006 A 3692	order for loan	Magazin

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Article ; Online: Enhancing the health knowledge and health literacy of recently resettled refugees through classroom-based instructional methods.

Agrawal, Pooja / Phadke, Manali / Du, Nan / Hosain, Fatima / Koons, Leslie / Brown, Camille / O'Malley, Shannon / Cheng, Frances Y

Health education research

2024 Volume 39, Issue 2, Page(s) 159–169

Abstract: Health education can elevate health literacy, which is associated with health knowledge, health-seeking behaviors and overall improved health outcomes. Refugees are particularly vulnerable to the effects of low health knowledge and literacy, which can ... ...

Abstract	Health education can elevate health literacy, which is associated with health knowledge, health-seeking behaviors and overall improved health outcomes. Refugees are particularly vulnerable to the effects of low health knowledge and literacy, which can exacerbate already poor health stemming from their displacement experience. Traditional learning methods including classroom-based instruction are typically how health-related information is presented to refugees. Through a series of interactive classes focused on specific health topics relevant to the resettled refugee population, this study evaluated the effectiveness of a classroom-based health education model in enhancing the health knowledge of recently resettled refugees. We used the Wilcoxon signed-rank test to evaluate differences in pre- and post-class knowledge through test performance. We found a significant improvement in health knowledge in two refugee groups: females and those who were employed. Culturally and socially sensitive considerations including language inclusiveness, class timing, transportation and childcare provisions are important when creating an educational program for individuals with refugee backgrounds. Developing focused approaches to instruction that enhance health knowledge could lead to better health literacy and ultimately improve health-related behaviors and outcomes in the refugee population.
MeSH term(s)	Female ; Humans ; Health Literacy ; Refugees ; Language ; Health Behavior
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632781-3
ISSN	1465-3648 ; 0268-1153
ISSN (online)	1465-3648
ISSN	0268-1153
DOI	10.1093/her/cyae001
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Article ; Online: Lobular neoplasia: morphology, biological potential and management in core biopsies.

O'Malley, Frances P

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2010 Volume 23 Suppl 2, Page(s) S14–25

Abstract: Lobular neoplasia has been traditionally recognized as a marker of increased risk for subsequent breast carcinoma development; however, molecular studies suggest that it also behaves in a non-obligate precursor manner. We do not know, as yet, how to ... ...

Abstract	Lobular neoplasia has been traditionally recognized as a marker of increased risk for subsequent breast carcinoma development; however, molecular studies suggest that it also behaves in a non-obligate precursor manner. We do not know, as yet, how to identify the subgroup of cases that is most likely to progress, but the epidemiological data would indicate that this progression occurs after a long period of time. Thus, the current approach of conservative management of these lesions when identified in excision specimens is justified. Recently, several variants of lobular carcinoma in situ (LCIS), most notably pleomorphic LCIS, have been recognized and these can be difficult to differentiate from ductal carcinoma in situ. Application of strict diagnostic criteria and the judicial use of immunohistochemistry, particularly E-cadherin, can be helpful in this differential diagnosis. Another challenging issue is the management of lobular neoplasia when diagnosed on core biopsy. This controversial issue will be discussed in detail. The goals of this review are (1) to describe the morphological criteria used to diagnose the spectrum of lobular neoplastic lesions, including atypical lobular hyperplasia, LCIS and variants of LCIS; (2) to discuss the data exploring the biological potential of lobular neoplasia from an epidemiological and molecular viewpoint; and (3) to outline the recommendations for management of lobular neoplasia when encountered in core biopsies.
MeSH term(s)	Biopsy ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/therapy ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/therapy ; Diagnosis, Differential ; Female ; Humans ; Prognosis
Language	English
Publishing date	2010-03-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/modpathol.2010.35
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.

Maurya, Vineet K / Szwarc, Maria M / Lonard, David M / Kommagani, Ramakrishna / Wu, San Pin / O'Malley, Bert W / DeMayo, Francesco J / Lydon, John P

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2023 Volume 37, Issue 12, Page(s) e23313

Abstract: Although we have shown that steroid receptor coactivator-2 (SRC-2), a member of the p160/SRC family of transcriptional coregulators, is essential for decidualization of both human and murine endometrial stromal cells, SRC-2's role in the earlier stages ... ...

Abstract	Although we have shown that steroid receptor coactivator-2 (SRC-2), a member of the p160/SRC family of transcriptional coregulators, is essential for decidualization of both human and murine endometrial stromal cells, SRC-2's role in the earlier stages of the implantation process have not been adequately addressed. Using a conditional SRC-2 knockout mouse (SRC-2
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Pregnancy ; Embryo Implantation/genetics ; Endometrium/metabolism ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition ; Mice, Knockout ; Nuclear Receptor Coactivator 2/genetics ; Uterus/metabolism
Chemical Substances	Nuclear Receptor Coactivator 2 ; Ncoa2 protein, mouse
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202301581R
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Article ; Online: Surgical Pulmonary Embolectomy Outcomes for Acute Pulmonary Embolism.

Choi, Jae Hwan / O'Malley, Thomas J / Maynes, Elizabeth J / Weber, Matthew P / D'Antonio, Nicholas D / Mellado, Martín / West, Frances M / Galanis, Taki / Gonsalves, Carin F / Marhefka, Gregary D / Awsare, Bharat K / Merli, Geno J / Tchantchaleishvili, Vakhtang

The Annals of thoracic surgery

2020 Volume 110, Issue 3, Page(s) 1072–1080

Abstract: ... 8, mm Hg; 95% CI, 53, 62.7) to the postoperative period (sPAP, 31.3 mm Hg; 24.9, 37.8); P < .01 ...

Abstract	Background: Acute pulmonary embolism (PE) is associated with significant mortality. Surgical embolectomy is a viable treatment option; however, it remains controversial as a result of variable outcomes. This review investigates patient outcomes after surgical embolectomy for acute PE. Methods: An electronic search was performed to identify articles reporting surgical embolectomy for treatment of PE. 32 studies were included comprising 936 patients. Demographic, perioperative, and outcome data were extracted and pooled for systematic review. Results: Mean patient age was 56.3 years (95% confidence interval [CI], 52.5, 60.1), and 50% were male (95% CI, 46, 55); 82% had right ventricular dysfunction (95% CI, 62, 93), 80% (95% CI, 67, 89) had unstable hemodynamics, and 9% (95% CI, 5, 16) experienced cardiac arrest. Massive PE and submassive PE were present in 83% (95% CI, 43, 97)] and 13% (95% CI, 2, 56) of patients, respectively. Before embolectomy, 33% of patients (95% CI, 14, 60) underwent systemic thrombolysis, and 14% (95% CI, 8, 24) underwent catheter embolectomy. Preoperatively, 47% of patients were ventilated (95% CI, 26; 70), and 36% had percutaneous cardiopulmonary support (95% CI, 11, 71). Mean operative time and mean cardiopulmonary bypass time were 170 minutes (95% CI, 101, 239) and 56 minutes (95% CI, 42, 70), respectively. Intraoperative mortality was 4% (95% CI, 2, 8). Mean hospital and intensive care unit stay were 10 days (95% CI, 6, 14) and 2 days (95% CI, 1, 3), respectively. Mean postoperative systolic pulmonary artery pressure (sPAP) was significantly decreased from the preoperative period (sPAP 57.8, mm Hg; 95% CI, 53, 62.7) to the postoperative period (sPAP, 31.3 mm Hg; 24.9, 37.8); P < .01). In-hospital mortality was 16% (95% CI, 12, 21). Overall survival at 5 years was 73% (95% CI, 64, 81). Conclusions: Surgical embolectomy is an acceptable treatment option with favorable outcomes.
MeSH term(s)	Acute Disease ; Embolectomy/methods ; Humans ; Operative Time ; Pulmonary Embolism/surgery ; Treatment Outcome
Language	English
Publishing date	2020-03-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2020.01.075
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Breast pathology

O'Malley, Frances P / Pinder, Sarah E / Mulligan, Anna Marie

(Foundations in diagnostic pathology)

2011

Author's details	edited by Frances P. O'Malley, Sarah E. Pinder, Anna Marie Mulligan
Series title	Foundations in diagnostic pathology
MeSH term(s)	Breast/pathology ; Breast Diseases
Language	English
Size	xvi, 377 p. :, ill.
Edition	2nd ed.
Publisher	Elsevier/Saunders
Publishing place	Philadelphia
Document type	Book
Note	"Expert consult"--Cover. ; Includes index.
ISBN	9781437717570 ; 1437717578
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Cytokeratin 5 and estrogen receptor immunohistochemistry as a useful adjunct in identifying atypical papillary lesions on breast needle core biopsy.

Grin, Andrea / O'Malley, Frances P / Mulligan, Anna Marie

The American journal of surgical pathology

2009 Volume 33, Issue 11, Page(s) 1615–1623

Abstract: ... when compared with atypical lesions (P<0.0001). Nonatypical lesions typically showed an ER-low/CK5-high profile ...

Abstract	The presence of atypical or usual epithelial proliferations within papillary breast lesions complicates their interpretation on core biopsy. We evaluated the combination of estrogen receptor (ER) and cytokeratin 5 (CK5) as an aid in the distinction of usual duct hyperplasia from atypical proliferations in this setting. Core biopsies from 185 papillary lesions were reviewed and of these, 82 cases were selected for immunohistochemical study based on the presence of an epithelial proliferation between the fibrovascular cores. Fifty-two cases were used as the test set and 30 cases, with subsequent surgical excision, were used as the validation set. The epithelial proliferation was evaluated for staining intensity and percentage of positive cells using CK5 and ER. Expression of both CK5 and ER was significantly different in nonatypical lesions when compared with atypical lesions (P<0.0001). Nonatypical lesions typically showed an ER-low/CK5-high profile and atypical lesions showed an ER-high/CK5-low profile with ER-high expression defined as diffuse strong staining in >90% of cells. CK5-high expression was defined as a mosaic pattern of staining in >20% of cells and CK5-low as absent or staining in <20% of cells. On the basis of their staining profile, 29 of the 30 validation cases were correctly classified using the excision specimen as the gold standard. Patterns and extent of ER and CK5 staining, when used together, are valuable adjunct stains to differentiate usual duct hyperplasia from atypical proliferations within papillary lesions on core biopsy.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Biopsy, Needle ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Intraductal, Noninfiltrating/metabolism ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Carcinoma, Papillary/metabolism ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Cell Count ; Diagnosis, Differential ; Female ; Humans ; Hyperplasia ; Immunoenzyme Techniques ; Keratin-5/metabolism ; Receptors, Estrogen/metabolism
Chemical Substances	Biomarkers, Tumor ; Keratin-5 ; Receptors, Estrogen
Language	English
Publishing date	2009-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	752964-8
ISSN	1532-0979 ; 0147-5185
ISSN (online)	1532-0979
ISSN	0147-5185
DOI	10.1097/PAS.0b013e3181aec446
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study protocol: improving response to malaria in the Amazon through identification of inter-community networks and human mobility in border regions of Ecuador, Peru and Brazil.

BMJ open

2024 Volume 14, Issue 4, Page(s) e078911

Abstract: Introduction: Understanding human mobility's role in malaria transmission is critical to successful control and elimination. However, common approaches to measuring mobility are ill-equipped for remote regions such as the Amazon. This study develops a ... ...

Abstract	Introduction: Understanding human mobility's role in malaria transmission is critical to successful control and elimination. However, common approaches to measuring mobility are ill-equipped for remote regions such as the Amazon. This study develops a network survey to quantify the effect of community connectivity and mobility on malaria transmission. Methods: We measure community connectivity across the study area using a respondent driven sampling design among key informants who are at least 18 years of age. 45 initial communities will be selected: 10 in Brazil, 10 in Ecuador and 25 in Peru. Participants will be recruited in each initial node and administered a survey to obtain data on each community's mobility patterns. Survey responses will be ranked and the 2-3 most connected communities will then be selected and surveyed. This process will be repeated for a third round of data collection. Community network matrices will be linked with each country's malaria surveillance system to test the effects of mobility on disease risk. Ethics and dissemination: This study protocol has been approved by the institutional review boards of Duke University (USA), Universidad San Francisco de Quito (Ecuador), Universidad Peruana Cayetano Heredia (Peru) and Universidade Federal Minas Gerais (Brazil). Results will be disseminated in communities by the end of the study.
MeSH term(s)	Humans ; Community Networks ; Peru/epidemiology ; Ecuador/epidemiology ; Brazil/epidemiology ; Malaria/epidemiology ; Malaria/prevention & control
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-078911
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Article ; Online: A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis.

Nature communications

2024 Volume 15, Issue 1, Page(s) 1947

Abstract: Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums for steroid ... ...

Abstract	Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums for steroid receptors are unidentified. Herein, we found that a common feed-forward mechanism between GREB1 and steroid receptors regulates the differential effect of GREB1 on steroid hormones in a physiological or pathological context. In physiological (receptive) endometrium, GREB1 controls P4-responses in uterine stroma, affecting endometrial receptivity and decidualization, while not affecting E2-mediated epithelial proliferation. Of mechanism, progesterone-induced GREB1 physically interacts with the progesterone receptor, acting as a cofactor in a positive feedback mechanism to regulate P4-responsive genes. Conversely, in endometrial pathology (endometriosis), E2-induced GREB1 modulates E2-dependent gene expression to promote the growth of endometriotic lesions in mice. This differential action of GREB1 exerted by a common feed-forward mechanism with steroid receptors advances our understanding of mechanisms that underlie cell- and tissue-specific steroid hormone actions.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Endometriosis/genetics ; Endometriosis/metabolism ; Endometrium/metabolism ; Estrogens/metabolism ; Neoplasm Proteins/metabolism ; Progesterone/metabolism ; Receptors, Progesterone/genetics ; Receptors, Progesterone/metabolism ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism ; Steroids/metabolism
Chemical Substances	Estrogens ; GREB1 protein, human ; Neoplasm Proteins ; Progesterone (4G7DS2Q64Y) ; Receptors, Progesterone ; Receptors, Steroid ; Steroids ; KIAA0575 protein, mouse
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46180-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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