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Article ; Online: Characterization of sphere cells derived from a patient-derived xenograft model of lung adenocarcinoma treated with ionizing radiation.

Choi, Jinhyang / Ko, Eun Jung / Ju, Eun Jin / Park, Seok Soon / Park, Jin / Shin, Seol Hwa / Jang, Se Jin / Lee, Jung Shin / Song, Si Yeol / Jeong, Seong-Yun / Choi, Eun Kyung

International journal of radiation biology

2020 Volume 96, Issue 11, Page(s) 1413–1422

Abstract: Purpose: Cancer stem cells (CSCs) are relatively resistant to radiation compared to their non-tumorigenic progeny. Ionizing radiation (IR) can expand the pool of CSCs that leads to more aggressive cancers, but the reason underlying CSC-induced cancer ... ...

Abstract	Purpose: Cancer stem cells (CSCs) are relatively resistant to radiation compared to their non-tumorigenic progeny. Ionizing radiation (IR) can expand the pool of CSCs that leads to more aggressive cancers, but the reason underlying CSC-induced cancer aggressiveness after radiation therapy remains unclear. To understand this, we investigated the phenotypic and molecular characteristics of sphere cells formed from IR-treated patient-derived xenograft (PDX) lung adenocarcinoma tumors. Materials and methods: After treatment with various modes of IR, we collected tumors from PDX mice and successfully obtained sphere cells. To compare tumorigenicity, we performed migration, invasion, and mouse transplantation assays with sphere cells from each group. To investigate the molecular features, we used a cDNA microarray and compared gene expression among groups. Results and conclusions: Tumorigenicity assays revealed that sphere cells from 2- or 5-Gy IR-treated tumors more aggressive than sphere cells from non-IR treated tumors. Microarray results showed that
MeSH term(s)	Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/radiotherapy ; Animals ; Biomarkers, Tumor/metabolism ; Cell Transformation, Neoplastic ; Humans ; Mice ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology ; Spheroids, Cellular/radiation effects
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2020.1793019
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Article: Role of p53 and Rb in ovarian cancer.

Corney, David C / Flesken-Nikitin, Andrea / Choi, Jinhyang / Nikitin, Alexander Yu

Advances in experimental medicine and biology

2008 Volume 622, Page(s) 99–117

MeSH term(s)	Animals ; Diagnostic Imaging ; Female ; Genes, Retinoblastoma ; Genes, p53 ; Humans ; Mutation ; Neoplasms, Glandular and Epithelial/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/therapy
Language	English
Publishing date	2008-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-0-387-68969-2_9
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Article ; Online: MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF.

Hwang, Chang-Il / Choi, Jinhyang / Zhou, Zongxiang / Flesken-Nikitin, Andrea / Tarakhovsky, Alexander / Nikitin, Alexander Yu

Cell cycle (Georgetown, Tex.)

2011 Volume 10, Issue 22, Page(s) 3834–3840

Abstract: MET, a receptor protein tyrosine kinase activated by hepatocyte growth factor (HGF), is a crucial determinant of metastatic progression. Recently, we have identified p53 as an important regulator of MET-dependent cell motility and invasion. This ... ...

Abstract	MET, a receptor protein tyrosine kinase activated by hepatocyte growth factor (HGF), is a crucial determinant of metastatic progression. Recently, we have identified p53 as an important regulator of MET-dependent cell motility and invasion. This regulation occurs via feedforward loop suppressing MET expression by miR-34-dependent and -independent mechanisms. Here, by using Dicer conditional knockout, we provide further evidence for microRNA-independent MET regulation by p53. Furthermore, we show that while MET levels increase immediately after p53 inactivation, mutant cells do not contain active phosphorylated MET and remain non-invasive for a long latency period at contrary to cell culture observations. Evaluation of mouse models of ovarian and prostate carcinogenesis indicates that formation of desmoplastic stroma, associated production of HGF by stromal cells and coinciding MET phosphorylation precede cancer invasion. Thus, initiation mutation of p53 is sufficient for preprogramming motile and invasive properties of epithelial cells, but the stromal reaction may represent a critical step for their manifestation during cancer progression.
MeSH term(s)	Animals ; Feedback, Physiological ; Gene Expression Regulation, Neoplastic ; Hepatocyte Growth Factor/physiology ; Male ; Mice ; MicroRNAs/physiology ; Neoplasm Invasiveness/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; Proto-Oncogene Proteins c-met/physiology ; Retinoblastoma Protein/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Protein p53/physiology
Chemical Substances	HGF protein, mouse ; MicroRNAs ; Retinoblastoma Protein ; Tumor Suppressor Protein p53 ; Hepatocyte Growth Factor (67256-21-7) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
Language	English
Publishing date	2011-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.10.22.18294
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Article ; Online: Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fimasartan, Amlodipine, and Hydrochlorothiazide, in Rats Using LC-MS/MS and Subsequent Application to Pharmacokinetic Drug Interaction with Red Ginseng Extract.

Jeon, So-Yeon / Jeon, Ji-Hyeon / Park, Jin-Hyang / Lee, Jihoon / Pang, Minyeong / Choi, Min-Koo / Song, Im-Sook

Toxics

2022 Volume 10, Issue 10

Abstract: Fimasartan, amlodipine, and hydrochlorothiazide are commonly used in combination therapies as antihypertensive drugs. This study aimed to develop and validate an analytical method for fimasartan, its active and major metabolite fimasartan-amide, ... ...

Abstract	Fimasartan, amlodipine, and hydrochlorothiazide are commonly used in combination therapies as antihypertensive drugs. This study aimed to develop and validate an analytical method for fimasartan, its active and major metabolite fimasartan-amide, amlodipine, and hydrochlorothiazide in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for fimasartan (1−500 ng/mL), its active and major metabolite fimasartan-amide (0.3−100 ng/mL), amlodipine (0.5−200 ng/mL), and hydrochlorothiazide (5−5000 ng/mL) were linear with R2 > 0.9964, and the inter- and intra-day accuracy and precision and stability were within the acceptable criteria. Using this validated analytical method, the pharmacokinetic interaction of these triple combination drugs between single administration and concomitant administration of the triple combination was investigated; the results did not reveal a significant difference in any of the pharmacokinetic parameters. Based on these results, we investigated the effects of red ginseng extract (RGE) on the pharmacokinetics of fimasartan, fimasartan-amide, amlodipine, and hydrochlorothiazide after oral administration of the combination in rats. No significant difference was observed in the pharmacokinetic parameters of fimasartan, fimasartan-amide, amlodipine, and hydrochlorothiazide, except for the Tmax values of amlodipine. The delayed Tmax value of amlodipine was attributed to its decreased intestinal permeability after repeated RGE treatments. In conclusion, using a combination of antihypertensive drugs and simultaneous analytical methods, we established efficient drug interaction and toxicokinetic studies using a small number of animals.
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics10100576
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Article ; Online: Enhanced bioavailability and hepatoprotective effect of silymarin by preparing silymarin-loaded solid dispersion formulation using freeze-drying method.

Lim, Dong Yu / Pang, Minyeong / Lee, Jaehyeok / Lee, Jihoon / Jeon, Ji-Hyeon / Park, Jin-Hyang / Choi, Min-Koo / Song, Im-Sook

Archives of pharmacal research

2022 Volume 45, Issue 10, Page(s) 743–760

Abstract: This study aimed to develop a solid dispersion formulation of silymarin (Silymarin-SD) using freeze-drying method to enhance its oral bioavailability (BA) by inhibiting the intestinal first-pass effect and increasing its solubility and permeability. ... ...

Abstract	This study aimed to develop a solid dispersion formulation of silymarin (Silymarin-SD) using freeze-drying method to enhance its oral bioavailability (BA) by inhibiting the intestinal first-pass effect and increasing its solubility and permeability. Silymarin-SD formulation (i.e., silymarin:tween 80:hydroxypropyl cellulose (HPC) = 1:1:3 (w/w/w) significantly increased silymarin permeability in the duodenum, jejunum, and ileum by decreasing the efflux ratio of silymarin and by inhibiting silymarin-glucuronidation activity, in which tween 80 played a crucial role. As a result, orally administered Silymarin-SD formulation increased plasma silymarin concentrations and decreased silymarin-glucuronide in rats compared with silymarin alone and silymmarin:D-α-tocopherol polyethylene glycol 1000 succinate (1:1, w/w) formulation. In addition to modulating intestinal first-pass effect, Silymarin-SD formulation showed a significantly higher cumulative dissolution for 120 min compared with that of silymarin from the physical mixture (PM) of the same composition as Silymarin-SD and silymarin alone; the relative BA of silymarin-SD increased to 215% and 589% compared with silymarin-PM and silymarin alone, respectively. This could be attributed to the amorphous status of the Silymarin-SD formulation without chemical interaction with excipients, such as tween 80 and HPC. Moreover, the hepatoprotective effect of Silymarin-SD in acetaminophen-induced acute hepatotoxicity, as estimated from the alanine aminotransferase and aspartate aminotransferase values, was superior to that of silymarin. In conclusion, the increase in the dissolution rate and intestinal permeability of silymarin, and the inhibition of silymarin-glucuronidation by the Silymarin-SD formulation, prepared using tween 80 and HPC, increased its plasma concentration and resulted in a superior hepatoprotective effect compared to silymarin.
MeSH term(s)	Rats ; Animals ; Biological Availability ; Silymarin/pharmacology ; Polysorbates ; Drug Compounding ; Solubility ; alpha-Tocopherol/pharmacology ; Administration, Oral
Chemical Substances	Silymarin ; Polysorbates ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2022-09-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-022-01407-0
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Article ; Online: Concomitant Administration of Red Ginseng Extract with Lactic Acid Bacteria Increases the Plasma Concentration of Deglycosylated Ginsenosides in Healthy Human Subjects.

Jeon, Ji-Hyeon / Park, Jin-Hyang / Jeon, So Yeon / Pang, Minyeong / Choi, Min-Koo / Song, Im-Sook

Biomolecules

2022 Volume 12, Issue 12

Abstract: With the increased frequency of red ginseng extract (RGE) and lactic acid bacteria (LAB) co-administration, we aimed to investigate the interactions between RGE and LAB with regard to in vitro and in vivo deglycosylation metabolism and the ... ...

Abstract	With the increased frequency of red ginseng extract (RGE) and lactic acid bacteria (LAB) co-administration, we aimed to investigate the interactions between RGE and LAB with regard to in vitro and in vivo deglycosylation metabolism and the pharmacokinetics of ginsenosides. As a proof-of-concept study, five healthy humans were administered RGE (104.1 mg of total ginsenosides/day) with or without co-administration of LAB (2 g, 1 billion CFU/day) for 2 weeks, and the plasma concentrations of ginsenosides in human plasma were monitored. The plasma exposure to compound K (CK), ginsenoside Rh2 (GRh2), protopanaxadiol (PPD), and protopanaxatriol (PPT) in the concomitant administration RGE and LAB groups increased by 2.7-, 2.1-, 1.6-, and 3.5-fold, respectively, compared to those in the RGE administration group, without a significant change in T
Language	English
Publishing date	2022-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12121896
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Article ; Online: Mouse models for cancer stem cell research.

Cheng, Le / Ramesh, Anirudh V / Flesken-Nikitin, Andrea / Choi, Jinhyang / Nikitin, Alexander Yu

Toxicologic pathology

2009 Volume 38, Issue 1, Page(s) 62–71

Abstract: The cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with ... ...

Abstract	The cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem cells represent an appealing target for development of more selective and efficient therapies. However, direct testing of the cancer stem cell concept and assessment of its therapeutic implications in human cancers have been complicated by the use of immunocompromised mice. Genetically defined immunocompetent autochthonous mouse models of human cancer provide a valuable tool to address this problem. Furthermore, they allow for a better understanding of the relevance of mechanisms controlling normal stem cell compartment to carcinogenesis. Advantages and disadvantages of some of the existing mouse models are reviewed, and future challenges in cancer stem cell research are outlined.
MeSH term(s)	Animals ; Brain Neoplasms/pathology ; Breast Neoplasms/pathology ; Disease Models, Animal ; Female ; Humans ; Intestinal Neoplasms/pathology ; Male ; Mice ; Neoplasm Transplantation ; Neoplastic Stem Cells/pathology ; Ovarian Neoplasms/pathology ; Prostatic Neoplasms/pathology ; Transplantation, Heterologous
Language	English
Publishing date	2009-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	841009-4
ISSN	1533-1601 ; 0192-6233
ISSN (online)	1533-1601
ISSN	0192-6233
DOI	10.1177/0192623309354109
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Article ; Online: Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency.

Choi, Jinhyang / Curtis, Stephen J / Roy, David M / Flesken-Nikitin, Andrea / Nikitin, Alexander Yu

The American journal of pathology

2010 Volume 177, Issue 5, Page(s) 2645–2658

Abstract: The cell of origin and pathogenesis of the majority of adult soft tissue sarcomas (STS) remains poorly understood. Because mutations in both the P53 and RB tumor suppressor genes are frequent in STS in humans, we inactivated these genes by Cre-loxP- ... ...

Abstract	The cell of origin and pathogenesis of the majority of adult soft tissue sarcomas (STS) remains poorly understood. Because mutations in both the P53 and RB tumor suppressor genes are frequent in STS in humans, we inactivated these genes by Cre-loxP-mediated recombination in mice with floxed p53 and Rb. Ninety-three percent of mice developed spindle cell/pleomorphic sarcomas after a single subcutaneous injection of adenovirus carrying Cre-recombinase. Similar to human STS, these sarcomas overexpress Cxcr4, which contributes to their invasive properties. Using irradiation chimeras generated by transplanting bone marrow cells from mice carrying either the Rosa26StoploxPLacZ or the Z/EG reporter, as well as the floxed p53 and Rb genes, into irradiated p53loxP/loxPRbloxP/loxP mice, it was determined that sarcomas do not originate from bone marrow-derived cells, such as macrophages, but arise from the local resident cells. At the same time, dermal mesenchymal stem cells isolated by strict plastic adherence and low levels of Sca-1 expression (Sca-1low, CD31negCD45neg) have shown enhanced potential for malignant transformation according to soft agar, invasion, and tumorigenicity assays, after the conditional inactivation of both p53 and Rb. Sarcomas formed after transplantation of these cells have features typical for undifferentiated high-grade pleomorphic sarcomas. Taken together, our studies indicate that local Sca-1low dermal mesenchymal stem/progenitor cells are preferential targets for malignant transformation associated with deficiencies in both p53 and Rb.
MeSH term(s)	Adult ; Animals ; Cell Transformation, Neoplastic ; Cells, Cultured ; Humans ; Male ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Mice ; Mice, Transgenic ; Radiation Chimera ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Sarcoma/genetics ; Sarcoma/pathology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Retinoblastoma Protein ; Tumor Suppressor Protein p53
Language	English
Publishing date	2010-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.2353/ajpath.2010.100306
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Article ; Online: A cisplatin‑incorporated liposome that targets the epidermal growth factor receptor enhances radiotherapeutic efficacy without nephrotoxicity.

Jung, Joohee / Jeong, Seong-Yun / Park, Seok Soon / Shin, Seol Hwa / Ju, Eun Jin / Choi, Jinhyang / Park, Jaesook / Lee, Jae Hee / Kim, Inki / Suh, Young-Ah / Hwang, Jung Jin / Kuroda, Shun'ichi / Lee, Jung Shin / Song, Si Yeol / Choi, Eun Kyung

International journal of oncology

2015 Volume 46, Issue 3, Page(s) 1268–1274

Abstract: Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). ... ...

Abstract	Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been well characterized as an effective radiosensitizer, its clinical application is limited by its severe nephrotoxic effects. In our current study, we developed a CDDP‑incorporated liposome (LP) conjugated with EGFR antibodies (EGFR:LP‑CDDP) and evaluated its potential to radiosensitize EGFR‑overexpressing cells without exerting nephrotoxic effects. EGFR:LP‑CDDP showed higher cytotoxicity than non‑targeting liposomal CDDP (LP‑CDDP) in the cells expressing EGFR in vitro. In an A549 cell‑derived xenograft tumor mouse model, increased delays in tumor growth were observed in the mice treated with a combination of EGFR:LP‑CDDP and radiation. Notably, the EGFR:LP‑CDDP‑treated animals showed no differences in body weight loss, survival rates of nephrotoxicity compared with untreated control mice. In contrast, the use of CDDP caused lower body weights and poorer survival outcomes accompanied by a significant level of nephrotoxicity [e.g., decreased kidney weight, increased blood urea nitrogen (BUN) and creatinine, and pathological change]. These findings suggest the feasibility of using EGFR:LP‑CDDP to radiosensitize cells in a targeted manner without inducing nephrotoxic effects. This compound may therefore have clinical potential as part of a tailored chemoradiotherapy strategy.
MeSH term(s)	Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemoradiotherapy/methods ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Drug Carriers ; Humans ; Kidney Diseases/chemically induced ; Kidney Diseases/prevention & control ; Liposomes ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Targeted Therapy/methods ; Radiation Injuries/prevention & control ; Radiation-Sensitizing Agents/administration & dosage ; Radiation-Sensitizing Agents/adverse effects ; Receptor, Epidermal Growth Factor/antagonists & inhibitors ; Treatment Outcome ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Chemical Substances	Drug Carriers ; Liposomes ; Radiation-Sensitizing Agents ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2015-03
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2014.2806
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Article ; Online: Multifunctional hollow gold nanoparticles designed for triple combination therapy and CT imaging.

Park, Jaesook / Park, Jin / Ju, Eun Jin / Park, Seok Soon / Choi, Jinhyang / Lee, Jae Hee / Lee, Kyoung Jin / Shin, Seol Hwa / Ko, Eun Jung / Park, Intae / Kim, Chulhee / Hwang, Jung Jin / Lee, Jung Shin / Song, Si Yeol / Jeong, Seong-Yun / Choi, Eun Kyung

Journal of controlled release : official journal of the Controlled Release Society

2015 Volume 207, Page(s) 77–85

Abstract: Hollow gold nanoparticles (HGNP) are a novel class of hybrid metal nanoparticles whose unique optical and morphological properties have spawned new applications including more effective cancer therapy. The shell thickness of HGNPs can tune the surface ... ...

Abstract	Hollow gold nanoparticles (HGNP) are a novel class of hybrid metal nanoparticles whose unique optical and morphological properties have spawned new applications including more effective cancer therapy. The shell thickness of HGNPs can tune the surface plasmon resonance to the near infrared light, resulting in photothermal ablation of tumors with optimal light penetration in tissue. The hollow cavity within a HGNP is able to accommodate a high payload of chemotherapeutic agents. They have also been used for enhancing radiosensitization in tumors during radiotherapy due to the high X-ray absorption capability of gold particles. However, no report has yet been published that utilize HGNPs for the triple combination therapy and CT imaging. In this study, we synthesized HGNPs which exhibit better response to radiation for therapy and imaging and demonstrated the effects of combined chemotherapy, thermal and radiotherapy. This combination strategy presented delayed tumor growth by 4.3-fold and reduced tumor's weight by 6.8-fold compared to control tumors. In addition, we demonstrated the feasibility of HGNP as a CT imaging agent. It is expected that translating these capabilities to human cancer patients could dramatically increase the antitumor effect and potentially overcome resistance to chemotherapeutic agents and radiation.
MeSH term(s)	Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/chemistry ; Apoptosis ; Cell Line, Tumor ; Chemistry, Pharmaceutical ; Chemoradiotherapy/methods ; Contrast Media/administration & dosage ; Contrast Media/chemistry ; DNA Breaks, Double-Stranded ; Doxorubicin/administration & dosage ; Doxorubicin/chemistry ; Drug Carriers ; Gold/administration & dosage ; Gold/chemistry ; Histones/metabolism ; Kinetics ; Laser Therapy/methods ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Metal Nanoparticles ; Mice, Inbred BALB C ; Mice, Nude ; Predictive Value of Tests ; Radiation Tolerance ; Solubility ; Technology, Pharmaceutical/methods ; Time Factors ; Tumor Burden ; X-Ray Microtomography/methods ; Xenograft Model Antitumor Assays
Chemical Substances	Antibiotics, Antineoplastic ; Contrast Media ; Drug Carriers ; H2AX protein, human ; Histones ; Gold (7440-57-5) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2015-04-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2015.04.007
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