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Article ; Online: Re: Stenting Prior to Cystectomy is an Independent Risk Factor for Upper Urinary Tract Recurrence: B. Kiss, M. A. Furrer, P. Y. Wuethrich, F. C. Burkhard, G. N. Thalmann and B. Roth J Urol 2017;198:1263-1268.

Zargar-Shoshtari, Kamran / Sexton, Wade J

2018 Volume 200, Issue 2, Page(s) 457–458

MeSH term(s)	Carcinoma, Transitional Cell/surgery ; Cystectomy ; Humans ; Neoplasm Recurrence, Local ; Risk Factors ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2018-05-14
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2018.02.3095
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

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Article: Laryngectomy in T3 laryngeal cancer.

Sexton, G P / Hinzte, J M / Kinsella, J / Timon, C / Fitzgerald, C W R / Lennon, P

Irish medical journal

2024 Volume 117, Issue 1, Page(s) 897

MeSH term(s)	Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy
Language	English
Publishing date	2024-01-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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Zs.B 148: Show issues

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Article ; Online: Epidemiology and management of oral cavity squamous cell carcinoma in Ireland.

Sexton, Gerard P / Hintze, J M / Walsh, Paul / Moriarty, Frank / Lennon, Paul / Fitzgerald, Conall W R / O'Neill, James Paul

American journal of otolaryngology

2024 Volume 45, Issue 3, Page(s) 104235

Abstract: ... p = 0.03), in particular for tongue primaries (p = 0.007). Primary surgery significantly improved ... DSS versus radiotherapy (HR 0.28, p < 0.0001). Survival of T4 disease managed surgically was superior ... survival (HR 0.8 p = 0.038) but not DSS (HR 0.87 p = 0.215).: Conclusion: Primary surgery remains ...

Abstract	Introduction: The epidemiology and management of oral cavity cancer have changed considerably in recent decades. This study examines epidemiological and management trends in oral cavity squamous cell carcinoma (OCSCC). Methods: A retrospective cohort study of data from the National Cancer Registry of Ireland between 1994 and 2014. Results: A total of 2725 patients were identified. The most common subsites were the tongue (34 %, n = 1025), lip (19 %, n = 575), floor of mouth (FOM) (18 %, n = 550), and retromolar trigone (RMT) (6 %, n = 189). The incidence of OCSCC remained largely unchanged (3.14 cases/100000/year) during the study period. 5-year disease-specific survival (DSS) was 58.6 % overall, varying between subsites (lip 85 %, RMT 62.9 %, tongue 54.7 %, and FOM 47.3 %). DSS improved over the study period (p = 0.03), in particular for tongue primaries (p = 0.007). Primary surgery significantly improved DSS versus radiotherapy (HR 0.28, p < 0.0001). Survival of T4 disease managed surgically was superior to that of T1 disease managed with radiotherapy. In node positive patients, chemotherapy improved overall survival (HR 0.8 p = 0.038) but not DSS (HR 0.87 p = 0.215). Conclusion: Primary surgery remains the standard of care in the management of OCSCC. Prognosis has improved in line with an increase in the use of primary surgery in the same time frame, though the incidence remains unchanged.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2024.104235
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Article: Crop modeling suggests limited transpiration would increase yield of sorghum across drought-prone regions of the United States.

Raymundo, Rubí / Mclean, Greg / Sexton-Bowser, Sarah / Lipka, Alexander E / Morris, Geoffrey P

Frontiers in plant science

2024 Volume 14, Page(s) 1283339

Abstract: ... which simulates interactions of genotype, environment, and management (G × E × M). In this study, the G component ...

Abstract	Breeding sorghum to withstand droughts is pivotal to secure crop production in regions vulnerable to water scarcity. Limited transpiration (LT) restricts water demand at high vapor pressure deficit, saving water for use in critical periods later in the growing season. Here we evaluated the hypothesis that LT would increase sorghum grain yield in the United States. We used a process-based crop model, APSIM, which simulates interactions of genotype, environment, and management (G × E × M). In this study, the G component includes the LT trait (G
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1283339
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Article ; Online: Hypokalaemic paralysis as the initial clinical presentation of Sjogren's syndrome induced distal renal tubular acidosis.

Kielty, Jennifer M / Ryan, Paul / Sexton, Donal / Kelly, Yvelynne P

BMJ case reports

2021 Volume 14, Issue 5

Abstract: A 41-year-old woman presented by ambulance with a 1-day history of new-onset paralysis and nausea and vomiting ongoing for 48 hours. She had no history of any similar episodes. Biochemical analysis showed profound hypokalaemia with a non-anion gap ... ...

Abstract	A 41-year-old woman presented by ambulance with a 1-day history of new-onset paralysis and nausea and vomiting ongoing for 48 hours. She had no history of any similar episodes. Biochemical analysis showed profound hypokalaemia with a non-anion gap metabolic acidosis. Her initial serum chloride was within the normal range. She had significant electrocardiographic changes on admission with ST depression, U waves and a prolonged QT interval. Urinary anion gap supported the diagnosis of a distal renal tubular acidosis. Subsequent connective tissue disease serology confirmed previously undiagnosed Sjogren's syndrome. Successful recovery for this patient required multidisciplinary input from the intensive care, nephrology and neurology teams.
MeSH term(s)	Acid-Base Equilibrium ; Acidosis, Renal Tubular/diagnosis ; Acidosis, Renal Tubular/etiology ; Adult ; Female ; Humans ; Hypokalemia/diagnosis ; Hypokalemia/etiology ; Paralysis/diagnosis ; Paralysis/etiology ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis
Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-241300
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Article ; Online: The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.

McNeill, Samantha M / Lu, Jessica / Marion C Carino, Carlo / Inoue, Asuka / Zhao, Peishen / Sexton, Patrick M / Wootten, Denise

Biochemical pharmacology

2024 Volume 222, Page(s) 116119

Abstract: The glucagon-like peptide 1 receptor (GLP-1R) is a validated clinical target for the treatment of type 2 diabetes and obesity. Unlike most G protein-coupled receptors (GPCRs), the GLP-1R undergoes an atypical mode of internalisation that does not require ...

Abstract	The glucagon-like peptide 1 receptor (GLP-1R) is a validated clinical target for the treatment of type 2 diabetes and obesity. Unlike most G protein-coupled receptors (GPCRs), the GLP-1R undergoes an atypical mode of internalisation that does not require β-arrestins. While differences in GLP-1R trafficking and β-arrestin recruitment have been observed between clinically used GLP-1R agonists, the role of G protein-coupled receptor kinases (GRKs) in affecting these pathways has not been comprehensively assessed. In this study, we quantified the contribution of GRKs to agonist-mediated GLP-1R internalisation and β-arrestin recruitment profiles using cells where endogenous β-arrestins, or non-visual GRKs were knocked out using CRISPR/Cas9 genome editing. Our results confirm the previously established atypical β-arrestin-independent mode of GLP-1R internalisation and revealed that GLP-1R internalisation is dependent on the expression of GRKs. Interestingly, agonist-mediated GLP-1R β-arrestin 1 and β-arrestin 2 recruitment were differentially affected by endogenous GRK knockout with β-arrestin 1 recruitment more sensitive to GRK knockout than β-arrestin 2 recruitment. Moreover, individual overexpression of GRK2, GRK3, GRK5 or GRK6 in a newly generated GRK2/3/4/5/6 HEK293 cells, rescued agonist-mediated β-arrestin 1 recruitment and internalisation profiles to similar levels, suggesting that there is no specific GRK isoform that drives these pathways. This study advances mechanistic understanding of agonist-mediated GLP-1R internalisation and provides novel insights into how GRKs may fine-tune GLP-1R signalling.
MeSH term(s)	Humans ; Arrestins/genetics ; Arrestins/metabolism ; beta-Arrestin 1/metabolism ; beta-Arrestin 2/genetics ; beta-Arrestin 2/metabolism ; beta-Arrestins/metabolism ; Diabetes Mellitus, Type 2 ; G-Protein-Coupled Receptor Kinases/genetics ; G-Protein-Coupled Receptor Kinases/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; HEK293 Cells ; Phosphorylation ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Arrestins ; beta-Arrestin 1 ; beta-Arrestin 2 ; beta-Arrestins ; G-Protein-Coupled Receptor Kinases (EC 2.7.11.16) ; Glucagon-Like Peptide-1 Receptor ; Receptors, G-Protein-Coupled ; GLP1R protein, human
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116119
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Zs.A 19: Show issues

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Article ; Online: Storylines of family medicine XI: professional identity formation-nurturing one's own story.

Ventres, William B / Stone, Leslie A / Wilson, Hamish J / Sexton, Sumi M / Doukas, David J / Cerdeña, Jessica P / Kelley, David M / Fetters, Michael D / Haney, Jeffrey J / Frey, John J

Family medicine and community health

2024 Volume 12, Issue Suppl 3

Abstract: Storylines of Family ... ...

Abstract	Storylines of Family Medicine
MeSH term(s)	Humans ; Family Practice ; Social Identification ; Physicians, Family ; Ambulatory Care Facilities ; Education, Medical
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2986753-8
ISSN	2009-8774 ; 2305-6983
ISSN (online)	2009-8774
ISSN	2305-6983
DOI	10.1136/fmch-2024-002827
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Article ; Online: P16 and HPV status in head and neck sarcomas and sarcomatoid carcinomas.

Shaker, Nuha / Mansoori, Parisa / Fattah, Yasmin H / Ellis, Monika / Sexton, Tammy / O'Neill, Stacey / Qasem, Shadi A

Annals of diagnostic pathology

2024 Volume 71, Page(s) 152307

Abstract: Human papillomavirus (HPV)-positive oropharyngeal carcinoma is a distinct type of head and neck carcinoma with improved prognosis. p16 immunostaining is often used as a surrogate marker for HPV infection in this particular setting. The aim of this study ... ...

Abstract	Human papillomavirus (HPV)-positive oropharyngeal carcinoma is a distinct type of head and neck carcinoma with improved prognosis. p16 immunostaining is often used as a surrogate marker for HPV infection in this particular setting. The aim of this study is to estimate the prevalence of p16 staining and HPV infection in head and neck sarcomatoid carcinomas as well as head and neck sarcomas. 21 sarcomatoid carcinomas and 28 head and neck sarcomas were tested for p16 positivity using immunohistochemical staining, and for high-risk HPV infection using In situ hybridization (ISH). 24 % of sarcomatoid carcinomas and 21 % of sarcomas were positive for p16 staining. All 49 cases were negative for HPV ISH. The results confirm that p16 staining is not specific and may not be associated with HPV infection in non-oropharyngeal head and neck sites. They also indicate that non-oropharyngeal head and neck sarcomatoid carcinomas are not likely to be HPV related.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2024.152307
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Zs.A 5463: Show issues

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Article ; Online: Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists.

Keov, Peter / Christopoulos, George / Hick, Caroline A / Glendorf, Tine / Ballarín-González, Borja / Wootten, Denise / Sexton, Patrick M

Molecular pharmacology

2024 Volume 105, Issue 5, Page(s) 359–373

Abstract: Dual amylin and calcitonin receptor agonists (DACRAs) show promise as efficacious therapeutics for treatment of metabolic disease, including obesity. However, differences in efficacy in vivo have been observed for individual DACRAs, indicating that ... ...

Abstract	Dual amylin and calcitonin receptor agonists (DACRAs) show promise as efficacious therapeutics for treatment of metabolic disease, including obesity. However, differences in efficacy in vivo have been observed for individual DACRAs, indicating that detailed understanding of the pharmacology of these agents across target receptors is required for rational drug development. To date, such understanding has been hampered by lack of direct, subtype-selective, functional assays for the amylin receptors (AMYRs). Here, we describe the generation of receptor-specific assays for recruitment of Venus-tagged Gs protein through fusion of luciferase to either the human calcitonin receptor (CTR), human receptor activity-modifying protein (RAMP)-1, RAMP1 (AMY
MeSH term(s)	Humans ; Receptors, Calcitonin/metabolism ; Receptor Activity-Modifying Proteins ; Receptors, Islet Amyloid Polypeptide ; Islet Amyloid Polypeptide ; Receptors, Peptide/metabolism ; Membrane Proteins/metabolism ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Obesity ; Metabolic Diseases
Chemical Substances	Receptors, Calcitonin ; Receptor Activity-Modifying Proteins ; Receptors, Islet Amyloid Polypeptide ; Islet Amyloid Polypeptide ; Receptors, Peptide ; Membrane Proteins ; Intracellular Signaling Peptides and Proteins ; Neuropeptides
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	124034-1
ISSN	1521-0111 ; 0026-895X
ISSN (online)	1521-0111
ISSN	0026-895X
DOI	10.1124/molpharm.123.000865
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Zs.A 525: Show issues

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Article: Interval colorectal cancers after negative faecal immunochemical test in the New Zealand Bowel Screening Pilot.

Saw, Kai Sheng / Sexton, Kerry / Frankish, Paul / Hulme-Moir, Mike / Bissett, Ian / Parry, Susan

BMJ open gastroenterology

2023 Volume 10, Issue 1

Abstract: Objective: Evaluate the diagnostic performance of faecal immunochemical test (FIT), identify risk factors for FIT-interval colorectal cancers (FIT-IC) and describe long-term outcomes of participants with colorectal cancers (CRC) in the New Zealand Bowel ...

Abstract	Objective: Evaluate the diagnostic performance of faecal immunochemical test (FIT), identify risk factors for FIT-interval colorectal cancers (FIT-IC) and describe long-term outcomes of participants with colorectal cancers (CRC) in the New Zealand Bowel Screening Pilot (BSP). Design: From 2012 to 2017, the BSP offered eligible individuals, aged 50-74 years, biennial screening using a quantitative FIT with positivity threshold of 15 µg haemoglobin (Hb)/g faeces. Retrospective review of prospectively maintained data extracted from the BSP Register and New Zealand Cancer Registry identified any CRC reported in participants who returned a definitive FIT result. Further details were obtained from hospital records. FIT-ICs were primary CRC diagnosed within 24 months of a negative FIT. Factors associated with FIT-ICs were identified using logistic regression. Results: Of 387 215 individuals invited, 57.4% participated with 6.1% returning positive FIT results. Final analysis included 520 CRC, of which 111 (21.3%) met FIT-IC definition. Overall FIT sensitivity for CRC was 78.7% (95% CI=74.9% to 82.1%), specificity was 94.1% (95% CI=94.0% to 94.2%). In 78 (70.3%) participants with FIT-IC, faecal Hb was reported as undetectable. There were no significant associations between FIT-IC and age, sex, ethnicity and deprivation. FIT-ICs were significantly associated with proximal tumour location, late stage at diagnosis, high-grade tumour differentiation and subsequent round screens. Median follow-up time was 74 (2-124) months. FIT-IC had significantly poorer overall survival. Conclusion: FIT sensitivity in BSP compared favourably to published data. FIT-ICs were more likely to be proximal tumours with poor long-term outcomes. Further lowering of FIT threshold would have minimal impact on FIT-IC.
MeSH term(s)	Humans ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; New Zealand/epidemiology ; Early Detection of Cancer/methods ; Occult Blood ; Hemoglobins/analysis
Chemical Substances	Hemoglobins
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2054-4774
ISSN	2054-4774
DOI	10.1136/bmjgast-2023-001233
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