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Article ; Online: Changes in Soybean Agglutinin (SBA) and Peanut Agglutinin (PNA) Binding Pattern in the Epidermis of the Developing Chick Embryo: (chick embryo/epidermis/lectins/differentiation).

Takata, Kuniaki / Hirano, Hiroshi

2023 Volume 25, Issue 3, Page(s) 299–305

Abstract: Lectin binding pattern in the developing chick embryonic epidermis was studied using peroxidase labeling method. The epidermis of the 13-day-old embryo is in an undifferentiated state. Little binding of soybean agglutinin (SBA), specific for N-acetyl-D- ... ...

Abstract	Lectin binding pattern in the developing chick embryonic epidermis was studied using peroxidase labeling method. The epidermis of the 13-day-old embryo is in an undifferentiated state. Little binding of soybean agglutinin (SBA), specific for N-acetyl-D-galactosamine, and peanut agglutinin (PNA), specific for β-D-galactose, was seen in such epidermal cells. As the epidermis developed toward keratinization, the cell membrane of the differentiating flattened cells was positively stained with SBA and PNA. The positive staining was also seen in the supranuclear region of the cells located between the flattened cells and the basal cells. The basal cells remained unstained in all the stages of development. Similar staining pattern with SBA and PNA was seen in the cultured skin explants during the epidermal differentiation in vitro. These observations show that the SBA- and PNA-reactive glycoconjugates accumulate during the epidermal cell differentiation, suggesting their important roles in the maintenance of the ordered structure of the epidermis.
Language	English
Publishing date	2023-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280433-5
ISSN	1440-169X ; 0012-1592
ISSN (online)	1440-169X
ISSN	0012-1592
DOI	10.1111/j.1440-169X.1983.00299.x
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Zs.A 194: Show issues

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Article ; Online: Differentiating Brown Tumor From Bone Metastasis in Parathyroid Cancer Using 18 F-FDG PET and 99m Tc-MIBI SPECT.

Tsukamoto, Suzune / Kawabata, Kazuna / Kawamura, Hitomi / Takata, Kuniaki / Hosono, Makoto

Clinical nuclear medicine

2024 Volume 49, Issue 5, Page(s) 444–446

Abstract: Abstract: A 69-year-old woman presented with a right clavicle pain. CT revealed a pathological fracture of the right clavicle, multiple osteolytic lesions, and a left cervical mass. 18 F-FDG PET/CT demonstrated a marked FDG uptake in the cervical mass ... ...

Abstract	Abstract: A 69-year-old woman presented with a right clavicle pain. CT revealed a pathological fracture of the right clavicle, multiple osteolytic lesions, and a left cervical mass. 18 F-FDG PET/CT demonstrated a marked FDG uptake in the cervical mass and osteolytic lesions indicative of metastatic parathyroid cancer. 99m Tc-MIBI SPECT/CT revealed either faint or no uptake in the osteolytic lesions. However, a histopathological analysis after a parathyroidectomy and right clavicle biopsy confirmed the diagnosis of parathyroid cancer and the presence of benign brown tumors secondary to hyperparathyroidism. Postoperative imaging showed sclerotic change and a decreased FDG uptake in the bone lesions.
MeSH term(s)	Female ; Humans ; Aged ; Fluorodeoxyglucose F18 ; Parathyroid Neoplasms/complications ; Positron Emission Tomography Computed Tomography/methods ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon ; Osteitis Fibrosa Cystica/complications ; Bone Neoplasms/secondary
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Technetium Tc 99m Sestamibi (971Z4W1S09)
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000005115
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Zs.A 1276: Show issues

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Book: Aquaporins: water channel proteins of the cell membrane

Takata, Kuniaki / Matsuzaki, Toshiyuki / Tajika, Yuki

(Progress in histochemistry and cytochemistry ; 39,1)

2004

Author's details	Kuniaki Takata ; Toshiyuki Matsuzaki ; Yuki Tajika
Series title	Progress in histochemistry and cytochemistry ; 39,1
Collection
Language	English
Size	83 S. : Ill.
Publisher	Urban & Fischer
Publishing place	Jena
Publishing country	Germany
Document type	Book
HBZ-ID	HT014052235
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Se 23 -39,1-	verfügbar in Königswinter	Königswinter

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Article ; Online: Safety and efficacy of high tracheostomy with inferior retraction of the thyroid isthmus.

Iokura, Daisuke / Okanoue, Yusuke / Otsuki, Shuya / Oe, Kengo / Takata, Kuniaki / Tarui, Akihito / Kojima, Tsuyoshi

Auris, nasus, larynx

2023 Volume 51, Issue 2, Page(s) 231–235

Abstract: Objective: In typical surgical tracheostomy, the thyroid isthmus is divided or retracted superiorly and preserved. However, at our institution, the thyroid isthmus is retracted inferiorly and preserved. Thereafter, a tracheal incision is made above the ... ...

Abstract	Objective: In typical surgical tracheostomy, the thyroid isthmus is divided or retracted superiorly and preserved. However, at our institution, the thyroid isthmus is retracted inferiorly and preserved. Thereafter, a tracheal incision is made above the thyroid isthmus. This method, hereinafter defined as high tracheostomy, has the advantage of facilitating immediate access to the trachea in a superficial position; moreover, it can be quickly replaced with cricothyrotomy in emergency situations. However, tracheotomies placed too high can potentially damage the cricoid cartilage, thereby causing subglottic granulation and tracheal stenosis. We aimed to validate the safety and efficacy of high tracheostomy with inferior retraction of the thyroid isthmus. Methods: This was a retrospective cohort analysis. We analyzed the operative method and other relevant characteristics of 90 patients who underwent surgical tracheostomy between April 2016 and June 2022. For those who underwent high tracheostomies, we analyzed the duration of surgery, amount of intraoperative bleeding, occurrence of complications, problems with stoma closure, and perioperative mortality. Results: High tracheostomy was performed in 73 patients. Subglottic granulation occurred in one patient, and the granulation tissue spontaneously shrank. Subcutaneous emphysema occurred in two patients. No patient developed wound infection or tracheoinnominate artery fistula. Moreover, no patient experienced false route tracheotomy tube insertion because the thyroid glands were located under the stoma. Conclusion: The frequency of complications was comparable to that reported in other studies on tracheostomy. Additionally, no patient developed tracheal stenosis secondary to tracheostomy above the thyroid isthmus. Therefore, high tracheostomy with inferior retraction and preservation of the thyroid isthmus is safe and advantageous.
MeSH term(s)	Humans ; Tracheostomy/methods ; Thyroid Gland/surgery ; Tracheal Stenosis/surgery ; Tracheal Stenosis/etiology ; Retrospective Studies ; Trachea/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604552-2
ISSN	1879-1476 ; 0385-8146
ISSN (online)	1879-1476
ISSN	0385-8146
DOI	10.1016/j.anl.2023.10.007
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Zs.A 1675: Show issues

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Article ; Online: Impact of cervical lymph node metastasis on transoral surgery for hypopharyngeal squamous cell carcinoma: A retrospective multicenter study.

Ushiro, Koji / Watanabe, Yoshiki / Kishimoto, Yo / Kawai, Yoshitaka / Fujimura, Shintaro / Asato, Ryo / Tsujimura, Takashi / Hori, Ryusuke / Kumabe, Yohei / Yasuda, Kaori / Tamaki, Hisanobu / Iki, Takehiro / Kitani, Yoshiharu / Kurata, Keisuke / Kojima, Tsuyoshi / Takata, Kuniaki / Kada, Shinpei / Takebayashi, Shinji / Shinohara, Shogo /

Hamaguchi, Kiyomi / Miyazaki, Masakazu / Ikenaga, Tadashi / Maetani, Toshiki / Harada, Hiroyuki / Haji, Tomoyuki / Omori, Koichi

Head & neck

2024

Abstract: Background: Hypopharyngeal carcinoma is likely to spread to the lymph nodes, but there is no established strategy for management in transoral surgery.: Methods: We compared oncologic and functional outcomes in a retrospective multicenter study of ... ...

Abstract	Background: Hypopharyngeal carcinoma is likely to spread to the lymph nodes, but there is no established strategy for management in transoral surgery. Methods: We compared oncologic and functional outcomes in a retrospective multicenter study of patients who underwent transoral surgery for hypopharyngeal carcinoma between 2015 and 2021. Results: Two-hundred and thirty-two patients were included. Comparing patients with and without adjuvant radiotherapy, 3-year regional recurrence-free survival (RRFS) was not significantly different in pN2b and pN2c, but was significantly worse in pN3b without adjuvant radiotherapy. In patients without neck dissection, the 3-year RRFS was 85.6%, 76.8%, and 70.0% for T1, T2, and T3 primary lesions, respectively, and was significantly worse for T2 or higher (p = 0.035). Conclusions: In the absence of extracapsular invasion, regional control did not deteriorate without adjuvant therapy. If prophylactic neck dissection is not performed, careful follow-up is necessary if the primary lesion is T2 or greater.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27666
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Zs.A 1493: Show issues

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Article ; Online: Complications including dysphagia following transoral non-robotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.

Hamaguchi, Kiyomi / Miyazaki, Masakazu / Ikenaga, Tadashi / Maetani, Toshiki / Harada, Hiroyuki / Haji, Tomoyuki / Omori, Koichi

Auris, nasus, larynx

2024 Volume 51, Issue 3, Page(s) 575–582

Abstract: Objective: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.: Methods: We compared clinical information, surgical complications, and swallowing function in patients who ... ...

Abstract	Objective: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy. Methods: We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study. Results: Six hundred and forty patients were included. Postoperative bleeding was observed in 20 cases (3.1%), and the risk factor was advanced T category. Postoperative laryngeal edema was observed in 13 cases (2.0%), and the risk factors were prior radiotherapy, advanced T stage, and concurrent neck dissection in patients with resected HPC. Dysphagia requiring nutritional support was observed in 29 cases (4.5%) at 1 month postoperatively and in 19 cases (3.0%) at 1 year postoperatively, respectively. The risk factors for long-term dysphagia were prior radiotherapy and advanced T category. Short-term risk factors for dysphagia were prior radiotherapy, advanced T category, and concurrent neck dissection, while long-term risk factors for dysphagia were only prior radiotherapy and advanced T category. Conclusion: Prior radiotherapy, advanced T stage, and concurrent neck dissection increased the incidence of postoperative laryngeal edema and short-term dysphagia, but concurrent neck dissection did not affect long-term dysphagia. Such features should be considered when considering the indication for transoral surgery and postoperative management.
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604552-2
ISSN	1879-1476 ; 0385-8146
ISSN (online)	1879-1476
ISSN	0385-8146
DOI	10.1016/j.anl.2024.03.005
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Zs.A 1675: Show issues

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Article ; Online: Pre-embedding Method of Electron Microscopy for Glycan Localization in Mammalian Tissues and Cells Using Lectin Probes.

Akimoto, Yoshihiro / Takata, Kuniaki / Kawakami, Hayato

Methods in molecular biology (Clifton, N.J.)

2016 Volume 1474, Page(s) 259–267

Abstract: In recent years, the study of glycans is progressing remarkably by the development of glycan analysis systems using mass spectrometry, glycan profiling systems using lectin microarrays, and glycoprotein analysis by the isotope-coded glycosylation site- ... ...

Abstract	In recent years, the study of glycans is progressing remarkably by the development of glycan analysis systems using mass spectrometry, glycan profiling systems using lectin microarrays, and glycoprotein analysis by the isotope-coded glycosylation site-specific tagging method. With these methodologies, glycan structures and biological functions are being elucidated. In the study of glycan function as well as disease diagnosis, it is important to examine the localization of glycans in tissues and cells. Histochemical methods using lectin probes can localize glycans in the tissues and cells. This chapter describes a pre-embedding electron microscopic method for glycan localization in which tissue sections and cells are incubated with lectin prior to embedding in resin.
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-6352-2_16
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Article ; Online: Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease: A Case Report.

Internal medicine (Tokyo, Japan)

2023

Abstract: We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal ... ...

Abstract	We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal hypertension with radiological and histopathological findings consistent with IPH, distinct from veno-occlusive disease (VOD) and graft-versus-host disease (GVHD) of the liver. This case highlights the importance of considering IPH-like disease as a potential cause of portal hypertension after allo-HSCT. Awareness of this complication can aid in the early diagnosis and appropriate management of patients post allo-HSCT.
Language	English
Publishing date	2023-10-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2489-23
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Zs.A 240: Show issues

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Article ; Online: Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial.

Takeshita, Yumie / Honda, Masao / Harada, Kenichi / Kita, Yuki / Takata, Noboru / Tsujiguchi, Hiromasa / Tanaka, Takeo / Goto, Hisanori / Nakano, Yujiro / Iida, Noriho / Arai, Kuniaki / Yamashita, Tatsuya / Mizukoshi, Eishiro / Nakamura, Hiroyuki / Kaneko, Shuichi / Takamura, Toshinari

Diabetes care

2022 Volume 45, Issue 9, Page(s) 2064–2075

Abstract: Objective: Nonalcoholic fatty liver disease (NAFLD) is a liver phenotype of type 2 diabetes and obesity. Currently, the efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors and sulfonylureas in liver pathology and hepatic gene expression ... ...

Abstract	Objective: Nonalcoholic fatty liver disease (NAFLD) is a liver phenotype of type 2 diabetes and obesity. Currently, the efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors and sulfonylureas in liver pathology and hepatic gene expression profiles for type 2 diabetes with NAFLD are unknown. Research design and methods: We conducted a 48 week, randomized, open-label, parallel-group trial involving participants with biopsy-confirmed NAFLD. A total of 40 participants were randomly assigned to receive once daily 20 mg tofogliflozin or 0.5 mg glimepiride. The primary outcome was the percentage of participants with at least an improvement in all individual scores for histological categories of steatosis, hepatocellular ballooning, lobular inflammation, and fibrosis by at least 1 point. The secondary end points were the changes in liver enzymes, metabolic markers, and hepatic gene expression profiles. Results: Fibrosis scores improved in the tofogliflozin group (60%, P = 0.001), whereas the change from baseline did not differ significantly between the groups (P = 0.172). The histological variables of steatosis (65%, P = 0.001), hepatocellular ballooning (55%, P = 0.002), and lobular inflammation (50%, P = 0.003) were improved in the tofogliflozin group, whereas only hepatocellular ballooning was improved in the glimepiride group (25%, P = 0.025). Hepatic gene expression profiling revealed histology-associated signatures in energy metabolism, inflammation, and fibrosis that were reversed with tofogliflozin. Conclusions: Tofogliflozin and, to a lesser degree, glimepiride led to liver histological and metabolic improvement in participants with type 2 diabetes and NAFLD, with no significant difference between the agents. The hepatic expression of the genes involved in energy metabolism, inflammation, and fibrosis was well correlated with liver histological changes and rescued by tofogliflozin. We need further confirmation through long-term larger-scale clinical trials of SGLT2 inhibitors.
MeSH term(s)	Benzhydryl Compounds ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Fibrosis ; Glucosides ; Humans ; Inflammation/complications ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/complications ; Sulfonylurea Compounds
Chemical Substances	Benzhydryl Compounds ; Glucosides ; Sulfonylurea Compounds ; glimepiride (6KY687524K) ; 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol (P8DD8KX4O4)
Language	English
Publishing date	2022-07-27
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc21-2049
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article ; Online: Local recurrence and metachronous multiple cancers after transoral nonrobotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.

Hamaguchi, Kiyomi / Miyazaki, Masakazu / Ikenaga, Tadashi / Maetani, Toshiki / Harada, Hiroyuki / Haji, Tomoyuki / Omori, Koichi

Head & neck

2023 Volume 46, Issue 1, Page(s) 118–128

Abstract: Background: Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.: Methods: We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in ... ...

Abstract	Background: Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers. Methods: We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study. Results: Four hundred and fifty-seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty-two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (p = 0.003) and positive horizontal margins of carcinoma in situ only (p = 0.032) were independent risk factors for local recurrence, and prior radiotherapy (p = 0.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (p = 0.049), but there was no significant difference in survival. Conclusions: Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/surgery ; Retrospective Studies ; Carcinoma, Squamous Cell/surgery ; Hypopharyngeal Neoplasms ; Head and Neck Neoplasms ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27564
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