Article ; Online: Identification and characterization of chemical constituents in Qi-Lin pills and their metabolites in rat bio-samples after oral administration using ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.
Journal of pharmaceutical and biomedical analysis
2020 Volume 188, Page(s) 113402
Abstract: Qi-Lin pill (QLP), a traditional Chinese medicine prescription (TCMP), composed of fifteen ...
Abstract | Qi-Lin pill (QLP), a traditional Chinese medicine prescription (TCMP), composed of fifteen herbal medicines, has been widely used for the treatment of male infertility. However, an in-depth understanding of the chemical constituents of QLP and its in vivo metabolic study is lacking. In this study, a method using ultra-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was established for comprehensive analysis of chemical constituents of QLP and their metabolites in plasma, urine, bile and feces after gastric perfusion. The method guaranteed the fast discovery of representative structural fragment information and provided efficient structure clues for identification based on data from MS |
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MeSH term(s) | Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Male ; Mass Spectrometry ; Qi ; Rats ; Rats, Sprague-Dawley |
Chemical Substances | Drugs, Chinese Herbal |
Language | English |
Publishing date | 2020-06-04 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 604917-5 |
ISSN | 1873-264X ; 0731-7085 |
ISSN (online) | 1873-264X |
ISSN | 0731-7085 |
DOI | 10.1016/j.jpba.2020.113402 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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