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  1. Article ; Online: Identification and characterization of chemical constituents in Qi-Lin pills and their metabolites in rat bio-samples after oral administration using ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.

    Tang, Xi-Yang / Zeng, Jia-Xing / Dai, Zi-Qin / Chen, Ming-Hao / Ye, Meng-Nan / Yao, Zhi-Hong / Dai, Yi / Yao, Xin-Sheng

    Journal of pharmaceutical and biomedical analysis

    2020  Volume 188, Page(s) 113402

    Abstract: Qi-Lin pill (QLP), a traditional Chinese medicine prescription (TCMP), composed of fifteen ...

    Abstract Qi-Lin pill (QLP), a traditional Chinese medicine prescription (TCMP), composed of fifteen herbal medicines, has been widely used for the treatment of male infertility. However, an in-depth understanding of the chemical constituents of QLP and its in vivo metabolic study is lacking. In this study, a method using ultra-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was established for comprehensive analysis of chemical constituents of QLP and their metabolites in plasma, urine, bile and feces after gastric perfusion. The method guaranteed the fast discovery of representative structural fragment information and provided efficient structure clues for identification based on data from MS
    MeSH term(s) Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Male ; Mass Spectrometry ; Qi ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2020.113402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: Lü lin chi mei qi yi

    Chen, Zhen

    (Li shi zhi shi du wu ; 历史知识读物)

    1974  

    Author's details Chen zhen
    Series title Li shi zhi shi du wu
    历史知识读物
    Keywords Peasant uprisings/History ; China
    Language Chinese
    Size 56 S, ill, 19 cm
    Edition Di 1 ban
    Publisher Zhong hua shu ju
    Publishing place Bei jing
    Document type Book
    Note Includes bibliographical references
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Intermolecular Enantioselective Benzylic C(sp

    Dai, Ling / Chen, Ying-Ying / Xiao, Li-Jun / Zhou, Qi-Lin

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 24, Page(s) e202304427

    Abstract: Chiral benzylic amines are privileged motifs in pharmacologically active molecules. Intramolecular enantioselective radical C( ... ...

    Abstract Chiral benzylic amines are privileged motifs in pharmacologically active molecules. Intramolecular enantioselective radical C(sp
    Language English
    Publishing date 2023-05-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202304427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A novel bacteriocin against multiple foodborne pathogens from

    Chen, Shi-Yu / Yang, Rui-Si / Ci, Bai-Quan / Xin, Wei-Gang / Zhang, Qi-Lin / Lin, Lian-Bing / Wang, Feng

    Current research in food science

    2023  Volume 6, Page(s) 100484

    Abstract: Foodborne pathogens and their biofilms pose a risk to human health through food chain. However, the bacteriocin resources combating this threat are still limited. Here, ...

    Abstract Foodborne pathogens and their biofilms pose a risk to human health through food chain. However, the bacteriocin resources combating this threat are still limited. Here,
    Language English
    Publishing date 2023-03-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9271
    ISSN (online) 2665-9271
    DOI 10.1016/j.crfs.2023.100484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genome-wide transcriptomics and microRNAomics analyses uncover multi-faceted mechanisms to cope with copper stress in ancient macrobenthos amphioxus.

    Yang, Lin-Yu / Zhu, Qian-Hua / Chen, Jun-Yuan / Lin, Lian-Bing / Liang, Ming-Zhong / Zhang, Qi-Lin

    Journal of hazardous materials

    2023  Volume 458, Page(s) 131594

    Abstract: The mechanisms underlying the toxicity of environmental stress are unclear for marine macrobenthos. Copper/Cu has posed the most serious threats to amphioxus, an ancient and model benthic cephalochordate. Herein, a dynamic change in the physiological ... ...

    Abstract The mechanisms underlying the toxicity of environmental stress are unclear for marine macrobenthos. Copper/Cu has posed the most serious threats to amphioxus, an ancient and model benthic cephalochordate. Herein, a dynamic change in the physiological parameters (GR, SOD, ATP, and MDA) was detected with ROS accumulation in Branchiostoma belcheri exposed to 0.3 mg·L
    MeSH term(s) Animals ; Transcriptome ; Lancelets ; Copper/toxicity ; Copper/metabolism ; Reactive Oxygen Species/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Adenosine Triphosphate/metabolism
    Chemical Substances Copper (789U1901C5) ; Reactive Oxygen Species ; MicroRNAs ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-05-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.131594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Spiro Phosphamide Catalyzed Enantioselective Proton Transfer of Ylides in a Free Carbene Insertion into N-H Bonds.

    Pan, Jia-Bin / Zhang, Xuan-Ge / Shi, Yi-Fan / Han, Ai-Cui / Chen, Yu-Jia / Ouyang, Jing / Li, Mao-Lin / Zhou, Qi-Lin

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 15, Page(s) e202300691

    Abstract: Free carbene readily causes multiple side reactions due to its high energy, thus its asymmetric transformation is very difficult. We present here our findings of high- ... ...

    Abstract Free carbene readily causes multiple side reactions due to its high energy, thus its asymmetric transformation is very difficult. We present here our findings of high-pK
    Language English
    Publishing date 2023-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202300691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Yang di huang di yao li ji qi lin chuang ying yong

    Chen, Erchang

    1979  

    Title translation Digitalis: pharmacology and clinical use.
    Author's details Chen Erchang bian zhu
    MeSH term(s) Digitalis Glycosides
    Language Chinese
    Size 4, 4, 266 p. :, ill.
    Edition Di 1 ban.
    Publisher Jilin ren min chu ban she
    Publishing place Changchun
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Differential oral and gut microbial structure related to systemic metabolism in kidney stone patients.

    Xu, Zi-Jie / Chen, Lei / Tang, Qi-Lin / Li, Deng / He, Chu-Jiang / Xu, Chao-Liang / Chen, Fei-Teng / Shao, Yi

    World journal of urology

    2024  Volume 42, Issue 1, Page(s) 6

    Abstract: Objectives: To investigate the role of the oral and gut microbiome related to systemic metabolism and clinical parameters in various types of kidney stone disease.: Patients and methods: We conducted a case-control study by analyzing 16S rRNA and ... ...

    Abstract Objectives: To investigate the role of the oral and gut microbiome related to systemic metabolism and clinical parameters in various types of kidney stone disease.
    Patients and methods: We conducted a case-control study by analyzing 16S rRNA and untargeted metabolomics profiling of 76 fecal, 68 saliva, 73 urine, and 43 serum samples from 76 participants aged 18-75 years old. The participants included 15 patients with uric acid stones, 41 patients with calcium oxalate stones, and 20 healthy controls. Correlations among microbiome, metabolism, and clinical parameters were identified through Spearman's correlation analysis. (Clinical trial No. ChiCTR2200055316).
    Results: Patients with uric acid stones exhibited reduced richness and diversity in their microbiome, as well as altered composition in both oral and gut microbiome. Furthermore, their fecal samples showed lower relative abundances of Bacteroides and Lachnospiraceae, while their saliva samples showed higher relative abundances of Porphyromonas and Neisseria. Predicted KEGG metabolism pathways, including amino acid and fatty acid metabolisms, were significantly altered in subjects with uric acid stones. Oral, gut microbiota, and metabolism were also associated with low water intake and urine pH. The area under the curve (AUC) of the specific microbiota and metabolite prediction models was over 0.85.
    Conclusion: The structure and composition of the oral and gut microbiome in different types of kidney stone disease, the correlations between oral and gut microbiome, and the associations among oral and gut microbiota, systemic metabolism and clinical parameters imply an important role that the oral and gut microbiome may play in kidney stone disease.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Gastrointestinal Microbiome/genetics ; Case-Control Studies ; Uric Acid ; RNA, Ribosomal, 16S/genetics ; Kidney Calculi/urine
    Chemical Substances Uric Acid (268B43MJ25) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-01-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04712-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1832: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Causal effect of air pollution on the risk of cardiovascular and metabolic diseases and potential mediation by gut microbiota.

    Liu, Chen-Xi / Liu, Yu-Bo / Peng, Yi / Peng, Jia / Ma, Qi-Lin

    The Science of the total environment

    2023  Volume 912, Page(s) 169418

    Abstract: Background: Epidemiological studies have explored the relationship between air pollution and cardiovascular and metabolic diseases (CVMDs). Accumulating evidence has indicated that gut microbiota deeply affects the risk of CVMDs. However, the findings ... ...

    Abstract Background: Epidemiological studies have explored the relationship between air pollution and cardiovascular and metabolic diseases (CVMDs). Accumulating evidence has indicated that gut microbiota deeply affects the risk of CVMDs. However, the findings are controversial and the causality remains uncertain. To evaluate whether there is the causal association of four air pollutants with 19 CVMDs and the potential effect of gut microbiota on these relationships.
    Methods: Genetic instruments for particulate matter (PM) with aerodynamic diameter < 2.5 μm (PM
    Results: Causal relationships between NO
    Conclusions: This study firstly provided the genetic evidence linking air pollution to CVMDs and gut microbiota may mediate the association of PM
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Diabetes Mellitus, Type 2 ; Reproducibility of Results ; Environmental Exposure ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Metabolic Diseases
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2023-12-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.169418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Combined analysis of transcriptomics and metabolomics provide insights into the antibacterial mechanism of bacteriocin XJS01 against multidrug-resistant Staphylococcus aureus.

    Ying, Jian-Ping / Fu, Chao-Min / Wu, Yan-Chun / Chen, Ya-Mei / Liu, Xiao-Yu / Zhang, Qi-Lin / Liu, Hui / Liang, Ming-Zhong

    The Science of the total environment

    2024  Volume 917, Page(s) 170412

    Abstract: Multidrug-resistant (MDR) bacteria are widespread in the environment and pose a serious threat to public health. It has been shown that bacteriocins have a great potential in controlling MDR pathogens, including Staphylococcus aureus. A previously ... ...

    Abstract Multidrug-resistant (MDR) bacteria are widespread in the environment and pose a serious threat to public health. It has been shown that bacteriocins have a great potential in controlling MDR pathogens, including Staphylococcus aureus. A previously reported Lactobacillus salivarius bacteriocin XJS01 exhibited good antibacterial activity against MDR S. aureus 2612:1606BL1486 (henceforth referred to as S. aureus_26), but its molecular mechanism remains unknown. Herein, we investigated the antibacterial mechanism of XJS01 on S. aureus_26 using an approach combining transcriptomics and metabolomics. The results showed that XJS01 induced significant changes at both transcriptional and metabolic levels in S. aureus_26. In total, 231 differentially expressed genes (DEGs) and 206 differentially abundance metabolites (DAMs) were identified in S. aureus_26 treated with 1 × MIC (minimum inhibition concentration) XJS01 compared with untreated (XJS01-free) cells (control). Functional analysis revealed that these DEGs and DAMs, alone with the related pathways and biological processes, were typically involved in stress response, being primarily related to metal uptake, cell virulence, self-help mechanism, amino acid and energy metabolism, bacterial stress response (e.g., two-component system), and membrane transport (e.g., phosphotransferase system). Overall, this study uncovered the multi-target effects of bacteriocins against MDR S. aureus at the genome-wide transcriptional and metabolic levels. These findings might be useful in the development of bacteriocins for the control of MDR S. aureus and other drug-resistant bacteria.
    MeSH term(s) Humans ; Bacteriocins/genetics ; Bacteriocins/metabolism ; Bacteriocins/pharmacology ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus/genetics ; Anti-Bacterial Agents/chemistry ; Staphylococcal Infections ; Bacteria/metabolism ; Microbial Sensitivity Tests ; Gene Expression Profiling
    Chemical Substances Bacteriocins ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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