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Article ; Online: Social disparities and unhealthy lifestyles increase risk of dementia, particularly at a young age.

Filippini, Tommaso / Vinceti, Marco

The lancet. Healthy longevity

2023 Volume 4, Issue 12, Page(s) e660–e661

MeSH term(s)	Humans ; Life Style ; Smoking ; Dementia/epidemiology ; Dementia/etiology
Language	English
Publishing date	2023-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2666-7568
ISSN (online)	2666-7568
DOI	10.1016/S2666-7568(23)00233-7
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Article: Reorganizing Italy's Territorial Healthcare: the Ministerial Decree No. 77/2022 and its Comparative Significance.

Vinceti, S R

Annali di igiene : medicina preventiva e di comunita

2023 Volume 35, Issue 3, Page(s) 367–371

Abstract: ... type of funding system and organizational framework. ...

Abstract	Abstract: As approved by the European Commission in 2021, Italy's National Recovery and Resilience Plan encompasses a far-reaching reform in the governance and structure of the national health service (NHS) that should shift the focus of assistance from large, centralized hospitals to a tight network of numerous smaller health centers dislocated in the country. In this respect, the adoption of the Ministerial Decree no. 77 on May 23, 2022, represented a key step in the execution of the intended reform, to the extent that the Decree set forth the main terms of the primary care reorganization process. This review summarizes the key elements of the Decree, foreshadows its legal and public health implications, acknowledges the uncertainties about the economic feasibility of the reform, and highlights its possible comparative significance for health systems facing similar challenges, especially those - such as the UK NHS - that share a comparable type of funding system and organizational framework.
MeSH term(s)	Humans ; State Medicine ; Delivery of Health Care ; Hospitals ; Public Health ; Italy
Language	English
Publishing date	2023-02-03
Publishing country	Italy
Document type	Review ; Classical Article
ZDB-ID	1018045-x
ISSN	1120-9135 ; 0029-6287
ISSN	1120-9135 ; 0029-6287
DOI	10.7416/ai.2023.2556
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Article ; Online: Ozone Treatment for the Management of Caries in Primary Dentition: A Systematic Review of Clinical Studies.

Veneri, Federica / Filippini, Tommaso / Consolo, Ugo / Vinceti, Marco / Generali, Luigi

Dentistry journal

2024 Volume 12, Issue 3

Abstract: Dental caries in children is a frequent and debilitating condition, whose management is often challenging. The aim of this systematic review was to investigate the effectiveness of ozone applications for the treatment of caries in primary dentition. ... ...

Abstract	Dental caries in children is a frequent and debilitating condition, whose management is often challenging. The aim of this systematic review was to investigate the effectiveness of ozone applications for the treatment of caries in primary dentition. According to PRISMA guidelines, a systematic literature search was performed up to 6 January 2024. Clinical studies using ozone to treat caries of deciduous teeth were considered for inclusion. Out of the 215 records retrieved, seven studies were eventually included in the review, all of which used gaseous ozone. Four studies were judged at high risk of bias, two at low risk, and one of some concerns. The great heterogeneity of designs, outcomes, and protocols made it impossible to conduct a meta-analysis. Despite some limitations, the evidence yielded by the included studies suggests that ozone application, regardless of the protocol applied, is comparable to other interventions in terms of clinical outcomes and anti-bacterial activity, with no reported adverse effects and good patient acceptance. Therefore, ozone application may be a non-invasive approach to treat caries in primary dentition, especially in very young and poorly cooperative patients. Further standardized and rigorous studies are, however, needed to identify the best clinical protocols for this specific field.
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681351-8
ISSN	2304-6767 ; 2304-6767
ISSN (online)	2304-6767
ISSN	2304-6767
DOI	10.3390/dj12030069
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Article ; Online: Correction: Comment on "Relation of fruit juice with adiposity and diabetes depends on how fruit juice is defined: a re-analysis of the EFSA draft scientific opinion on the tolerable upper intake level for dietary sugars" by Chen et al. 2023.

Valtueña Martínez, Silvia / Turck, Dominique / Craciun, Ionut / Vinceti, Marco

European journal of clinical nutrition

2023 Volume 78, Issue 2, Page(s) 170

Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-023-01388-3
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Article ; Online: Comment on "Relation of fruit juice with adiposity and diabetes depends on how fruit juice is defined: a re-analysis of the EFSA draft scientific opinion on the tolerable upper intake level for dietary sugars" by Chen et al. 2023.

Valtueña Martínez, Silvia / Turck, Dominique / Craciun, Ionut / Vinceti, Marco

European journal of clinical nutrition

2023 Volume 77, Issue 12, Page(s) 1176–1177

MeSH term(s)	Humans ; Adiposity ; Fruit and Vegetable Juices ; Dietary Sugars/adverse effects ; Obesity ; Diabetes Mellitus
Chemical Substances	Dietary Sugars
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-023-01337-0
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Article ; Online: Cadmium exposure and cardiovascular disease risk: A systematic review and dose-response meta-analysis.

Verzelloni, Pietro / Urbano, Teresa / Wise, Lauren A / Vinceti, Marco / Filippini, Tommaso

Environmental pollution (Barking, Essex : 1987)

2024 Volume 345, Page(s) 123462

Abstract: Exposure to toxic metals is a global public health threat. Among other adverse effects, exposure to the heavy metal cadmium has been associated with greater risk of cardiovascular disease (CVD). Nonetheless, the shape of the association between cadmium ... ...

Abstract	Exposure to toxic metals is a global public health threat. Among other adverse effects, exposure to the heavy metal cadmium has been associated with greater risk of cardiovascular disease (CVD). Nonetheless, the shape of the association between cadmium exposure and CVD risk is not clear. This systematic review summarizes data on the association between cadmium exposure and risk of CVD using a dose-response approach. We carried out a literature search in PubMed, Web of Science, and Embase from inception to December 30, 2023. Inclusion criteria were: studies on adult populations, assessment of cadmium exposure, risk of overall CVD and main CVD subgroups as endpoints, and observational study design (cohort, cross-sectional, or case-control). We retrieved 26 eligible studies published during 2005-2023, measuring cadmium exposure mainly in urine and whole blood. In a dose-response meta-analysis using the one-stage method within a random-effects model, we observed a positive association between cadmium exposure and risk of overall CVD. When using whole blood cadmium as a biomarker, the association with overall CVD risk was linear, yielding a risk ratio (RR) of 2.58 (95 % confidence interval-CI 1.78-3.74) at 1 μg/L. When using urinary cadmium as a biomarker, the association was linear until 0.5 μg/g creatinine (RR = 2.79, 95 % CI 1.26-6.16), after which risk plateaued. We found similar patterns of association of cadmium exposure with overall CVD mortality and risks of heart failure, coronary heart disease, and overall stroke, whereas for ischemic stroke there was a positive association with mortality only. Overall, our results suggest that cadmium exposure, whether measured in urine or whole blood, is associated with increased CVD risk, further highlighting the importance of reducing environmental pollution from this heavy metal.
MeSH term(s)	Adult ; Humans ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/epidemiology ; Cadmium/toxicity ; Cross-Sectional Studies ; Metals, Heavy ; Biomarkers ; Observational Studies as Topic
Chemical Substances	Cadmium (00BH33GNGH) ; Metals, Heavy ; Biomarkers
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123462
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Article: Adverse human health effects of climate change: an update.

Filippini, Tommaso / Paduano, Stefania / Veneri, Federica / Barbolini, Giulia / Fiore, Gianluca / Vinceti, Marco

Annali di igiene : medicina preventiva e di comunita

2024 Volume 36, Issue 3, Page(s) 281–291

Abstract: Background: The world is currently facing a process of climate change, which may adversely impact human health in many different ways. The safety of food, water and urban environments is endangered by the consequences of climate change. Sea level and ... ...

Abstract	Background: The world is currently facing a process of climate change, which may adversely impact human health in many different ways. The safety of food, water and urban environments is endangered by the consequences of climate change. Sea level and temperature rise, along with more frequent and longer heat waves, represent only a few of the effects of climate change. The increased risk of extreme climate events (e.g., cyclones, droughts and floods) is another serious public health issue. These adverse effects are enhanced in areas and countries not having the capacity to effectively deal with climate change. Study design: We primarily aimed at summarizing the impacts of climate change on public health. A further aim was to identify the most concerning consequences of this phenomenon and the vulnerability factors that amplify the negative effects of climate change. Methods: PubMed and other literature databases were used as literature sources for this narrative review based on the search terms 'climate change' and 'diseases categories' up to January 2024, in order to assess the most recent and relevant scientific evidence about the relation between climate change and public health, identify knowledge gaps and priorities for future research. We also screened the websites of major agencies devoted to human health protection and environmental health. Results and conclusions: Climate change appears to induce a broad spectrum of generally adverse effects on public health. It may increase the risk of infectious diseases, psychiatric disorders, cancer and other diseases. Currently, we are not effectively counteracting this phenomenon, since pollutant and greenhouse gas emissions have been increasing alongside temperatures. A host of measures are required in order to prevent and fight climate change and related health effects. These include the adoption of a holistic approach and the collaboration of different kinds of expertise in order to design more effective strategies. Special attention should be paid to those who live in disadvantaged countries, and those who are more vulnerable to the adverse health consequences of climate change.
MeSH term(s)	Humans ; Climate Change ; Communicable Diseases ; Public Health ; Temperature
Language	English
Publishing date	2024-02-01
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1018045-x
ISSN	1120-9135 ; 0029-6287
ISSN	1120-9135 ; 0029-6287
DOI	10.7416/ai.2024.2595
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Article ; Online: A Potential Role for Zinc to Enhance Treatment for Coronavirus Disease 2019 (COVID-19)?

Vinceti, Marco / Filippini, Tommaso / Fairweather-Tait, Susan

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 76, Issue 2, Page(s) 192–193

MeSH term(s)	Humans ; COVID-19 ; Zinc/therapeutic use ; Double-Blind Method ; SARS-CoV-2 ; Patients
Chemical Substances	Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac849
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Artificial light at night and risk of mental disorders: A systematic review.

Tancredi, Stefano / Urbano, Teresa / Vinceti, Marco / Filippini, Tommaso

The Science of the total environment

2022 Volume 833, Page(s) 155185

Abstract: Background: Emerging evidence suggests a possible association between artificial light at night (LAN) exposure and physiological and behavioral changes, with implications on mood and mental health. Due to the increased amount of individuals' LAN ... ...

Abstract	Background: Emerging evidence suggests a possible association between artificial light at night (LAN) exposure and physiological and behavioral changes, with implications on mood and mental health. Due to the increased amount of individuals' LAN exposure, concerns have been raised regarding harmful impact of light pollution on mental health at the population level. Aim: To perform a systematic review of observational studies to investigate if light at night, assessed both indoor and outdoor, may be associated with an increased risk of mental diseases in humans. Methods: We reviewed the epidemiological evidence on the association between LAN exposure, assessed either via satellite photometry or via measurements of bedroom brightness, and mental disorders. We systematically searched the PubMed, Embase and Web of Science databases up to April 1, 2022. Studies were included if they assessed the link between indoor or outdoor artificial light at night and one or more mental disorders in human populations. Results: Nine eligible studies were included in this review: six studies had a cross-sectional design, two had a longitudinal design with a median follow-up of 24 months, and one was a case-cohort study. Overall, we found moderate evidence of a positive association between LAN exposure and depressive symptoms and to a lesser extent other mental disorders, though the number of studies was limited and potential residual confounding such as socioeconomic factors, noise, or air pollution may have influenced the results. Conclusions: Although more robust evidence is needed, the epidemiological evidence produced so far seems to support an association between LAN and risk of depressive disorders.
MeSH term(s)	Air Pollution ; Cohort Studies ; Cross-Sectional Studies ; Humans ; Light Pollution ; Mental Disorders/epidemiology
Language	English
Publishing date	2022-04-10
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.155185
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Article ; Online: Selenium status and immunity.

Fairweather-Tait, Susan J / Filippini, Tommaso / Vinceti, Marco

The Proceedings of the Nutrition Society

2022 Volume 82, Issue 1, Page(s) 32–38

Abstract: Selenium is found at the active centre of twenty-five selenoproteins which have a variety of roles, including the well-characterised function of antioxidant defense, but it also is claimed to be involved in the immune system. However, due to limited and ... ...

Abstract	Selenium is found at the active centre of twenty-five selenoproteins which have a variety of roles, including the well-characterised function of antioxidant defense, but it also is claimed to be involved in the immune system. However, due to limited and conflicting data for different parameters of immune function, intakes of selenium that have an influence on immune function are uncertain. This review covers the relationship between selenium and immune function in man, focusing on the highest level of evidence, namely that generated by randomised controlled trials (RCT), in which the effect of selective administration of selenium, in foods or a supplement, on immune function was assessed. A total of nine RCT were identified from a systematic search of the literature, and some of these trials reported effects on T and natural killer cells, which were dependent on the dose and form of selenium administered, but little effect of selenium on humoral immunity. There is clearly a need to undertake dose-response analysis of cellular immunity data in order to derive quantitative relationships between selenium intake and measures of immune function. Overall, limited effects on immunity emerged from experimental studies in human subjects, though additional investigation on the potential influence of selenium status on cellular immunity appears to be warranted.
MeSH term(s)	Humans ; Antioxidants ; Dietary Supplements ; Nutritional Status ; Selenium/pharmacology ; Selenoproteins
Chemical Substances	Antioxidants ; Selenium (H6241UJ22B) ; Selenoproteins
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	391142-1
ISSN	1475-2719 ; 0029-6651
ISSN (online)	1475-2719
ISSN	0029-6651
DOI	10.1017/S0029665122002658
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