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  1. Article: [Evaluations of the morphology and position of condyle and fossa of adolescent temporomandibular joint with Class Ⅱsubdivision malocclusions].

    Ding, Yuan-Feng / Song, Li-Juan

    Shanghai kou qiang yi xue = Shanghai journal of stomatology

    2021  Volume 29, Issue 6, Page(s) 656–660

    Abstract: Purpose: To evaluate the morphology and position of condyle and fossa and joint space of adolescent temporomandibular joint with Class Ⅱ subdivision malocclusion, in order to provide a reference for diagnosis before treatment.: Methods: The study ... ...

    Abstract Purpose: To evaluate the morphology and position of condyle and fossa and joint space of adolescent temporomandibular joint with Class Ⅱ subdivision malocclusion, in order to provide a reference for diagnosis before treatment.
    Methods: The study sample consisted of 30 adolescent patients with Class Ⅱ subdivision malocclusions(9 males, 21 females, mean age 12.5 years) as the experimental group and 30 adolescent patients with Class Ⅰ malocclusions (11 males, 19 females, mean age 12 years) as the control group treated from June 2018 to December 2019 in Suzhou Stomatological Hospital. The long axis of condyle, short axis of condyle, the distance from the outer pole of condyle to sagittal midline, horizontal angle of condyle, Joint space(medial, inner, outer, anterior, superior, posterior), vertical height of condyle, width of joint fossa, depth of joint fossa, angle of posterior wall of the articular tubercle and vertical distance of bilateral condyle to horizontal line were measured on cone-beam CT(CBCT) images and analyzed with Dolphin Imaging 11.95. SPSS 23.0 software package was used for statistical analysis of the data.
    Results: In Angle Class Ⅱ subdivision malocclusion patients, there were significant differences in posterior joint space, horizontal angle of condyle, vertical height of condyle, width of joint fossa, depth of joint fossa and angle of posterior wall of the articular tubercle between neutral side and distal side(P<0.01). In Angle Class Ⅰ malocclusion patients, there was no significant difference in joint fossa morphology, condyle morphology and condyle position between right side and left side (P>0.05).
    Conclusions: There may be differences in condyle position, condyle shape and joint fossa shape between patients with Class Ⅱ subdivision malocclusions and Class Ⅰ malocclusion patients. More attention should be paid to the temporomandibular joint in initial clinical examination and clinical orthodontic treatment.
    MeSH term(s) Adolescent ; Cone-Beam Computed Tomography ; Humans ; Malocclusion/diagnostic imaging ; Malocclusion, Angle Class I ; Malocclusion, Angle Class II/diagnostic imaging ; Mandibular Condyle/diagnostic imaging ; Temporomandibular Joint/diagnostic imaging
    Language Chinese
    Publishing date 2021-01-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 2269714-7
    ISSN 1006-7248
    ISSN 1006-7248
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  2. Article: Sequential 2.5 mg letrozole/FSH therapy is more effective for promoting pregnancy in infertile women with PCOS: a pragmatic randomized controlled trial.

    Chen, Li-Juan / Liu, Yi / Zhang, Ling / Li, Jing-Yi / Xiong, Wen-Qian / Li, Tao / Ding, Hui / Li, Bing-Jie

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1294339

    Abstract: Study question: In infertile women with polycystic ovary syndrome (PCOS), is the sequential use of letrozole 2.5 mg/follicle stimulating hormone(FSH) more effective than letrozole 5 mg/FSH in stimulating ovulation and promoting pregnancy?: Research ... ...

    Abstract Study question: In infertile women with polycystic ovary syndrome (PCOS), is the sequential use of letrozole 2.5 mg/follicle stimulating hormone(FSH) more effective than letrozole 5 mg/FSH in stimulating ovulation and promoting pregnancy?
    Research design and methods: The study was designed as a prospective, single-center, randomized, controlled pragmatic clinical trial. 220 infertile women between the ages of 20 and 40, who matched the Rotterdam criteria for PCOS and had no other identified reasons for infertility were enrolled from April 2023 to July 2023.The participants were randomly assigned to two groups in a 1:1 ratio. One group received 2.5 mg of letrozole on cycle days 3-7 with a sequential injection of 75 IU FSH on cycle days 8-10 (n = 110), while the other group received 5 mg of letrozole on cycle days 3-7 with a sequential injection of 75 IU FSH on cycle days 8-10 (n = 110). The duration of FSH treatment varied depending on the follicular development stage. Each participant underwent one to three treatment cycles until achieving pregnancy.The primary outcome was the cumulative pregnancy rate of all the participants. Secondary outcomes included characteristics and clinical pregnancy rates of all the intervention cycles.
    Results: For all 220 participants, the sequential letrozole 2.5 mg/FSH treatment group had a significantly higher cumulative pregnancy rate compared to the letrozole 5 mg/FSH treatment group (72.7% versus 59.1%, RR (95%CI) = 1.23 (1.02, 1.49), P-value = 0.033). For all 468 intervention cycles, letrozole 2.5 mg/FSH group had a significantly higher clinical pregnancy rate than the letrozole 5 mg/FSH group (36.2% versus 26.3%, P-value = 0.021), no statistically significant differences were observed in ovulation rates or adverse effects.
    Conclusions: The data indicate that the sequential letrozole 2.5mg/FSH protocol may be more effective than the sequential letrozole 5mg/FSH protocol for promoting pregnancy in infertile women with PCOS.
    Clinical trial registration: www.chictr.org.cn, identifier ChiCTR2300069638.
    MeSH term(s) Pregnancy ; Female ; Humans ; Young Adult ; Adult ; Letrozole/therapeutic use ; Infertility, Female/complications ; Infertility, Female/drug therapy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Prospective Studies ; Fertility Agents, Female/therapeutic use ; Ovulation Induction/methods ; Follicle Stimulating Hormone/therapeutic use ; Follicle Stimulating Hormone, Human/therapeutic use
    Chemical Substances Letrozole (7LKK855W8I) ; Fertility Agents, Female ; Follicle Stimulating Hormone (9002-68-0) ; Follicle Stimulating Hormone, Human
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Pragmatic Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1294339
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  3. Article: Comparison analysis of PD-1/PD-L1 inhibitors plus lenvatinib or gemcitabine/cisplatin as first-line treatment for patients with advanced intrahepatic cholangiocarcinoma.

    Huang, Jia-Xin / Liu, Bo / Li, Yu / Li, Xi / Ding, Li-Juan / Wang, Nan-Ya

    Frontiers in oncology

    2023  Volume 13, Page(s) 1204486

    Abstract: Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive primary liver cancer, with increasing incidence worldwide. Effective first-line treatments for advanced ICC patients are currently limited. Therefore, our study aimed to assess the ...

    Abstract Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive primary liver cancer, with increasing incidence worldwide. Effective first-line treatments for advanced ICC patients are currently limited. Therefore, our study aimed to assess the efficacy and safety of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors in combination with gemcitabine/cisplatin (GC) and lenvatinib as first-line treatment in advanced ICC patients.
    Methods: This retrospective cohort study included 51 advanced ICC patients, among whom 25 patients were administered with PD-1/PD-L1 plus lenvatinib and 26 patients were administered with PD-1/PD-L1 plus GC. Baseline characteristics including demographic information, medical history, clinical characteristics, laboratory data, and imaging examination were collected. The primary endpoints were progression-free survival (PFS) and sixth- and ninth-month overall survival (OS) rate. Survival curve was plotted by the Kaplan-Meier method. A Cox proportion risk model was performed to investigate independent risk factors of PFS and OS. The secondary outcomes were objective response rate (ORR), disease control rate (DCR), and adverse events.
    Results: The median age of advanced ICC patients in our study was 58.0 (95% confidence interval [95% CI] = 48.0-72.4) years, with 33 male and 18 female patients. Patients in the PD-1/PD-L1 inhibitors plus lenvatinib group were more likely to be in ECOG grade above 1, develop ascites, and have an elevated level of ALT. The ORR was 16.0% in the PD-1/PD-L1 inhibitors plus lenvatinib group and 23.1% in the GC group (
    Conclusion: PD-1/PD-L1 inhibitors in combination with lenvatinib or GC all demonstrated significant efficacy and safety as first-line treatment in patients with advanced ICC. As for patients who refuse or are intolerant to chemotherapy, PD-1/PD-L1 plus lenvatinib would be recommended.
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1204486
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  4. Article: Endoscopic management of postoperative fistulas using purse-string suture combined with cyanoacrylate.

    Zhang, Ding-Guo / Ye, Li-Juan / Wang, Li-Sheng / Li, De-Feng

    Revista espanola de enfermedades digestivas

    2022  Volume 115, Issue 1, Page(s) 54–55

    Abstract: A 65-year-old man complained of choking and hoarseness for fifteen days, and was diagnosed with thyroid carcinoma infiltrating esophagus and trachea. Therefore, the patient underwent thyroidectomy, partial esophagectomy, and partial tracheal resection, ... ...

    Abstract A 65-year-old man complained of choking and hoarseness for fifteen days, and was diagnosed with thyroid carcinoma infiltrating esophagus and trachea. Therefore, the patient underwent thyroidectomy, partial esophagectomy, and partial tracheal resection, and histopathology confirmed primary squamous cell carcinoma of the thyroid. Unfortunately, on the tenth postoperative day, an esophagogastroduodenoscopy showed a large fistula (25 mm*20 mm) in esophageal introitus, and diagnosed with tracheoesophageal fistula due to sustained choking. The patient failed to response to conservative treatment within 14 days. Consequently, endoscopic management was performed that the fistula was partly closed by purse-string suture using endoloop and hemostatic clips, then 1 ml of cyanoacrylate (Compon, China) was injected into the fistulous tract through a catheter. Interestingly, the patient's symptom was relieved after the procedure. And, esophagogastroduodenoscopy revealed healing of the fistula 14 days later.
    MeSH term(s) Male ; Humans ; Aged ; Cyanoacrylates/therapeutic use ; Tracheoesophageal Fistula/surgery ; Esophageal Neoplasms/surgery ; Carcinoma, Squamous Cell/surgery ; Sutures ; Suture Techniques
    Chemical Substances Cyanoacrylates
    Language English
    Publishing date 2022-06-24
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2022.9017/2022
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  5. Article ; Online: Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo.

    Xu, Zhi-Chang / Ma, Xiu-Rong / Zhang, Li-Juan / Chen, Hui-Ting / Qing, Ding-Mei / Li, Rong-Tao / Ye, Rui-Rong / Wang, Rui-Rui

    Journal of inorganic biochemistry

    2024  Volume 255, Page(s) 112522

    Abstract: With the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal ... ...

    Abstract With the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)
    MeSH term(s) Humans ; Animals ; Mice ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Fluconazole/pharmacology ; Fluconazole/therapeutic use ; Candida albicans ; Ruthenium/pharmacology ; Candidiasis/drug therapy ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Fluconazole (8VZV102JFY) ; Ruthenium (7UI0TKC3U5)
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2024.112522
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  6. Article ; Online: HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway.

    Li, Ming-Rui / Chen, En-Xiang / Li, Zhuo-Hang / Song, Hong-Lan / Zhang, Yi / Li, Fang-Fang / Xie, You-Long / Tang, Jing / Ding, Yu-Bin / Fu, Li-Juan

    Biology of reproduction

    2024  

    Abstract: Objective: The purpose of this study is to investigate the role of high mobility group protein B1 (HMGB1) in placental development and fetal growth.: Methods: We employed the Cre-loxP recombination system to establish a placenta-specific HMGB1 ... ...

    Abstract Objective: The purpose of this study is to investigate the role of high mobility group protein B1 (HMGB1) in placental development and fetal growth.
    Methods: We employed the Cre-loxP recombination system to establish a placenta-specific HMGB1 knockout mouse model. Breeding HMGB1flox/flox mice with Elf5-Cre mice facilitated the knockout, leveraging Elf5 expression in extra-embryonic ectoderm, ectoplacental cone, and trophoblast giant cells at 12.5 days of embryonic development. The primary goal of this model was to elucidate the molecular mechanism of HMGB1 in placental development, assessing parameters such as placental weight, fetal weight, and bone development. Additionally, we utilized lentiviral interference and overexpression of HMGB1 in human trophoblast cells to further investigate HMGB1's functional role.
    Results: Our findings indicate that HMGB1flox/floxElf5cre/+ mouse display fetal growth restriction (FGR), characterized by decreased placental and fetal weight and impaired bone development. And the absence of HMGB1 inhibits autophagosome formation, impairs lysosomal degradation, and disrupts autophagic flux. Depletion of HMGB1 in human trophoblast cells also suppresses cell viability, proliferation, migration, and invasion by inhibiting the ERK signaling pathway. Overexpression of HMGB1 observed the opposite phenotypes.
    Conclusions: HMGB1 participates in the regulation of autophagy through the ERK signaling pathway and affects placental development.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioae064
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  7. Article: F18:A-:B1 Plasmids Carrying

    Zhang, Li-Juan / Yang, Jin-Tao / Chen, Hai-Xin / Liu, Wen-Zi / Ding, Yi-Li / Chen, Rui-Ai / Zhang, Rong-Min / Jiang, Hong-Xia

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: We determined the prevalence and molecular characteristics ... ...

    Abstract We determined the prevalence and molecular characteristics of
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12060961
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  8. Article ; Online: "Antagonistic" cooperation of control regions in bilingual language production: An effective connectivity study.

    Li, Shijie / Li, Le / Zou, Lijuan / Yan, Xin / Zhang, Juan / Yang, Menghan / Ding, Guosheng

    Neuropsychologia

    2022  Volume 167, Page(s) 108165

    Abstract: The dorso-lateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC) are two main regions that support bilingual language control during language production. Previous studies have suggested that the regions work together in language ... ...

    Abstract The dorso-lateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC) are two main regions that support bilingual language control during language production. Previous studies have suggested that the regions work together in language control processes. However, how they cooperate with each other during bilingual language production is far from clear. We addressed this issue by recruiting bimodal bilingual participants whose two languages could be separated at a neural level. Functional magnetic resonance imaging scans were acquired from the participants as they performed a dual-language production task and a spoken-production task. Dynamic causal modelling (DCM) was used to analyse the effective connectivity between the ACC and the DLPFC as well as the causal relationships among the control regions and language regions. We found that the ACC had positive effective connectivity to the DLPFC, left precentral gyrus and left superior temporal gyrus, while the DLPFC had negative effective connectivity to the other three regions. A similar pattern of effective connectivity between the control regions and language regions was also found in the spoken-production task. These results showed that the ACC may promote the production of the target language, while the DLPFC has an inhibitory effect in language production. The findings suggest an antagonistic relationship between the DLPFC and ACC that cooperatively ensures fluent language production in bilinguals.
    MeSH term(s) Gyrus Cinguli ; Humans ; Language ; Magnetic Resonance Imaging ; Multilingualism ; Prefrontal Cortex
    Language English
    Publishing date 2022-01-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2022.108165
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  9. Article ; Online: Integrated analysis of transcriptome and small RNAome reveals regulatory network of rapid and long-term response to heat stress in Rhododendron moulmainense.

    Liu, Si-Jia / Cai, Chang / Cai, Hong-Yue / Bai, Yu-Qing / Wang, Ding-Yue / Zhang, Hua / Peng, Jin-Gen / Xie, Li-Juan

    Planta

    2024  Volume 259, Issue 5, Page(s) 104

    Abstract: Main conclusion: The post-transcriptional gene regulatory pathway and small RNA pathway play important roles in regulating the rapid and long-term response of Rhododendron moulmainense to high-temperature stress. The Rhododendron plays an important role ...

    Abstract Main conclusion: The post-transcriptional gene regulatory pathway and small RNA pathway play important roles in regulating the rapid and long-term response of Rhododendron moulmainense to high-temperature stress. The Rhododendron plays an important role in maintaining ecological balance. However, it is difficult to domesticate for use in urban ecosystems due to their strict optimum growth temperature condition, and its evolution and adaptation are little known. Here, we combined transcriptome and small RNAome to reveal the rapid response and long-term adaptability regulation strategies in Rhododendron moulmainense under high-temperature stress. The post-transcriptional gene regulatory pathway plays important roles in stress response, in which the protein folding pathway is rapidly induced at 4 h after heat stress, and alternative splicing plays an important role in regulating gene expression at 7 days after heat stress. The chloroplasts oxidative damage is the main factor inhibiting photosynthesis efficiency. Through WGCNA analysis, we identified gene association patterns and potential key regulatory genes responsible for maintaining the ROS steady-state under heat stress. Finally, we found that the sRNA synthesis pathway is induced under heat stress. Combined with small RNAome, we found that more miRNAs are significantly changed under long-term heat stress. Furthermore, MYBs might play a central role in target gene interaction network of differentially expressed miRNAs in R. moulmainense under heat stress. MYBs are closely related to ABA, consistently, ABA synthesis and signaling pathways are significantly inhibited, and the change in stomatal aperture is not obvious under heat stress. Taken together, we gained valuable insights into the transplantation and long-term conservation domestication of Rhododendron, and provide genetic resources for genetic modification and molecular breeding to improve heat resistance in Rhododendron.
    MeSH term(s) Transcriptome/genetics ; Rhododendron/genetics ; Rhododendron/metabolism ; Ecosystem ; Heat-Shock Response/genetics ; MicroRNAs/genetics ; Gene Expression Profiling
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/s00425-024-04375-5
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  10. Article ; Online: [No title information]

    Ding, Li-Juan / Liu, Cong / Tan, Cheng

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2020  Volume 18, Issue 7, Page(s) 774–776

    Title translation Strang aus nodulären Hautveränderungen entlang des Beins.
    Language German
    Publishing date 2020-07-26
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14126_g
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