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Article ; Online: Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.

Cheng, Wenli / Tan, Luyi / Yu, Susu / Song, Jia / Li, Ziyin / Peng, Xinyue / Wei, Qinzhi / He, Zhini / Zhang, Wenjuan / Yang, Xingfen

International immunopharmacology

2024 Volume 131, Page(s) 111820

Abstract: Exogenous hydrogen peroxide ( ... ...

Abstract	Exogenous hydrogen peroxide (H
MeSH term(s)	Humans ; Phosphatidylinositol 3-Kinases ; Phosphatidylinositol 3-Kinase ; Hydrogen Peroxide ; Kidney ; Iridoids/pharmacology ; Apoptosis ; Oxidative Stress ; RNA ; Methyltransferases ; Forkhead Box Protein O1 ; Proto-Oncogene Proteins c-akt ; Adenine
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; geniposide (145295QLXY) ; 6-methyladenine ; Hydrogen Peroxide (BBX060AN9V) ; Iridoids ; RNA (63231-63-0) ; Methyltransferases (EC 2.1.1.-) ; FOXO1 protein, human ; Forkhead Box Protein O1 ; AKT3 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Adenine (JAC85A2161)
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111820
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Article ; Online: Innovative wound management: creating dynamic Alg-Mg/SF hydrogels for controlled Mg

Dai, Chaolun / Wu, Binxin / Chen, Min / Gao, Yisheng / Zhang, Miao / Li, Wanhua / Li, Guicai / Xiao, Qinzhi / Zhao, Yahong / Yang, Yumin

RSC advances

2024 Volume 14, Issue 16, Page(s) 10874–10883

Abstract: Antibacterial hydrogels have gained considerable attention for soft tissue repair, particularly in preventing infections associated with wound healing. However, developing an antibacterial hydrogel that simultaneously possesses excellent cell affinity ... ...

Abstract	Antibacterial hydrogels have gained considerable attention for soft tissue repair, particularly in preventing infections associated with wound healing. However, developing an antibacterial hydrogel that simultaneously possesses excellent cell affinity and controlled release of metal ions remains challenging. This study introduces an antibacterial hydrogel based on alginate modified with bisphosphonate, forming a coordination complex with magnesium ions. The hydrogel, through an interpenetrating network with silk fibroin, effectively controls the release of magnesium ions and enhances strain resistance. The Alg-Mg/SF hydrogel not only demonstrates outstanding biocompatibility and broad-spectrum antibacterial properties but also stimulates macrophages to secrete anti-inflammatory factors. This advanced Alg-Mg/SF hydrogel provides a convenient therapeutic approach for chronic wound management, showcasing its potential applications in wound healing and other relevant biomedical fields.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d4ra00793j
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Article: Facile Access to gem-Trifluoromethyl/Boron-Functionalized Polymers via Free-Radical Copolymerization and Cotelomerization

Zeng, Yang / Zhou, Yang / Quan, Qinzhi / Chen, Mao

Macromolecules. 2022 Feb. 18, v. 55, no. 5

2022

Abstract: Functional fluoropolymers are important for various applications due to the integrated characteristics of functional groups and fluorocarbon segments. Herein, we developed (1) thermally initiated and visible-light-initiated copolymerization of ( ... ...

Abstract	Functional fluoropolymers are important for various applications due to the integrated characteristics of functional groups and fluorocarbon segments. Herein, we developed (1) thermally initiated and visible-light-initiated copolymerization of (trifluoromethyl)vinyl boronic esters (CF₃VBs) and unconjugated alkenes (18 examples, including vinyl ethers, esters, and amides), enabling the efficient synthesis of a broad scope of fluoropolymers in 71–92% yield and variable fractions of gem-CF₃/B substituents (FCF₃VB = 0.26–0.84) at different molar masses (Mₙ = 5.2–33.4 kDa) and (2) visible-light-initiated cotelomerization of CF₃VB and unconjugated alkenes with p-tolyl disulfide as a telogen (Mₙ = 3.6–13.0 kDa). Reactivity ratios for copolymerization were determined by the Meyer–Lowry method at 65 °C (for BVE: rCF₃VB = 1.254, rBVE = 0.006; for VAc: rCF₃VB = 0.235, rVAc = 0.042; for NVP: rCF₃VB = 1.067, rNVP = 0.063). The achieved high fractions of CF₃VBs in copolymers are also confirmed by density functional theory (DFT) calculation results. Through post-polymerization modifications, gem-CF₃/B units could transform into various copolymers and terpolymers with geminal functionalities (e.g., gem-CF₃/OH, gem-CF₃/vinyl, gem-CF₃/furan). The increase of geminal functionalities enables clearly amplified chemical responsiveness toward pH variation, as demonstrated by fluoropolymers with gem-CF₃/OH.
Keywords	alkenes ; amides ; composite polymers ; copolymerization ; density functional theory ; disulfides ; pH ; perfluorocarbons
Language	English
Dates of publication	2022-0218
Size	p. 1524-1532.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1491942-4
ISSN	1520-5835 ; 0024-9297
ISSN (online)	1520-5835
ISSN	0024-9297
DOI	10.1021/acs.macromol.2c00023
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Organocatalyzed Controlled Radical Copolymerization toward Hybrid Functional Fluoropolymers Driven by Light.

Zeng, Yang / Quan, Qinzhi / Wen, Peng / Zhang, Zexi / Chen, Mao

Angewandte Chemie (International ed. in English)

2022 , Page(s) e202215628

Abstract: Photo-controlled polymerizations are attractive to tailor macromolecules of complex compositions with spatiotemporal regulation. In this work, with a convenient synthesis for trifluorovinyl boronic ester (TFVB), we report a light-driven organocatalyzed ... ...

Abstract	Photo-controlled polymerizations are attractive to tailor macromolecules of complex compositions with spatiotemporal regulation. In this work, with a convenient synthesis for trifluorovinyl boronic ester (TFVB), we report a light-driven organocatalyzed copolymerization of vinyl monomers and TFVB for the first time, which enabled the controlled synthesis of a variety of hybrid fluorine/boron polymers with low dispersities and good chain-end fidelity. The good behaviors of "ON/OFF" switch, chain-extension polymerizations and post-modifications further highlight the versatility and reliability of this copolymerization. Furthermore, we demonstrate that the combination of fluorine and boron could furnish copolymer electrolytes of high lithium-ion transference number (up to 0.83), bringing new opportunities of engineering high-performance materials for energy storage purposes.
Language	English
Publishing date	2022-11-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202215628
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Article ; Online: The generation of glioma organoids and the comparison of two culture methods.

Zhang, Yang / Shao, Yunxiang / Li, Yanyan / Li, Xuetao / Zhang, Xuewen / E, Qinzhi / Wang, Weichao / Jiang, Zuoyu / Gan, Wenjuan / Huang, Yulun

Cancer medicine

2024 Volume 13, Issue 4, Page(s) e7081

Abstract: Background: The intra- and inter-tumoral heterogeneity of gliomas and the complex tumor microenvironment make accurate treatment of gliomas challenging. At present, research on gliomas mainly relies on cell lines, stem cell tumor spheres, and ... ...

Abstract	Background: The intra- and inter-tumoral heterogeneity of gliomas and the complex tumor microenvironment make accurate treatment of gliomas challenging. At present, research on gliomas mainly relies on cell lines, stem cell tumor spheres, and xenotransplantation models. The similarity between traditional tumor models and patients with glioma is very low. Aims: In this study, we aimed to address the limitations of traditional tumor models by generating patient-derived glioma organoids using two methods that summarized the cell diversity, histological features, gene expression, and mutant profiles of their respective parent tumors and assess the feasibility of organoids for personalized treatment. Materials and methods: We compared the organoids generated using two methods through growth analysis, immunohistological analysis, genetic testing, and the establishment of xenograft models. Results: Both types of organoids exhibited rapid infiltration when transplanted into the brains of adult immunodeficient mice. However, organoids formed using the microtumor method demonstrated more similar cellular characteristics and tissue structures to the parent tumors. Furthermore, the microtumor method allowed for faster culture times and more convenient operational procedures compared to the Matrigel method. Discussion: Patient-derived glioma organoids, especially those generated through the microtumor method, present a promising avenue for personalized treatment strategies. Their capacity to faithfully mimic the cellular and molecular characteristics of gliomas provides a valuable platform for elucidating tumor biology and evaluating therapeutic modalities. Conclusion: The success rates of the Matrigel and microtumor methods were 45.5% and 60.5%, respectively. The microtumor method had a higher success rate, shorter establishment time, more convenient passage and cryopreservation methods, better simulation of the cellular and histological characteristics of the parent tumor, and a high genetic guarantee.
MeSH term(s)	Adult ; Humans ; Animals ; Mice ; Glioma/pathology ; Cell Culture Techniques/methods ; Organoids/metabolism ; Organoids/pathology ; Neoplastic Stem Cells ; Tumor Microenvironment
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.7081
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Article ; Online: Constructing Phase-Transitional NiS

Chang, Nana / Yin, Yanbin / Song, Yang / Wang, Shengnan / Zhang, Huamin / Lai, Qinzhi / Li, Xianfeng

ACS applied materials & interfaces

2021 Volume 13, Issue 16, Page(s) 19008–19015

Abstract: Alkaline zinc-based batteries are becoming promising candidates for green and economical energy-storage systems, thanks to their low cost and high energy density. The exploitation of the stable cathode materials with high rate capability and cycling ... ...

Abstract	Alkaline zinc-based batteries are becoming promising candidates for green and economical energy-storage systems, thanks to their low cost and high energy density. The exploitation of the stable cathode materials with high rate capability and cycling stability is crucial for their further development. Herein, a series of NiS
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c02067
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Article ; Online: Interactions between PCSK9 and NLRP3 inflammasome signaling in atherosclerosis.

Wang, Yanan / Fang, Dan / Yang, Qinzhi / You, Jingcan / Wang, Liqun / Wu, Jianbo / Zeng, Min / Luo, Mao

Frontiers in immunology

2023 Volume 14, Page(s) 1126823

Abstract: Atherosclerosis is an early pathological basis of numerous cardiovascular events that result in death or disability. Recent studies have described PCSK9 as a novel target for the treatment of atherosclerosis; PCSK9 is capable of degrading LDLR on the ... ...

Abstract	Atherosclerosis is an early pathological basis of numerous cardiovascular events that result in death or disability. Recent studies have described PCSK9 as a novel target for the treatment of atherosclerosis; PCSK9 is capable of degrading LDLR on the surface of hepatocytes through the regulation of lipid metabolism, and it can function as a novel inflammatory modulator in atherosclerosis. Inflammasomes are important intracellular multiprotein complexes that promote the inflammatory response in atherosclerosis. Among inflammasomes, the NLRP3 inflammasome is particularly notable because of its important role in the development of atherosclerotic disease. After activation, NLRP3 forms a complex with ASC and pro-caspase-1, converting pro-caspase-1 into activated caspase-1, which may trigger the release of IL-1β and IL-18 and contribute to the inflammatory response. Several recent studies have indicated that there may be interactions between PCSK9 and the NLRP3 inflammasome, which may contribute to the inflammatory response that drives atherosclerosis development and progression. On the one hand, the NLRP3 inflammasome plays an important role
MeSH term(s)	Humans ; Atherosclerosis/metabolism ; Caspase 1/metabolism ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Proprotein Convertase 9
Chemical Substances	Caspase 1 (EC 3.4.22.36) ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; NLRP3 protein, human
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1126823
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Article: Dissecting the HGT network of carbon metabolic genes in soil-borne microbiota.

Li, Liangzhi / Liu, Yongjun / Xiao, Qinzhi / Xiao, Zhipeng / Meng, Delong / Yang, Zhaoyue / Deng, Wenqiao / Yin, Huaqun / Liu, Zhenghua

Frontiers in microbiology

2023 Volume 14, Page(s) 1173748

Abstract: The microbiota inhabiting soil plays a significant role in essential life-supporting element cycles. Here, we investigated the occurrence of horizontal gene transfer (HGT) and established the HGT network of carbon metabolic genes in 764 soil-borne ... ...

Abstract	The microbiota inhabiting soil plays a significant role in essential life-supporting element cycles. Here, we investigated the occurrence of horizontal gene transfer (HGT) and established the HGT network of carbon metabolic genes in 764 soil-borne microbiota genomes. Our study sheds light on the crucial role of HGT components in microbiological diversification that could have far-reaching implications in understanding how these microbial communities adapt to changing environments, ultimately impacting agricultural practices. In the overall HGT network of carbon metabolic genes in soil-borne microbiota, a total of 6,770 nodes and 3,812 edges are present. Among these nodes, phyla Proteobacteria, Actinobacteriota, Bacteroidota, and Firmicutes are predominant. Regarding specific classes, Actinobacteria, Gammaproteobacteria, Alphaproteobacteria, Bacteroidia, Actinomycetia, Betaproteobacteria, and Clostridia are dominant. The Kyoto Encyclopedia of Genes and Genomes (KEGG) functional assignments of glycosyltransferase (18.5%), glycolysis/gluconeogenesis (8.8%), carbohydrate-related transporter (7.9%), fatty acid biosynthesis (6.5%), benzoate degradation (3.1%) and butanoate metabolism (3.0%) are primarily identified. Glycosyltransferase involved in cell wall biosynthesis, glycosylation, and primary/secondary metabolism (with 363 HGT entries), ranks first overwhelmingly in the list of most frequently identified carbon metabolic HGT enzymes, followed by pimeloyl-ACP methyl ester carboxylesterase, alcohol dehydrogenase, and 3-oxoacyl-ACP reductase. Such HGT events mainly occur in the peripheral functions of the carbon metabolic pathway instead of the core section. The inter-microbe HGT genetic traits in soil-borne microbiota genetic sequences that we recognized, as well as their involvement in the metabolism and regulation processes of carbon organic, suggest a pervasive and substantial effect of HGT on the evolution of microbes.
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1173748
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Article ; Online: LncRNAs associated with oxidative stress in diabetic wound healing: Regulatory mechanisms and application prospects.

Yang, Qinzhi / Fang, Dan / Chen, Jinxiang / Hu, Shaorun / Chen, Ni / Jiang, Jun / Zeng, Min / Luo, Mao

Theranostics

2023 Volume 13, Issue 11, Page(s) 3655–3674

Abstract: Diabetes is a group of chronic diseases with blood glucose imbalance, and long-term hyperglycaemia causes sustained damage to various organs of the body, resulting in vascular lesions, neuropathy and impaired wound healing. Diabetic wound formation ... ...

Abstract	Diabetes is a group of chronic diseases with blood glucose imbalance, and long-term hyperglycaemia causes sustained damage to various organs of the body, resulting in vascular lesions, neuropathy and impaired wound healing. Diabetic wound formation involves a variety of complex mechanisms, and they are characterized by a persistent chronic inflammatory response, degradation of angiogenesis and imbalance of extracellular matrix regulation, all of which are related to oxidative stress. Additionally, repair and healing of diabetic wounds require the participation of a variety of cells, cytokines, genes, and other factors, which together constitute a complex biological regulatory network. Recent studies have shown that long noncoding RNAs (lncRNAs) can be involved in the regulation of several key biological pathways and cellular functions demonstrating their critical role in diabetic wound healing. LncRNAs are a major family of RNAs with limited or no protein-coding function. Numerous studies have recently reported a strong link between oxidative stress and lncRNAs. Given that both lncRNAs and oxidative stress have been identified as potential drivers of diabetic wound healing, their link in diabetic wound healing can be inferred. However, the specific mechanism of oxidative stress related to lncRNAs in diabetic wound healing is still unclear, and elucidating the functions of lncRNAs in these processes remains a major challenge. This article reviews the mechanisms of lncRNAs related to oxidative stress in several stages of diabetic wound healing and discusses diagnostic and treatment potential of lncRNAs to treat diabetic wounds by improving oxidative stress, as well as the challenges of using lncRNAs for this purpose. It is hoped that these results will provide new targets and strategies for the diagnosis and treatment of impaired wound healing in diabetic patients.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Diabetes Mellitus/genetics ; Oxidative Stress ; Inflammation ; Wound Healing/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-06-26
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.85823
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Article ; Online: Long Noncoding RNAs as Emerging Regulators of COVID-19.

Yang, Qinzhi / Lin, Fang / Wang, Yanan / Zeng, Min / Luo, Mao

Frontiers in immunology

2021 Volume 12, Page(s) 700184

Abstract: Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical ... ...

Abstract	Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical treatment of COVID-19, such as antivirals (radecivir, baritinib), monoclonal antibodies (tocilizumab), and glucocorticoids (dexamethasone). Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are essential regulators of virus infections and antiviral immune responses including biological processes that are involved in the regulation of COVID-19 and subsequent disease states. Upon viral infections, cellular lncRNAs directly regulate viral genes and influence viral replication and pathology through virus-mediated changes in the host transcriptome. Additionally, several host lncRNAs could help the occurrence of viral immune escape by inhibiting type I interferons (IFN-1), while others could up-regulate IFN-1 production to play an antiviral role. Consequently, understanding the expression and function of lncRNAs during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection will provide insights into the development of lncRNA-based methods. In this review, we summarized the current findings of lncRNAs in the regulation of the strong inflammatory response, immune dysfunction and thrombosis induced by SARS-CoV-2 infection, discussed the underlying mechanisms, and highlighted the therapeutic challenges of COVID-19 treatment and its future research directions.
MeSH term(s)	Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Biomarkers/analysis ; COVID-19/complications ; COVID-19/genetics ; COVID-19/immunology ; COVID-19 Testing/methods ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation, Viral/drug effects ; Gene Expression Regulation, Viral/immunology ; Host Microbial Interactions/drug effects ; Host Microbial Interactions/genetics ; Host Microbial Interactions/immunology ; Humans ; Immune Evasion/genetics ; Immunity, Innate/genetics ; Pandemics/prevention & control ; RNA, Long Noncoding/analysis ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Long Noncoding/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Signal Transduction/genetics ; Signal Transduction/immunology ; Thrombosis/genetics ; Thrombosis/immunology ; Thrombosis/virology ; Virus Replication/drug effects ; Virus Replication/genetics ; Virus Replication/immunology ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Biomarkers ; Cytokines ; RNA, Long Noncoding
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.700184
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