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  1. Article ; Online: Renal Salt Wasting Following Cisplatin.

    Latcha, Sheron / Chughtai, Shahzaib

    Kidney360

    2024  Volume 5, Issue 4, Page(s) 604–606

    MeSH term(s) Humans ; Cisplatin/adverse effects ; Antineoplastic Agents/adverse effects ; Male ; Kidney/drug effects ; Hyponatremia/chemically induced ; Middle Aged
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Case Reports
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High-Cutoff Hemodialysis Therapy for Patients with Light Chain Cast Nephropathy and AKI Requiring Dialysis: PRO.

    Latcha, Sheron / Leung, Nelson

    Kidney360

    2023  Volume 4, Issue 8, Page(s) 1021–1023

    MeSH term(s) Humans ; Renal Dialysis ; Multiple Myeloma/therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000151
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  3. Article ; Online: Rescue Therapies for AKI in Onconephrology: Rasburicase and Glucarpidase.

    Latcha, Sheron / Shah, Chintan V

    Seminars in nephrology

    2023  Volume 42, Issue 6, Page(s) 151342

    Abstract: Tumor lysis syndrome (TLS) and high-dose methotrexate (HD MTX) toxicity can present with potentially severe complications, including acute kidney injury, in patients with malignancy. Guidelines for using rasburicase and glucarpidase as rescue therapies ... ...

    Abstract Tumor lysis syndrome (TLS) and high-dose methotrexate (HD MTX) toxicity can present with potentially severe complications, including acute kidney injury, in patients with malignancy. Guidelines for using rasburicase and glucarpidase as rescue therapies for TLS and HD MTX toxicity, respectively, are widely used by clinicians intending to mitigate organ toxicity and decrease morbidity and mortality as a consequence of cancer therapy. This review discusses the pathogenesis of TLS and HD MTX-associated toxicity, to understand the mechanism of action of these therapeutic agents and to review the currently available evidence supporting their use.
    MeSH term(s) Humans ; gamma-Glutamyl Hydrolase/therapeutic use ; Urate Oxidase/therapeutic use ; Tumor Lysis Syndrome/drug therapy ; Tumor Lysis Syndrome/complications ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/complications
    Chemical Substances glucarpidase (2GFP9BJD79) ; rasburicase (08GY9K1EUO) ; gamma-Glutamyl Hydrolase (EC 3.4.19.9) ; Urate Oxidase (EC 1.7.3.3)
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151342
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    Se 784: Show issues Location:
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  4. Article ; Online: Decision making for the initiation and termination of dialysis in patients with advanced cancer.

    Latcha, Sheron

    Seminars in dialysis

    2019  Volume 32, Issue 3, Page(s) 215–218

    Abstract: Age is a risk factor for both cancer and end-stage renal disease (ESRD). Newer cancer treatments are allowing patients to live longer with their cancer, the renal toxicity from the cancer itself or from the therapies that was used to treat the malignancy. ...

    Abstract Age is a risk factor for both cancer and end-stage renal disease (ESRD). Newer cancer treatments are allowing patients to live longer with their cancer, the renal toxicity from the cancer itself or from the therapies that was used to treat the malignancy. Consequently, nephrologists will increasingly be asked to evaluate and counsel patients with ESRD and advanced cancer regarding the initiation of dialysis. Data on morbidity, mortality, and quality of life (QOL) outcomes in this population are sparse. Expectations regarding what dialysis can reasonably accomplish in this cohort can be unrealistically high among patients, their family members and the rest of the health care team. This article will discuss some results from the available studies on mortality and QOL outcomes in this cohort and advise the nephrologist about how to approach these challenging discussions.
    MeSH term(s) Decision Making ; Humans ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/therapy ; Neoplasms/complications ; Nephrologists/standards ; Renal Dialysis/methods
    Language English
    Publishing date 2019-03-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.12780
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    Zs.A 2879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Anemia management in cancer patients with chronic kidney disease.

    Latcha, Sheron

    Seminars in dialysis

    2019  Volume 32, Issue 6, Page(s) 513–519

    Abstract: Cancer and kidney disease are linked by causality and comorbidities. Observational data show an increased risk of malignancy as renal function declines. Erythropoietin stimulating agents (ESAs), which are the cornerstone therapy for anemia patients with ... ...

    Abstract Cancer and kidney disease are linked by causality and comorbidities. Observational data show an increased risk of malignancy as renal function declines. Erythropoietin stimulating agents (ESAs), which are the cornerstone therapy for anemia patients with chronic kidney disease and cancer, are associated with increased risks for cancer, cancer-related mortality, progression of disease, and thromboembolic events. This article examines the recently published guidelines for ESA use in cancer patients from the American Society of Clinical Oncology and American Society of Hematology and attempts to contextualize them to the care of patients with coexistent CKD, cancer, and anemia.
    MeSH term(s) Anemia/drug therapy ; Anemia/etiology ; Cause of Death ; Comorbidity ; Disease Progression ; Female ; Hematinics/administration & dosage ; Hematinics/adverse effects ; Humans ; Injections, Subcutaneous ; Male ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Practice Guidelines as Topic ; Prognosis ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Risk Assessment ; Societies, Medical ; Survival Analysis ; United States
    Chemical Substances Hematinics
    Language English
    Publishing date 2019-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.12841
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: High Dose Methotrexate-Induced Acute Kidney Injury: Incidence, Risk Factors, and Recovery.

    Latcha, Sheron / Gupta, Mohit / Lin, I-Hsin / Jaimes, Edgar A

    Kidney international reports

    2022  Volume 8, Issue 2, Page(s) 360–364

    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.10.029
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  7. Article ; Online: Cancer Screening in End-Stage Kidney Disease.

    Shirazian, Shayan / Starakiewicz, Piotr / Latcha, Sheron

    Advances in chronic kidney disease

    2022  Volume 28, Issue 5, Page(s) 502–508.e1

    Abstract: The incidence of cancer is higher in patients with end-stage kidney disease (ESKD) than among the general population. Despite this, screening for cancer is generally not cost-effective and may worsen quality of life in these patients. This is due to high ...

    Abstract The incidence of cancer is higher in patients with end-stage kidney disease (ESKD) than among the general population. Despite this, screening for cancer is generally not cost-effective and may worsen quality of life in these patients. This is due to high mortality rates (patients are not living long enough to reap the benefits of screening), the inaccuracy of cancer screening tests, and the increased risks associated with therapy in patients with ESKD. Specific groups of patients with ESKD who have a longer-than-expected life expectancy or higher-than-expected cancer risk may benefit from screening. These groups include patients on peritoneal dialysis, patients on home hemodialysis, Black and Asian-American patients, transplant-eligible patients, and those at higher risk of cancer including patients with acquired cystic kidney disease, those who have been previously exposed to cytotoxic agents or aristolochic acid, and patients with a genetic predisposition to cancer. In this narrative review, we will examine the prevalence of and risk factors for cancer in patients with ESKD and the effectiveness of cancer screening, and discuss specific situations in which cancer screening may be effective.
    MeSH term(s) Early Detection of Cancer ; Humans ; Incidence ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Neoplasms/complications ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Quality of Life ; Renal Dialysis/adverse effects
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2021.09.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Case of Proteinuria, Worsening Hypertension, and Glomerular Endotheliosis With Erlotinib and Gefitinib.

    Latcha, Sheron / Jaimes, Edgar A / Gutgarts, Victoria / Seshan, Surya

    Kidney international reports

    2018  Volume 3, Issue 6, Page(s) 1477–1481

    Language English
    Publishing date 2018-07-10
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2018.07.005
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  9. Article ; Online: How to determine kidney function in cancer patients?

    Sprangers, Ben / Abudayyeh, Ala / Latcha, Sheron / Perazella, Mark A / Jhaveri, Kenar D

    European journal of cancer (Oxford, England : 1990)

    2020  Volume 132, Page(s) 141–149

    Abstract: A precise and efficient method for estimating kidney function in cancer patients is important to determine their eligibility for clinical trials and surgery and to allow for appropriate dose adjustment of anti-cancer drugs, especially toxic drugs with a ... ...

    Abstract A precise and efficient method for estimating kidney function in cancer patients is important to determine their eligibility for clinical trials and surgery and to allow for appropriate dose adjustment of anti-cancer drugs, especially toxic drugs with a narrow therapeutic index. Since direct measurement of glomerular filtration rate (GFR) is cumbersome, several formulae have been developed to estimate kidney function. Most of these are based on serum creatinine concentration. Though the CKD-EPI formula is recognised as being the most accurate, there is an ongoing debate on which is the optimal formula for cancer patients. In this review, we provide an overview of different GFR estimating equations for kidney function and the advantages and disadvantages of each method and compare their performance in cancer patients. We discuss the importance of body surface area-indexing and propose a framework for evaluating kidney function in cancer patients.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Glomerular Filtration Rate ; Humans ; Kidney Function Tests ; Neoplasms/drug therapy ; Neoplasms/pathology ; Prognosis ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/pathology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2020.03.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 583: Show issues

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  10. Article: Perspectives From an Onconephrology Interest Group: Conference Report.

    Kitchlu, Abhijat / Chan, Christopher T / Leung, Nelson / Chen, Sheldon / Latcha, Sheron / Tam, Paul

    Canadian journal of kidney health and disease

    2020  Volume 7, Page(s) 2054358120962589

    Abstract: Introduction and objective: Onconephrology is a new and evolving field that deals with kidney complications in patients with cancer as well as the management of cancer in patients with preexisting kidney disease. With increasing numbers of patients with ...

    Abstract Introduction and objective: Onconephrology is a new and evolving field that deals with kidney complications in patients with cancer as well as the management of cancer in patients with preexisting kidney disease. With increasing numbers of patients with cancer with kidney-related complications, the field has garnered increased attention. Thus, an annual Greater Toronto Area Onconephrology Interest Group symposium was held in May 2019. The objective of the meeting was to demonstrate the junctures between oncology and nephrology by highlighting recent data regarding (1) kidney impairment in solid organ malignancies, (2) management and treatment of kidney cancer, (3) kidney impairment in hematologic malignancies, (4) malignancy and kidney transplantation, and (5) hyponatremia in patients with cancer.
    Methods and sources of information: Through a structured presentation, the group explored key topics discussed at a Kidney Disease Improving Global Outcomes (KDIGO) Controversies Conference on Onconephrology. Expert opinions, clinical trial findings, and publication summaries were used to illustrate patient and treatment-related considerations in onconephrology.
    Key findings: Kidney complications in patients with cancer are a central theme in onconephrology. An estimated 12% to 25% of patients with solid organ malignancies have chronic kidney disease (CKD), although in certain cancers, the prevalence of CKD is higher. Kidney impairment is also a common complication of some hematologic malignancies. The incidence of renal failure in patients with multiple myeloma is estimated at 18% to 56% and light chain cast nephropathy is seen in approximately 30% of these patients. In addition, there appears to be a bidirectional relationship between kidney cancer and CKD, with some data sets suggesting the risk increases as kidney function declines. Cancer is also of concern in patients with preexisting kidney disease. Kidney transplant recipients have a greater risk of cancer and a higher risk of cancer-related mortality. Kidney complications have also been associated with novel cancer therapies, such as immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cell therapy. An estimated 2% to 4% of patients initiating an immune checkpoint inhibitor may develop nephrotoxicity, whereas up to 40% of patients on CAR T-cell therapy experience cytokine release syndrome (CRS). Tumor lysis syndrome and electrolyte abnormalities, such as hyponatremia, have also been reported with CAR T-cell therapy. While the incidence and prevalence of hyponatremia vary depending on the cancer type and serum sodium cutoff point, hyponatremia may be seen in up to 46% of patients hospitalized in cancer centers.
    Conclusions: Onconephrology is a developing field and the themes arising from this meeting indicate a need for greater collaboration between oncologists and nephrologists. Educational symposia and onconephrology fellowship programs may allow for improved cancer care for patients with kidney disease.
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2765462-X
    ISSN 2054-3581
    ISSN 2054-3581
    DOI 10.1177/2054358120962589
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