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Article ; Online: 20 Years of Shaping Molecular Biology.

Pham, John / Plosky, Brian / Evans, Allyson / Tsai, Miao-Chih / Neuman, Nicole / Sollier, Julie

2018 Volume 71, Issue 3, Page(s) 363

MeSH term(s)	Humans ; Molecular Biology/trends ; Research/trends ; Research Design
Language	English
Publishing date	2018-08-03
Publishing country	United States
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2018.07.021
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Article ; Online: Inducible lncRNA transgenic mice reveal continual role of

Ma, Qing / Yang, Liuyi / Tolentino, Karen / Wang, Guiping / Zhao, Yang / Litzenburger, Ulrike M / Shi, Quanming / Zhu, Lin / Yang, Chen / Jiao, Huiyuan / Zhang, Feng / Li, Rui / Tsai, Miao-Chih / Chen, Jun-An / Lai, Ian / Zeng, Hong / Li, Lingjie / Chang, Howard Y

eLife

2022 Volume 11

Abstract: ... ...

Abstract	HOTAIR
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Chromatin ; Gene Expression Regulation ; Gene Expression Regulation, Neoplastic ; Mice, Transgenic ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Lung Neoplasms/secondary
Chemical Substances	Chromatin ; RNA, Long Noncoding ; HOTAIR long untranslated RNA, human
Language	English
Publishing date	2022-12-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.79126
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Article: The Epidemiology, Management and Therapeutic Outcomes of Subdural Empyema in Neonates with Acute Bacterial Meningitis.

Lee, Wei-Ju / Tsai, Ming-Horng / Hsu, Jen-Fu / Chu, Shih-Ming / Chen, Chih-Chen / Yang, Peng-Hong / Huang, Hsuan-Rong / Chi, Miao-Ching / Lee, Chiang-Wen / Ou-Yang, Mei-Chen

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13040377
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Article ; Online: Long intergenic noncoding RNAs: new links in cancer progression.

Tsai, Miao-Chih / Spitale, Robert C / Chang, Howard Y

Cancer research

2011 Volume 71, Issue 1, Page(s) 3–7

Abstract: The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs ( ... ...

Abstract	The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.
MeSH term(s)	Disease Progression ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; RNA, Untranslated/genetics
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2011-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-10-2483
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Article ; Online: Investigating causal relationships between extensive peripheral immune cell phenotypes and preeclampsia: A bi-directional Mendelian randomization analysis.

Liao, Chung-Chih / Ku, Ju-Chun / Lin, Cheng-Li / Li, Ju-Wan / Tsai, Fuu-Jen / Li, Jung-Miao

American journal of reproductive immunology (New York, N.Y. : 1989)

2024 Volume 91, Issue 4, Page(s) e13840

Abstract: Problem: Preeclampsia, a multifaceted condition during pregnancy characterized by hypertension and organ dysfunction, poses significant risks to both maternal and fetal health. This study aims to investigate the bidirectional causal relationship between ...

Abstract	Problem: Preeclampsia, a multifaceted condition during pregnancy characterized by hypertension and organ dysfunction, poses significant risks to both maternal and fetal health. This study aims to investigate the bidirectional causal relationship between peripheral immune cell phenotypes and preeclampsia using a two-sample Mendelian randomization (MR) approach. Method of study: Genetic data from two sizable cohorts were utilized: 3757 individuals from Sardinia, providing information on 731 immune traits, and 200 929 Finnish adult females, encompassing 6663 preeclampsia cases. Single-nucleotide polymorphisms served as instrumental variables. The MR analyses employed the inverse variance-weighted (IVW) method as the primary tool, supplemented by MR-Egger, weighted median, and weighted mode methods to enhance reliability and address potential heterogeneity and horizontal pleiotropy. Results: Among the 731 immune cell phenotypes studied, 18 displayed a suggestive positive association (IVW p < .05) with heightened preeclampsia risk, while 20 exhibited a suggestive negative association linked to reduced risk. Following false discovery rate (FDR) adjustment, four immune phenotypes showed significant associations with decreased preeclampsia risk: CD27 on CD24+ CD27+ B cells (B-cell panel) (odds ratio [OR] = 0.927, P Conclusions: This study provides quantifiable evidence linking specific immune cell phenotypes to the risk of developing preeclampsia. This novel understanding of the immunological aspects underlying preeclampsia's pathogenesis could lead to innovative therapeutic strategies centered on immune modulation.
MeSH term(s)	Adult ; Female ; Pregnancy ; Humans ; Pre-Eclampsia/genetics ; Mendelian Randomization Analysis ; Reproducibility of Results ; Hypertension ; Phenotype
Language	English
Publishing date	2024-04-01
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	604542-x
ISSN	1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
ISSN (online)	1600-0897
ISSN	0271-7352 ; 8755-8920 ; 1046-7408
DOI	10.1111/aji.13840
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Article ; Online: RNA templating the epigenome: long noncoding RNAs as molecular scaffolds.

Spitale, Robert C / Tsai, Miao-Chih / Chang, Howard Y

Epigenetics

2011 Volume 6, Issue 5, Page(s) 539–543

Abstract: Cellular pathways must be synergized, controlled and organized to manage homeostasis. To achieve high selectivity within the crowded cellular milieu the cell utilizes scaffolding complexes whose role is to bring molecules in proximity thereby controlling ...

Abstract	Cellular pathways must be synergized, controlled and organized to manage homeostasis. To achieve high selectivity within the crowded cellular milieu the cell utilizes scaffolding complexes whose role is to bring molecules in proximity thereby controlling and enhancing intermolecular interactions and signaling events. To date, scaffolds have been shown to be composed of proteinaceous units; however, recent evidence has supported the idea that non-coding RNAs may also play a similar role. In this point of view article we discuss recent data on ncRNA scaffolds, with particular focus on ncRNA HOTAIR. Using our current knowledge of signaling networks we discuss the role that RNA may play in writing and regulating histone modifications and the information needed for correct gene expression. Further, we speculate on additional, yet undiscovered roles that ncRNAs may be playing as molecular scaffolds.
MeSH term(s)	Chromatin/genetics ; Epigenomics ; Gene Expression Regulation ; Histones/genetics ; Histones/metabolism ; Polycomb-Group Proteins ; RNA/genetics ; RNA/metabolism ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism ; Repressor Proteins/genetics ; Signal Transduction/genetics
Chemical Substances	Chromatin ; Histones ; Polycomb-Group Proteins ; RNA, Untranslated ; Repressor Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2011-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.4161/epi.6.5.15221
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Article: Microtubules are involved in anterior-posterior axis formation in C. elegans embryos.

Tsai, Miao-Chih / Ahringer, Julie

The Journal of cell biology

2007 Volume 179, Issue 3, Page(s) 397–402

Abstract: Microtubules deliver positional signals and are required for establishing polarity in many different organisms and cell types. In Caenorhabditis elegans embryos, posterior polarity is induced by an unknown centrosome-dependent signal. Whether ... ...

Abstract	Microtubules deliver positional signals and are required for establishing polarity in many different organisms and cell types. In Caenorhabditis elegans embryos, posterior polarity is induced by an unknown centrosome-dependent signal. Whether microtubules are involved in this signaling process has been the subject of controversy. Although early studies supported such an involvement (O'Connell, K.F., K.N. Maxwell, and J.G. White. 2000. Dev. Biol. 222:55-70; Wallenfang, M.R., and G. Seydoux. 2000. Nature. 408:89-92; Hamill, D.R., A.F. Severson, J.C. Carter, and B. Bowerman. 2002. Dev. Cell. 3:673-684), recent work involving RNA interference knockdown of tubulin led to the conclusion that centrosomes induce polarity independently of microtubules (Cowan, C.R., and A.A. Hyman. 2004. Nature. 431:92-96; Sonneville, R., and P. Gonczy. 2004. Development. 131: 3527-3543). In this study, we investigate the consequences of tubulin knockdown on polarity signaling. We find that tubulin depletion delays polarity induction relative to wild type and that polarity only occurs when a small, late-growing microtubule aster is visible at the centrosome. We also show that the process of a normal meiosis produces a microtubule-dependent polarity signal and that the relative levels of anterior and posterior PAR (partitioning defective) polarity proteins influence the response to polarity signaling. Our results support a role for microtubules in the induction of embryonic polarity in C. elegans.
MeSH term(s)	Animals ; Caenorhabditis elegans/physiology ; Cell Polarity/physiology ; Centrosome/metabolism ; Centrosome/ultrastructure ; Fertilization ; Gene Expression Regulation, Developmental ; Microscopy, Fluorescence ; Microscopy, Video ; Microtubules/chemistry ; Microtubules/metabolism ; Microtubules/physiology ; Models, Biological ; RNA Interference ; Signal Transduction ; Sperm-Ovum Interactions ; Tubulin/chemistry ; Zygote/physiology
Chemical Substances	Tubulin
Language	English
Publishing date	2007-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.200708101
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Article ; Online: Suspension Trapping-Based Sample Preparation Workflow for In-Depth Plant Phosphoproteomics.

Chen, Chin-Wen / Tsai, Chia-Feng / Lin, Miao-Hsia / Lin, Shu-Yu / Hsu, Chuan-Chih

Analytical chemistry

2023 Volume 95, Issue 33, Page(s) 12232–12239

Abstract: Plant phosphoproteomics provides a global view of phosphorylation-mediated signaling in plants; however, it demands high-throughput methods with sensitive detection and accurate quantification. Despite the widespread use of protein precipitation for ... ...

Abstract	Plant phosphoproteomics provides a global view of phosphorylation-mediated signaling in plants; however, it demands high-throughput methods with sensitive detection and accurate quantification. Despite the widespread use of protein precipitation for removing contaminants and improving sample purity, it limits the sensitivity and throughput of plant phosphoproteomic analysis. The multiple handling steps involved in protein precipitation lead to sample loss and process variability. Herein, we developed an approach based on suspension trapping (S-Trap), termed tandem S-Trap-IMAC (immobilized metal ion affinity chromatography), by integrating an S-Trap micro-column with a Fe-IMAC tip. Compared with a precipitation-based workflow, the tandem S-Trap-IMAC method deepened the coverage of the Arabidopsis (
MeSH term(s)	Arabidopsis/metabolism ; Workflow ; Chromatography, Affinity/methods ; Phosphopeptides/chemistry ; Phosphorylation
Chemical Substances	Phosphopeptides
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c00786
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Article ; Online: Acupuncture Is Effective at Reducing the Risk of Stroke in Patients with Migraines: A Real-World, Large-Scale Cohort Study with 19-Years of Follow-Up.

Liao, Chung-Chih / Chien, Chi-Hsien / Shih, Ying-Hsiu / Tsai, Fuu-Jen / Li, Jung-Miao

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: Migraines are common headache disorders and risk factors for subsequent strokes. Acupuncture has been widely used in the treatment of migraines; however, few studies have examined whether its use reduces the risk of strokes in migraineurs. This study ... ...

Abstract	Migraines are common headache disorders and risk factors for subsequent strokes. Acupuncture has been widely used in the treatment of migraines; however, few studies have examined whether its use reduces the risk of strokes in migraineurs. This study explored the long-term effects of acupuncture treatment on stroke risk in migraineurs using national real-world data. We collected new migraine patients from the Taiwan National Health Insurance Research Database (NHIRD) from 1 January 2000 to 31 December 2017. Using 1:1 propensity-score matching, we assigned patients to either an acupuncture or non-acupuncture cohort and followed up until the end of 2018. The incidence of stroke in the two cohorts was compared using the Cox proportional hazards regression analysis. Each cohort was composed of 1354 newly diagnosed migraineurs with similar baseline characteristics. Compared with the non-acupuncture cohort, the acupuncture cohort had a significantly reduced risk of stroke (adjusted hazard ratio, 0.4; 95% confidence interval, 0.35-0.46). The Kaplan-Meier model showed a significantly lower cumulative incidence of stroke in migraine patients who received acupuncture during the 19-year follow-up (log-rank test,
MeSH term(s)	Humans ; Cohort Studies ; Follow-Up Studies ; Stroke/epidemiology ; Stroke/prevention & control ; Stroke/etiology ; Acupuncture Therapy/adverse effects ; Risk Factors ; Proportional Hazards Models ; Migraine Disorders/epidemiology ; Migraine Disorders/therapy ; Migraine Disorders/complications ; Taiwan/epidemiology ; Incidence ; Retrospective Studies
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20031690
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Article ; Online: Tumor suppression by the histone demethylase UTX.

Tsai, Miao-Chih / Wang, Jordon K / Chang, Howard Y

Cell cycle (Georgetown, Tex.)

2010 Volume 9, Issue 11, Page(s) 2043–2044

MeSH term(s)	Animals ; Drosophila ; Drosophila Proteins/metabolism ; G1 Phase ; Gene Expression Regulation, Neoplastic ; Histone Demethylases/metabolism ; Histones/metabolism ; Humans ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Methylation ; Neoplasms/metabolism ; Neoplasms/pathology ; Nuclear Proteins/metabolism ; Oxidoreductases, N-Demethylating/metabolism ; Retinoblastoma Binding Proteins/metabolism ; Retinoblastoma Protein/metabolism ; S Phase
Chemical Substances	Drosophila Proteins ; Histones ; Nuclear Proteins ; Retinoblastoma Binding Proteins ; Retinoblastoma Protein ; Histone Demethylases (EC 1.14.11.-) ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; KDM6A protein, human (EC 1.14.11.-) ; Oxidoreductases, N-Demethylating (EC 1.5.-) ; UTX protein, Drosophila (EC 1.5.-)
Language	English
Publishing date	2010-06-01
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.9.11.11845
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