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Article ; Online: Acid and Glutathione Dual-Responsive, Injectable and Self-Healing Hydrogels for Controlled Drug Delivery.

Zhu, Benshun / Zong, Tong / Zheng, Ruifu / Chen, Xing / Zhou, Yakun / Liu, Yuandong / Yan, Jinhao / Zhao, Bingjie / Yin, Jun

Biomacromolecules

2024 Volume 25, Issue 3, Page(s) 1838–1849

Abstract: Considering the complexity of physiological microenvironments and the risks of surgical infection, there still remains critical demand to develop a hydrogel as a drug release platform with multifunctional properties, including good neutral stability and ... ...

Abstract	Considering the complexity of physiological microenvironments and the risks of surgical infection, there still remains critical demand to develop a hydrogel as a drug release platform with multifunctional properties, including good neutral stability and sensitive multiple stimuli-responsive behaviors, as well as injectable and self-healing properties. Herein, we present a facile preparation of injectable, self-healing hydrogels with acid and glutathione (GSH) dual-responsiveness for controlled drug delivery. Initially, the anticancer drug camptothecin (CPT) was premodified with disulfide bonds and attached to poly(ethylenimine) (PEI) via the Schiff base reaction, resulting in PEI-CPT. Subsequently, OSA-IR780 was synthesized through the Schiff base reaction involving IR780 with amine groups (IR780-NH
MeSH term(s)	Hydrogels/chemistry ; Schiff Bases ; Drug Delivery Systems ; Antineoplastic Agents ; Glutathione/metabolism ; Drug Liberation
Chemical Substances	Hydrogels ; Schiff Bases ; Antineoplastic Agents ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c01274
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: [Retracted] IL‑33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF‑κB pathways.

Yin, Honglei / Li, Peicheng / Hu, Fudong / Wang, Yakun / Chai, Xiaoyan / Zhang, Yan

Molecular medicine reports

2022 Volume 26, Issue 6

Abstract: An interested reader of an article published in the ... ...

Abstract	An interested reader of an article published in the journal
Language	English
Publishing date	2022-10-05
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2022.12868
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Correction: Liu et al. The EFP Formation and Penetration Capability of Double-Layer Shaped Charge with Wave Shaper.

Liu, Yakun / Yin, Jianping / Wang, Zhijun / Zhang, Xuepeng / Bi, Guangjian

Materials (Basel, Switzerland)

2021 Volume 14, Issue 9

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2021-04-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14092210
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: N-Coordinated Cu-Ni Dual-Single-Atom Catalyst for Highly Selective Electrocatalytic Reduction of Nitrate to Ammonia.

Wang, Yunlong / Yin, Haibo / Dong, Feng / Zhao, Xiaoguang / Qu, Yakun / Wang, Lixin / Peng, Yue / Wang, Dingsheng / Fang, Wei / Li, Junhua

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 20, Page(s) e2207695

Abstract: As a traditional method of ammonia ( ... ...

Abstract	As a traditional method of ammonia (NH
Language	English
Publishing date	2023-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202207695
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Article: Application of vagus nerve stimulation on the rehabilitation of upper limb dysfunction after stroke: a systematic review and meta-analysis.

Wang, Xu / Ding, Qixin / Li, Tianshu / Li, Wanyue / Yin, Jialin / Li, Yakun / Li, Yuefang / Zhuang, Weisheng

Frontiers in neurology

2023 Volume 14, Page(s) 1189034

Abstract: Objective: This study aimed to elucidate the efficacy, safety, and long-term implications of vagus nerve stimulation (VNS) as a viable therapeutic option for patients with upper limb dysfunction following a stroke.: Methods: Data from the following ... ...

Abstract	Objective: This study aimed to elucidate the efficacy, safety, and long-term implications of vagus nerve stimulation (VNS) as a viable therapeutic option for patients with upper limb dysfunction following a stroke. Methods: Data from the following libraries were searched from inception to December 2022: PubMed, Wanfang, Scopus, China Science and Technology Journal Database, Embase, Web of Science, China Biology Medicine Disc, Cochrane Library, and China National Knowledge Infrastructure. Outcomes included indicators of upper limb motor function, indicators of prognosis, and indicators of safety (incidence of adverse events [AEs] and serious AEs [SAEs]). Two of the authors extracted the data independently. A third researcher arbitrated when disputes occurred. The quality of each eligible study was evaluated using the Cochrane Risk of Bias tool. Meta-analysis and bias analysis were performed using Stata (version 16.0) and RevMan (version 5.3). Results: Ten trials (VNS combined with rehabilitation group vs. no or sham VNS combined with rehabilitation group) with 335 patients were included in the meta-analysis. Regarding upper extremity motor function, based on Fugl-Meyer assessment scores, VNS combined with other treatment options had immediate (mean difference [MD] = 2.82, 95% confidence interval [CI] = 1.78-3.91, Conclusion: VNS is an effective and safe treatment for upper extremity motor dysfunction after a stroke. For the functional restoration of the upper extremities, noninvasive integrated therapy and lower-frequency VNS may be more effective. In the future, further high-quality studies with larger study populations, more comprehensive indicators, and thorough data are required to advance the clinical application of VNS. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42023399820.
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1189034
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Article: The EFP Formation and Penetration Capability of Double-Layer Shaped Charge with Wave Shaper.

Liu, Yakun / Yin, Jianping / Wang, Zhijun / Zhang, Xuepeng / Bi, Guangjian

Materials (Basel, Switzerland)

2020 Volume 13, Issue 20

Abstract: Detonation waves will bypass a wave shaper and propagate in the form of a horn wave in shaped charge. Horn waves can reduce the incidence angle of a detonation wave on a liner surface and collide with each other at the charge axis to form overdriven ... ...

Abstract	Detonation waves will bypass a wave shaper and propagate in the form of a horn wave in shaped charge. Horn waves can reduce the incidence angle of a detonation wave on a liner surface and collide with each other at the charge axis to form overdriven detonation. Detection electronic components of small-caliber terminal sensitive projectile that are limited by space are often placed inside a wave shaper, which will cause the wave shaper to no longer be uniform and dense, and weaken the ability to adjust detonation waves. In this article, we design a double-layer shaped charge (DLSC) with a high-detonation-velocity explosive in the outer layer and low-detonation-velocity explosive in the inner layer. Numerical and experimental simulation are combined to compare and analyze the forming process and penetration performance of explosively formed projectile (EFP) in DLSC and ordinary shaped charge (OSC). The results show that, compared with OSC, DLSC can also adjust and optimize the shape of the detonation wave when the wave shaper performance is poor. DLSC can obtain long rod EFPs with a large length-diameter ratio, which greatly improves the penetration performance of EFP.
Language	English
Publishing date	2020-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13204519
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Article: Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.

Ren, Yakun / Zhao, Hao / Yin, Chunyan / Lan, Xi / Wu, Litao / Du, Xiaojuan / Griffiths, Helen R / Gao, Dan

Frontiers in endocrinology

2022 Volume 13, Page(s) 873699

Abstract: Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases. Inflammation in ATs is characterized by macrophage infiltration and the ... ...

Abstract	Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases. Inflammation in ATs is characterized by macrophage infiltration and the activation of inflammatory pathways mediated by NF-κB, JNK, and NLRP3 inflammasomes. Adipokines, hepatokines and myokines - proteins secreted from AT, the liver and skeletal muscle play regulatory roles in AT inflammation
MeSH term(s)	Adipokines/metabolism ; Adipose Tissue/metabolism ; Cytokines/metabolism ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Obesity/complications ; Obesity/metabolism ; Retinol-Binding Proteins, Plasma/metabolism
Chemical Substances	Adipokines ; Cytokines ; RBP4 protein, human ; Retinol-Binding Proteins, Plasma
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.873699
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Article ; Online: Research on the Dynamic Characteristics of Mechanical Seal under Different Extrusion Fault Degrees

Yin Luo / Yakun Fan / Yuejiang Han / Weqi Zhang / Emmanuel Acheaw

Processes, Vol 8, Iss 1057, p

2020 Volume 1057

Abstract: In order to explore the dynamic characteristics of the mechanical seal under different fault degrees, this paper selected the upstream pumping mechanical seal as the object of study. The research established the rotating ring-fluid film-stationary ring ... ...

Abstract	In order to explore the dynamic characteristics of the mechanical seal under different fault degrees, this paper selected the upstream pumping mechanical seal as the object of study. The research established the rotating ring-fluid film-stationary ring 3D model, which was built to analyze the fault mechanism. To study extrusion fault mechanism and characteristics, different dynamic parameters were used in the analysis process. Theoretical analysis, numerical simulation, and comparison were conducted to study the relationship between the fault degree and dynamic characteristics. It is the first time to research the dynamic characteristics of mechanical seals in the specific extrusion fault. This paper proved feasibility and effectiveness of the new analysis method. The fluid film thickness and dynamic characteristics could reflect the degree of the extrusion fault. Results show that the fluid film pressure fluctuation tends to be more intensive under the serious extrusion fault condition. The extrusion fault is more likely to occur when the fluid film thickness is too large or too small. Results illustrate the opening force is affected with the fluid film lubrication status and seal extrusion fault degrees. The fluid film stiffness would not always increase with the rotating speed growth. The seal fault would occur with the increasing of rotating speeds, and the leakage growth fluctuations could reflect the fault degree.
Keywords	mechanical seal ; dynamic characteristics ; extrusion fault ; numerical simulation ; sealing performance ; fluent ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parallel-Inception CNN Approach for Facial sEMG based Silent Speech Recognition.

Wu, Jinghan / Zhao, Tao / Zhang, Yakun / Xie, Liang / Yan, Ye / Yin, Erwei

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 554–557

Abstract: With the purpose of providing an external human-machine interaction platform for the elderly in need, a novel facial surface electromyography based silent speech recognition system was developed. In this study, we propose a deep learning architecture ... ...

Abstract	With the purpose of providing an external human-machine interaction platform for the elderly in need, a novel facial surface electromyography based silent speech recognition system was developed. In this study, we propose a deep learning architecture named Parallel-Inception Convolutional Neural Network (PICNN), and employ up-to-date feature extraction method log Mel frequency spectral coefficients (MFSC). To better meet the requirements of our target users, a 100-class dataset containing daily life-related demands was designed and generated for the comparative experiments. According to experimental results, the highest recognition accuracy of 88.44% was achieved by proposed recognition framework based on MFSC and PICNN, exceeding the performance of state-of-the-art deep learning algorithms such as CNN, VGGNet and Inception CNN (3.22%, 4.09% and 1.19%, respectively). These findings suggest that the newly developed silent speech approach holds promise to provide a more reliable communication channel, and the application scenery of speech recognition technology has been expanded at the same time.
MeSH term(s)	Aged ; Algorithms ; Electromyography ; Humans ; Neural Networks, Computer ; Speech ; Speech Perception
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630373
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Article ; Online: Long non-coding RNA CASC15 promotes melanoma progression by epigenetically regulating PDCD4

Yakun Yin / Bin Zhao / Dongqin Li / Guangwen Yin

Cell & Bioscience, Vol 8, Iss 1, Pp 1-

2018 Volume 13

Abstract: Abstract Background Long non-coding RNAs (LncRNAs) have been identified as critical regulators in a variety of cancer types. Cancer susceptibility candidate 15 (CASC15), a lncRNA located at chromosome 6p22.3, has been discovered to participate in ... ...

Abstract	Abstract Background Long non-coding RNAs (LncRNAs) have been identified as critical regulators in a variety of cancer types. Cancer susceptibility candidate 15 (CASC15), a lncRNA located at chromosome 6p22.3, has been discovered to participate in melanoma progression and phenotype switching. Nevertheless, the roles and molecular mechanisms of CASC15 in melanoma are far from being understood. Results We found that CASC15 expression was up-regulated in melanoma tissues and associated with advanced pathological stages. Function experiments displayed that CASC15 knockdown hindered proliferation, facilitated apoptosis and suppressed invasion, while CASC15 overexpression facilitated proliferation and invasion in melanoma cells. Further mechanistic analysis showed that CASC15 epigenetically silenced the expression of programmed cell death 4 (PDCD4) by recruiting EZH2 and increasing H3K27me3 level at the promoter region of PDCD4. Additionally, PDCD4 overexpression inhibited proliferation, enhanced apoptosis and decreased invasion of melanoma cells. Moreover, CASC15-knockdown-induced anti-cancer effects were abated by PDCD4 down-regulation. Furthermore, depletion of CASC15 blocked tumor growth of melanoma by up-regulating PDCD4 in vivo. Conclusions CASC15 acts as an oncogene by negatively regulating PDCD4 expression via recruiting EZH2 and subsequently increasing H3K27me3 level. Together, our study indicates that CASC15/EZH2/PDCD4 may serve as a promising therapeutic target for melanoma intervention.
Keywords	Melanoma ; LncRNA ; CASC15 ; PDCD4 ; EZH2 ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	570
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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